BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic...BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.展开更多
目的:探讨高电压刺激治疗慢性下肢静脉性溃疡(chronic venous leg ulcer,CVLU)的临床效果。方法:60例住院治疗的CVLU患者随机分为试验组和对照组各30例。两组均行手术治疗,术后高电压刺激组患者给予高电压刺激治疗及常规换药,对照组患...目的:探讨高电压刺激治疗慢性下肢静脉性溃疡(chronic venous leg ulcer,CVLU)的临床效果。方法:60例住院治疗的CVLU患者随机分为试验组和对照组各30例。两组均行手术治疗,术后高电压刺激组患者给予高电压刺激治疗及常规换药,对照组患者仅行常规换药,比较两组治疗后的溃疡完全愈合率、溃疡面积以及渗液量和肉芽组织生长情况。结果:治疗4周后,高电压刺激组患者的溃疡完全愈合率明显高于对照组,差异有统计学意义(P<0.05)。治疗1周、2周及4周时,高电压刺激组患者的溃疡面积均明显小于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组患者的溃疡渗液量均较多,且肉芽组织生长不明显。治疗2周后,肉眼可观察到两组患者的溃疡面渗液量均逐渐减少,以高电压刺激组患者渗液量减少更明显,且颜色较黄且粘稠;两组均观察到肉芽组织及上皮组织生长,以高电压刺激组患者更为明显。结论:高电压刺激治疗CVLU的临床效果显著,能够加速溃疡创面愈合。展开更多
基金Supported by Shenzhen Longhua District Science and Innovation Bureau for Key Laboratory Construction,No.20160919A0410022Shenzhen Longhua District Science and Innovation Bureau Fund for Medical Institutions,No.2020038 and No.2017136。
文摘BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.
文摘目的:探讨高电压刺激治疗慢性下肢静脉性溃疡(chronic venous leg ulcer,CVLU)的临床效果。方法:60例住院治疗的CVLU患者随机分为试验组和对照组各30例。两组均行手术治疗,术后高电压刺激组患者给予高电压刺激治疗及常规换药,对照组患者仅行常规换药,比较两组治疗后的溃疡完全愈合率、溃疡面积以及渗液量和肉芽组织生长情况。结果:治疗4周后,高电压刺激组患者的溃疡完全愈合率明显高于对照组,差异有统计学意义(P<0.05)。治疗1周、2周及4周时,高电压刺激组患者的溃疡面积均明显小于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组患者的溃疡渗液量均较多,且肉芽组织生长不明显。治疗2周后,肉眼可观察到两组患者的溃疡面渗液量均逐渐减少,以高电压刺激组患者渗液量减少更明显,且颜色较黄且粘稠;两组均观察到肉芽组织及上皮组织生长,以高电压刺激组患者更为明显。结论:高电压刺激治疗CVLU的临床效果显著,能够加速溃疡创面愈合。
