Serum protein profiles suggest a possible link between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Objective:To identify potential serum protein candidates involved in linking the traditional Chinese medicine(TCM)-defined qi deficiency constitution(QDC)to Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Using participants with the TCM-defined balanced constitution as a control population,labelfree quantitative proteomics was adopted to identify differentially expressed proteins(DEPs)in serum samples from two case populations:case population 1(participants with QDC)and case population 2(patients with PQDS of CSG).The DEPs discovered in both case populations were analyzed to identify common DEPs as potential candidates for proteins involved in the link between QDC and PQDS.Based on Kyoto Encyclopedia of Genes and Genomes pathway(KEGG)and Gene Ontology(GO)enrichment analysis and analysis of proteineprotein interaction networks,we evaluated the possible functions of these potential serum candidates.Results:We discovered 24 and 28 proteins that were differentially expressed in case populations 1 and 2,respectively,compared with the control population.Hierarchical clustering analysis showed that the expression profile of DEPs of individuals from the same population clustered well,while those from different populations were segregated.Furthermore,GO analysis revealed the 10 DEPs that were common to both case populations to be mainly associated with negative regulation of cellular metabolic and immune system processes while KEGG analysis indicated these proteins to be associated with complement and coagulation cascades and peroxisome proliferator-activated receptor signaling.Notably,serum levels of C4b-binding protein beta chain,glycosylphosphatidylinositol-specific phospholipase D1 and MS-F1 light chain variable region proteins were notably higher in the two case populations compared with the control,particularly in the case of CSG with PQDS.Conclusion:The results presented here provide new insights into the molecular mechanisms underlying development of PQDS of CSG from QDC,and suggest candidate serum biomarkers for future application in integrative medicine.

Screening for blood leukocyte microRNA biomarkers responsible for association between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Objective:To screen for blood leukocyte microRNA(miRNA)biomarkers responsible for the association between the traditional Chinese medicine(TCM)qi deficiency constitution(QDC)and the Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Peripheral blood leukocytes were separated from people of two TCM constitutions(balance and qi deficiency)and from CSG patients with PQDS.Total RNA was isolated from the leukocytes and subjected to subsequent high-throughput miRNA sequencing to identify the miRNAs that are specifically and highly expressed in persons of QDC and CSG patients with PQDS.In addition,the target genes of the associated miRNAs were predicted.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway-based enrichment analyses of these target genes were performed to further evaluate the associated miRNA candidates as potential biomarkers responsible for the association between QDC and PQDS of CSG.Results:Compared with the control group with a balance constitution(P<.05,fold change>1.5 or<0.5),31 and 38 differentially expressed miRNAs were found in persons of QDC and CSG patients with PQDS,respectively.In particular,hsa-miR-145-5p and hsa-miR-146a-3p were highly expressed in both the persons of QDC and CSG patients with PQDS.GO analysis of the target genes of the two common miRNAs showed that they were mainly associated with functions related to synthesis and metabolism,such as cellular nitrogen compound metabolic processes,biosynthetic processes,cellular protein modification processes,and cellular component assembly.KEGG analysis identified the common pathways enriched among the target genes,including the Hippo signaling pathway and the transcriptional misregulation pathway.The common target genes of the two miRNAs seemed to be associated with the spliceosome pathway and the RNA degradation pathway.Conclusion:Hsa-miR-145-5p and hsa-miR-146a-3p may serve as candidate biomarkers responsible for the association between QDC and PQDS of CSG.

Clinical Observation on 34 Cases of Chronic Atrophic Gastritis Treated with Shenlian Twelve Flavors

[Objectives]The research aimed to observe the curative effect of Shenlian Twelve Flavors in treating CAG patients with spleen deficiency and blood stasis toxin.[Methods]66 cases of CAG patients with spleen deficiency and blood stasis toxin were selected,32 cases in the control group and 34 cases in the observation group were generated according to the random number table method.The control group was treated with Moluodan;the observation group was treated with Shenlian Twelve Flavors.After treatment,the effective rate,TCM symptom score,gastroscopic score,pathological score,serum gastrin 17(G-17)level,and adverse reactions were compared between the two groups.[Results]The total effective rates of control group and observation group were 84.37%and 91.18%,respectively,and there was no statistical significance between the two groups(P>0.05).For the improvement of TCM symptom score,both groups were improved significantly compared with that before treatment,and observation group was better than control group(P<0.05).For the improvement of gastroscopic score,both groups were improved compared with that before treatment,and observation group was better than control group(P<0.05).For the improvement of pathological scores,both groups were improved compared with that before treatment,but there was no statistical significance between the two groups(P>0.05).[Conclusions]Shenlian Twelve Flavors has definite clinical efficacy in the treatment of CAG with spleen deficiency and blood stasis toxin.It could improve clinical symptoms,delay pathological progress,and regulate the level of G-17.There is no obvious adverse reaction,and it is worthy of clinical reference.

Study on the Drug Selection Law for Treatment of Chronic Gastritis with Spleen Deficiency and Stomach Dryness by Complex System Entropy Cluster

Objective:To study on Prof. GAO Zhong-ying’s drug selection law for treatment of chronic gastritis with data mining technique. Methods: The 407 medical records of chronic gastritis treated by Prof. GAO Zhong-ying were collected and the study on these drugs in the recipes was carried out with data mining method. Among them, the recipe composed of one drug was studied with frequency statistical method, correlativity between drug pairs with improved mutual information, correlativity among multi-drugs with complex system entropy cluster technique. Results: In treatment of chronic gastritis by Prof. GAO Zhong-ying there were 30 drugs with a higher use frequency of over 38 times, 94 commonly-used drug pairs with correlation coefficient of over 0.05, 11 commonly-used drug core combinations. Conclusion: The results attained with data mining technique for studying experience of famous and old TCM physicians conform to the clinical practice and the method is of an important significance for summarization of famous and old TCM physicians’ experiences.

COMPARATIVE OBSERVATIONS ON THE TYPES OF ATROPHIC GASTRITIS AND BIOPSY PATHOLOGY OF GASTRIC MUCOSA

300 cases of chronic atrophic gastritis were classified into 3 types of qi-dificiency of spleen and stomach, yang-deficiency of spleen and stomach, and yin-deficiency of spleen and stomach according to syndrom differentiation of traditional Chinese medicine. The biopsy specimens of gastric mucosa were examined histopathologically and for the presence of pyloric spirobaeteria. The results showed that the type of yin-deficiency was the most seri-ous in the degree of pathologic changes, or the glandular atrophy and the interstitial inflam-matory cellular infiltration, while the rate of pyloric spirobacteria presence was comparable in all types.

黄连汤合柴龙逆萎汤联合四联疗法治疗慢性非萎缩性胃炎伴糜烂临床研究

目的:观察黄连汤合柴龙逆萎汤联合四联疗法治疗慢性非萎缩性胃炎(CNAG)伴糜烂的临床效果。方法:选取2020年6月—2023年6月于安阳市中医院治疗的144例肝胃不和兼脾胃湿热型CNAG伴糜烂患者,采用随机数字表法分为对照组和观察组各72例,2组均采用常规四联疗法治疗,观察组加用黄连汤合柴龙逆萎汤加减治疗。2组均治疗4周。治疗前后评估2组患者的中医证候评分,检测血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)]水平及胃功能指标[胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)],评估胃黏膜糜烂评分、慢性炎症评分,统计治疗期间不良反应发生情况。比较2组的临床疗效。结果:治疗4周后,观察组总有效率高于对照组(P<0.05)。2组中医证候主症积分、次症积分、总积分及胃黏膜糜烂评分、慢性炎症评分均较治疗前降低(P<0.05),观察组以上5项评分值均低于对照组(P<0.05)。2组TNF-α、IL-1β、IL-8、PGⅡ水平均较治疗前降低,G-17、PGⅠ水平均较治疗前升高,差异均有统计学意义(P<0.05)。观察组TNF-α、IL-1β、IL-8、PGⅡ水平均低于对照组(P<0.05),G-17、PGⅠ水平均高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在四联疗法基础上加用黄连汤合柴龙逆萎汤治疗肝胃不和兼脾胃湿热型CNAG伴糜烂患者能够有效缓解症状,提高临床疗效,减轻机体炎症及胃黏膜糜烂程度,安全性较高。

基于脾虚毒损胃络假说探讨慢性萎缩性胃炎伴肠上皮化生的防治

胃癌前病变(Precancerous lesion of gastric cancer,PLGC)是从正常胃黏膜向胃癌转化过程的一个重要阶段,具有病程长、难治愈的特点,慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)伴胃黏膜病理肠上皮化生(Intestinal metaplasia,IM)是该阶段较常见的病理变化。现代研究表明,中医药对PLGC的黏膜萎缩和肠化生具有重要延缓作用,甚至可以逆转其进展。“毒邪”贯穿于CAG病变之始终,文章基于“脾虚毒损胃络”假说,认为脾胃虚弱、痰湿瘀毒互结为CAG伴肠上皮化生的重要病机;从毒论治,将健脾解毒法用于慢性萎缩性胃炎伴肠上皮化生的防治,可为临床提供新的思路与方法。

慢性萎缩性胃炎脾胃虚弱证中医研究进展

慢性萎缩性胃炎(CAG)是一种发病率较高的胃癌前状态,备受临床关注。中医将CAG分为不同证型,既往多项研究认为,脾胃虚弱证为CAG的发生、传变之源,早期治疗有助于延缓疾病的下一步传变,甚至起到逆转作用。中医治疗随证加减用药,对症状及病理改善均起到明显疗效,具有其特色优势,故将中医辨证与现代医学的微生态认识、血清学检查、胃镜检查等相结合,分析各指标及镜下表现等与中医辨证的关联性,并从中医病因病机、用药、选方、外治法等综述CAG脾胃虚弱证的研究进展,以期为后续CAG相关研究提供参考。

半夏泻心汤加减治疗脾胃湿热型慢性浅表性胃炎的临床效果分析

目的分析脾胃湿热型慢性浅表性胃炎患者采用半夏泻心汤加减的实际治疗效果。方法纳入平舆县东和店镇中心卫生院2022年1月至2024年1月收治的脾胃湿热型慢性浅表性胃炎患者(82例)为研究对象,按随机单双数抽签法划分组别,41例单数入对照组,予西医常规治疗;另外41例双数者入研究组,在西医常规治疗基础上应用半夏泻心汤加减治疗。对比两组治疗有效率,治疗前后中医症候积分、胃肠症状评定量表(GSRS)评分及炎性因子指标[C反应蛋白(CRP)与白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)]。结果研究组治疗有效率(97.56%)高于对照组(80.49%),差异具有统计学意义(P<0.05);治疗前,两组胃痛、纳差、痞满、嗳气积分比较,差异无统计学意义(P>0.05),治疗后,两组各项中医症候积分均低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05);治疗前,两组GSRS评分比较,差异无统计学意义(P>0.05),治疗后,两组GSRS评分低于治疗前,且研究组评分低于对照组,差异具有统计学意义(P<0.05);治疗前,两组各炎症因子水平比较,差异无统计学意义(P>0.05),治疗后,两组CRP、TNF-α、IL-6低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论半夏泻心汤是针对脾胃湿热型慢性浅表性胃炎较理想的一种中医方剂,疗效确切且具有抗炎作用,值得应用。

Study on the pathological basis of classification of spleen deficiency in chronic gastritis

Background Spleen in Traditional Chinese Medicine (TCM) is not actually the spleen in the anatomic sense designated in western medicine because its functions basically belong to the physiological category of digestive system in modern medicine, and it represents a macroscopic concept of digestion, absorption and nutrition metabolism Spleen deficiency syndrome refers to the clinical phenomena such as hypofunction of digestion, absorption and nutrition metabolism By integrating TCM with modern medicine , this paper is intended to explore the pathological basis of classification of spleen deficiency in chronic gastritis Method By means of optical microscope, scanning electron microscope (SEM), transmission electron microscope (TEM) and histochemical staining, we conducted histopathological and subcellular ultrastructural (nuclei and mitochondrial) analysis of gastric mucosa of 188 patients of spleen deficiency, and that of 42 voluntary blood donors without clinical symptoms Results The gastric mucosa of patients with spleen Qi deficiency (SQD) and spleen yang deficiency (SyangD) could either be affected by organic lesion (type G-occurring on the basis of chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG)) or unaffected (type F-chiefly belonging to functional indigestion); spleen yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS) both occurred on the basis of CSG and CAG; and the degree of mucosa inflammatory cells infiltration, the degree of decrease in glands propria, and the incidence of IMⅡ b in CSG and CAG were more serious than those of G-SQD and G-SyangD, P <0 05-0 01 Conclusion Spleen deficiency syndrome is likely to occur on the basis of organic lesion of gastric mucosa (disease with symptoms of both CSG or CAG and spleen deficiency symptoms), as well as on the basis of inorganic lesion of gastric mucosa (nondisease with symptoms, which is, despite spleen deficiency symptoms, there is no CSG or CAG) Besides, the clinical phenomenon of disease without symptoms (despite CSG or CAG, there is no spleen deficiency symptoms) occurres because of such factors as genetic diathesis and compensation The lesion degree of CSG or CAG and the incidence of IMⅡ b of SyinD and SDQS are more serious than those CSG and CAG of G-SQD and G-Syang D.

Bioinformatics Research on Chronic Superficial Gastritis of Pi-deficiency Syndrome by Gene Arrays

Objective： To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis （CSG） with the Pi-deficiency syndrome （PDS） and those of the non- Pi-deficiency syndrome （non-PDS）, i.e. patients of CSG with Pi （脾）-Wei （胃） dampnese-heat syndrome and healthy persons. Methods： With the BRB-Array Tools software package, original data collection and bioinformatic analysis of gene arrays were conducted in 6 CSG patients of PDS （CSG-PDS）, 6 CSG patients of non-PDS （CSG-nPDS）, and 6 healthy volunteers （Normal）. Results： Compared with non-PDS, the gene expressions in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly. Conclusions： The two kinds of samples, CSG-PDS/Normal and CSG-PDS/CSG-nPDS, have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.

益胃宁胶囊联合瑞巴派特片治疗慢性萎缩性胃炎脾胃气虚证临床研究

目的观察益胃宁胶囊联合瑞巴派特片治疗慢性萎缩性胃炎(CAG)脾胃气虚证的临床疗效。方法采用随机数字表法将80例CAG患者分为研究组和对照组各40例,2组均予瑞巴派特片,0.1 g/次,每日3次,口服;研究组在此基础上予益胃宁胶囊,2 g/次,每日3次,口服。2组均连续治疗12周。观察2组治疗前后中医疗效、胃镜疗效和病理疗效,比较2组治疗前后中医症状评分,监测2组不良反应。结果2组均无病例脱落。研究组中医疗效总有效率为92.5%(37/40),对照组为70.0%(28/40),研究组中医疗效优于对照组(P<0.01)。与本组治疗前比较,2组治疗后中医症状总分下降(P<0.05,P<0.01);2组治疗后比较,研究组中医症状总分低于对照组(P<0.01)。研究组胃镜疗效总有效率(82.5%)优于对照组(67.5%),研究组病理疗效总有效率(87.5%)优于对照组(70.0%),差异均有统计学意义(P<0.05,P<0.01)。2组未见明显不良反应。结论益胃宁胶囊联合瑞巴派特片可有效改善CAG患者的临床症状、胃镜表现及黏膜病变程度,疗效显著。

田耀洲教授辨治慢性萎缩性胃炎经验采撷

慢性萎缩性胃炎(CAG)是消化系统常见病,具有病情反复、缠绵难愈的特点。病理主要以胃腺体的萎缩、伴或不伴有肠上皮化生或异型增生为特征。肠上皮化生和异型增生属于癌前病变,与胃癌的发生关系密切,积极控制CAG患者的临床症状,延缓其病理进展或逆转其病理变化,有利于改善患者的生活质量、减轻经济负担及预防胃癌发生。田耀洲教授认为此病属本虚标实,脾胃虚弱是本,气滞、湿郁、瘀血为标,虚、滞、湿、瘀相互胶结推动着疾病的进展,在辨证上推崇微观与宏观相结合,用药上推崇中西医结合,并擅用经方与药对,精准辨治与用药。田教授开创的自拟方剂芪芝方,疗效显著,可有效改善脾胃湿热型CAG的临床症状。今将田教授辨治CAG之经验及自拟方剂分享给大家,以期为临床辨治CAG提供参考借鉴。

李延从脾胃论治冠心病的临床经验

冠心病为临床中常见的心血管疾病,可归属中医学的“胸痹”“心痛”等疾病范畴。李延教授认为本病之病性总属本虚标实之证,以脾虚、脾胃健运失常为本,标实在于痰浊、血瘀、气滞、寒凝等有形实邪痹阻心脉。治疗时重视调理脾胃,重用黄芪、白术、党参、五味子等健脾养心以治本,结合通阳化浊、活血化瘀、疏肝理气、温阳散寒等治法,标本兼治,通补兼顾,使脾气健旺,心气充沛,瘀去痰消,胸阳得以舒展,则心之血脉恢复畅通,胸痹心痛诸症得到缓解。李延教授从脾胃论治冠心病的经验可为中医临床诊治冠心病提供参考。

消痞汤对脾胃虚弱证慢性萎缩性胃炎患者的临床疗效

目的考察消痞汤对脾胃虚弱证慢性萎缩性胃炎患者的临床疗效。方法97例患者随机分为对照组(48例)和观察组(49例),2组均采用常规治疗,同时对照组给予枸橼酸莫沙必利片和胰酶肠溶片,观察组给予消痞汤,疗程4周。检测临床疗效、脑肠肽指标(CGRP、5-HT、SP、NPY)、Hp转阴率、胃液成分(游离酸、胃蛋白酶、亚硝酸盐、总酸)、胃肠激素(GAS、MLT、SS)、胃黏膜病理评分、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组脑肠肽指标、NPY、SS、游离酸、胃蛋白酶、总酸升高(P<0.05),MLT、亚硝酸盐、黏膜炎症和黏膜萎缩评分降低(P<0.05),以观察组更明显(P<0.05)。2组Hp转阴率、不良反应发生率比较,差异无统计学意义(P>0.05)。结论消痞汤可安全有效地缓解胃黏膜炎症和萎缩,改善胃液成分和胃肠激素,其机制可能与调节脑-肠轴有关。

温中和胃汤联合耳穴压豆对脾胃虚寒型慢性胃炎患者治疗疗效及对血清VIP、MTL水平的影响

目的 温中和胃汤联合耳穴压豆对脾胃虚寒型慢性胃炎(CG)患者的治疗疗效及对血清VIP、MTL水平的影响。方法 选取2021年1月—2022年5月该院接收的脾胃虚寒型CG患者90例,采用随机数字表法分为观察组47例和对照组43例。所有患者均行常规治疗,同时对照组给予耳穴压豆治疗,观察组在对照组基础上联合温中和胃汤治疗。对比两组的治疗疗效、中医证候评分、不良反应发生情况。治疗前后,检测两组患者外周血胃肠功能指标[胃动素(MTL)、血管活性肽(VIP)]以及炎症指标[白细胞介素-1β(IL-1β)以及白细胞介素-6(IL-6)]表达水平。在患者停药3个月后,对其进行为期半年的跟踪随访调查,记录其复发情况。结果 观察组、对照组治疗总有效率分别为93.62%、76.74%,不良反应总共发生率分别为17.02%、9.30%,6个月内复发率分别为0.00%、13.95%。,观察组治疗总有效率较高、6个月复发率较低(P<0.05),两组不良反应发生率无差异(P>0.05)。治疗后中医证候对比,观察组胃隐痛、喜温喜按、劳累/受凉后症状加重和泛吐清水评分低于对照组(P<0.05),两组神疲倦怠、舌淡胖评分无差异(P>0.05)。治疗后,观察组血清MTL高于对照组(P<0.05),VIP、IL-1β低于对照组(P<0.05),两组IL-6浓度无差异(P>0.05)。结论 温中和胃汤联合耳穴压豆可有效提高脾胃虚寒型CG治疗疗效,降低VIP和IL-1β表达,同时提高MTL表达水平,降低短期内复发率。

艾灸治疗脾胃虚寒型胃炎研究进展

慢性胃炎是由多种病理因素引起的胃黏膜的慢性炎症,是最常见的消化系统疾患之一。而脾胃虚寒是慢性胃炎中最为常见的证型,在中医特色疗法中,艾灸疗法的应用相对广泛。因此,文章总结了艾灸治疗脾胃虚寒型胃炎患者的应用,以艾灸的不同方式,如隔药灸、隔姜灸、悬起灸、雷火灸、温针灸、温灸器灸等方面进行综述,以期为艾灸疗法改善脾胃虚寒型胃炎患者症状提供综合参考。

四合汤对脾胃虚弱证慢性萎缩性胃炎的影响

目的 探究加味四合汤对脾胃虚弱型慢性萎缩性胃炎的疗效。方法 选取2020年8月—2023年6月河南省永城市人民医院门诊收治的脾胃虚弱证慢性萎缩性胃炎患者120例,根据随机数字表法分为观察组和对照组,每组60例,观察组采用加味四合汤治疗,对照组采用西药治疗,比较2组中医证候积分、胃镜下黏膜表现、组织病理结果的改变。结果 观察组疗效明显优于对照组,差异具有统计学意义(P<0.05)。结论 加味四合汤对脾胃虚弱证慢性萎缩性胃炎患者疗效显著,能有效改善患者临床中医证候、症状、胃镜黏膜表现、组织病理的变化,部分患者黏膜腺体萎缩出现逆转。

穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎伴Hp感染临床研究

目的:观察穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎(CAG)伴幽门螺杆菌(Hp)感染的临床疗效。方法:选取112例脾胃虚弱型CAG伴Hp感染患者,采用随机数字表法分为对照组(予四联疗法治疗)和观察组(予穴位埋线辅助四联疗法治疗)各56例。治疗结束后,2组均随访5个月。比较2组临床疗效、胃黏膜功能指标[胃泌素17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)]、健康调查简表(SF-36)评分、中医证候积分、病理评分、不良反应发生率及复发率。结果:总有效率观察组96.43%,高于对照组80.36%(P<0.05)。治疗后3个月,2组血清G-17、PGⅠ水平均较治疗前升高(P<0.05),观察组上述2项指标水平均高于对照组(P<0.05)。治疗后1个月、3个月,2组SF-36评分均较治疗前升高(P<0.05),观察组SF-36评分均高于同期对照组(P<0.05)。治疗后3个月,2组中医证候积分均较治疗前降低(P<0.05),观察组中医证候积分低于对照组(P<0.05)。治疗后5个月,2组病理评分均较治疗前下降(P<0.05),观察组病理评分低于对照组(P<0.05)。不良反应发生率观察组8.93%,与对照组3.57%比较,差异无统计学意义(P>0.05)。治疗后5个月,复发率观察组1.85%,低于对照组15.56%(P<0.05)。结论:穴位埋线辅助四联疗法治疗脾胃虚弱型CAG伴Hp感染,可减轻患者的临床症状,改善胃黏膜功能,提高生活质量,降低复发率,且安全性好。

半夏泻心汤加味联合四联疗法对脾胃湿热型Hp相关慢性胃炎患者Hp清除率及胃肠黏膜功能的影响

[目的]探究半夏泻心汤加味联合四联疗法对脾胃湿热型幽门螺杆菌(Hp)相关慢性胃炎患者Hp清除率及胃肠黏膜功能的影响。[方法]收集2020年3月-2022年3月在本院收治的92例脾胃湿热型Hp相关慢性胃炎患者,将患者按照随机法分为对照组45例、研究组47例。对照组患者采用四联疗法予以治疗,而研究组患者则是在对照组的基础上联合半夏泻心汤加味进行治疗,比较两组患者的Hp清除率、胃肠黏膜功能、中医证候积分、胃肠道激素、临床疗效的情况变化。[结果]治疗后两组患者主症、次症积分、丙二醛(MDA)、血管活性肠肽(VIP)表达水平降低,胃泌素-17(GAS-17)、血清胃蛋白酶原I(PGI)、前列腺素E_(2)(PGE_(2))、胃动素、瘦素表达水平升高,且研究组较对照组有所改善(P<0.05)。与对照组比较,研究组的Hp清除率、临床总有效率升高(P<0.05)。研究组的临床总有效率比对照组高(P<0.05)。[结论]半夏泻心汤加味联合四联疗法对治疗脾胃湿热型Hp相关慢性胃炎患者效果显著,可有效减轻患者的中医症状,提升Hp清除率,调节体内的肠道菌群,改善胃肠黏膜功能,值得临床应用。