A novel copper（Ⅱ） complex based on chiral amino-alcohol derived Schiff base ligand,[Cu_4（R-L）_4（H_2O）_2]·（CH_3COOH）_2·（H_2O）（1,（R）-H_2 L =（R）-3-phenyl-2-（2-hydroxy-3-methoxybenzylideneamino...A novel copper（Ⅱ） complex based on chiral amino-alcohol derived Schiff base ligand,[Cu_4（R-L）_4（H_2O）_2]·（CH_3COOH）_2·（H_2O）（1,（R）-H_2 L =（R）-3-phenyl-2-（2-hydroxy-3-methoxybenzylideneamino） propane-1-ol）,was synthesized and characterized by EA,IR,UV-Vis,ESI-MS,circular dichroism spectra and single-crystal X-ray diffraction.Complex 1 crystallizes in orthorhombic,space group Ρ2_12_12 with a = 15.7660（14）,b = 49.526（3）,c = 10.4213（9） A,V = 8137.2（12） A^3,Ζ = 4,C_（72）H_（81）Cu_4N_4O_（19）,Mr = 1560.57,μ = 1.096 mm^-1,F（000） = 3244,Flack = 0.06（3）,the final R = 0.0924 and w R = 0.2451（I 〉 2σ（I）） for 41108 observed reflections.The interactions of the complex with calf thymus DNA（CT-DNA） were investigated by some spectroscopic technique methods.The results show the complex exhibits strong binding with CT-DNA.In addition,in vitro cytotoxicity test of 1 towards four kinds of human cancerous cell lines（He La,HL-60,Caco-2 and A549） showed substantial cytotoxic activity.The experimental investigations indicated that the chirality of complex 1 play an important role in cytotoxicity and interactions with DNA.展开更多
基金supported by the Natural Science Foundation of Shandong Province(No.ZR2013BM017)the Natural Science Foundation of China(No.21105042)
文摘A novel copper（Ⅱ） complex based on chiral amino-alcohol derived Schiff base ligand,[Cu_4（R-L）_4（H_2O）_2]·（CH_3COOH）_2·（H_2O）（1,（R）-H_2 L =（R）-3-phenyl-2-（2-hydroxy-3-methoxybenzylideneamino） propane-1-ol）,was synthesized and characterized by EA,IR,UV-Vis,ESI-MS,circular dichroism spectra and single-crystal X-ray diffraction.Complex 1 crystallizes in orthorhombic,space group Ρ2_12_12 with a = 15.7660（14）,b = 49.526（3）,c = 10.4213（9） A,V = 8137.2（12） A^3,Ζ = 4,C_（72）H_（81）Cu_4N_4O_（19）,Mr = 1560.57,μ = 1.096 mm^-1,F（000） = 3244,Flack = 0.06（3）,the final R = 0.0924 and w R = 0.2451（I 〉 2σ（I）） for 41108 observed reflections.The interactions of the complex with calf thymus DNA（CT-DNA） were investigated by some spectroscopic technique methods.The results show the complex exhibits strong binding with CT-DNA.In addition,in vitro cytotoxicity test of 1 towards four kinds of human cancerous cell lines（He La,HL-60,Caco-2 and A549） showed substantial cytotoxic activity.The experimental investigations indicated that the chirality of complex 1 play an important role in cytotoxicity and interactions with DNA.
