Dihydroxydibutylether （DHBE） is a choleretic drug used for the treatment of gallstone and hepatic disorders due to its choleretic activity and hepatoprotective action. The drug is a mixture of three regioisomers. Th...Dihydroxydibutylether （DHBE） is a choleretic drug used for the treatment of gallstone and hepatic disorders due to its choleretic activity and hepatoprotective action. The drug is a mixture of three regioisomers. The main re- gioisomer 3-（3-hydroxylbutoxy）-1-butanol （III） contains four stereoisomers, including （R）-3-（（R）-3-hydroxyl- butoxy）-1-butanol （IIIa）, （R）-3-（（S）-3-hydroxylbutoxy）-1-butanol （IIIh）, （S）-3-（（R）-3-hydroxylbutoxy）-1-butanol （Ille） and （S）-3-（（S）-3-hydroxylbutoxy）-1-butanol （IIId）. In this paper, the four stereoisomers are synthesized separately for the first time.展开更多
文摘Dihydroxydibutylether （DHBE） is a choleretic drug used for the treatment of gallstone and hepatic disorders due to its choleretic activity and hepatoprotective action. The drug is a mixture of three regioisomers. The main re- gioisomer 3-（3-hydroxylbutoxy）-1-butanol （III） contains four stereoisomers, including （R）-3-（（R）-3-hydroxyl- butoxy）-1-butanol （IIIa）, （R）-3-（（S）-3-hydroxylbutoxy）-1-butanol （IIIh）, （S）-3-（（R）-3-hydroxylbutoxy）-1-butanol （Ille） and （S）-3-（（S）-3-hydroxylbutoxy）-1-butanol （IIId）. In this paper, the four stereoisomers are synthesized separately for the first time.
