Metabolic dynamics in chronic gastritis:Examining urinary profiles post Helicobacter pylori eradication

Chronic gastritis is the persistent and insidious inflammation of the gastric lining.Helicobacter pylori(H.pylori)has been identified as the most common cause of chronic gastritis and consequently elimination of H.pylori can lead to its cure.This editorial explores the use of urinary metabolic profiles before and after eradication to identify biomarkers that can aid in prognosis and treatment.Despite providing promising insights,there are limitations such as a small sample size(17 patients),a narrow treatment period of 2 wk,and treatment heterogeneity,which raise concerns.Nevertheless,these findings have opened a gateway to enhancing the treatment and prognosis of chronic gastritis through urinary metabolomics.

Effect of He-Ne Laser on the Expressions of EGF and EGFR in Gastric Mucosa of Chronic Atrophic Gastritis

To investigate the histological change and the expressions of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in atrophic gastric mucosa in rats so as to appraise the effect of these regulators on the formation of atrophic gastritis, to study the expressions of EGF and EGFR in rats with chronic atrophic gastritis (CAG) after the irradiation of He-Ne laser, and to investigate the relations of He-Ne laser and precancerous lesion or apoptosis. The rats were divided into normal group, model group and laser group. The models of CAG rats were established with enema which was the mixed liquor consisted of sodium salicylate and alcohol, combined with irregular fasting and compulsive sporting as pathogenic factors. He-Ne laser(3.36 J/cm2 ) was used to irradiate CAG rats, once a day for 7 min, 20 days as a course of treatment; the expressions of EGF and EGFR were detected with immunohistochemical method. During the process of antral atrophy, the expressions of EGF and EGFR increased, they were higher in model group than those in normal group (P<0.05). After the irradiation of He-Ne laser, the expressions of EGF and EGFR were obviously lower than those in model group (P<0.05). We draw the conclusion as follows: gastric mucosa of model rat is in a hyper-proliferation status, with high protein expressions of apoptosis suppressor EGF and EGFR. CAG has some correlation with the imbalance between cell proliferation and apoptosis. He-Ne laser (3.36 J/cm2 ) can reduce the expressions of EGF and EGFR, which is an effective physiostimulator to stimulate the gastric mucosa of rat. The appropriate secretions of EGF and EGFR are propitious to the repair and regeneration for the gastric mucosa tissues, thus preventing CAG to canceration.

A cross-sectional study on traditional Chinese medicine syndromes distribution for chronic atrophic gastritis based on data mining

Background:Chronic atrophic gastritis(CAG)is a common digestive system disease characterized by reduced gastric mucosa inherent glands and often accompanied by intestinal metaplasia and dysplasia.Traditional Chinese medicine believes that syndrome elements dampness and blood stasis are closely related to the occurrence and development of CAG and promote the occurrence of precancerous lesions of gastric cancer.However,there is a lacking of more in-depth and detailed study on the above syndrome elements.This study aimed to made a quantitative description by cross-sectional study on the frequency of key syndrome elements dampness and blood stasis of CAG.Methods:201 CAG patients who met with inclusion criteria were divided into 4 groups including:only dampness group,only blood stasis group,none of dampness and blood stasis group,dampness and blood stasis group according to their four diagnostic information.The severities and levels of patients’clinical symptoms,pathological signs and patient-reported outcome scale used as evaluation indexes were collected.Data mining method of exploratory factor analysis was used for statistics.Results:The results suggested that the frequencies of dampness and blood stasis were reflected in the severity and levels of gastric symptoms,helicobacter pylori infection and the distribution and severity of dysplasia.And blood stasis played a more prominent role in promoting the progression of the CAG to cancer.Conclusion:Our results might provide a quantitative syndrome description for the traditional Chinese medicine differentiation in treating precancerous lesions of gastric cancer and preventing gastric cancer.

Dynamic observation of the progression of chronic gastritis to gastric cancer in a diseasee-TCM pattern rat model

Objective:To dynamically observe the progression of chronic gastritis to gastric cancer(GC)in diseasetraditional Chinese medicine(TCM)pattern rats to provide data for understanding the disease progression and effective approaches for drug screening and mechanism exploration.Methods:Wistar rats were randomly divided into control(n=96,half female and half male)and model(n=336,half female and half male)groups.Model rats received free access to N-methyl-N0-nitro-Nnitrosoguanidine(120 mg/mL),sodium deoxycholate(20 mmol/L),and alcohol(45%),and were subjected to intermittent fasting.Mortality rate,body weight,water consumption,food intake,gastric pathology,blood content analysis,and liver and kidney function of model rats were dynamically monitored over 30 weeks.In the 30th week,pattern characteristics were assessed.Gastric pathology and pattern characteristics were observed for an additional 8 weeks to evaluate stability.Results:The overall mortality of the model group was 34.82%(33.10%for females and 36.55%for males)at 30 weeks post-intervention.Inflammatory cell infiltration,glandular atrophy,atypical hyperplasia,and GC manifested successively in the gastric mucosa of rats.In model rats,N-methyl-N0-nitro-N-nitrosoguanidine intake was lower in males than in females,whereas pathological changes in the gastric mucosa occurred earlier in females than in males.Notably,gastric mucosal lesions were more severe in males than in females.Our modeling methods maintained stable gastric mucosal lesions for at least 8 weeks after final intervention.The pattern characteristics observed in model rats at the 30th and 38th week were consistent with those of spleen deficiency,blood stasis,and yin deficiency pattern.Blood content and indexes of liver and kidney function in the model group were normal.Conclusion:Our findings provide evidence for the pathological stages underscoring the progression of chronic gastritis to GC in disease-TCM pattern rats,which may facilitate development of relevant pharmacotherapies.

时效性激励模式下的延伸护理在老年慢性萎缩性胃炎癌前病变患者中的应用效果

目的探讨时效性激励模式下的延伸护理在老年慢性萎缩性胃炎癌前病变患者中的应用效果。方法选取该院2020年7月至2022年7月收治的老年慢性萎缩性胃炎癌前病变患者100例作为研究对象,按照随机数字表法将其分成观察组与常规组,每组50例。常规组采用常规延伸护理,观察组在常规组的基础上采用时效性激励模式下的延伸护理,两组均持续干预3个月。对比两组遵医行为、护理满意度[采用纽卡斯尔护理服务满意度量表(NSNS)评分进行评估],比较两组干预前后自我效能感[采用一般自我效能感量表(GSES)评分进行评估]、应对方式[采用简易应对方式量表(SCSQ)评分进行评估]、健康行为[采用健康促进生活方式量表(HPLP-Ⅱ)评分进行评估]、自我管理能力[采用成年人健康自我管理能力测评表(AHSMSRS)评分进行评估]及生活质量[采用慢性病患者生命质量测定量表体系-慢性胃炎(QLICD-CG)评分进行评估]情况。结果观察组遵医率(98.00%)和护理满意度(100.00%)均高于常规组(84.00%、88.00%),差异均有统计学意义(P<0.05)。干预后,观察组GSES、HPLP-Ⅱ、AHSMSRS、QLICD-CG评分均高于常规组(P<0.05)。与常规组相比,干预后观察组积极应对评分升高,而消极应对评分降低,差异均有统计学意义(P<0.05)。结论时效性激励模式下的延伸护理可提高老年慢性萎缩性胃炎癌前病变患者自我效能感,增强其自我管理能力及遵医行为,提高患者生活质量水平及护理满意度。

国医大师李佃贵基于“浊毒”理论辨治慢性萎缩性胃炎癌前病变胃黏膜屏障功能障碍

国医大师李佃贵以“浊毒”理论为指导,基于本病脾虚毒损胃络的病机特点,分别采用化浊解毒、补虚荣络、祛瘀通络的治法以改善或增强胃黏膜屏障功能,降低慢性萎缩性胃炎癌变率。

慢性萎缩性胃炎的中医辨治思路与对策

慢性萎缩性胃炎(CAG)是临床上公认的胃癌前疾病,中医药治疗CAG具有明显的优势及鲜明的特色。从CAG病因病机等方面的研究入手,对中医药治疗CAG提出治本独取阳明,补虚泻实,顾护脾胃,升降气机,调气和血,祛瘀通络,祛邪解毒,甘平凉润,和胃护络的辨治思路与对策,以期进一步提高中医药治疗CAG的临床疗效。

Clinical Study of Weishu Capsule (胃舒胶囊)in Treating Precancerous Lesions of Chronic Atrophic Gastritis

Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC, 胃舒胶囊) in treating precancerous lesions of chronic atrophic gastritis (CAG).Methods: Seventy five cases of precancerous lesions of CAG were distributed to two groups randomly, the WSC group (45 patients) treated with WSC taken orally and the Weining granule (WNG) group (30 patients) treated with Weining granule orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores of atrophy,intestinal metaplasia (IM) and its subgroups, dysplasia, carcinoembryonic antigen and proliferating cell nuclear antigen expression were observed before and after treatment. Results:The total effective rate was 91% and the effective rate of atrophy, IM, dysplasia in the WSC group were 64%, 67% and 65% respectively, and the respective scores were lowered significantly after treatment. Compared with the WNG group, the difference between the two groups was statistically significant ( P <0.01, P <0.05). Immunohistochemical test showed that WSC could inhibit the subgroups of IM, circinoembryonic antigen and proliferating cell nuclear antigen expression significantly ( P <0.01). Conclusions: WSC could significantly improve the clinical and pathological changes in the precancerous lesions of CAG. The mechanism might be related to the inducing and promoting effect of WSC on the differentiation and maturity of IM cells and dysplasia cells. WSC could also inhibit and correct the abnormal proliferation of cells.

胃癌前病变病证结合动物模型研究进展

中医药在胃癌前病变(precancerous lesions of gastric cancer,PLGC)诊疗中发挥着重要作用,病证结合动物模型是进行PLGC相关实验研究的前提。文章从模型动物选择、胃癌前病变疾病模型和病证结合模型三方面,对近年来PLGC病证结合模型的制备方法进行了归纳分析,介绍了脾胃虚弱、胃阴不足、肝胃气滞、脾胃湿热和胃络瘀血5个常见PLGC病证结合模型的造模方法,并对当前模型制备中存在的问题提出了思考与展望。

中医药治疗胃癌前病变研究进展

胃癌前病变是临床常见且需及时干预的一类疾病,其病因复杂,病机多样,治疗标准不一,若未经干预易发生进展,甚至发生癌变,威胁生命。中医药治疗胃癌前病变独具特色且收效颇丰,无论是中药内服、针灸外治,还是中医特色疗法以及民族医药疗法均对胃癌前病变的治疗具有明显优势。综述近10年来中医药治疗胃癌前病变的相关研究文献,为其临床治疗提供思路和参考。

慢性萎缩性胃炎及癌前病变复合造模法评价

目的 评价复合造模法构建慢性萎缩性胃炎(chronic atrophic gastritis, CAG)及胃癌前病变(precancerous lesions of gastric cancer, PLGC)大鼠模型的可行性。方法 将60只SPF级雄性SD大鼠随机分为对照组(n=10)及模型组(n=50)。对照组正常饲养,模型组用N-甲基-N′-硝基-N-亚硝基胍(MNNG)自由饮用+水杨酸钠隔日灌胃+脱氧胆酸钠隔日灌胃+不定期禁食复合造模法构建慢性萎缩性胃炎大鼠模型,造模时间为6个月。于造模第3,4,5,6个月比较模型组与对照组大鼠胃黏膜病理程度,造模后采血,采用ELISA检测血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及胃泌素17(G-17)。结果 模型组大鼠复合刺激4个月开始出现胃腺体萎缩,5个月出现纤维化,6个月出现胃腺消失及异型增生,1只出现癌变。模型组6只大鼠异常死亡,造模死亡率为12%。与对照组比较,模型组血清PGⅠ升高(P<0.05),PGⅠ与PGⅡ比值(PG R)降低(P<0.05),G-17降低(P<0.05)。结论 采用复合造模法制备大鼠CAG模型成功率高,结果较稳定,但制备时间较长,且由于大鼠个体差异,造模进程难以完全统一,所有大鼠均出现胃黏膜萎缩,部分大鼠出现PLGC特征,个别大鼠出现癌变。

趋化因子CXCL5与慢性萎缩性胃炎及胃癌前病变的相关性

目的明确慢性萎缩性胃炎(CAG)及胃癌前病变(PLGC)患者血清及胃组织中CXCL5水平变化情况,并探究CXCL5用于诊断CAG及PLGC的预测价值。方法纳入2022年6月至2023年6月在安徽中医药大学第二附属医院脾胃科收治并行胃镜及病理确诊的CAG 72例,以及同期在我科接受胃镜检查的健康受试者68例。收集所有受试者的临床信息和实验室结果,通过logistic回归分析方法明确CAG的影响因素及CXCL5的诊断价值。此外,为了明确CXCL5在CAG发展进程中的作用,选取2023年6-12月于本院收治的CAG、肠化、异型增生患者各15例,以及健康受试者15例。采用ELISA法、PCR法和免疫组化法验证各组CXCL5的表达情况以及与临床病理程度之间的关系,对CXCL5的诊断效能进行验证评估。结果本病的影响因素包括肿瘤家族史、吸烟史、饮酒史、饮食规律与否、幽门螺杆菌感染、病灶数量、病理程度、胃功能三项、CXCL5等(P<0.05)。受试者工作特征(ROC)曲线显示,曲线下面积(AUC)为1.00,约登指数为0.986,展现了良好的预测能力。ELISA结果显示,与正常组相比,CAG、肠化和异型增生组患者血清CXCL5表达水平显著升高,且与病理程度呈正相关;PCR及免疫组化染色结果显示,与正常组相比,CAG、肠化和异型增生组患者胃组织CXCL5 mRNA及蛋白表达水平均显著升高,且与病理程度呈正相关。结论CXCL5在CAG和PLGC患者血清及胃组织中呈高表达,其表达水平与病理程度呈正相关。因此,CXCL5有望成为诊断CAG及PLGC的预测指标和新的治疗靶点。

安胃汤含药血清对胃黏膜肠上皮化生模型细胞自噬及凋亡的影响

目的探讨安胃汤(半夏、黄连、干姜、乌药、百合等)含药血清对胃黏膜肠上皮化生(Gastric intestinalmetaplasia,GIM)模型细胞自噬及凋亡的影响。方法采用鹅去氧胆酸(CDCA)诱导人胃黏膜上皮细胞GES-1,制备GIM细胞模型。实验分为正常组(正常胃黏膜上皮细胞GES-1常规培养)、模型组(经CDCA复制成GIM模型后常规培养)、空白对照组(GIM模型细胞以等量空白血清培养)、安胃汤组(GIM模型细胞+7%安胃汤含药血清),各组细胞干预24 h后检测。采用流式细胞术(Annexin V-PE/7-AAD双染法)检测细胞凋亡;免疫荧光双标法检测肠上皮化生相关蛋白SOX2、CDX2的表达情况;透射电镜观察细胞超微结构及自噬情况;qRT-PCR法检测细胞LC3、Bax mRNA表达情况;Western Blot法检测细胞MUC2、KLF4、LC3、Bax蛋白表达情况。结果与正常组比较,模型组细胞的MUC2、KLF4蛋白表达显著上调(P<0.01),细胞的凋亡率明显降低(P<0.05);SOX2荧光强度明显降低(P<0.05),CDX2荧光强度显著增高(P<0.01);细胞结构紊乱,细胞核萎缩畸形,内质网和线粒体等细胞器肿胀破裂及空泡化严重,自噬小体及自噬溶酶体明显增多;Bax mRNA及蛋白表达明显下调(P<0.05),LC3 mRNA表达显著上调(P<0.01),LC3Ⅱ/LC3Ⅰ蛋白表达比值显著升高(P<0.01)。与空白对照组比较,安胃汤组细胞的凋亡率显著增高(P<0.01);SOX2荧光强度显著增高(P<0.01),CDX2荧光强度明显降低(P<0.05);细胞结构较完整,镜下可见自噬小体和自噬溶酶体略有减少;Bax mRNA及蛋白表达显著上调(P<0.01),LC3 mRNA表达显著下调(P<0.01),LC3Ⅱ/LC3Ⅰ蛋白表达比值显著降低(P<0.01)。结论安胃汤可能通过调节GIM模型细胞自噬,并促进其凋亡,从而改善胃黏膜上皮细胞的肠上皮化生情况。

从“中焦如衡”论治胃癌前病变

“中焦如衡”是清代医家吴鞠通基于脾胃的生理特点,提出的脾胃病治疗大法。后世医家在此论点基础上,结合大量临床实践不断深化,形成了以“中焦如衡”为切入点的论治脾胃病病因病机与治疗大法为一体的理论体系。胃癌前病变(PLGC)是具有较高癌变风险的病理改变。从“中焦如衡”理论探讨PLGC的病因病机,立足于脾胃的生理病理特点,以“中焦如衡,以平为期”为切入点,认为本病由多种因素叠加导致胃黏膜遭受持续损害,而在正邪交争中,胃黏膜的保护和防御机制被激活,动态平衡机制被打破,出现以脾胃虚损为本、毒瘀损络为要、升降失衡为主要表现的病机特点,随之而出现病理改变和临床表现。通过调和气血、虚实、气机等多种因素,以调和中焦为手段,以恢复脾胃平衡、气机升降为目的,从而防治PLGC。

基于网络药理学-分子对接技术及体内实验探讨化瘀消痞汤干预萎缩性胃炎癌前病变的作用机制

目的基于网络药理学和分子对接技术预测化瘀消痞汤干预萎缩性胃炎癌前病变(Precancerous lesions of gastric cancer,PLGC)作用靶点和分子机制,并进行实验验证。方法60只SPF级SD雄性大鼠,随机选取10只为空白对照,其余大鼠进行PLGC模型复制,造模成功后随机分为模型组,叶酸组(2 mg·kg^(-1)·d^(-1)),化瘀消痞汤高、中、低剂量组(24.8、12.4、6.2 g·kg^(-1)·d^(-1)),连续给药干预90天,记录大鼠体质量和3 h进食量,HE染色观察大鼠胃组织病理形态;采用网络药理学和分子对接技术预测化瘀消痞汤干预PLGC的潜在靶点,采取Western blot技术对核心靶点进行验证。结果与空白组比较,模型组大鼠体质量和3 h进食量明显降低(P<0.05),镜下见大鼠胃黏膜明显变薄,腺体明显减少并且排列紊乱,部分区域可见肠上皮化生的杯状细胞及大量炎性细胞浸润,与模型组相比较,各给药组大鼠体质量和3 h进食量不同程度改善,化瘀消痞汤中、高剂量改善明显(P<0.05),大鼠胃黏膜不同程度的修复,腺体排列趋于整齐,间质炎性细胞逐渐减少。网络药理学及分子对接结果表明TP53、JUN、MAPK3/1(ERK1/2)是化瘀消痞汤干预PLGC的核心靶点。分子生物学检测结果显示:与空白组相比较,模型组大鼠胃组织中TP53、c-Jun、ERK1/2蛋白磷酸化水平显著升高(P<0.05);与模型组相比较,各给药组大鼠胃组织中TP53、c-Jun、ERK1/2蛋白磷酸化水平不同程度降低,其中化瘀消痞汤高、中剂量组显著降低(P<0.05)。结论化瘀消痞汤可明显改善PLGC大鼠生存状况,促进胃黏膜修复,其具体机制可能与化瘀消痞汤降低PLGC大鼠胃组织中ERK1/2、c-Jun、TP53蛋白磷酸化水平,进而调节下游信号分子响应有关。

从“态靶辨治”角度分析蔡淦治疗脾虚瘀热型胃癌前病变经验

从“态靶辨治”角度介绍蔡淦教授治疗脾虚瘀热型胃癌前病变的经验。认为其基本病机为脾失健运,湿阻热蕴,气滞血瘀胶着于胃腑;临证强调“态靶辨治”,把握“基本态”、紧扣“疾病靶”、把控“症状靶”、参考“指标靶”;治疗时灵活运用经验方莪连颗粒健脾益气、化瘀清热以调态,并通过抗幽门螺杆菌、调节炎症因子及肿瘤指标表达水平、提高机体免疫力、影响相关信号通路等途径“精确打靶”,疗效突出。并附验案1则。

从“虚、滞、郁、瘀”病机理论探讨慢性萎缩性胃炎癌前病变微观辨治

魏玮教授认为“虚、滞、郁、瘀”是慢性萎缩性胃炎癌前病变发生发展的核心病机,本病的发病主要与脾胃虚损、阻滞不通、情志郁结、脉络瘀阻等因素有关,立足辨证论治,广泛汲取和采纳现代科学技术手段,结合“虚、滞、郁、瘀”核心病机及其物质基础、胃镜检查结果、病理检查结果等,从宏观与微观结合辨治等多角度系统探索慢性萎缩性胃炎癌前病变的物质基础与中医微观辨证的关系,实现中医药客观化、标准化的诊治策略,为本病的病机理论阐释与临床精准辨治提供参考。

半夏泻心汤治疗慢性萎缩性胃炎的机制研究进展

慢性萎缩性胃炎是公认的胃癌前病变,既往研究显示其病理状态正处于“炎-癌”转换的关键时期。早期识别并恰当干预是截断病程、逆转萎缩、防止癌变的核心环节。现代医学和中医传统医学均对此疾病展开了大量研究,以期可以挖掘其内在机制,从而提高临床疗效。大量研究显示中医中药在防治萎缩性胃炎方面表现出了卓越的优势,尤其以“半夏泻心汤”为代表的经典方剂研究最为深入。越来越多的基础及临床研究从不同角度阐述了“半夏泻心汤”治疗萎缩性胃炎的内在机制,但其散乱地分散在大量文献中,缺少系统的归纳及整理,给后续研究者从整体上了解“半夏泻心汤”治疗此疾病的内在机制造成了一定困扰。文章将从“半夏泻心汤”对胃蛋白酶及胃泌素水平的调节、辅助根除幽门螺杆菌、调控炎症、凋亡、血管新生等多种生物学过程以及靶向抑制PD-1、改善胃内微环境等5个方面,将近年来以“半夏泻心汤”为核心方剂治疗慢性萎缩性胃炎的相关机制研究做一综述,以期为后续研究提供参考。

参佛胃康治疗慢性萎缩性胃炎胃癌前病变作用机制研究

目的:探讨参佛胃康治疗慢性萎缩性胃炎胃癌前病变的作用机制。方法:利用Wistar大鼠制备胃癌前病变模型,空白组6只不造模,其余大鼠通过综合性N-甲基-N'-硝基-N-亚硝基胍(1-Methyl-3-nitro-1-nitrosoguanidine,MNNG)复合造模方法制备胃癌前病变模型,将建模成功的大鼠随机分为模型组、参佛胃康组、丽珠得乐组,空白组及模型组灌胃生理盐水,参佛胃康组及丽珠得乐组予相应剂量参佛胃康1.22 g/(kg·d)和丽珠得乐0.18 g/(kg·d),各组均干预4周。干预结束后,观察各组大鼠一般情况;苏木素-伊红(hematoxylin-eosin,HE)染色观察大鼠胃组织病理学变化情况;Western Blot法检测胃黏膜组织中磷脂酰肌醇3-激酶/蛋白激酶B(phosphatidylinositol 3-kinase/protein kinase B,PI3K/Akt)信号通路相关蛋白及B细胞淋巴瘤2(B cell lymphoma-2 protein,Bcl-2)蛋白表达水平。结果:参佛胃康组大鼠毛色、精神状况、体质量、食欲、大便等一般情况优于模型组。与模型组比较,丽珠得乐组大鼠胃黏膜腺体数量减少,排列欠规则,但炎性细胞浸润程度较模型组轻,部分区域可见充血、水肿以及淋巴细胞聚集;参佛胃康组大鼠胃黏膜上皮相对完整,细胞形态相对均匀,腺体数量较多,分布排列相对整齐且规则。与模型组比较,丽珠得乐组和参佛胃康组Bcl-2蛋白的相对表达降低,p-PI3K/PI3K、p-Akt/Akt比例均降低(P<0.05),参佛胃康组低于丽珠得乐组(P<0.05)。结论:参佛胃康能够改善慢性萎缩性胃炎胃癌前病变大鼠一般情况及其胃黏膜病理状态,其作用机制可能与参佛胃康调控PI3K/Akt信号通路,抑制PI3K、Akt、Bcl-2蛋白表达,影响细胞凋亡有关。

基于湿热理论的蒿芩清胆汤治疗慢性萎缩性胃炎癌前病变临床研究

目的探究基于湿热理论的蒿芩清胆汤治疗慢性萎缩性胃炎癌前病变的临床研究。方法回顾性研究医院2021年1月—2021年12月中医科收治的116例萎缩性胃炎患者,根据治疗方法不同将患者分为观察组与对照组,观察组60例,对照组56例,对照组使用常规的治疗方法,观察组则在对照组基础上联合使用蒿芩清胆汤治疗。观察两组患者治疗前后中医证候积分、周期蛋白E(cyclin E)、E-钙黏着蛋白(E-cadherin)、基质金属蛋白酶9(matrix metalloproteinase 9,MMP-9)蛋白表达及血清肿瘤标志物干扰素-γ(interferon γ,IFN-γ)、白介素-2(HUMAN IL-2)、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白介素-10(HUMAN,IL-10)。观察两组患者病理结果改善情况、临床疗效、不良反应。结果治疗后观察组中医证候积分显著低于对照组(P<0.05)。治疗后观察组MMP-9、CyclinE水平显著低于对照组,且E-cadherin水平显著高于对照组(P<0.05)。治疗后观察组IFN-γ、TNF-α较对照组显著降低,且IL-2、IL-10较对照组显著升高(P<0.05)。治疗后观察组胃黏膜萎缩病理结果改善有效率均高于对照组(P<0.05);且观察组总有效率91.66%显著高于对照组76.77%(χ^(2)=4.892,P=0.027)。观察组不良反应发生率为4.98%,显著低于对照组不良反应发生率8.92%,但两组患者不良反应发生率比较差异无统计学意义(χ^(2)=0.696,P=0.404)。结论蒿芩清胆汤能降低癌前病变中肿瘤标志物水平,提高患者疗效,降低患者不良反应,提升患者生活质量。