Objectives: To study the ambulatory measured blood pressure (ABPM) profile in normotensive patients with mild cognitive impairment (MCI). Patients and Methods: The study was designed as a case control study including ...Objectives: To study the ambulatory measured blood pressure (ABPM) profile in normotensive patients with mild cognitive impairment (MCI). Patients and Methods: The study was designed as a case control study including 50male patients with mild cognitive impairment in the age group of 30 - 50 years old. The control group included 30 volunteers with no cognitive impairment and in the same age group (30 - 50 years old) and same gender. Mini-mental estate examination, office and ABP monitoring (ABPM) and brain MRI scans were done for cases and controls. Results: Thirty patients (60%) with MCI revealed a non-dipper blood pressure pattern. Sleeping systolic blood pressure and sleeping systolic load were significantly higher in patients with MCI than in normal volunteers (p = 0.01). MRI brain showed more white matter lesions (WMLs) in patients with MCI than in normal volunteers;however, this didn’t reach significance level (p = 0.056). Conclusion: MCI in normotensive young adult patients could reflect an abnormal circadian blood pressure rhythm. Ambulatory blood pressure monitoring could be an essential investigation in young adult MCI patients.展开更多
目的探讨高血压合并脑白质疏松患者血压昼夜节律与认知功能水平的相关性。方法选取2018年5月至2019年7月间,在延津县人民医院住院治疗的103例高血压患者作为研究对象,根据颅脑MRI表现,采用Fazekas等级评分法对患者脑白质疏松程度进行评...目的探讨高血压合并脑白质疏松患者血压昼夜节律与认知功能水平的相关性。方法选取2018年5月至2019年7月间,在延津县人民医院住院治疗的103例高血压患者作为研究对象,根据颅脑MRI表现,采用Fazekas等级评分法对患者脑白质疏松程度进行评估,同时采用蒙特利尔认知评估量表(Montreal Cognitive Assessment Scale,MoCA)对其认知功能水平进行评估,并收集患者昼夜血压动态变化数据,对比不同脑白质疏松程度患者的认知功能及血压水平,并进行相关性分析。结果103例高血压患者中合并脑白质疏松患者84例,伴有昼夜节律异常者50例,认知功能异常者34例。不同程度脑白质疏松患者24 h收缩压变异性(24 hour systole blood pressure variability,24 h SBPV)、24 h舒张压变异性(24 hour diastolic blood pressure variability,24 h DBPV)水平、昼夜节律异常人数及认知功能异常人数均有显著差异(P<0.05),24 h SBPV、24 h DBPV水平、昼夜节律异常人数及认知功能异常人数也有所增加。经Spearman相关性分析显示,脑白质分级与24 h SBPV、24 h DBPV、MoCA评分均呈正相关(P<0.05),MoCA评分与脑白质分级、24 h SBPV、24 h DBPV呈负相关(P<0.05)。结论血压昼夜节律异常和认知功能异常的发生率可随着高血压患者脑白质疏松严重程度的加重而增加,且血压昼夜节律变化程度与认知功能障碍的发生具有相关性。展开更多
文摘Objectives: To study the ambulatory measured blood pressure (ABPM) profile in normotensive patients with mild cognitive impairment (MCI). Patients and Methods: The study was designed as a case control study including 50male patients with mild cognitive impairment in the age group of 30 - 50 years old. The control group included 30 volunteers with no cognitive impairment and in the same age group (30 - 50 years old) and same gender. Mini-mental estate examination, office and ABP monitoring (ABPM) and brain MRI scans were done for cases and controls. Results: Thirty patients (60%) with MCI revealed a non-dipper blood pressure pattern. Sleeping systolic blood pressure and sleeping systolic load were significantly higher in patients with MCI than in normal volunteers (p = 0.01). MRI brain showed more white matter lesions (WMLs) in patients with MCI than in normal volunteers;however, this didn’t reach significance level (p = 0.056). Conclusion: MCI in normotensive young adult patients could reflect an abnormal circadian blood pressure rhythm. Ambulatory blood pressure monitoring could be an essential investigation in young adult MCI patients.
文摘目的探讨高血压合并脑白质疏松患者血压昼夜节律与认知功能水平的相关性。方法选取2018年5月至2019年7月间,在延津县人民医院住院治疗的103例高血压患者作为研究对象,根据颅脑MRI表现,采用Fazekas等级评分法对患者脑白质疏松程度进行评估,同时采用蒙特利尔认知评估量表(Montreal Cognitive Assessment Scale,MoCA)对其认知功能水平进行评估,并收集患者昼夜血压动态变化数据,对比不同脑白质疏松程度患者的认知功能及血压水平,并进行相关性分析。结果103例高血压患者中合并脑白质疏松患者84例,伴有昼夜节律异常者50例,认知功能异常者34例。不同程度脑白质疏松患者24 h收缩压变异性(24 hour systole blood pressure variability,24 h SBPV)、24 h舒张压变异性(24 hour diastolic blood pressure variability,24 h DBPV)水平、昼夜节律异常人数及认知功能异常人数均有显著差异(P<0.05),24 h SBPV、24 h DBPV水平、昼夜节律异常人数及认知功能异常人数也有所增加。经Spearman相关性分析显示,脑白质分级与24 h SBPV、24 h DBPV、MoCA评分均呈正相关(P<0.05),MoCA评分与脑白质分级、24 h SBPV、24 h DBPV呈负相关(P<0.05)。结论血压昼夜节律异常和认知功能异常的发生率可随着高血压患者脑白质疏松严重程度的加重而增加,且血压昼夜节律变化程度与认知功能障碍的发生具有相关性。
