BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous growth.Currently reported local palliative therapeutic modalities...BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous growth.Currently reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and disadvantages.We have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since 2010.AIM To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of IPNB.METHODS Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were included.PTCS-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with electrocautery.The primary outcome was its feasibility,indicated by technical success.The secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and safety.RESULTS Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were included.Low-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,respectively.Repeated cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type IPNB.All five patients achieved technical success of PTCS-BP.Four patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN had residual tumors.All four patients with mucin-hypersecreting IPNB achieved clinical success.The patient with polypoid type IPNB achieved curative resection.There were no PTCS-BP-related serious adverse events.CONCLUSION PTCS-BP appears to be feasible,efficacious,and safe for local palliative treatment of both mucin-hypersecreting cast-like and polypoid type IPNB.展开更多
国产信创升级改造,通常更多关注产品的性能,认为产品性能符合要求就能满足国产化的需求,而忽视了产品和业务的匹配,极易出现应用程序崩溃、语法错误等问题。为解决此问题,本文提出了一种基于POC(Proof of Concept)测试的信创改造升级方...国产信创升级改造,通常更多关注产品的性能,认为产品性能符合要求就能满足国产化的需求,而忽视了产品和业务的匹配,极易出现应用程序崩溃、语法错误等问题。为解决此问题,本文提出了一种基于POC(Proof of Concept)测试的信创改造升级方法。首先,通过对现有信息系统现状的分析,明确了系统改造升级的规模和复杂度。在此基础上设计了比核心业务更为复杂的应用,并基于此应用分别进行了单产品测试、联合产品测试,最终形成测试的数据和结果。通过对比分析结果来辅助企业进行信创产品升级策略的制定。此方法可以有效的解决国产化产品和业务不匹配的问题。展开更多
Irregular seismic data causes problems with multi-trace processing algorithms and degrades processing quality. We introduce the Projection onto Convex Sets （POCS） based image restoration method into the seismic data...Irregular seismic data causes problems with multi-trace processing algorithms and degrades processing quality. We introduce the Projection onto Convex Sets （POCS） based image restoration method into the seismic data reconstruction field to interpolate irregularly missing traces. For entire dead traces, we transfer the POCS iteration reconstruction process from the time to frequency domain to save computational cost because forward and reverse Fourier time transforms are not needed. In each iteration, the selection threshold parameter is important for reconstruction efficiency. In this paper, we designed two types of threshold models to reconstruct irregularly missing seismic data. The experimental results show that an exponential threshold can greatly reduce iterations and improve reconstruction efficiency compared to a linear threshold for the same reconstruction result. We also analyze the anti- noise and anti-alias ability of the POCS reconstruction method. Finally, theoretical model tests and real data examples indicate that the proposed method is efficient and applicable.展开更多
文摘BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous growth.Currently reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and disadvantages.We have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since 2010.AIM To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of IPNB.METHODS Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were included.PTCS-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with electrocautery.The primary outcome was its feasibility,indicated by technical success.The secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and safety.RESULTS Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were included.Low-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,respectively.Repeated cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type IPNB.All five patients achieved technical success of PTCS-BP.Four patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN had residual tumors.All four patients with mucin-hypersecreting IPNB achieved clinical success.The patient with polypoid type IPNB achieved curative resection.There were no PTCS-BP-related serious adverse events.CONCLUSION PTCS-BP appears to be feasible,efficacious,and safe for local palliative treatment of both mucin-hypersecreting cast-like and polypoid type IPNB.
文摘国产信创升级改造,通常更多关注产品的性能,认为产品性能符合要求就能满足国产化的需求,而忽视了产品和业务的匹配,极易出现应用程序崩溃、语法错误等问题。为解决此问题,本文提出了一种基于POC(Proof of Concept)测试的信创改造升级方法。首先,通过对现有信息系统现状的分析,明确了系统改造升级的规模和复杂度。在此基础上设计了比核心业务更为复杂的应用,并基于此应用分别进行了单产品测试、联合产品测试,最终形成测试的数据和结果。通过对比分析结果来辅助企业进行信创产品升级策略的制定。此方法可以有效的解决国产化产品和业务不匹配的问题。
基金financially supported by National 863 Program (Grants No.2006AA 09A 102-09)National Science and Technology of Major Projects ( Grants No.2008ZX0 5025-001-001)
文摘Irregular seismic data causes problems with multi-trace processing algorithms and degrades processing quality. We introduce the Projection onto Convex Sets （POCS） based image restoration method into the seismic data reconstruction field to interpolate irregularly missing traces. For entire dead traces, we transfer the POCS iteration reconstruction process from the time to frequency domain to save computational cost because forward and reverse Fourier time transforms are not needed. In each iteration, the selection threshold parameter is important for reconstruction efficiency. In this paper, we designed two types of threshold models to reconstruct irregularly missing seismic data. The experimental results show that an exponential threshold can greatly reduce iterations and improve reconstruction efficiency compared to a linear threshold for the same reconstruction result. We also analyze the anti- noise and anti-alias ability of the POCS reconstruction method. Finally, theoretical model tests and real data examples indicate that the proposed method is efficient and applicable.
