Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain elusiv...Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain elusive.We sought to unveil the expression profile and biological role of circMYBL2 in HCC.Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of circMYBL2.Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression.Furthermore,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and E2F1.CircMYBL2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell lines.Elevated expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting effects.Mechanistically,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging miR-1205.Our findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.展开更多
Helicity-dependent photocurrent(HDPC)of the surface states in a high-quality topological insulator(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplate grown by chemical vapor deposition(CVD)is investigated.By investigating the angle...Helicity-dependent photocurrent(HDPC)of the surface states in a high-quality topological insulator(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplate grown by chemical vapor deposition(CVD)is investigated.By investigating the angle-dependent HDPC,it is found that the HDPC is mainly contributed by the circular photogalvanic effect(CPGE)current when the incident plane is perpendicular to the connection of the two contacts,whereas the circular photon drag effect(CPDE)dominates the HDPC when the incident plane is parallel to the connection of the two contacts.In addition,the CPGE of the(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplate is regulated by temperature,light power,excitation wavelength,the source–drain and ionic liquid top-gate voltages,and the regulation mechanisms are discussed.It is demonstrated that(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplates may provide a good platform for novel opto-spintronics devices.展开更多
Endothelial-mesenchymal transition(EndoMT) is associated with damage to blood-brain barrier(BBB) integrity.Circular RNAs(circRNAs) are highly expressed in the brain and are involved in brain diseases;however,whether c...Endothelial-mesenchymal transition(EndoMT) is associated with damage to blood-brain barrier(BBB) integrity.Circular RNAs(circRNAs) are highly expressed in the brain and are involved in brain diseases;however,whether circR NAs regulate the EndoM T in the brain remains unknown.Our study demonstrated that circH ECW2 regulated the EndoM T by directly binding to MIR30 D,a significantly downregulated miR NA from miR NA profiling,which subsequently caused an increased expression of ATG5.These findings shed new light on the understanding of the noncanonical role of ATG5 in the EndoMT induced by methamphetamine or lipopolysaccharide.The in vivo relevance was confirmed as microinjection of circHecw2 siRNA lentivirus into the mouse hippocampus suppressed the EndoMT induced by LPS.These findings provide novel insights regarding the contribution of circHECW2 to the nonautophagic role of ATG5 in the EndoMT process in the context of drug abuse and the broad range of neuroinflammatory disorders.展开更多
Based on our 2D BEM software THBEM2 which can be applied to thesimulation of an elastic body with randomly distributed identicalcircular holes, a scheme of BEM for the simulation of elastic bodieswith randomly distrib...Based on our 2D BEM software THBEM2 which can be applied to thesimulation of an elastic body with randomly distributed identicalcircular holes, a scheme of BEM for the simulation of elastic bodieswith randomly distributed circular inclusions is proposed. Thenumerical examples given show that the bound- ary element method ismore accurate and more effective than the finite element method forsuch a problem. The scheme presented van also be successfully used toestimate the effective elastic properties of composite Materials.展开更多
Under spinning conditions, lubricant on islandic spot patterned M2 steel disc experiences centrifugal and tangential force components. Depending upon the relative position of the spots and the flow of lubricant, accum...Under spinning conditions, lubricant on islandic spot patterned M2 steel disc experiences centrifugal and tangential force components. Depending upon the relative position of the spots and the flow of lubricant, accumulation of lubricant in front of patterned islandic spots creates thrusting to mating part and subsequently reduces contact between the mating couple. Whilst wear debris is likely to be spun off the plateau of the spots to their neighbouring valleys so as to reduce wear. Hence, it gives favorable tribological characteristics. Aiming at verifying such mechanisms, studies were performed on M2 steel disc specimens slid with ASSAB 17 tool steel pin. The M2 steel disc specimens were respectively （i） machined with non-patterned （NP）, （ii） etched to produce in-lined （INE） islandic patterns, and （iii） etched to produce staggered （STE） islandic spot patterns. Results indicated that the INE patterned discs gave most favorable wear characteristics, the NP of the worse characteristics whilst the STE ranged in the middle. However, the actual contact mechanism leads to the descending sequence of favorable friction behaviors nominally as： NP, INE and STE.展开更多
In array signal processing, 2-D spatial-spectrum estimation is required to determine DOA of multiple signals. The circular array of sensors is found to possess several nice properties for DOA estimation of wide-band s...In array signal processing, 2-D spatial-spectrum estimation is required to determine DOA of multiple signals. The circular array of sensors is found to possess several nice properties for DOA estimation of wide-band sources. C. U. Padmini, et al.(1994) had suggested that the frequency-direction ambiguity in azimuth estimation of wide-baud signals received by a uniform linear array (ULA) can be avoided by using a circular array, even without the use of any delay elements. In 2-D spatial-spectrum estimation for wide-band signals, the authors find that it is impossible to avoid the ambiguity in source frequency-elevation angle pairs using a circular array. In this paper, interpolated circular arrays are used to perform 2-D spatial-spectrum estimation for wide-band sources. In the estimation, a large aperture circular array (Υ】λmin/2) is found to possess superior resolution capability and robustness.展开更多
This paper extends the Non-Circular MUltiple SIgnal Classification(MUSIC)(NC-MUSIC) method for the common array geometries including Uniform Circular Arrays(UCAs) and Uniform Rectangular Arrays(URAs),which enables the...This paper extends the Non-Circular MUltiple SIgnal Classification(MUSIC)(NC-MUSIC) method for the common array geometries including Uniform Circular Arrays(UCAs) and Uniform Rectangular Arrays(URAs),which enables the algorithm to estimate 2-D Direction Of Arrival(DOA).A comparison between UCAs and URAs of NC-MUSIC is made in this paper.The simulations show that the NC-MUSIC method doubles the maximum estimation number of standard MUSIC.Using non-circular signals,the performance of URAs is improved remarkably while the improvement of UCAs is not so significantly.Moreover,the influence of arrays structures on the NC-MUSIC method is discussed.展开更多
基金supported by the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515010403,Ning Lyu)Natural Science Foundation of Guangdong Province,China(No.1914050001553,Dong Chen).
文摘Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain elusive.We sought to unveil the expression profile and biological role of circMYBL2 in HCC.Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of circMYBL2.Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression.Furthermore,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and E2F1.CircMYBL2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell lines.Elevated expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting effects.Mechanistically,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging miR-1205.Our findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62074036,61674038,and 11574302)the Foreign Cooperation Project of Fujian Province,China(Grant No.2023I0005)+2 种基金the Open Research Fund Program of the State Key Laboratory of Low-Dimensional Quantum Physics(Grant No.KF202108)the National Key Research and Development Program of China(Grant No.2016YFB0402303)the Foundation of Fujian Provincial Department of Industry and Information Technology of China(Grant No.82318075)。
文摘Helicity-dependent photocurrent(HDPC)of the surface states in a high-quality topological insulator(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplate grown by chemical vapor deposition(CVD)is investigated.By investigating the angle-dependent HDPC,it is found that the HDPC is mainly contributed by the circular photogalvanic effect(CPGE)current when the incident plane is perpendicular to the connection of the two contacts,whereas the circular photon drag effect(CPDE)dominates the HDPC when the incident plane is parallel to the connection of the two contacts.In addition,the CPGE of the(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplate is regulated by temperature,light power,excitation wavelength,the source–drain and ionic liquid top-gate voltages,and the regulation mechanisms are discussed.It is demonstrated that(Bi_(0.7)Sb_(0.3))_(2)Te_(3)nanoplates may provide a good platform for novel opto-spintronics devices.
文摘Endothelial-mesenchymal transition(EndoMT) is associated with damage to blood-brain barrier(BBB) integrity.Circular RNAs(circRNAs) are highly expressed in the brain and are involved in brain diseases;however,whether circR NAs regulate the EndoM T in the brain remains unknown.Our study demonstrated that circH ECW2 regulated the EndoM T by directly binding to MIR30 D,a significantly downregulated miR NA from miR NA profiling,which subsequently caused an increased expression of ATG5.These findings shed new light on the understanding of the noncanonical role of ATG5 in the EndoMT induced by methamphetamine or lipopolysaccharide.The in vivo relevance was confirmed as microinjection of circHecw2 siRNA lentivirus into the mouse hippocampus suppressed the EndoMT induced by LPS.These findings provide novel insights regarding the contribution of circHECW2 to the nonautophagic role of ATG5 in the EndoMT process in the context of drug abuse and the broad range of neuroinflammatory disorders.
基金the National Natural Science Foundation of China(No.19772025)
文摘Based on our 2D BEM software THBEM2 which can be applied to thesimulation of an elastic body with randomly distributed identicalcircular holes, a scheme of BEM for the simulation of elastic bodieswith randomly distributed circular inclusions is proposed. Thenumerical examples given show that the bound- ary element method ismore accurate and more effective than the finite element method forsuch a problem. The scheme presented van also be successfully used toestimate the effective elastic properties of composite Materials.
基金the National Natural Science Foundation of China(No. 50575173).
文摘Under spinning conditions, lubricant on islandic spot patterned M2 steel disc experiences centrifugal and tangential force components. Depending upon the relative position of the spots and the flow of lubricant, accumulation of lubricant in front of patterned islandic spots creates thrusting to mating part and subsequently reduces contact between the mating couple. Whilst wear debris is likely to be spun off the plateau of the spots to their neighbouring valleys so as to reduce wear. Hence, it gives favorable tribological characteristics. Aiming at verifying such mechanisms, studies were performed on M2 steel disc specimens slid with ASSAB 17 tool steel pin. The M2 steel disc specimens were respectively （i） machined with non-patterned （NP）, （ii） etched to produce in-lined （INE） islandic patterns, and （iii） etched to produce staggered （STE） islandic spot patterns. Results indicated that the INE patterned discs gave most favorable wear characteristics, the NP of the worse characteristics whilst the STE ranged in the middle. However, the actual contact mechanism leads to the descending sequence of favorable friction behaviors nominally as： NP, INE and STE.
文摘In array signal processing, 2-D spatial-spectrum estimation is required to determine DOA of multiple signals. The circular array of sensors is found to possess several nice properties for DOA estimation of wide-band sources. C. U. Padmini, et al.(1994) had suggested that the frequency-direction ambiguity in azimuth estimation of wide-baud signals received by a uniform linear array (ULA) can be avoided by using a circular array, even without the use of any delay elements. In 2-D spatial-spectrum estimation for wide-band signals, the authors find that it is impossible to avoid the ambiguity in source frequency-elevation angle pairs using a circular array. In this paper, interpolated circular arrays are used to perform 2-D spatial-spectrum estimation for wide-band sources. In the estimation, a large aperture circular array (Υ】λmin/2) is found to possess superior resolution capability and robustness.
文摘This paper extends the Non-Circular MUltiple SIgnal Classification(MUSIC)(NC-MUSIC) method for the common array geometries including Uniform Circular Arrays(UCAs) and Uniform Rectangular Arrays(URAs),which enables the algorithm to estimate 2-D Direction Of Arrival(DOA).A comparison between UCAs and URAs of NC-MUSIC is made in this paper.The simulations show that the NC-MUSIC method doubles the maximum estimation number of standard MUSIC.Using non-circular signals,the performance of URAs is improved remarkably while the improvement of UCAs is not so significantly.Moreover,the influence of arrays structures on the NC-MUSIC method is discussed.
