The saccharide-based chiral bifunctional thiourea-phosphines were developed as chiral organocatalysts for the intramolecular Morita-Baylis-Hillman reaction of o^-formyl-enones. With only 2 tool% of thiourea-phosphine ...The saccharide-based chiral bifunctional thiourea-phosphines were developed as chiral organocatalysts for the intramolecular Morita-Baylis-Hillman reaction of o^-formyl-enones. With only 2 tool% of thiourea-phosphine cata- lyst 3c, chiral functionalized cyclohexenes were achieved under mild reaction conditions with excellent yields and enantioselectivities.展开更多
A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from（1R,3S）-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to b...A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from（1R,3S）-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.展开更多
文摘The saccharide-based chiral bifunctional thiourea-phosphines were developed as chiral organocatalysts for the intramolecular Morita-Baylis-Hillman reaction of o^-formyl-enones. With only 2 tool% of thiourea-phosphine cata- lyst 3c, chiral functionalized cyclohexenes were achieved under mild reaction conditions with excellent yields and enantioselectivities.
基金supported by the Department of Science and Technology (DST)New Delhi, India (No. SR/FT/CS-013/2010)
文摘A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from（1R,3S）-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.
