Objective To evaluate the toxic effects and efficacy of the intra-arterial chrono-chemotherapy on patients with liver metastasis arised from colorectal cancer. Methods Chemotherapy of 42 patients were randomly divided...Objective To evaluate the toxic effects and efficacy of the intra-arterial chrono-chemotherapy on patients with liver metastasis arised from colorectal cancer. Methods Chemotherapy of 42 patients were randomly divided into group A (n = 20) with continuously constant arterial infusion, and group B (n = 22) with arterial chrono-modulated infusion. And the toxic effects and efficacy of two groups were compared. Results A significant difference was found in the toxic effects of digestive system between the two groups. The treatment response was similar in the two groups. Conclusions Intra-arterial chrono-chemotherapy may decrease the toxic effects and improve the life quality of these patients. (J Intervent Radiol, 2006, 15: 487-490)展开更多
通过系统检索PubMed、Web of Science、Embase、Scopus和中国知网等数据库中与择时运动、代谢综合征相关的文献,分析择时运动、昼夜节律与代谢综合征的关系。发现:一天中不同时间的运动会影响血糖代谢反应,择时运动对血糖代谢的影响与...通过系统检索PubMed、Web of Science、Embase、Scopus和中国知网等数据库中与择时运动、代谢综合征相关的文献,分析择时运动、昼夜节律与代谢综合征的关系。发现:一天中不同时间的运动会影响血糖代谢反应,择时运动对血糖代谢的影响与进餐时间有关;择时运动能够降低代谢与心血管风险,与早上运动相比,晚上运动对降低血压有更大益处;AMPK、PGC1α以及HIF1α在运动调节昼夜节律影响代谢性疾病中发挥重要作用,这可能是择时运动影响代谢健康的潜在机制。认为:择时运动可作为昼夜节律紊乱相关病理的有效处方,将择时运动和进餐时间与分子时钟同步会最大限度地发挥运动对全身代谢健康的促进作用。未来研究可尝试探索不同运动在一天中的不同时间对机体代谢的影响,以最大限度地提高运动效益。展开更多
文摘Objective To evaluate the toxic effects and efficacy of the intra-arterial chrono-chemotherapy on patients with liver metastasis arised from colorectal cancer. Methods Chemotherapy of 42 patients were randomly divided into group A (n = 20) with continuously constant arterial infusion, and group B (n = 22) with arterial chrono-modulated infusion. And the toxic effects and efficacy of two groups were compared. Results A significant difference was found in the toxic effects of digestive system between the two groups. The treatment response was similar in the two groups. Conclusions Intra-arterial chrono-chemotherapy may decrease the toxic effects and improve the life quality of these patients. (J Intervent Radiol, 2006, 15: 487-490)
文摘通过系统检索PubMed、Web of Science、Embase、Scopus和中国知网等数据库中与择时运动、代谢综合征相关的文献,分析择时运动、昼夜节律与代谢综合征的关系。发现:一天中不同时间的运动会影响血糖代谢反应,择时运动对血糖代谢的影响与进餐时间有关;择时运动能够降低代谢与心血管风险,与早上运动相比,晚上运动对降低血压有更大益处;AMPK、PGC1α以及HIF1α在运动调节昼夜节律影响代谢性疾病中发挥重要作用,这可能是择时运动影响代谢健康的潜在机制。认为:择时运动可作为昼夜节律紊乱相关病理的有效处方,将择时运动和进餐时间与分子时钟同步会最大限度地发挥运动对全身代谢健康的促进作用。未来研究可尝试探索不同运动在一天中的不同时间对机体代谢的影响,以最大限度地提高运动效益。
