Introduction In our previous papers,we reported that SDS could produce a strong enhancment effect on chromogenic reaction systems,such as Be;-ECAB,Al;-ECAB,Cu;-ECAB and Pd;-ECAB,but made no effect on the absorption sp...Introduction In our previous papers,we reported that SDS could produce a strong enhancment effect on chromogenic reaction systems,such as Be;-ECAB,Al;-ECAB,Cu;-ECAB and Pd;-ECAB,but made no effect on the absorption spectra of the systems if ECAB was replaced by CAS.So far, no report on the solubilizing and enhancment effect of anionic surfactant on metallic-acidic triphenylmethane dye system studied by means of NMR has been published.In this paper the interaction be-展开更多
The effects of Zn content on the microstxucture and the mechanical and corrosion properties of as-cast low-alloyed Mg-xZn~.2Ca alloys （x = 0.6wt%, 2.0wt%, 2.5wt%, hereafter denoted as 0.6Zn, 2.0Zn, and 2.5Zn alloys, ...The effects of Zn content on the microstxucture and the mechanical and corrosion properties of as-cast low-alloyed Mg-xZn~.2Ca alloys （x = 0.6wt%, 2.0wt%, 2.5wt%, hereafter denoted as 0.6Zn, 2.0Zn, and 2.5Zn alloys, respectively） axe investigated. The results show that the Zn content not only influences grain refinement but also induces different phase precipitation behaviors. The as-cast microstxucture of the 0.6Zn alloy is composed of ct-Mg, Mg2Ca, and Ca2Mg6Zn3 phases, whereas 2.0Zn and 2.5Zn alloys only contain ct-Mg and Ca2Mg6Zn3 phases, as revealed by X-ray diffraction （XRD） and txonsmission electron microscopy （TEM） analyses. Moreover, with in- creasing Zn content, both the ultimate tensile strength （UTS） and the elongation to fracture first increase and then decrease. Among the three investigated alloys, the largest UTS （178 MPa） and the highest elongation to fracture （6.5%） are obtained for the 2.0Zn alloy. In addition, the corrosion rate increases with increasing Zn content. This paper provides on updated investigation of the alloy composi- tion-microstxucture-property relationships of different Zn-containing Mg-Zn-Ca alloys.展开更多
Background: The prevalence of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, is projected to increase twofold by 2030. Leucine-rich repeat kinase 2 (LRRK2) is the most commonly observ...Background: The prevalence of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, is projected to increase twofold by 2030. Leucine-rich repeat kinase 2 (LRRK2) is the most commonly observed gene in both familial and sporadic PD cases. Notably, there is a substantial augmentation in motor activity during both larval and adult stages of zebrafish lacking the lrrk2 gene. Nevertheless, the precise genetic abnormalities accountable for eliciting these phenotypes in zebrafish are yet to be elucidated. Methods: Real-time polymerase chain reaction (PCR) was conducted on zebrafish larvae at 6 days post fertilization (dpf) belonging to both the wild-type and lrk2(-/-) groups. Guide RNA was designed and subsequently employed in the PCR process. Electrophoresis was performed to facilitate identification. Results: The expression of CNTF mRNA was significantly diminished in lrrk2(-/-), in comparison to the wildtype zebrafish larvae. This finding implies that CNTF may have crucial implications in the regulated functioning of lrrk2, which is widely acknowledged as the predominant genetic factor contributing to hereditary PD. The primers for CNTF DNA were meticulously designed, and the electrophoresis results of the PCR product were subsequently presented. The wild type zebrafish embryos were meticulously prepared for micro-injection, and the resulting efficiency identification displayed the presence of the mutant PCR product, which exhibited the presence of several debris. Conclusions: The present study demonstrates the successful generation of CNTF mutant zebrafish using the CRISPR/Cas9 genome editing technique. Further investigations are necessary to deepen our understanding of the exogenous CNTF gene’s functionality.展开更多
People will never forget a scene at the First National Conference of Model Workers held in 1959,when the No.1 blast furnace of the No.1 Steelworks under the Benxi Iron & Steel Corporation was named a national stan...People will never forget a scene at the First National Conference of Model Workers held in 1959,when the No.1 blast furnace of the No.1 Steelworks under the Benxi Iron & Steel Corporation was named a national standard bearer of the Red Flag,with its productivity ratio having won the national championship.The story was reported by the People’s Daily,Soviet Women’s Journal and Benxi Daily.As the young leader of the cited team of furnacemen, Li Yiyi became known to all. Time flies by and 34 years have elapsed since then.展开更多
In the festivedays whencelebrating the50th anniversa-ry of the found-ing of the Peo-ple’s Republic,and the 50th an-niversary of thefounding of theChinese Acad-emy of Scienc-es (CAS), it isnatural for thepeople to thi...In the festivedays whencelebrating the50th anniversa-ry of the found-ing of the Peo-ple’s Republic,and the 50th an-niversary of thefounding of theChinese Acad-emy of Scienc-es (CAS), it isnatural for thepeople to thinkwith pride ofChina’s展开更多
文摘Introduction In our previous papers,we reported that SDS could produce a strong enhancment effect on chromogenic reaction systems,such as Be;-ECAB,Al;-ECAB,Cu;-ECAB and Pd;-ECAB,but made no effect on the absorption spectra of the systems if ECAB was replaced by CAS.So far, no report on the solubilizing and enhancment effect of anionic surfactant on metallic-acidic triphenylmethane dye system studied by means of NMR has been published.In this paper the interaction be-
基金supported by the National Natural Science Foundation of China(No.51671017)Fundamental Research Funds for the Central Universities(No.FRF-GF-17-B3)+1 种基金Beijing Laboratory of Metallic Materials and Processing for Modern Transportation,the Opening Research Fund of State Key Laboratory for Advanced Metals and Materials(Nos.2016Z-11,2017Z-08)State's Key Project of Research and Development Plan(No.2016YFB0300801)
文摘The effects of Zn content on the microstxucture and the mechanical and corrosion properties of as-cast low-alloyed Mg-xZn~.2Ca alloys （x = 0.6wt%, 2.0wt%, 2.5wt%, hereafter denoted as 0.6Zn, 2.0Zn, and 2.5Zn alloys, respectively） axe investigated. The results show that the Zn content not only influences grain refinement but also induces different phase precipitation behaviors. The as-cast microstxucture of the 0.6Zn alloy is composed of ct-Mg, Mg2Ca, and Ca2Mg6Zn3 phases, whereas 2.0Zn and 2.5Zn alloys only contain ct-Mg and Ca2Mg6Zn3 phases, as revealed by X-ray diffraction （XRD） and txonsmission electron microscopy （TEM） analyses. Moreover, with in- creasing Zn content, both the ultimate tensile strength （UTS） and the elongation to fracture first increase and then decrease. Among the three investigated alloys, the largest UTS （178 MPa） and the highest elongation to fracture （6.5%） are obtained for the 2.0Zn alloy. In addition, the corrosion rate increases with increasing Zn content. This paper provides on updated investigation of the alloy composi- tion-microstxucture-property relationships of different Zn-containing Mg-Zn-Ca alloys.
文摘Background: The prevalence of Parkinson’s disease (PD), a chronic and progressive neurodegenerative disorder, is projected to increase twofold by 2030. Leucine-rich repeat kinase 2 (LRRK2) is the most commonly observed gene in both familial and sporadic PD cases. Notably, there is a substantial augmentation in motor activity during both larval and adult stages of zebrafish lacking the lrrk2 gene. Nevertheless, the precise genetic abnormalities accountable for eliciting these phenotypes in zebrafish are yet to be elucidated. Methods: Real-time polymerase chain reaction (PCR) was conducted on zebrafish larvae at 6 days post fertilization (dpf) belonging to both the wild-type and lrk2(-/-) groups. Guide RNA was designed and subsequently employed in the PCR process. Electrophoresis was performed to facilitate identification. Results: The expression of CNTF mRNA was significantly diminished in lrrk2(-/-), in comparison to the wildtype zebrafish larvae. This finding implies that CNTF may have crucial implications in the regulated functioning of lrrk2, which is widely acknowledged as the predominant genetic factor contributing to hereditary PD. The primers for CNTF DNA were meticulously designed, and the electrophoresis results of the PCR product were subsequently presented. The wild type zebrafish embryos were meticulously prepared for micro-injection, and the resulting efficiency identification displayed the presence of the mutant PCR product, which exhibited the presence of several debris. Conclusions: The present study demonstrates the successful generation of CNTF mutant zebrafish using the CRISPR/Cas9 genome editing technique. Further investigations are necessary to deepen our understanding of the exogenous CNTF gene’s functionality.
文摘People will never forget a scene at the First National Conference of Model Workers held in 1959,when the No.1 blast furnace of the No.1 Steelworks under the Benxi Iron & Steel Corporation was named a national standard bearer of the Red Flag,with its productivity ratio having won the national championship.The story was reported by the People’s Daily,Soviet Women’s Journal and Benxi Daily.As the young leader of the cited team of furnacemen, Li Yiyi became known to all. Time flies by and 34 years have elapsed since then.
文摘In the festivedays whencelebrating the50th anniversa-ry of the found-ing of the Peo-ple’s Republic,and the 50th an-niversary of thefounding of theChinese Acad-emy of Scienc-es (CAS), it isnatural for thepeople to thinkwith pride ofChina’s
