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受阻胺光稳定剂3-苯基丙烯酸(2,2,6,6-四甲基-4-哌啶基)酯的合成研究
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作者 胡新利 王树清 《塑料助剂》 CAS 2024年第2期10-13,共4页
以3-苯基丙烯酸甲酯、2,2,6,6-四甲基-4-羟基哌啶为原料,在溶剂和催化剂的作用下合成了3-苯基丙烯酸(2,2,6,6-四甲基-4-哌啶基)酯。考察了反应时间、溶剂类型及用量、催化剂种类及用量、原料配比等对产品收率的影响。结果表明,优化工艺... 以3-苯基丙烯酸甲酯、2,2,6,6-四甲基-4-羟基哌啶为原料,在溶剂和催化剂的作用下合成了3-苯基丙烯酸(2,2,6,6-四甲基-4-哌啶基)酯。考察了反应时间、溶剂类型及用量、催化剂种类及用量、原料配比等对产品收率的影响。结果表明,优化工艺条件为:以钛酸四丁酯为催化剂,石油醚为溶剂,n(3-苯基丙烯酸甲酯)∶n(2,2,6,6-四甲基-4-羟基哌啶)∶n(石油醚)∶n(钛酸四丁酯)为1∶1.15∶2.47∶0.05,反应温度为120~125℃,反应时间8 h,此条件下产品收率达96.09%。 展开更多
关键词 3-苯基丙烯酸(2 2 6 6-四甲基-4-哌啶基)酯 3-苯基丙烯酸甲酯 2 2 6 6-四甲基-4-羟基哌啶
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气相色谱法测定黄芪中2,2-双(4-氯苯基)-1,1-二氯乙烯
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作者 蒲晓亚 郭亮 +2 位作者 胡莹莹 宋高林 杨丽娟 《兰州大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第4期536-541,共6页
建立一种气相色谱条件下有机氯农药残留2,2-双(4-氯苯基)-1,1-二氯乙烯(p,p′-DDE)的检测分析方法.收集8批黄芪样品,采用分析柱、验证柱和加标试验进行分析,通过质谱方法验证干扰物质,在GC-63Ni-ECD条件下成功实现干扰物质的分离和目标... 建立一种气相色谱条件下有机氯农药残留2,2-双(4-氯苯基)-1,1-二氯乙烯(p,p′-DDE)的检测分析方法.收集8批黄芪样品,采用分析柱、验证柱和加标试验进行分析,通过质谱方法验证干扰物质,在GC-63Ni-ECD条件下成功实现干扰物质的分离和目标成分的测定.p,p′-DDE在1.06~106.09 ng/mL范围的线性关系良好(R=0.9996),阴性样品的回收率为81.31%~88.27%,阳性样品的回收率为75.81%~79.94%.阴性样品的加标溶液在24 h内稳定性良好(相对标准偏差≤3.21%).该方法的检出限为0.21μg/kg,定量限为0.71μg/kg.结果表明,黄芪中存在干扰p,p′-DDE测定的物质,检测过程中应予以高度关注.该检测方法准确、可靠、成本低,可用于黄芪中有机氯农药残留p,p′-DDE的测定. 展开更多
关键词 黄芪 气相色谱法 2 2-双(4-氯苯基)-1 1-二氯乙烯 有机氯农药残留
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吡唑醚菌酯关键中间体1-(4-氯苯基)-3-吡唑醇的合成工艺研究
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作者 兰世林 刘金桥 +6 位作者 周兴 钟坤 竺来发 刘国文 张海涛 陈郭芹 杜升华 《精细化工中间体》 CAS 2024年第2期17-20,共4页
1-(4-氯苯基)-3-吡唑醇是甲氧基丙烯酸酯类杀菌剂吡唑醚菌酯的关键中间体。以对氯苯胺为原料,采用动态管连续法合成对氯苯肼盐酸盐,与丙烯酸乙酯环化反应得到中间体1-(4-氯苯基)-3-吡唑酮,然后用双氧水低温光催化连续氧化得到1-(4-氯苯... 1-(4-氯苯基)-3-吡唑醇是甲氧基丙烯酸酯类杀菌剂吡唑醚菌酯的关键中间体。以对氯苯胺为原料,采用动态管连续法合成对氯苯肼盐酸盐,与丙烯酸乙酯环化反应得到中间体1-(4-氯苯基)-3-吡唑酮,然后用双氧水低温光催化连续氧化得到1-(4-氯苯基)-3-吡唑醇,对不同反应条件下的实验结果进行了分析,优化反应条件为:重氮化物料停留时间为40 min、反应温度5℃、搅拌速率150 r/min,环合反应温度为60℃,在UVA光源下进行氧化反应,产品总收率大于88.0%,纯度大于98.0%。该方法重氮化反应和氧化反应本质安全,原材料价廉易得,产品收率和纯度高,操作简单,适合于工业化生产。 展开更多
关键词 1-(4-氯苯基)-3-吡唑醇 吡唑醚菌酯关键中间体 杀菌剂 连续化合成
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Synthesis and Crystal Structure of N-tert-butyl-N′-(2,4-dichlorobenzoyl)-N- [1-(4-chlorophenyl)-1, 4-dihydro-6-methylpyridazine-4-oxo-3-carbonyl] hydrazine 被引量:2
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作者 邹霞娟 金桂玉 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2001年第5期344-348,共5页
The title compound N-tert-butyl-N(-(2,4-dichlorobenzoyl)-N-[1-(4-chlorophenyl)- 1,4-dihydro-6-methylpyridazine-4-oxo-3-carbonyl]hydrazine [(C23H_21N4O3Cl3)2·1.5H_2O, Mr = 1042.60] was prepared by the reaction of ... The title compound N-tert-butyl-N(-(2,4-dichlorobenzoyl)-N-[1-(4-chlorophenyl)- 1,4-dihydro-6-methylpyridazine-4-oxo-3-carbonyl]hydrazine [(C23H_21N4O3Cl3)2·1.5H_2O, Mr = 1042.60] was prepared by the reaction of 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6- methylpyridazine-3-carboxylic acid with chloroformate ethyl ester, then with N′-tert-butyl-N- (2,4-dichlorobenzoyl) hydrazine in the present of triethylamine. The crystal structure has been determined by X-ray diffraction. The crystal belongs to Monoclinic, space group P21/c, with unit cell constants a =11.4948(9), b=12.7495(10), c=35.854(3) ?, β =92.964(2)°, Z=4, V=5247.6(7) ?3, Dc = 1.320 Mg/m3, F(000) = 2156 , μ (MoKa)= 0.385, R = 0.0661, wR = 0.1875, for 9151 observed reflections( I >2σ(I)). The structure is a dimer linked by intermolecular hydrogen bond which can be observed between N(1)- H...O(6), N(5)- H...O(3). The distances are 2.068 and 2.027? respectively. 展开更多
关键词 N-tert-butyl- N (-(2 4-dichlorobenzoyl)-N- [1-(4-chlorophenyl)-1 4-dihydro-6- methylpyridazine-4-oxo-3-carbonyl] hydrazine crystal structure synthesis
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Synthesis and Crystal Structure of 4-tert-Butyl-6-(4-chlorophenyl)-3,6-dihydro-2H-1,3-thiazin-2-iminium Chloride 被引量:1
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作者 夏林 胡艾希 +2 位作者 曹高 王宇 叶姣 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第1期33-36,共4页
The title compound, 4-tert-butyl-6-(4-chlorophenyl)-3,6-dihydro-2H-1,3-thiazin- 2-iminium chloride (C14H18C12N2S), has been synthesized by the reaction of 1-(4-chlorophenyl)- 4,4-dimethylpent-1-en-3-one with thi... The title compound, 4-tert-butyl-6-(4-chlorophenyl)-3,6-dihydro-2H-1,3-thiazin- 2-iminium chloride (C14H18C12N2S), has been synthesized by the reaction of 1-(4-chlorophenyl)- 4,4-dimethylpent-1-en-3-one with thiourea, and its crystal structure was determined by single- crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P211c with a = 16.3064(11), b = 9.4471(6), c = 11.2626 (8)A, β = 108.400(1)°, Z = 4, V = 1646.28(19) A^3, Mr = 317.26, Dc = 1.280 g/cm^3, S = 1.078,μ = 0.510 mm^-1, F(000) = 664, the final R = 0.0514 and wR = 0.1412 for 3210 observed reflections (I 〉 2σ(I)). The thiazine ring system displays a twisted boat conformation, and three N-H,..Cl hydrogen bonds exist in the crystal. The combination of two N-H...Cl hydrogen bonds generate an R2^1 (6) ring. 展开更多
关键词 crystal structure SYNTHESIS 4-tert-butyl-6-(4-chlorophenyl)-3 6-dihydro- 2H- 1 3-thiazin-2-iminium chloride
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Synthesis,Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole
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作者 应华洲 孙茂堂 +1 位作者 刘滔 胡永洲 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2008年第10期1171-1174,共4页
The title compound 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4- diethoxy- 2,3,3a, 4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole 2 (C29H30Cl2N3O7P, Mr = 633.44) was synthesized and its structure was cha... The title compound 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4- diethoxy- 2,3,3a, 4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole 2 (C29H30Cl2N3O7P, Mr = 633.44) was synthesized and its structure was characterized by IR, MS, ^1H NMR, ^13C NMR, ^31p NMR, elemental analysis and single-crystal X-ray diffraction. It crystallizes in triclinic, space group P1^-, a = 9.1549(3), b = 10.7168(4), c = 17.6272(6)A, α = 102.9363(12), β = 90.2713(9), γ = 117.4265(10)°, V= 1484.41(9)A^3, Z= 2,μ(MoKa) = 0.323, F(000) = 658, Z= 2, De= 1.417 g/cm^3, the final R = 0.0687 and wR = 0.2066 for 4943 observed reflections (I 〉 2σ(I)). X-ray analysis reveals that the diazaphospholine ring is almost planar and the two ethoxy groups bonded on the 3a- and 4-positions are in trans configurations. Its antiproliferative activity was also tested in vitro against four human tumor cell lines. 展开更多
关键词 SYNTHESIS crystal structure 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a 4-diethoxy-2 3 3a 4-tetrahydrochromeno[3 4-d] [1 2 3]dlazaphosphole ANTITUMOR
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Synthesis,Crystal Structure and Antifungal Activity of N-(Pyridine-2-methyl)-2-(4-chlorophenyl)-3-methylbutanamide
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作者 陈龙 薛思佳 +2 位作者 方治坤 尹安琴 胥杨 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第8期990-994,共5页
A novel compound N-(pyridine-2-methyl)-2-(4-chlorophenyl)-3-methylbutanamide, a racemic compound, has been synthesized with 2-(4-chlorophenyl)-3-methylbutyric acid and pyridin- 2-methylanamine as the raw materia... A novel compound N-(pyridine-2-methyl)-2-(4-chlorophenyl)-3-methylbutanamide, a racemic compound, has been synthesized with 2-(4-chlorophenyl)-3-methylbutyric acid and pyridin- 2-methylanamine as the raw materials, and its crystal structure (C17H19C1N2O, Mr = 302.79) was determined by single-crystal X-ray diffraction analysis. The crystal belongs to monoclinic, space group P21/n with a = 9.624(9), b = 23.14(2), c = 15.626(15)A, β = 106.199(14)°, V = 3342(5) A^3, Z = 8, Dc = 1.204 g/cm^3,μ = 0.23 mm^-1, F(000) = 1280, S = 1.032, R = 0.0681 and wR = 0.1508 for 6513 unique reflections (Rint = 0.0421) with 3375 observed ones. In the crystal structure, there are some intermolecular hydrogen bonds which stabilize the crystal structure. The preliminary bioassay shows that the title compound exhibits good antifungal activity against Botrytis cinerea, Gibberella zeae, Dothiorella gregaria and Colletotrichum gossypii. 展开更多
关键词 2-(4-chlorophenyl)-3-methylbutyric acid crystal structure SYNTHESIS antifungaiactivity
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Synthesis and Biological Activities of 2,4-Dichlorophenoxyacetyl(thio)urea and S-(+)-3-Methyl-2-(4-chlorophenyl)butyramide Derivatives
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作者 LIU Li XUE Si-jia BU Hong-fei CHEN Long 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2010年第6期929-932,共4页
2,4-Dichlorophenoxyacetyl(thio)urea and S-(+)-3-methyl-2-(4-chlorophenyl)butyramides were synthesized via acylation,aminolysis,esterification and addition reactions,and the partial new compounds have desirable ... 2,4-Dichlorophenoxyacetyl(thio)urea and S-(+)-3-methyl-2-(4-chlorophenyl)butyramides were synthesized via acylation,aminolysis,esterification and addition reactions,and the partial new compounds have desirable bioactive activity. 展开更多
关键词 2 4-Dichlorophenoxyacetyl(thio)urea S-(+)-3-Methyl-2-(4-chlorophenyl)butyramide Herbicidal activity Fungicidal activity
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Synthesis and Crystal Structure of S-(+)-N′-Tertbutylaminocarbonyl-N-[3-methyl-2-(4-chlorophenyl)butyryl] Thiourea
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作者 SUN Chuan-Wen ZHANG Xiao-Dong 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第2期153-156,共4页
The title compound S-(+)-N'-tertbutylaminocarbonyl-N-[3-methyl-2-(4-chlorophenyl)butyryl] thiourea has been synthesized and its crystal structure was determined by singlecrystal X-ray diffraction analysis. There... The title compound S-(+)-N'-tertbutylaminocarbonyl-N-[3-methyl-2-(4-chlorophenyl)butyryl] thiourea has been synthesized and its crystal structure was determined by singlecrystal X-ray diffraction analysis. There exist intramolecular N(2)-H(2A)…O(1), C(17)-H(17A)… O(2) and N(3)-H(3A)…S(1) hydrogen bonds as well as intermolecular N-H…O interaction between the carbonyl and amidogen groups. Crystallographic data: CITH24ClN3O2S, Mr = 369.90, monoclinic, space group C2/c with a = 22.9922(19), b = 14.4844(12), c = 12.4618(11) A, β = 92.608(2)°, V = 4145.8(6) ]k3, Z = 8, Dc = 1.185 g/cm^3, F(000) = 1568, g(MoKa) = 0.298 mm^-1, R = 0.0578 and wR = 0.1308. 展开更多
关键词 crystal structure S-(+)-3-methyl-2-(4-chlorophenyl)butyryl thiourea antiviral activity
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Crystal Structure and Biological Activities of (R)-N′-[2-(4-Methoxy-6-chloro)-pyrimidinyl]-N-[3-methyl-2-(4-chlorophenyl)butyryl]-urea
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作者 LI Jing-Zhi XUE Si-Jia LIU Guo-Hua 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第8期903-908,共6页
The title compound (R)-N′-[2-(4-methoxy-6-chloro)-pyrimidyl]-N-[3-methyl-2-(4- chlorophenyl)butyryl]-urea has been synthesized, and its crystal structure and biological behaviors were studied. Crystallographic ... The title compound (R)-N′-[2-(4-methoxy-6-chloro)-pyrimidyl]-N-[3-methyl-2-(4- chlorophenyl)butyryl]-urea has been synthesized, and its crystal structure and biological behaviors were studied. Crystallographic data: C17H18C12N4O3, Mr = 397.25, monoclinic, space group P21/c, a = 12.331(2), b = 14.025(3), c = 23.085(5) A, β = 99.607(4)°, Z = 8, V = 3936.2(13) A3, Dc = 1.341 g/cm^3, F(000) = 1648, R = 0.0718, wR = 0.1585 and/t(MoKα) = 0.353 mm^-1. The preliminary biological tests showed that the title compound has definite insecticidal and fungicidal activities. 展开更多
关键词 crystal structure biological activity (R)-3-methyl-2-(4-chlorophenyl)butyric acid 2-amino-6-chloro-4-methoxy-pyrimidine
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Synthesis, Crystal Structure and Biological Activities of 3-Bromo-5-(4-chlorophenyl)-4-cyanopyrrole-N,N-dimethyl-2-carboxamide
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作者 许庆博 华云涛 +3 位作者 唐强 周宝晗 陈坤 徐保明 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2018年第5期747-752,共6页
The title compound 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-N,N-dimethyl-2-amide(3) was synthesized with 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(1) and N,N-dimethylformamide... The title compound 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-N,N-dimethyl-2-amide(3) was synthesized with 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile(1) and N,N-dimethylformamide(2) by the α-C acylation reaction catalyzed by potassium t-butoxide, and characterized by IR, 1H-NMR and X-ray single-crystal diffraction. It crystallizes in monoclinic, space group P2(1/n)with a = 12.789(2), b = 13.783(2), c = 17.980(3) °, β = 109.230(3)°, V = 2992.5 A3, Mr = 352.62, Dc = 1.565 mg/m3, Z = 8, m = 2.924 mm-1, F(000) = 1408, the final R = 0.0424 and w R = 0.0973 for 3518 observed reflections with I 〉 2σ(I). A total of 23559 reflections were collected, of which 6242 were independent(Rint = 0.0566). The insecticidal, herbicidal and antibacterial activities of compound 3 were determined, and the experimental results showed that the mortality of 3 at the concentration of 100 ppm on the Fipronil against Linnaeus was 76.6%, the growth inhibition rate of 3 against Cynodon Dactylon under the condition of 100 ppm was 35.8% and the inhibitory activity of 3 at the concentration of 25 ppm against Fusarium graminearum reached 50.9%. Hence, the title compound has the value of further research and application prospect. 展开更多
关键词 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-N N-dimethyl-2-amide SYNTHESIS crystal structure biological activity
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Studies on Mechanism of Chemiluminescence Reaction of 2, 6, 7-Trihydroxyl -9- (4'-chlorophenyl ) -3-fluoroner
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作者 Xie Zeng-Hong (Department of Chemistry, Fuzhou University, Fuzhou 350002) 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 1998年第5期377-382,共6页
Catalytic chemiluminescence of over twenty metallic ions in the systemof 2, 6, 7-tihydroxyl-9- (4'-chlorophenyl)-3-fluorone (Cl-PF )-H2O2 has been tested.Trace amount of Co(Ⅱ) strong1y catalysed this chemilumines... Catalytic chemiluminescence of over twenty metallic ions in the systemof 2, 6, 7-tihydroxyl-9- (4'-chlorophenyl)-3-fluorone (Cl-PF )-H2O2 has been tested.Trace amount of Co(Ⅱ) strong1y catalysed this chemiluminescence reaction, especiallyin presence of cationic surfactant cetyltrimethylammonium bromide (CTMAB), andthe chemiluminescence intensity was proportional to the concentraction of Co(Ⅱ) in therange 0. 5~6ng. ml-1 Co(Ⅱ). Two steps could be involved in the chemiluminescentreaction of C1-PF. In alkaline solution, the O2 radical ion should attack an oxygenbridge between the benzene rings of Cl-PF with break in oxygen bridge bond to produce reaction product which is excited by the energy derived from this chemical reaction. The electronic excited state emits the radiation(560 nm) on falling to the groundstate, followed by formation of polyphenol derivatives. the polyphenol derivatives arefurther oxidized to produce chemiluminescence (480 nm) which is due to emission fromsinglet oxygen. 展开更多
关键词 2 6 7-trihydroxyl-9-(4'-chlorophenyl)-3-fluorone CHEMILUMINESCENCE Huckel molecular orbital method
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常压催化氢化合成2,2,6,6-四甲基-4-哌啶醇的研究 被引量:10
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作者 王多禄 张泽朋 +4 位作者 陈立功 许正双 王东华 崔现宝 黄红梅 《化学工业与工程》 CAS 1998年第3期20-24,共5页
本文对用2,2,6,6-四甲基-4-哌啶酮以常压催化氢化法合成2,2,6,6-四甲基-4-哌啶醇进行了研究。重点研究采用塔式反应器时影响催化氢化的有关因素,如催化剂的性能、用量、三丙酮胺的浓度、溶剂的选择等。建立了常... 本文对用2,2,6,6-四甲基-4-哌啶酮以常压催化氢化法合成2,2,6,6-四甲基-4-哌啶醇进行了研究。重点研究采用塔式反应器时影响催化氢化的有关因素,如催化剂的性能、用量、三丙酮胺的浓度、溶剂的选择等。建立了常压催化氢化合成哌啶醇的方法。确定了有关技术参数,在最佳条件下哌啶醇的产率达97%,纯度达99%。 展开更多
关键词 甲四基 哌啶醇 加氢 催化剂 催化氢化
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4-氯苯异氰酸酯绿色合成工艺研究 被引量:4
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作者 冯桂荣 张会茹 +1 位作者 关俊霞 张日焓 《化学世界》 CAS CSCD 北大核心 2011年第4期236-238,共3页
用"绿色化学品"碳酸二甲酯(DMC)代替光气与4-氯苯胺反应合成4-氯苯异氰酸酯。研究了反应物质量比、温度、时间、催化剂用量对合成目标物产率的影响,建立了获得目标产物的最佳工艺条件。实验结果表明,ZnO催化剂用量为0.06 g,... 用"绿色化学品"碳酸二甲酯(DMC)代替光气与4-氯苯胺反应合成4-氯苯异氰酸酯。研究了反应物质量比、温度、时间、催化剂用量对合成目标物产率的影响,建立了获得目标产物的最佳工艺条件。实验结果表明,ZnO催化剂用量为0.06 g,物料比n(DMC)∶n(4-氯苯胺)为8∶1,反应温度80℃,反应时间6 h,收率为62.18%。 展开更多
关键词 碳酸二甲酯 4-氯苯胺 4-氯苯异氰酸酯 绿色合成
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2-(4-氯苯基)-3-甲基丁酸的消旋 被引量:8
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作者 彭阳峰 何诠 +1 位作者 薛伯勇 蔡水洪 《合成化学》 CAS CSCD 2003年第4期338-340,共3页
以酸酐及有机惰性溶剂作混合溶剂 ,少量叔胺等作催化剂 ,2 -( 4-氯苯基 ) -3 -甲基丁酸能在比较温和的条件下基本完全消旋 ,收率接近 90 %。
关键词 2-(4-氯苯基)-3-甲基丁酸 消旋 氰戊菊酯 拟除虫菊酯类农药 杀虫剂 叔胺 酸酐
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4-(4-氯苯基)-3-甲基-2,4-二氧代丁酸乙酯的合成 被引量:2
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作者 武利强 杨春广 +1 位作者 符方方 郝智慧 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第12期840-841,共2页
对氯苯丙酮经烯胺化得4-[(Z)-1-(4-氯苯基)丙烯基]吗啉,再与草酰氯单乙酯缩合得利莫那班合成中间体4-(4-氯苯基)-3-甲基-2,4-二氧代丁酸乙酯,纯度91%,粗收率66%。
关键词 4-(4-氯苯基)-3-甲基-2 4-二氧代丁酸乙酯 利莫那班 减肥药 中间体 合成
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2,6-二甲基-4-(2-氯苯基)-1,4-二氢-3,5-吡啶二羧酸二甲酯对大鼠野百合碱性肺动脉高压的防治作用 被引量:3
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作者 李志超 张福琴 +2 位作者 赵德化 梅其炳 孙本韬 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 1997年第3期194-198,共5页
用野百合碱(MCT)复制大鼠慢性肺动脉高压(PH)病理模型,探讨钙拮抗剂2,6-二甲基-4-(2-氯苯基)-1,4-二氢-3,5-吡啶二羧酸二甲酯(DCDDP)对PH的防治作用.DCDDP5,50,500μg·k... 用野百合碱(MCT)复制大鼠慢性肺动脉高压(PH)病理模型,探讨钙拮抗剂2,6-二甲基-4-(2-氯苯基)-1,4-二氢-3,5-吡啶二羧酸二甲酯(DCDDP)对PH的防治作用.DCDDP5,50,500μg·kg-1ip,每日1次,连续28d;MCT60mg·kg-1在第1次给DCDDP后30minsc.观察肺血流动力学指标变化,血浆和肺匀浆中内皮素样免疫反应物(ir-ET),一氧化氮(NO)含量,超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的改变.三种不同剂量的DCDDP分别使平均肺动脉压从4.5±0.9kPa(MCT组)降至3.2±0.2,3.5±0.6和3.8±0.9kPa,肺血管阻力从118±17kPa·min-1·L-1(MCT组)降至65±16,68±18和76±18kPa·min-1·L-1(P<0.01),提示在本实验剂量范围内,中,低剂量DCDDP防治效果似较好.DCDDP不影响MCT性PH时血浆和肺匀浆中ir-ET的改变,但可显著升高肺匀浆中NO的含量和SOD活性,使肺匀浆中MDA含量降至正常,这可能是其降低肺动脉压的机理之一. 展开更多
关键词 野百合碱 肺动脉高压 防治 吡啶二羧酸 二甲酯
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1-[(4-氯苯基)苄基]哌嗪单一对映体的制备 被引量:1
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作者 王立升 朱红元 +2 位作者 郭鑫 纪良霞 乔红运 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第12期738-739,共2页
以正三丙胺为溶剂兼缚酸剂,由α-(4-氯苯基)苄胺的单一对映体与N,N-二(2-氯乙基)-对甲苯磺酰胺进行闭环反应,然后脱保护基得到标题化合物,总收率60%以上。
关键词 1-[(4-氯苯基)苯甲基]哌嗪 西替利嗪 单一对映体 中间体 制备
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4-(N-甲酰基-N′-邻氯苯基硫脲)-N-邻氯苯基苯氧乙酰胺的核磁共振研究 被引量:1
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作者 李英俊 张治广 +3 位作者 靳焜 彭勤纪 孙亚珍 闻利平 《分析化学》 SCIE EI CAS CSCD 北大核心 2006年第5期709-712,共4页
在超声波辐射下,以PEG-400为固-液相转移催化剂,用邻氯苯胺与双酰基异硫氰酸酯反应,合成出了一种新的化合物——4-(N-甲酰基-N′-邻氯苯基硫脲)-N-邻氯苯基苯氧乙酰胺。实验中观察到了取代和加成反应的竞争。利用元素分析,1H、13C、APT... 在超声波辐射下,以PEG-400为固-液相转移催化剂,用邻氯苯胺与双酰基异硫氰酸酯反应,合成出了一种新的化合物——4-(N-甲酰基-N′-邻氯苯基硫脲)-N-邻氯苯基苯氧乙酰胺。实验中观察到了取代和加成反应的竞争。利用元素分析,1H、13C、APT及二维核磁共振技术确定了所合成的新化合物的结构。给出了该化合物的化学位移数据。所得的结果对这类化合物的结构解析很有价值。 展开更多
关键词 4-(N-甲酰基-N′-邻氯苯基硫脲)-N-邻氯苯基苯氧乙酰胺 核磁共振波谱 结构解析 化学位移
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1-(4-氯苯基)-3-吡唑醇的合成工艺 被引量:4
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作者 陆阳 范荣胜 +1 位作者 陶京朝 周志莲 《农药科学与管理》 CAS 2012年第1期18-21,共4页
以对氯苯肼为原料经环合、氯化,合成1-(4-氯苯基)-3-吡唑醇。本文研究了其合成工艺和投料比、反应温度、反应时间,催化剂用量和溶剂种类对收率的影响。用IR、1H NMR表征了其结构,在最优条件下,1-(4-氯苯基)-3-吡唑醇合成的总收率为68.3... 以对氯苯肼为原料经环合、氯化,合成1-(4-氯苯基)-3-吡唑醇。本文研究了其合成工艺和投料比、反应温度、反应时间,催化剂用量和溶剂种类对收率的影响。用IR、1H NMR表征了其结构,在最优条件下,1-(4-氯苯基)-3-吡唑醇合成的总收率为68.35%,含量为98.5%,该路线简单经济,条件温和,收率高,适合工业化生产。 展开更多
关键词 对氯苯肼 1-(4-氯苯基)-3-吡唑醇 合成
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