Changes in trace substances in human metabolites, which are related to disease processes and health status, can serve as chemical markers for disease diagnosis and symptom monitoring. Real-time online detection is an ...Changes in trace substances in human metabolites, which are related to disease processes and health status, can serve as chemical markers for disease diagnosis and symptom monitoring. Real-time online detection is an inevitable trend for the future of health monitoring, and the construction of chips for detection faces major challenges. The response of sensors often fails to meet the requirements for chipbased detection of trace substances due to the low efficiency of interfacial heterogeneous reactions, necessitating a rational design approach for micro-and nano-structures to improve sensor performance with respect to sensitivity and detection limits. This review focuses on the influence of micro-and nanostructures that used in chip on sensing. Firstly, this review categorizes sensors into chemiresistors, electrochemical sensors, fluorescence sensors, and surface enhanced Raman scattering(SERS) sensors based on their sensing principle, which have significant applications in disease diagnosis. Subsequently, commencing from the application requirements in the field of sensing, this review focuses on the different structures of nanoparticle(NP) assemblies, including wire, layered, core-shell, hollow, concave and deformable structures. These structures change in the size, shape, and morphology of conventional structures to achieve characteristics such as ordered alignment, high specific surface area, space limitation,vertical diffusion, and swaying behavior with fluid, thereby addressing issues such as poor signal transmission efficiency, inadequate adsorption and capture capacity, and slow mass transfer speed during sensing. Finally, the design direction of micro-and nano-structures, and possible obstacles and solutions to promote chip-based detection have been discussed. It is hope that this article will inspire the exploration of interface micro-and nano-structures modulated sensing methods.展开更多
Chip-based atom interferometers bring together the advantages of atom chips and Bose-Einstein condensates. Their central prerequisite is that a condensate can be coherently split into two halves with a determined rela...Chip-based atom interferometers bring together the advantages of atom chips and Bose-Einstein condensates. Their central prerequisite is that a condensate can be coherently split into two halves with a determined relative phase. This paper demonstrates the dynamical splitting and merging of an atom cloud with two U-wires on an atom chip. Symmetrical and asymmetrical splittings are realized by applying a bias field with different directions and magnitudes. The trajectories of the splitting are consistent with theoretical calculations. The atom chip is a good candidate for constructing an atom interferometer.展开更多
基金financially supported by the National Natural Science Foundation of China (No.21925405)。
文摘Changes in trace substances in human metabolites, which are related to disease processes and health status, can serve as chemical markers for disease diagnosis and symptom monitoring. Real-time online detection is an inevitable trend for the future of health monitoring, and the construction of chips for detection faces major challenges. The response of sensors often fails to meet the requirements for chipbased detection of trace substances due to the low efficiency of interfacial heterogeneous reactions, necessitating a rational design approach for micro-and nano-structures to improve sensor performance with respect to sensitivity and detection limits. This review focuses on the influence of micro-and nanostructures that used in chip on sensing. Firstly, this review categorizes sensors into chemiresistors, electrochemical sensors, fluorescence sensors, and surface enhanced Raman scattering(SERS) sensors based on their sensing principle, which have significant applications in disease diagnosis. Subsequently, commencing from the application requirements in the field of sensing, this review focuses on the different structures of nanoparticle(NP) assemblies, including wire, layered, core-shell, hollow, concave and deformable structures. These structures change in the size, shape, and morphology of conventional structures to achieve characteristics such as ordered alignment, high specific surface area, space limitation,vertical diffusion, and swaying behavior with fluid, thereby addressing issues such as poor signal transmission efficiency, inadequate adsorption and capture capacity, and slow mass transfer speed during sensing. Finally, the design direction of micro-and nano-structures, and possible obstacles and solutions to promote chip-based detection have been discussed. It is hope that this article will inspire the exploration of interface micro-and nano-structures modulated sensing methods.
基金Project supported by the State Key Basic Research Program of China (Grant No 2006CB921202)the National Natural Science Foundation of China (Grant No 10334050)
文摘Chip-based atom interferometers bring together the advantages of atom chips and Bose-Einstein condensates. Their central prerequisite is that a condensate can be coherently split into two halves with a determined relative phase. This paper demonstrates the dynamical splitting and merging of an atom cloud with two U-wires on an atom chip. Symmetrical and asymmetrical splittings are realized by applying a bias field with different directions and magnitudes. The trajectories of the splitting are consistent with theoretical calculations. The atom chip is a good candidate for constructing an atom interferometer.
