Chronic spinal cord lesions （CSCL） which result in irreversible neurologic deficits remain one of tbe most devastating clinical problems. Its patbophysiological mechanism has not been fully clarified. As a crucial f...Chronic spinal cord lesions （CSCL） which result in irreversible neurologic deficits remain one of tbe most devastating clinical problems. Its patbophysiological mechanism has not been fully clarified. As a crucial factor in the outcomes following traumatic spinal cord injury （SCI）, the blood-spinal cord barrier （BSCB） disruption is considered as an important pathogenic factor contributing to the neurologic impairment in SCI. Vascular endothelial growth factor （VEGF） is a multirole element in the spinal cord vascular event. On one hand, VEGF administrations can result in rise of BSCB permeability in acute or sub-acute periods and even last for chronic process. On the other band, VEGF is regarded to be correlated with anglo- genesis, neurogenesis and improvement of locomotor ability. Hypoxia inducible factor-I （HIFq） is a primary regulator of VEGF during hypoxic conditions. Therefore, hypoxia-mediated up-regulation of VEGF may play multiple roles in the BSCB disruption and react on functional restoration of CSCL. The purpose of this article is to further explore the relationship among HIF-1, hypoxia-mediated VEGF and BSCB dysfunction, and investigate the roles of these elements on CSCL.展开更多
基金This research was supported by the National Natural Science Foundation project，Province Natural Science Fund of Guangdong project
文摘Chronic spinal cord lesions （CSCL） which result in irreversible neurologic deficits remain one of tbe most devastating clinical problems. Its patbophysiological mechanism has not been fully clarified. As a crucial factor in the outcomes following traumatic spinal cord injury （SCI）, the blood-spinal cord barrier （BSCB） disruption is considered as an important pathogenic factor contributing to the neurologic impairment in SCI. Vascular endothelial growth factor （VEGF） is a multirole element in the spinal cord vascular event. On one hand, VEGF administrations can result in rise of BSCB permeability in acute or sub-acute periods and even last for chronic process. On the other band, VEGF is regarded to be correlated with anglo- genesis, neurogenesis and improvement of locomotor ability. Hypoxia inducible factor-I （HIFq） is a primary regulator of VEGF during hypoxic conditions. Therefore, hypoxia-mediated up-regulation of VEGF may play multiple roles in the BSCB disruption and react on functional restoration of CSCL. The purpose of this article is to further explore the relationship among HIF-1, hypoxia-mediated VEGF and BSCB dysfunction, and investigate the roles of these elements on CSCL.
