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Effect of Single-walled Carbon Nanotubes on Cellulose Phenylcarbamate Chiral Stationary Phases 被引量:9
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作者 CHANG Yin-xia REN Chao-xing +1 位作者 RUAN Qiong YUAN Li-ming 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2007年第6期646-649,共4页
Single-walled carbon nanotubes(SWNTs) have a high adsorption ability and nanoscale interactions. Cellulose trisphenylcarbamates possess high enantioseparation ability in high-performance liquid chromatography(HPLC... Single-walled carbon nanotubes(SWNTs) have a high adsorption ability and nanoscale interactions. Cellulose trisphenylcarbamates possess high enantioseparation ability in high-performance liquid chromatography(HPLC). Single-walled carbon nanotubes mixed with cellulose trisphenylcarbamate are coated on the silica gel as chiral stationary phases and higher enantioseparation factors are obtained. After a single-walled carbon nanotube is linked to the 6-pesition of cellulose 2,3-bisphenylcarbamate, its enantioseparation resolution increases compared to that of the cellulose trisphenylcarbamate. It is the first time that SWNTs have been applied to enantioseparation. The results indicate that the single-walled carbon nanotubes are good promoters of chiral recognition. This method can be used to improve the enantioseparation efficiency of the polysaccharide chiral stationary phases. 展开更多
关键词 Single-walled carbon nanotube Cellulose 2 3-bisphenylcarbamate-6-SWNT Cellulose trisphenylcarbamate chiral stationary phase High-performance liquid chromatography
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Glucose,cellobiose,lactose and raffinose used as chiral stationary phases in HPLC 被引量:4
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作者 Jian Yu Wang Feng Zhao Mei Zhang Ya Peng Li Ming Yuan 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第10期1248-1251,共4页
This paper presents the enantioseparation using glucose, cellobiose, lactose and raffinose as chiral selector bonded to silica gel via an arm in HPLC. Surprisingly, they also possess high enantioseparation selectivity... This paper presents the enantioseparation using glucose, cellobiose, lactose and raffinose as chiral selector bonded to silica gel via an arm in HPLC. Surprisingly, they also possess high enantioseparation selectivity, may be used in normal-phase and reversed- phase mode, and there is a big chiral discriminating complementary. This work indicates that oligosaccharides could soon become very attractive as a new class of chiral stationary phase for HPLC. 展开更多
关键词 OLIGOSACCHARIDES chiral stationary phase HPLC
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Synthesis of novel chiral stationary phases for high-performance liquid chromatography 被引量:3
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作者 Xu Lin Tan Shi Cong Hou Qing Hua Bian Min Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第4期461-464,共4页
Three novel chiral selectors 4a-c were synthesized from (S)-amino acids and (R)-1-phenyl-2-(4-methylphenyl)ethylamine. 4a-c were connected to 3-aminopropylsilanized silica gel to be used as the chiral stationary... Three novel chiral selectors 4a-c were synthesized from (S)-amino acids and (R)-1-phenyl-2-(4-methylphenyl)ethylamine. 4a-c were connected to 3-aminopropylsilanized silica gel to be used as the chiral stationary phase for HPLC. Five amino acid derivatives and two pyrethroid insecticides were fairly resolved on these three new chiral stationary phases under normal phase condition. 展开更多
关键词 ENANTIOSEPARATION chiral stationary phase Amino acid derivatives Pyrethroid insecticides
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Preparation of new hybrid organic/inorganic polymeric chiral stationary phases for ligand-exchange chromatography 被引量:2
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作者 Rui Juan Song Yu Fu +2 位作者 Na Yao Yuan De Long Tian Bao Huang 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第10期1250-1252,共3页
Three new hybrid organic/inorganic polymeric ligand-exchange chiral stationary phases were developed by radical chain transfer reaction and surface grafting on silica gel, and successfully used for the enantioseparati... Three new hybrid organic/inorganic polymeric ligand-exchange chiral stationary phases were developed by radical chain transfer reaction and surface grafting on silica gel, and successfully used for the enantioseparations of DL-amino acids and DL-hydroxyl adds. The resolutions were achieved by using water containing 2.0 × 10^-4 mol/L of CuAc2 as a mobile phase, column temperature of 40 ℃, flow rate of 1.0 mL/min and detection at UV 254 nm. The elution order of D-isomer before L-isomer was observed for all DL-amino acids resolved except DL-Pro. 展开更多
关键词 chiral stationary phase Ligand-exchange chromatography DL-Hydroxyl acid Surface grafting DL-Amino acid
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Modification of Chiral Stationary Phases with L-Proline as a Selector for Ligand-exchange Chromatography via Introducing Hydrophobic Groups 被引量:1
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作者 SHI Hong-yu ZHANG Hai-zhu +1 位作者 LONG Yuan-de HUANG Tian-bao 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2009年第6期822-826,共5页
Three chiral stationary phases(CSPl, CSP2 and CSP3) for ligand-exchange chromatography were prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol groups on the surfa... Three chiral stationary phases(CSPl, CSP2 and CSP3) for ligand-exchange chromatography were prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol groups on the surface of silica gel, and then modifying the surface of silica gel with allyl glycidyl ether and alkenes through the hydrosilation reaction, and lastly introducing L-proline as a chiral selector. The enantiomer resolutions of 14 amino acids and 2 hydroxyl acids were completed on the CSPs by using an aqueous solution of Cu(Ac)2 as mobile phase at a flow rate of 1.0 mL/min and column temperature of 40 ℃ with detection at UV 254 nm. In terms of enantioseleetivity a, column efficiency and resolution Rs, the chromatographic behaviors of the analytes on the CSPs were discussed via comparing them to those on the CSP4 prepared via the reference method. The results show that enantioselectivity a, column efficiency and resolution Rs of the analytes on the CSPs could be improved by using the above modifying method. 展开更多
关键词 Ligand exchange chromatography chiral stationary phase ENANTIOSEPARATION Amino acid Hydroxyl acid
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Comparison of different polysaccharide-based chiral stationary phases for enantioselective resolution of Naftopidil and its derivatives by HPLC
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作者 刘夏雯 袁牧 季红 《Journal of Chinese Pharmaceutical Sciences》 CAS 2010年第4期293-299,共7页
Effective enantioseparation of Naftopidil and its derivatives by HPLC was accomplished using several different polysaccharide-based chiral stationary phases(CSPs).In normal-phase mode,the compounds were eluted on fo... Effective enantioseparation of Naftopidil and its derivatives by HPLC was accomplished using several different polysaccharide-based chiral stationary phases(CSPs).In normal-phase mode,the compounds were eluted on four coated-and two immobilized-columns with the mixture of n-hexane,isopropanol and diethylamine(DEA).Polysaccharide tris(3,5- dimethylphenyl carbamate) was shown to be the best enantiomer selector.In addition,the immobilized column packed with Chiralpak IA or IB was applied under polar-organic and reversed-phase conditions,both of which exhibited excellent enantioselectivity for Naftopidil and its derivatives.Furthermore,the underlying possible chiral recognition mechanisms were discussed. 展开更多
关键词 Polysaccharide-based chiral stationary phases Enantioselective separation Naftopidil and its derivatives
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Separation of substituted phenylpiperazine derivatives with immobilized polysaccharide-based chiral stationary phases by supercritical and subcritical fluid chromatography
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作者 黄珺珺 袁牧 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2013年第3期244-251,共8页
Six newly synthesized racemic 1-(substituted phenyl)-4-[3-(indole-4-yl-oxy)-2-hydroxypropyl]-piperazine 1-6 were successfully resolved by carbon dioxide supercritical fluid chromatography (SFC) on an analytical ... Six newly synthesized racemic 1-(substituted phenyl)-4-[3-(indole-4-yl-oxy)-2-hydroxypropyl]-piperazine 1-6 were successfully resolved by carbon dioxide supercritical fluid chromatography (SFC) on an analytical scale column packed with immobilized polysaccharide-based chiral stationary phases (CSPs). We found that separation on the Chiralpak IA CSP was superior to the other two immobilized CSPs (Chiralpak IB and Chiralpak IC), and isopropanol (IPA) was a superior modifier compared to the other five solvents including ethanol, methanol, tetrahydrofuran, acetonitrile and dichloromethane. The effects of organic modifier composition, back pressure, and column temperature for enantioseparation of all six compounds were studied. Of the physical parameters studied, modifier composition had the greatest impact on retention. Changing temperature generally had less impact on retention but produced the greatest selectivity changes. The optimum condition was found as follows: Chiralpak IA column, column temperature 35 ~C, back pressure 120 bar, 35% IPA containing 0.1% diethylamine (v/v) in mobile phase, flow rate of mobile phase 3.0 mL/min, UV detection 283 nm. Separation of all six racemic compounds was completed within 10 rain and excellent resolution was obtained. Thus, SFC was found to be the methodology of choice for resolving the enantiomers of this class of compounds. 展开更多
关键词 Supercritical fluid chromatography Immobilized polysaccharide-based chiral stationary phases Enantiomerresolution Phenylpiperazine derivatives
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Enantiomer Separation of α-Dimethyl Dicarboxylate Biphenyl and Related Biphenyl Compounds by Normal Phase HPLC on Polysaccharide Based Chiral Stationary Phases 被引量:2
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作者 刘月启 韩小茜 +3 位作者 齐邦峰 柳春辉 李永民 陈立仁 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2002年第7期663-669,共7页
Cellulose tris(4-methylphenylcarbamate), amylosetris(3,5-di-methylphenylcarbamate) and amylose tris (phenylcarbamate) were prepared by the methodreported by Okamoto and were coated onto an aminopropylated mesoporous s... Cellulose tris(4-methylphenylcarbamate), amylosetris(3,5-di-methylphenylcarbamate) and amylose tris (phenylcarbamate) were prepared by the methodreported by Okamoto and were coated onto an aminopropylated mesoporous spherical silica gel. Thesefinal products were used as chiral stationary phases of high performance liquid chromatography forthe eighteen structurally related biphenyl compounds. The resolution was made using normal-phasemethodology with a mobile phase consisting of n-hexane-alcohol (ethanol, 1-propanol, 2-pro-panol or1-butanol). The effects of various aliphatic alcohols in the mobile phase were studied. Thestructural features of the solutes that influence then- k′ were discussed. A dominant effect oftrifluoroacetic acid on chiral separation of acidic solutes was noted. 展开更多
关键词 enantiomer separation HPLC chiral stationary phase α-dimethyldicarboxylate biphenyl and related biphenyl compounds
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Preparation and Enantioseparation Property of Chiral Stationary Phases Based on Cellulose Tris(3,5-dimethylbenzoate)——A New Way to Prepare Polysaccharide-coating Type Chiral Stationary Phases 被引量:1
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作者 Wei Chen Rong Duan +2 位作者 Qing-chun Fan 柏正武 黄少华 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2014年第4期458-466,共9页
A new method to prepare polysaccharide-coating type chiral stationary phases (CSPs) was developed in this work. As a typical example, naked silica gel was coated by cellulose, which was then derivatized with 3,5-dim... A new method to prepare polysaccharide-coating type chiral stationary phases (CSPs) was developed in this work. As a typical example, naked silica gel was coated by cellulose, which was then derivatized with 3,5-dimethylbenzoyl chloride to afford cellulose tris(3,5-dimethylbenzoate)-silica gel (CTDBS) complex. The silanols on CTDBS were end-capped with 3- aminopropyltriethoxysilane to obtain CSP 1. The amino groups on CSP 1 were further end-capped with 3,5-dimethylbenzoyl chloride to give CSP 2. The silanols on CTDBS were end-capped with methyltrimethoxysilane to yield CSP 3. CSPs 1-3 were characterized by FTIR, solid-state 13C-NMR and elemental analysis. The enantioseparation abilities of CSPs 1-3 were evaluated with structurally various chiral analytes. The enantioseparation results demonstrated that the end-capping moieties on CSPs 1 and 2 significantly affected enantioseparation. In addition, the effect of the structures of chiral analytes and end- capping moieties on the retention factors and the resolutions was discussed. 展开更多
关键词 Cellulose tris(3 5-dimethylbenzoate) chiral recognition chiral stationary phase High-performance liquidchromatography.
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Investigation of Peptoid Chiral Stationary Phases Terminated with N'-Substituted PhenyI-L-proline/leucine Amide
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作者 Wu Haibo Song Guangjun +1 位作者 Liang Xinmiao Ke Yanxiong 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第12期2791-2797,共7页
Eight peptoid chiral stationary phases (CSPs) terminated with N'substituted phenyl-L-proline or L-leucine amide were prepared and evaluated under normal phase mode. With 59 racemic analytes, we compared the enantio... Eight peptoid chiral stationary phases (CSPs) terminated with N'substituted phenyl-L-proline or L-leucine amide were prepared and evaluated under normal phase mode. With 59 racemic analytes, we compared the enantio- meric separations on CSPs terminated with p-methylphenyl, p-chlorophenyl and unsubstituted phenyl. For short peptoid selectors containing only one S-N-(1-phenylethyl) glycine (Nspe) unit, the terminal p-methyl substituent did not affect chiral recognition abilities significantly. In L-proline amide terminated CSPs, p-chloro substituent resulted in obviously inferior selectivity while in L-leucine amide terminated CSPs, it worked much better. Longer peptoid selectors containing two more Nspe units generally performed much better than the shorter ones, due to the great contributions of peptoid chain to chiral recognition. Meanwhile, the effects of the terminal substituent on selectivity were found changed on these CSPs. For CSPs terminated with L-leucine amide, the terminal p-chloro substituent in longer selector no longer produced the best recognition ability; the CSP with unsubstituted phenyl instead performed best. Comparison of these peptoid CSPs varied in terminal substituents and chain length was conducted to gain a better understanding of the chiral recognition mechanism of this type CSP and promote the development of more useful CSPs. 展开更多
关键词 chiral stationary phase PEPTOID enantiomeric separation proline amide leucine amide
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High performance liquid chromatographic separation of thirteen drugs collected in Chinese Pharmacopoeia 2010(Ch.P2010) on cellulose ramification chiral stationary phase 被引量:4
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作者 Ying Zhoua,b, Chao Maa, Yan Wanga, Qi-Ming Zhangb, Yi-Ying Zhanga, Jie Fua, Hong Gaoc, Li-Xun Zhaoc aState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China bNational Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China cInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China 《Journal of Pharmaceutical Analysis》 SCIE CAS 2012年第1期48-55,共8页
The enantiomers separation of thirteen drugs collected in Ch.P2010 was performed on chiral stationary phase of cellulose ramification (chiralpak OD and chiralpak OJ) by high performance liquid chromatographic (HPLC) m... The enantiomers separation of thirteen drugs collected in Ch.P2010 was performed on chiral stationary phase of cellulose ramification (chiralpak OD and chiralpak OJ) by high performance liquid chromatographic (HPLC) methods, which included ibuprofen (C1), ketoprofen (C2), nitrendipine (C3), nimodipine (C4), felodipine (C5), omeprazole (C6), praziquantel (C7), propranolol hydrochloride (C8), atenolol (C9), sulpiride (C10), clenbuterol hydrochloride (C11), verapamil hydrochloride (C12), and chlorphenamine maleate (C13). The mobile phase consisted of isopropanol and n-hexane. The detection wavelength was set at 254 nm and the fiow rate was 0.7 mL/min. The enantiomers separation of these thirteen racemates on chiralpak OD column and chiralpak OJ column was studied, while the effects of proportion of organic additives, alcohol displacer and temperature on the separation were studied. And the mechanism of some of racemates was discussed. The results indicated that thirteen chiral drugs could be separated onchiral stationary phase of cellulose ramification in normal phase chromatographic system. The chromatographic retention and resolution of enantiomers could be adjusted by factors including column temperature and the concentration of alcohol displacer and organic alkaline modifier in mobile phase. It was shown that the resolution was improved with reducing concentration of alcohol displacer. When concentration of organic alkaline modifier was 0.2% (v/v), the resolution and the peak shape were fairly good. Most racemates mentioned above had better resolution at column temperature of 25 1C. When racemates were separated, the temperature should be kept so as to obtain stable separation results. 展开更多
关键词 HPLC chiral stationary phase Optical enantiomers Cellulose ramification
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COVALENTLY BONDING CHIRAL POLYURETHANE ON AMINATED SILICA GEL:A NEW STRATEGY TO PREPARE CHIRAL STATIONARY PHASE FOR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY 被引量:2
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作者 柏正武 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2006年第2期107-114,共8页
Two polyurethanes of different molecular weights were prepared by the copolymerization of phenyl diisocyanate and diisopropyl tartrate. The polyurethanes having terminal isocyanate groups were reacted with 3-aminoprop... Two polyurethanes of different molecular weights were prepared by the copolymerization of phenyl diisocyanate and diisopropyl tartrate. The polyurethanes having terminal isocyanate groups were reacted with 3-aminopropyl silica gel to afford two chiral stationary phases. The M^- n of the two polyurethanes were 4057 g/mol and 6442 g/mol. The polyurethanes and the corresponding chiral stationary phases were characterized by FT-IR,^1 H NMR and elemental analysis. The loading capacities of the polyurethanes on silica gel were 0.68 mmol units/g and 0.61 mmol units/g, respectively. The separation performance and the influence of additives, triethylamine and trichloroacetic acid, on the separation of chiral compounds were investigated by HPLC. The chiral stationary phase prepared from polyurethane with M^- n of 4057 g/mol demonstrated better enantioseparation capability than that with M^- n of 6442 g/mol. Additionally, it was found that the addition of triethylamine and trichloroacetic acid in the mobile phases significantly improved the enantioseparation for these two chiral stationary phases. 展开更多
关键词 POLYURETHANE chiral stationary phase ENANTIOSEPARATION Additive HPLC
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Preparation and chiral recognitio of a novel chiral stationary phase for HPLC,based on mono(6~A-N-1-(2-hydroxyl)-phenylethylimino-6~A-deoxy)-β-cyclodextrin and covalently bonded silica gel 被引量:2
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作者 Xiao Ping Chen Zhi Ming Zhou Hao Yuan Zi Hui Meng 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第7期797-800,共4页
A novel chiral stationary phase (CSP) was prepared by immobilizing mono(6A-N-1-(2-hydroxyl)-phenylethylimino-6A- deoxy)-β-cyclodextrin onto the surface of silica gel via a longer spacer. This chiral stationary ... A novel chiral stationary phase (CSP) was prepared by immobilizing mono(6A-N-1-(2-hydroxyl)-phenylethylimino-6A- deoxy)-β-cyclodextrin onto the surface of silica gel via a longer spacer. This chiral stationary phase exhibited good enantioselectivity for a variety of chiral compounds under reversed-phase conditions. 展开更多
关键词 CYCLODEXTRIN Enandoseparation chiral stationary phase Ferrocene derivatives
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The Optical Resolution of Chiral Tetrahedrone-type Clusters Contai- ning SCoFeM (M=Mo or W) Using High Performance Liquid Chromatography Chiral Stationary Phase 被引量:2
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作者 Xiao Qian HAN Yong Min LI +2 位作者 Yu Hua ZHANG Sheng Xiang JIANG Li Ren CHEN 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第12期1193-1194,共2页
Amylose tris (phenylcarbamate) chiral stationary phase (ATPC-CSP) was prepared and used for optical resolution of clusters 1 and 2. n-Hexane/2-propanol ( 99/1; v/v) were found to be the most suitable mobile phase on ... Amylose tris (phenylcarbamate) chiral stationary phase (ATPC-CSP) was prepared and used for optical resolution of clusters 1 and 2. n-Hexane/2-propanol ( 99/1; v/v) were found to be the most suitable mobile phase on ATPC-CSP. 展开更多
关键词 Optical resolution amylose tris (phenylcarbamate) chiral stationary phase chiral tetrahedrone type cluster.
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MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography 被引量:1
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作者 Xiaodong Sun Bing Niu +1 位作者 Qi Zhang Qin Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第3期509-516,共8页
Homochiral metal-organic frameworks(MOFs)have attracted considerable attention in many fields of research,such as chiral catalysis and chiral chromatography.However,only few homochiral MOFs can be effectively used in ... Homochiral metal-organic frameworks(MOFs)have attracted considerable attention in many fields of research,such as chiral catalysis and chiral chromatography.However,only few homochiral MOFs can be effectively used in capillary electrochromatography(CEC)and their performances are far from adequate.In this study,we successfully synthesized achiral nanocrystalline MIL-53.A facile post-synthetic modification strategy was then implemented to functionalize the product,yielding a homochiral MOF:L-His-NH-MIL-53.This MOF was then employed as a chiral coating in open-tubular CEC mode(OT-CEC),and,as such,it exhibited high enantioselectivities for several racemic drugs.The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electron microscopy,scanning electron microscopy(with energy-dispersive X-ray spectrometry),Fourier-transform infrared spectroscopy,X-ray diffractometry,thermogravimetric analysis,circular dichroism spectroscopy,Brunauer-Emmett-Teller surface area measurements,and X-ray photoelectron spectroscopy.This study is expected to provide a new strategy for the design and establishment of MOF-based chiral OT-CEC systems. 展开更多
关键词 Homochiral MOF L-His-NH-MIL-53 chiral stationary phase Capillary electrochromatography ENANTIOSEPARATION
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Preparation of novel chiral stationary phase based on click chemistry for ligand exchange chromatography 被引量:1
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作者 Chun Mei Fu Hong Yu Shi +1 位作者 Guang Sheng Qian Zhang Wan Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第11期1345-1347,共3页
Click chemistry was applied to immobilize L-proline derivative onto azide-modified silica gel to give a novel chiral stationary phase (denoted as click-CSP) for ligand exchange chromatography. The developed protocol... Click chemistry was applied to immobilize L-proline derivative onto azide-modified silica gel to give a novel chiral stationary phase (denoted as click-CSP) for ligand exchange chromatography. The developed protocol combines the benefits of operational simplicity, exceptionally mild conditions and high surface loadings. The enantioselectivity α of some DL-arnino acids on the click- CSP were found to be in the range from 1.13 to 3.46. The chromatographic resolutions of some DL-amino acids and the stability study firmly illustrate the potential of click chemistry for preparation chiral stationary phase for ligand exchange chromatography. 展开更多
关键词 Click chemistry Ligand exchange chromatography chiral stationary phase vL-amino acids
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Molecular Imprinting of (R)-(+)-α-Methylbenzylamine for Chiral Stationary Phase 被引量:1
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作者 Zi Hui MENG Liang Mo ZHOU Qing Hai WANG and Dao Qian ZHU(Dalian Institute of Chewical Physics, Chinese Academy of Sciences, Dalian 116012) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第4期345-346,共2页
A new type of molecular imprinting stationary phase was prepared by using R- (+)-α -methylbenzy lamine as the print molecule. Experiments of high performance liquid chromatography show that the new stationary phase h... A new type of molecular imprinting stationary phase was prepared by using R- (+)-α -methylbenzy lamine as the print molecule. Experiments of high performance liquid chromatography show that the new stationary phase has high enantio-selectivity and discriminates (R, S) -(± )- α -methylbenzylamine successful ly with α value of 1. 67 展开更多
关键词 AIBN Methylbenzylamine for chiral stationary Phase Molecular Imprinting of
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Two Side Chain β-CD Polysiloxanes Used as New Stationary Phase for Chiral Separation by HRGC 被引量:1
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作者 Han Bang ZHANG Yun LING +1 位作者 Ruo Nong FU Yu Xiu WEN(Department of Chemical Engineering. Beijing Institute of Technology. Beijing 100081) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第2期165-166,共2页
Two new stationary phases : (Ⅰ) [bikis(2,6-di-O-pentyl-3-O-hex-6O-pentyl-3-O-methyl)-β-CD-polysiloxane] and (Ⅱ) [heptkis(2,6-di-O-methyl-3-O-hex-6-enyl)-β-CD-polysiloxane] were synthesized and successfully used fo... Two new stationary phases : (Ⅰ) [bikis(2,6-di-O-pentyl-3-O-hex-6O-pentyl-3-O-methyl)-β-CD-polysiloxane] and (Ⅱ) [heptkis(2,6-di-O-methyl-3-O-hex-6-enyl)-β-CD-polysiloxane] were synthesized and successfully used for GC separation of chiral isomers.The possess high column efficiency and exhibit fine chiral separation ability. 展开更多
关键词 HRGC CD Polysiloxanes Used as New stationary Phase for chiral Separation by HRGC Two Side Chain
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Comparative Optical Separation of Racemic Ibuprofen by Using Chiral Stationary Phase
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作者 Dalkeun PARK +3 位作者 Joong Kee LEE 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2002年第6期681-685,共5页
Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-()-enantiomer is not only inactive but also has ... Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-()-enantiomer is not only inactive but also has many side effects. Thus it is necessary to separate R-enantiomer from racemic ibuprofen. We studied optical separation of racemic Ibuprofen with chiral high performance liquid chromatography (HPLC). Out of three different chiral stationary phases, which were selected on the basis of structure and availability, two were found to be ef-fective. There was optimum eluent composition for each stationary phase for good resolution in optical separation. Resolution decreased with increase of eluent flow rate, but effect of injection volume on resolution was insignificant at high eluent flow rate. 展开更多
关键词 IBUPROFEN ENANTIOMER separation high performance liquid chromatography chiral stationary phase
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Comparison of the performance of chiral stationary phase for separation of fluoxetine enantiomers
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作者 ZHOU Jie ZHOU Jie +2 位作者 YANG Yi-wen WEI Feng WU Ping-dong 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第1期56-59,共4页
Separation of fluoxetine enantiomers on five chiral stationary phases (chiralcel OD-H, chiralcel OJ-H, chiralpak AD-H, cyclobond 1 2000 DM and kromasil CHI-TBB) was investigated. The optimal mobile phase composition... Separation of fluoxetine enantiomers on five chiral stationary phases (chiralcel OD-H, chiralcel OJ-H, chiralpak AD-H, cyclobond 1 2000 DM and kromasil CHI-TBB) was investigated. The optimal mobile phase compositions of fluoxetine separation on each column were hexane/isopropanol/diethyl amine (98/2/0.2, v/v/v), hexane/isopropanol/diethyl amine (99/1/0. l, v/v/v), hexane/isopropanol/diethyl amine (98/2/0.2, v/v/v), methanol/0.2% triethylamine acetic acid (TEAA) (25/75, v/v; pH 3.8) and hexane/isopropanol/diethyl amine (98/2/0.2, v/v/v), respectively. Experimental results demonstrated that baseline separation (Rs〉1.5) of fluoxetine enantiomers was obtained on chiralcel OD-H, chiralpak AD-H, and cyclobond I 2000 DM while the best separation was obtained on the last one. The eluate orders of fluoxetine enantiomers on the columns were determined. The first eluate by chiralcel OJ-H and kromasil CHI-TBB is the S-enantiomer, while by chiralpak AD-H and cyclobond 12000 DM is the R-enantiomer. 展开更多
关键词 FLUOXETINE chiral stationary phase Enantiomeric separation High performance liquid chromatography (HPLC)
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