A novel liquid crystal compound with a carboxyl group at one end, cholest-5-en-3-ol- (3β) hydrogen decanedioate (1) was successfuly prepared by the reaction of cholesterol with sebacoyl chloride. Its chemical struc...A novel liquid crystal compound with a carboxyl group at one end, cholest-5-en-3-ol- (3β) hydrogen decanedioate (1) was successfuly prepared by the reaction of cholesterol with sebacoyl chloride. Its chemical structure and liquid crystalline properties were characterized by FTIR, CNMR, 1HNMR, POM and DSC. The compound with an active carboxyl group shows 13 themortropic liquid crystalline behaviour.展开更多
Formation and structure of liquid crystal in lecithin-water-oleic acid system were studied. It was found that different from the lecithin-water system, there are two types of llquid crystal present. The lamellar liqui...Formation and structure of liquid crystal in lecithin-water-oleic acid system were studied. It was found that different from the lecithin-water system, there are two types of llquid crystal present. The lamellar liquid crystal was formed at lower content of oleic acid, the values of interlayer spacing are larger tha-n the values in the corresponding liquid crystal without oleic acid. The inverse hexangonaJ liquid crysta1 was formed at higher content of oleic acid. In lecithin-water-oleic acid(containing 15 % cholesterol) system the phase behavior of liquid crystal is sidrilax to that in the lecithin-water-oleic acid system. The solubillzation rate of solid cholesterol in lammellar liquid crystal of lecithinwater-oleic acid system is more faster than that of lecithin-water system.展开更多
The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully understanding of lipid raft was attr...The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully understanding of lipid raft was attributed by the studies of T cell activation, virus entry/budding, and other membrane events. During the interaction of T cell and antigen presenting cell, a highly organized structure is formed at the interface of the two cells, where cholesterol and sphingolipids are enriched, and form a liquid ordered phase that facilitates the signaling proteins on and off. Lipid rafts are also involved in virus entry and assembly. In this review, we will discuss cholesterolsphingolipid floating microdomain, the lipid raft as a unique compartment of the plasma membrane, with biological functions that ensure correct intracellular traffic of proteins and lipids, such as protein-protein interactions by concentrating certain proteins in these microdomains, while excluding others. We also discuss the disruption of lipid rafts is related to different diseases and aging, and we especially exploit the lipid rafts as pharmaceutical targets for anti-virus and anti-inflammation, particularly a new approach to control HIV infection for AIDS prevention and protection by inhibition or disruption of lipid rafts. Cellular ＆ Molecular Immunology.展开更多
基金support by the National Natural Science Foundation of China(Grant No.29925411)the Key Laboratory of Cellulose and Lingnocellulosics Chemistry(LCLC-2003-142)are gratefully appreciated.
文摘A novel liquid crystal compound with a carboxyl group at one end, cholest-5-en-3-ol- (3β) hydrogen decanedioate (1) was successfuly prepared by the reaction of cholesterol with sebacoyl chloride. Its chemical structure and liquid crystalline properties were characterized by FTIR, CNMR, 1HNMR, POM and DSC. The compound with an active carboxyl group shows 13 themortropic liquid crystalline behaviour.
文摘Formation and structure of liquid crystal in lecithin-water-oleic acid system were studied. It was found that different from the lecithin-water system, there are two types of llquid crystal present. The lamellar liquid crystal was formed at lower content of oleic acid, the values of interlayer spacing are larger tha-n the values in the corresponding liquid crystal without oleic acid. The inverse hexangonaJ liquid crysta1 was formed at higher content of oleic acid. In lecithin-water-oleic acid(containing 15 % cholesterol) system the phase behavior of liquid crystal is sidrilax to that in the lecithin-water-oleic acid system. The solubillzation rate of solid cholesterol in lammellar liquid crystal of lecithinwater-oleic acid system is more faster than that of lecithin-water system.
文摘The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully understanding of lipid raft was attributed by the studies of T cell activation, virus entry/budding, and other membrane events. During the interaction of T cell and antigen presenting cell, a highly organized structure is formed at the interface of the two cells, where cholesterol and sphingolipids are enriched, and form a liquid ordered phase that facilitates the signaling proteins on and off. Lipid rafts are also involved in virus entry and assembly. In this review, we will discuss cholesterolsphingolipid floating microdomain, the lipid raft as a unique compartment of the plasma membrane, with biological functions that ensure correct intracellular traffic of proteins and lipids, such as protein-protein interactions by concentrating certain proteins in these microdomains, while excluding others. We also discuss the disruption of lipid rafts is related to different diseases and aging, and we especially exploit the lipid rafts as pharmaceutical targets for anti-virus and anti-inflammation, particularly a new approach to control HIV infection for AIDS prevention and protection by inhibition or disruption of lipid rafts. Cellular ＆ Molecular Immunology.
