Using polyethylene oxide (PEO) with 4 amino N (2 pyrimidinyl) benzene sulfonamide (APBS) and hydroxyl end groups (PEO a h ) as parent compounds, PEO with diethylenetriaminepentaacetic acid (DTPA) and APBS end groups (...Using polyethylene oxide (PEO) with 4 amino N (2 pyrimidinyl) benzene sulfonamide (APBS) and hydroxyl end groups (PEO a h ) as parent compounds, PEO with diethylenetriaminepentaacetic acid (DTPA) and APBS end groups (PEO a d ) was prepared by functionization of PEO a h . After complexation of PEO a d with isotopes of 153 Sm and 99 Tc, and injecting the polymer drug into the Kunming white mouse transplanted with Sarcoma 180, it was confirmed by γ counter that the PEO a d could be concentrated selectively in the tumour tissues, the ratio of concentration of the polymer drug in tumour tissue to that in ordinary organs such as liver, heart, spleen, muscle, blood and bone marrow is about 2.3:1 or even 10:1.展开更多
文摘Using polyethylene oxide (PEO) with 4 amino N (2 pyrimidinyl) benzene sulfonamide (APBS) and hydroxyl end groups (PEO a h ) as parent compounds, PEO with diethylenetriaminepentaacetic acid (DTPA) and APBS end groups (PEO a d ) was prepared by functionization of PEO a h . After complexation of PEO a d with isotopes of 153 Sm and 99 Tc, and injecting the polymer drug into the Kunming white mouse transplanted with Sarcoma 180, it was confirmed by γ counter that the PEO a d could be concentrated selectively in the tumour tissues, the ratio of concentration of the polymer drug in tumour tissue to that in ordinary organs such as liver, heart, spleen, muscle, blood and bone marrow is about 2.3:1 or even 10:1.
