Primate sanctuaries across Africa play a pivotal role in the rescue and rehabilitation of confiscated and rescued wild primates, many of whom have had extensive contact with humans prior to their arrival and throughou...Primate sanctuaries across Africa play a pivotal role in the rescue and rehabilitation of confiscated and rescued wild primates, many of whom have had extensive contact with humans prior to their arrival and throughout the rehabilitation process, heightening the risk of disease transmission. While tuberculosis is not naturally occurring in free-living chimpanzees, it has been extensively observed in captive primates that have been in close proximity to humans or other captive primates infected with Mycobacterium tuberculosis. This case report delves into an outbreak of extra-pulmonary tuberculosis among juvenile chimpanzees within a sanctuary, detailing the associated diagnostic challenges and treatment approaches. The five cases had close contact with a caregiver infected with tuberculosis, subsequently transmitting the infection to other in-contact chimpanzees. Prolonged treatment, employing the human protocol of quadri-therapy (rifampicin, isoniazid, pyrazinamide, and ethambutol), followed by bi-therapy (rifampicin and isoniazid), resulted in complete resolution for all five cases. These cases underscore the critical importance of maintaining high levels of biosecurity, implementing effective quarantine measures, and adhering to strict hygiene practices when working with non-human primates.展开更多
Hepatitis C virus(HCV) infection is characterized by a high propensity for development of life-long viral persistence. An estimated 170 million people suffer from chronic hepatitis caused by HCV. Currently,there is no...Hepatitis C virus(HCV) infection is characterized by a high propensity for development of life-long viral persistence. An estimated 170 million people suffer from chronic hepatitis caused by HCV. Currently,there is no approved prophylactic HCV vaccine available.With the near disappearance of the most relevant animal model for HCV,the chimpanzee,we review the progression that has been made regarding prophylactic vaccine development against HCV. We describe the results of the individual vaccine evaluation experiments in chimpanzees,in relation to what has been observed in humans. The results of the different studies indicate that partial protection against infection can be achieved,but a clear correlate of protection has thus far not yet been defined.展开更多
The metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. The quantitati...The metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. The quantitative extent of urinary and fecal elimination was similar in both species. The rats excreted 16.5% ofthedosein urine and 1.7% in feces. For chimpanzees the respective values were 14.8 and 1.2%. Experiments with rats demonstrated that the major route of elimination was by exhalation. With a total elimination via the lungs of 72.6%, rats expired 10.3% of the dose as unchanged 1-NP. Five polar metabolites were isolated from the urine of chimpanzees. The two major metabolites were identified as 3-hydroxypropionic acid and 7V-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide (NMPA). Both substances were also excreted in rat urine. The two identified metabolites indicate that 1-NP was degraded to propionic acid, part of which was modified to 3-hydroxypropionic acid or NMPA. A hypothetical pathway for the biochemical generation of NMPA is suggested.(c)1989 Academic Press, Inc.展开更多
One hundred and eighteen (118) tree species were identified, among which 58 species produced fruit within the two-year study. Fruit of only 26.3% of the latter is eaten by chimpanzees. The consumption of each of these...One hundred and eighteen (118) tree species were identified, among which 58 species produced fruit within the two-year study. Fruit of only 26.3% of the latter is eaten by chimpanzees. The consumption of each of these fruits was generally low, with only two species constituting more than 25% consumption. Only about 1.7% of woody biomass is relied upon by chimpanzees in Kalinzu for food. The major tree species in chimpanzee diet monitored showed that fruit production varies monthly and seasonally. Apart from Musanga leo-errerae and Ficus spp. whose fruiting was consistent throughout the year, general fruit phenology was positively correlated with rainfall. Only three species namely: Craterispermum laurinum, Aframomum angustifolium and Beilschmiedia ugandensis produced fruit in the dry seasons. Correlation between fruit availability and consumption was significantly positive for only one species, Landlophia dawei. This indicated that frugivory of chimpanzees in Kalinzu was not opportunistic;they search for what they like to eat. Chimpanzees would have to range furthest in periods of scarcity and asynchronous fruiting hence a lot of energy expenditure in the food search alone. Therefore, diversity in fruit phenology is important for chimpanzees’ energy conservation, health and survival. Selective logging and other selective human activities that involve cutting down trees that are palatable would in future affect the food diversity and consequently the health of frugivores if not done sustainably. Since patterns of fruit phenology are also linked to patterns of rainfall, changes in the former can assist in predicting the influence of climate change on food availability for big frugivores like chimpanzees.展开更多
This study determined the influence of nutritional fruit content on their consumption by chimpanzees in Kalinzu forest. Fruits consumption frequencies were obtained from analysis of chimpanzee faecal samples picked ov...This study determined the influence of nutritional fruit content on their consumption by chimpanzees in Kalinzu forest. Fruits consumption frequencies were obtained from analysis of chimpanzee faecal samples picked over a period of two years. Fruit content was analyzed using freeze dried fresh samples using standard techniques. Musanga leo-errerae (76.14%), Ficus spp (66.05%) and (18.68%) were the most commonly eaten fruits of all faecal samples (N = 2683). Generally, fruit consumption increased for fruits with total phenols and tannins below 1% per gram except for Musanga leo-errerae, Uvariopsis congoensis and Aframomum angustifolium. Multiple regression revealed that of the 15 nutrient parameters investigated, only calcium, tannins, crude fat, protein and energy content of the fruits that constitute the major food components for basic animal body needs and functioning of energy, body building and a healthy skeleton significantly predicted 76.86% of consumption (R2 = 76.86%;P = 0.019). However, the fact that some of the most eaten fruits like Aframomum angustifolium and Musanga leo-errerae were recorded to have the highest amounts in tannins shows that there must be additional factors into play. Other than fruit availability, consideration of effect of fruit size and handling within the existing models of chimpanzees’ diet could hence enhance further the understanding of fruit consumption.展开更多
Can we teach a chimpanzee a language?Different researchers have different opinions.R.A.Gardner and B.T.Gardner,Terrace,and Rumbaugh and Savage-Rumbaugh raised chimpanzees Washoe,NeamChimsky(Nim),and Lana respectively ...Can we teach a chimpanzee a language?Different researchers have different opinions.R.A.Gardner and B.T.Gardner,Terrace,and Rumbaugh and Savage-Rumbaugh raised chimpanzees Washoe,NeamChimsky(Nim),and Lana respectively and tried to teach a language to them.R.A.Gardner and B.T.Gardner’s study is well designed by choosing and teaching Washoe America Sign Language(ASL).However,ASL is only used in a small number of people;therefore,even the chimp can master it,the result is not representative enough to include all major human languages.Also,using limitation as a training method is successful and a surprising result is obtained:Washoe was claimed to perform delayed imitation.One result claimed by R.A.Gardner and B.T.Gardner is that Washoe showed motive for communication,which is not convincing.However,other results of Washoe’s abilities of“vocabulary”,“differentiation”,and“transfer”seem convincing because they could be explained by its understanding that the sign can represent meanings.The methodology of Terrace’s study seems more rigorous.The aim of his study is to explore whether apes can create sentences by analysing Nim’s combinations of signs and their differences with that of children.The analysis of results of sign combinations is not convincing.However,what is convincing is that the results show huge differences between Nim’s and children’s utterances.In terms of methodology,the training methods in Rumbaugh’s study seem to have no big difference from R.A.Gardner and B.T.Gardner’s and Terrace’s.In terms of the results,Lana was claimed to perform communication with companions.Another result of the experiment is that Lana was claimed to master the ability to use names.展开更多
Increasing our understanding of primate gestural communication can provide new insights into language evolution.A key question in primate communication is the association between the social relationships of primates a...Increasing our understanding of primate gestural communication can provide new insights into language evolution.A key question in primate communication is the association between the social relationships of primates and their repertoire of gestures.Such analyses can reveal how primates use their repertoire of gestural communication to maintain their networks of family and friends,much as humans use language to maintain their social networks.In this study we examined the association between the repertoire of gestures(overall,manual and bodily gestures,and gestures of different modalities)and social bonds(presence of reciprocated grooming),coordinated behaviors(travel,resting,co-feeding),and the complexity of ecology(e.g.noise,illumination)and sociality(party size,audience),in wild East African chimpanzees(Pan troglodytes schweinfurthii).A larger repertoire size of manual,visual gestures was associated with the presence of a relationship based on reciprocated grooming and increases in social complexity.A smaller repertoire of manual tactile gestures occurred when the relationship was based on reciprocated grooming.A smaller repertoire of bodily gestures occurred between partners who jointly traveled for longer.Whereas gesture repertoire size was associated with social complexity,complex ecology also influenced repertoire size.The evolution of a large repertoire of manual,visual gestures may have been a key factor that enabled larger social groups to emerge during evolution.Thus,the evolution of the larger brains in hominins may have co-occurred with an increase in the cognitive complexity underpinning gestural communication and this,in turn,may have enabled hominins to live in more complex social groups.展开更多
SARS-CoV-2 infection is a global public health threat.Vaccines are considered amongst the most important tools to control the SARS-CoV-2 pandemic.As expected,deaths from SARS-CoV-2 infection have dropped dramatically ...SARS-CoV-2 infection is a global public health threat.Vaccines are considered amongst the most important tools to control the SARS-CoV-2 pandemic.As expected,deaths from SARS-CoV-2 infection have dropped dramatically with widespread vaccination.However,there are concerns over the duration of vaccine-induced protection,as well as their effectiveness against emerging variants of concern.Here,we constructed a recombinant chimpanzee adenovirus vectored vaccine expressing the full-length spike of SARS-CoV-2(Ad C68-S).Rapid and high levels of humoral and cellular immune responses were observed after immunization of C57BL/6J mice with one or two doses of Ad C68-S.Notably,neutralizing antibodies were observed up to at least six months after vaccination,without substantial decline.Single or double doses Ad C68-S immunization resulted in lower viral loads in lungs of mice against SARS-CoV-2 challenge both in the short term(21 days)and long-term(6 months).Histopathological examination of Ad C68-S immunized mice lungs showed mild histological abnormalities after SARS-CoV-2 infection.Taken together,this study demonstrates the efficacy and durability of the Ad C68-S vaccine and constitutes a promising candidate for clinical evaluation.展开更多
The discovery of Paranthropus deyiremeda in 3.3 - 3.5 million-year-old fossil sites in Afar, together with 30% of the gorilla genome showing lineage sorting between humans and chimpanzees, and a NUMT (“nuclear mitoch...The discovery of Paranthropus deyiremeda in 3.3 - 3.5 million-year-old fossil sites in Afar, together with 30% of the gorilla genome showing lineage sorting between humans and chimpanzees, and a NUMT (“nuclear mitochondrial DNA segment”) on chromosome 5 that is shared by both gorillas, humans and chimpanzees, and shown to have diverged at the time of the Pan-Homo split rather than the Gorilla/Pan-Homo split, provides conclusive evidence that introgression from the gorilla lineage caused the Pan-Homo split, and the speciation of both the Australopithecus lineage and the Paranthropus lineage.展开更多
The paper studied the imperatives of health psychologists in the control and management of HIV/ AIDS. HIV/AIDS is a relatively new disease, but has caused more deaths than any other disease in human history, and there...The paper studied the imperatives of health psychologists in the control and management of HIV/ AIDS. HIV/AIDS is a relatively new disease, but has caused more deaths than any other disease in human history, and there is no known cure yet. Even though, HIV/AIDS is a death sentence, experts agreed that early detection, and early commencement of treatment may prolong the life of the patients, and that early detection may prevent or reduce the transmission of the virus. Early detection, commencement of treatment, and compliance with medical advice are the responsibilities of the health psychologist. This paper therefore, concludes that health psychologist is indispensable in effective control, and management of HIV/AIDS, and so recommends that awareness be created on the roles of health psychologists in this regard, through health education.展开更多
Virtual simulated environments provide multiple ways of testing cognitive function and evaluatingproblem solving with humans (e.g., Woollett et al. 2009). The use of such interactive technologyhas increasingly becom...Virtual simulated environments provide multiple ways of testing cognitive function and evaluatingproblem solving with humans (e.g., Woollett et al. 2009). The use of such interactive technologyhas increasingly become an essential part of modern life (e.g., autonomously driving vehicles, glo-bal positioning systems (GPS), and touchscreen computers; Chinn and Fairlie 2007; Brown 2011).While many nonhuman animals have their own forms of technology, such as chimpanzees whocreate and use tools, in captive animal environments the opportunity to actively participate withinteractive technology is not often made available. Exceptions can be found in some state-of-the-art zoos and laboratory facilities (e.g., Mallavarapu and Kuhar 2005). When interactive technologyis available, captive animals often selectively choose to engage with it. This enhances the animal'ssense of control over their immediate surroundings (e.g., Clay et al. 2011; Ackerman 2012). Suchself-efficacy may help to fulfill basic requirements in a species' daily activities using problem solv-ing that can involve foraging and other goal-oriented behaviors. It also assists in fulfilling thestrong underlying motivation for contrafreeloading and exploration expressed behaviorally bymany species in captivity (Young 1999). Moreover, being able to present nonhuman primates vir-tual reality environments under experimental conditions provides the opportunity to gain insightinto their navigational abilities and spatial cognition. It allows for insight into the generation andapplication of internal mental representations of landmarks and environments under multiple con-ditions (e.g., small- and large-scale space) and subsequent spatial behavior. This paper reviewsmethods using virtual reality developed to investigate the spatial cognitive abilities of nonhumanprimates, and great apes in particular, in comparison with that of humans of multiple age groups.We make recommendations about training, best practices, and also pitfalls to avoid.展开更多
Both observational and indirect evidence are widely used to determine the diets of wild animals.Direct observations are often assumed to provide the most comprehensive reflection of diet,but many wild animals are logi...Both observational and indirect evidence are widely used to determine the diets of wild animals.Direct observations are often assumed to provide the most comprehensive reflection of diet,but many wild animals are logistically challenging to observe.Despite the regular use of observa-tional and indirect methods for inferring diet in wild animals,they have rarely been compared in detail for the same study population.Over 12 months this study assessed the congruence of methods in estimating the diet of a montane community of eastern chimpanzees Pan troglodytes schweinfurthii in Nyungwe National Park,Rwanda using observational scan samples and macro-scopic fecal inspection.The assessment of the number of food species consumed each month was comparable between methods,but the estimation of the composition of items in the diet differed significantly.Most notably,the fecal samples significantly underestimated the consumption of flowers,and certain fruit species,which based on direct behavioral observations were seasonally consumed at very high rates.Conversely,direct observations underestimated the consumption of leaves and pith in comparison to results present in the fecal samples.These results suggest that combining methods where possible is most useful for accurate monitoring of dietary trends,particularly for species that experience significant seasonal shifts in their diet.展开更多
文摘Primate sanctuaries across Africa play a pivotal role in the rescue and rehabilitation of confiscated and rescued wild primates, many of whom have had extensive contact with humans prior to their arrival and throughout the rehabilitation process, heightening the risk of disease transmission. While tuberculosis is not naturally occurring in free-living chimpanzees, it has been extensively observed in captive primates that have been in close proximity to humans or other captive primates infected with Mycobacterium tuberculosis. This case report delves into an outbreak of extra-pulmonary tuberculosis among juvenile chimpanzees within a sanctuary, detailing the associated diagnostic challenges and treatment approaches. The five cases had close contact with a caregiver infected with tuberculosis, subsequently transmitting the infection to other in-contact chimpanzees. Prolonged treatment, employing the human protocol of quadri-therapy (rifampicin, isoniazid, pyrazinamide, and ethambutol), followed by bi-therapy (rifampicin and isoniazid), resulted in complete resolution for all five cases. These cases underscore the critical importance of maintaining high levels of biosecurity, implementing effective quarantine measures, and adhering to strict hygiene practices when working with non-human primates.
基金Supported by In part the Fifth framework program from the EU,No.BIO-CT98-0357,QLK2-CT-1999-00356 and ERC2008-Ad G-233130-HEPCENT(Verstrepen BE)by the Virgo consortium,funded by the Dutch government project,No.FES0908(Boonstra A)
文摘Hepatitis C virus(HCV) infection is characterized by a high propensity for development of life-long viral persistence. An estimated 170 million people suffer from chronic hepatitis caused by HCV. Currently,there is no approved prophylactic HCV vaccine available.With the near disappearance of the most relevant animal model for HCV,the chimpanzee,we review the progression that has been made regarding prophylactic vaccine development against HCV. We describe the results of the individual vaccine evaluation experiments in chimpanzees,in relation to what has been observed in humans. The results of the different studies indicate that partial protection against infection can be achieved,but a clear correlate of protection has thus far not yet been defined.
文摘The metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. The quantitative extent of urinary and fecal elimination was similar in both species. The rats excreted 16.5% ofthedosein urine and 1.7% in feces. For chimpanzees the respective values were 14.8 and 1.2%. Experiments with rats demonstrated that the major route of elimination was by exhalation. With a total elimination via the lungs of 72.6%, rats expired 10.3% of the dose as unchanged 1-NP. Five polar metabolites were isolated from the urine of chimpanzees. The two major metabolites were identified as 3-hydroxypropionic acid and 7V-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide (NMPA). Both substances were also excreted in rat urine. The two identified metabolites indicate that 1-NP was degraded to propionic acid, part of which was modified to 3-hydroxypropionic acid or NMPA. A hypothetical pathway for the biochemical generation of NMPA is suggested.(c)1989 Academic Press, Inc.
文摘One hundred and eighteen (118) tree species were identified, among which 58 species produced fruit within the two-year study. Fruit of only 26.3% of the latter is eaten by chimpanzees. The consumption of each of these fruits was generally low, with only two species constituting more than 25% consumption. Only about 1.7% of woody biomass is relied upon by chimpanzees in Kalinzu for food. The major tree species in chimpanzee diet monitored showed that fruit production varies monthly and seasonally. Apart from Musanga leo-errerae and Ficus spp. whose fruiting was consistent throughout the year, general fruit phenology was positively correlated with rainfall. Only three species namely: Craterispermum laurinum, Aframomum angustifolium and Beilschmiedia ugandensis produced fruit in the dry seasons. Correlation between fruit availability and consumption was significantly positive for only one species, Landlophia dawei. This indicated that frugivory of chimpanzees in Kalinzu was not opportunistic;they search for what they like to eat. Chimpanzees would have to range furthest in periods of scarcity and asynchronous fruiting hence a lot of energy expenditure in the food search alone. Therefore, diversity in fruit phenology is important for chimpanzees’ energy conservation, health and survival. Selective logging and other selective human activities that involve cutting down trees that are palatable would in future affect the food diversity and consequently the health of frugivores if not done sustainably. Since patterns of fruit phenology are also linked to patterns of rainfall, changes in the former can assist in predicting the influence of climate change on food availability for big frugivores like chimpanzees.
文摘This study determined the influence of nutritional fruit content on their consumption by chimpanzees in Kalinzu forest. Fruits consumption frequencies were obtained from analysis of chimpanzee faecal samples picked over a period of two years. Fruit content was analyzed using freeze dried fresh samples using standard techniques. Musanga leo-errerae (76.14%), Ficus spp (66.05%) and (18.68%) were the most commonly eaten fruits of all faecal samples (N = 2683). Generally, fruit consumption increased for fruits with total phenols and tannins below 1% per gram except for Musanga leo-errerae, Uvariopsis congoensis and Aframomum angustifolium. Multiple regression revealed that of the 15 nutrient parameters investigated, only calcium, tannins, crude fat, protein and energy content of the fruits that constitute the major food components for basic animal body needs and functioning of energy, body building and a healthy skeleton significantly predicted 76.86% of consumption (R2 = 76.86%;P = 0.019). However, the fact that some of the most eaten fruits like Aframomum angustifolium and Musanga leo-errerae were recorded to have the highest amounts in tannins shows that there must be additional factors into play. Other than fruit availability, consideration of effect of fruit size and handling within the existing models of chimpanzees’ diet could hence enhance further the understanding of fruit consumption.
文摘Can we teach a chimpanzee a language?Different researchers have different opinions.R.A.Gardner and B.T.Gardner,Terrace,and Rumbaugh and Savage-Rumbaugh raised chimpanzees Washoe,NeamChimsky(Nim),and Lana respectively and tried to teach a language to them.R.A.Gardner and B.T.Gardner’s study is well designed by choosing and teaching Washoe America Sign Language(ASL).However,ASL is only used in a small number of people;therefore,even the chimp can master it,the result is not representative enough to include all major human languages.Also,using limitation as a training method is successful and a surprising result is obtained:Washoe was claimed to perform delayed imitation.One result claimed by R.A.Gardner and B.T.Gardner is that Washoe showed motive for communication,which is not convincing.However,other results of Washoe’s abilities of“vocabulary”,“differentiation”,and“transfer”seem convincing because they could be explained by its understanding that the sign can represent meanings.The methodology of Terrace’s study seems more rigorous.The aim of his study is to explore whether apes can create sentences by analysing Nim’s combinations of signs and their differences with that of children.The analysis of results of sign combinations is not convincing.However,what is convincing is that the results show huge differences between Nim’s and children’s utterances.In terms of methodology,the training methods in Rumbaugh’s study seem to have no big difference from R.A.Gardner and B.T.Gardner’s and Terrace’s.In terms of the results,Lana was claimed to perform communication with companions.Another result of the experiment is that Lana was claimed to master the ability to use names.
基金the Economic and Social Research Council,UK,and National Science Centre,Poland,Grant Number:UMO-2018/31/D/NZ8/01144(‘Understanding origins of social brains and communication in wild primates’).
文摘Increasing our understanding of primate gestural communication can provide new insights into language evolution.A key question in primate communication is the association between the social relationships of primates and their repertoire of gestures.Such analyses can reveal how primates use their repertoire of gestural communication to maintain their networks of family and friends,much as humans use language to maintain their social networks.In this study we examined the association between the repertoire of gestures(overall,manual and bodily gestures,and gestures of different modalities)and social bonds(presence of reciprocated grooming),coordinated behaviors(travel,resting,co-feeding),and the complexity of ecology(e.g.noise,illumination)and sociality(party size,audience),in wild East African chimpanzees(Pan troglodytes schweinfurthii).A larger repertoire size of manual,visual gestures was associated with the presence of a relationship based on reciprocated grooming and increases in social complexity.A smaller repertoire of manual tactile gestures occurred when the relationship was based on reciprocated grooming.A smaller repertoire of bodily gestures occurred between partners who jointly traveled for longer.Whereas gesture repertoire size was associated with social complexity,complex ecology also influenced repertoire size.The evolution of a large repertoire of manual,visual gestures may have been a key factor that enabled larger social groups to emerge during evolution.Thus,the evolution of the larger brains in hominins may have co-occurred with an increase in the cognitive complexity underpinning gestural communication and this,in turn,may have enabled hominins to live in more complex social groups.
基金the National Natural Science Foundation of China(No.32070933 to J.M.Lan and Y.F.Yao)the Natural Science Foundation of Shanghai(No.20ZR1463900 to J.M.Lan)+3 种基金financially the STS regional key project(KFJ-STS-QYZD-2021-12-001 to Z.M.Yuan and C.Shan)from Chinese Academy of SciencesNational Key R&D Program of China 2021YFE0201900 to C.Shan and 2021YFC0863300 to Z.M.Yuan and C.Shanthe National Key R&D Program of China(No.2021YFC0863400)funding from Institut Pasteur,Fondation Merieux and the Chinese Academy of Sciences to G.W。
文摘SARS-CoV-2 infection is a global public health threat.Vaccines are considered amongst the most important tools to control the SARS-CoV-2 pandemic.As expected,deaths from SARS-CoV-2 infection have dropped dramatically with widespread vaccination.However,there are concerns over the duration of vaccine-induced protection,as well as their effectiveness against emerging variants of concern.Here,we constructed a recombinant chimpanzee adenovirus vectored vaccine expressing the full-length spike of SARS-CoV-2(Ad C68-S).Rapid and high levels of humoral and cellular immune responses were observed after immunization of C57BL/6J mice with one or two doses of Ad C68-S.Notably,neutralizing antibodies were observed up to at least six months after vaccination,without substantial decline.Single or double doses Ad C68-S immunization resulted in lower viral loads in lungs of mice against SARS-CoV-2 challenge both in the short term(21 days)and long-term(6 months).Histopathological examination of Ad C68-S immunized mice lungs showed mild histological abnormalities after SARS-CoV-2 infection.Taken together,this study demonstrates the efficacy and durability of the Ad C68-S vaccine and constitutes a promising candidate for clinical evaluation.
文摘The discovery of Paranthropus deyiremeda in 3.3 - 3.5 million-year-old fossil sites in Afar, together with 30% of the gorilla genome showing lineage sorting between humans and chimpanzees, and a NUMT (“nuclear mitochondrial DNA segment”) on chromosome 5 that is shared by both gorillas, humans and chimpanzees, and shown to have diverged at the time of the Pan-Homo split rather than the Gorilla/Pan-Homo split, provides conclusive evidence that introgression from the gorilla lineage caused the Pan-Homo split, and the speciation of both the Australopithecus lineage and the Paranthropus lineage.
文摘The paper studied the imperatives of health psychologists in the control and management of HIV/ AIDS. HIV/AIDS is a relatively new disease, but has caused more deaths than any other disease in human history, and there is no known cure yet. Even though, HIV/AIDS is a death sentence, experts agreed that early detection, and early commencement of treatment may prolong the life of the patients, and that early detection may prevent or reduce the transmission of the virus. Early detection, commencement of treatment, and compliance with medical advice are the responsibilities of the health psychologist. This paper therefore, concludes that health psychologist is indispensable in effective control, and management of HIV/AIDS, and so recommends that awareness be created on the roles of health psychologists in this regard, through health education.
文摘Virtual simulated environments provide multiple ways of testing cognitive function and evaluatingproblem solving with humans (e.g., Woollett et al. 2009). The use of such interactive technologyhas increasingly become an essential part of modern life (e.g., autonomously driving vehicles, glo-bal positioning systems (GPS), and touchscreen computers; Chinn and Fairlie 2007; Brown 2011).While many nonhuman animals have their own forms of technology, such as chimpanzees whocreate and use tools, in captive animal environments the opportunity to actively participate withinteractive technology is not often made available. Exceptions can be found in some state-of-the-art zoos and laboratory facilities (e.g., Mallavarapu and Kuhar 2005). When interactive technologyis available, captive animals often selectively choose to engage with it. This enhances the animal'ssense of control over their immediate surroundings (e.g., Clay et al. 2011; Ackerman 2012). Suchself-efficacy may help to fulfill basic requirements in a species' daily activities using problem solv-ing that can involve foraging and other goal-oriented behaviors. It also assists in fulfilling thestrong underlying motivation for contrafreeloading and exploration expressed behaviorally bymany species in captivity (Young 1999). Moreover, being able to present nonhuman primates vir-tual reality environments under experimental conditions provides the opportunity to gain insightinto their navigational abilities and spatial cognition. It allows for insight into the generation andapplication of internal mental representations of landmarks and environments under multiple con-ditions (e.g., small- and large-scale space) and subsequent spatial behavior. This paper reviewsmethods using virtual reality developed to investigate the spatial cognitive abilities of nonhumanprimates, and great apes in particular, in comparison with that of humans of multiple age groups.We make recommendations about training, best practices, and also pitfalls to avoid.
基金the University of Western Australia,UWA Postgraduate Student Association and Baslcr Stiftung fiir Biologischc Forschung(Switzerland).
文摘Both observational and indirect evidence are widely used to determine the diets of wild animals.Direct observations are often assumed to provide the most comprehensive reflection of diet,but many wild animals are logistically challenging to observe.Despite the regular use of observa-tional and indirect methods for inferring diet in wild animals,they have rarely been compared in detail for the same study population.Over 12 months this study assessed the congruence of methods in estimating the diet of a montane community of eastern chimpanzees Pan troglodytes schweinfurthii in Nyungwe National Park,Rwanda using observational scan samples and macro-scopic fecal inspection.The assessment of the number of food species consumed each month was comparable between methods,but the estimation of the composition of items in the diet differed significantly.Most notably,the fecal samples significantly underestimated the consumption of flowers,and certain fruit species,which based on direct behavioral observations were seasonally consumed at very high rates.Conversely,direct observations underestimated the consumption of leaves and pith in comparison to results present in the fecal samples.These results suggest that combining methods where possible is most useful for accurate monitoring of dietary trends,particularly for species that experience significant seasonal shifts in their diet.