Although approximately one million sudden cardiac deaths occur yearly in the US and Europe,cardiac arrest (CA)remains a clinical condition still characterized by a poor prognosis.In an effort to improve the cardio- pu...Although approximately one million sudden cardiac deaths occur yearly in the US and Europe,cardiac arrest (CA)remains a clinical condition still characterized by a poor prognosis.In an effort to improve the cardio- pulmonary resuscitation(CPR)technique,the 2005 American Heart Association(AHA)Guidelines for CPR gave the impedance threshold device(ITD)a Class IIa recommendation.The AHA recommendation means that there is strong evidence to demonstrate that ITD enhances circulation,improves hemodynamics and increases the likelihood of resuscitation in patients in CA.During standard CPR,venous blood return to the heart relies on the natural elastic recoil of the chest which creates a transient decrease in intrathoracic pressure.The ITD further decreases intrathoracic pressure by preventing respiratory gases from entering the lungs during the decompression phase of CPR. Thus,although ITD is placed into the respiratory circuit it works as a circulatory enhancer device that provides its therapeutic benefit with each chest decompression. The ease of use of this device,its ability to be incor- porated into a mask and other airway devices,the absence of device-related adverse effects and few requirements in additional training,suggest that ITD may be a favorable new device for improving CPR efficiency.Since the literature is short of studies with clinically meaningful outcomes such as neurological outcome and long term survival,further evidence is still needed.展开更多
Nanomaterials show promising opportunities to address clinical problems （such as insufficient capture of circulating tumor cells; CTCs） via the high surface area-to-volume ratio and high affinity for biological cell...Nanomaterials show promising opportunities to address clinical problems （such as insufficient capture of circulating tumor cells; CTCs） via the high surface area-to-volume ratio and high affinity for biological cells. However, how to apply these nanomaterials as a nano-bio interface in a microfluidic device for efficient CTC capture with high specificity remains a challenge. In the present work, we first found that a titanium dioxide （TiO2） nanorod array that can be conveniently prepared on multiple kinds of substrates has high affinity for tumor cells. Then, the TiO2 nanorod array was vertically grown on the surface of a microchannel with hexagonally patterned Si micropillars via a hydrothermal reaction, forming a new kind of a micro-nano 3D hierarchically structured microfluidic device. The vertically grown TiO2 nanorod array was used as a sensitive nano-bio interface of this 3D hierarchically structured microfluidic device, which showed high efficiency of CTC capture （76.7% ± 7.1%） in an artificial whole-blood sample.展开更多
Circulating tumor cells(CTCs)are cancer cells that have propagated from primary tumor sites,spreading into the bloodstream as the cellular origin of fatal metastasis,and to secondary tumor sites.Capturing and analyzin...Circulating tumor cells(CTCs)are cancer cells that have propagated from primary tumor sites,spreading into the bloodstream as the cellular origin of fatal metastasis,and to secondary tumor sites.Capturing and analyzing CTCs is a kind of‘‘liquid biopsy'of the tumor that provides information about cancer changes over time and tailoring treatment[1].CTC enrichment and detection remains technologically challenging due to their extremely low concentra-展开更多
文摘Although approximately one million sudden cardiac deaths occur yearly in the US and Europe,cardiac arrest (CA)remains a clinical condition still characterized by a poor prognosis.In an effort to improve the cardio- pulmonary resuscitation(CPR)technique,the 2005 American Heart Association(AHA)Guidelines for CPR gave the impedance threshold device(ITD)a Class IIa recommendation.The AHA recommendation means that there is strong evidence to demonstrate that ITD enhances circulation,improves hemodynamics and increases the likelihood of resuscitation in patients in CA.During standard CPR,venous blood return to the heart relies on the natural elastic recoil of the chest which creates a transient decrease in intrathoracic pressure.The ITD further decreases intrathoracic pressure by preventing respiratory gases from entering the lungs during the decompression phase of CPR. Thus,although ITD is placed into the respiratory circuit it works as a circulatory enhancer device that provides its therapeutic benefit with each chest decompression. The ease of use of this device,its ability to be incor- porated into a mask and other airway devices,the absence of device-related adverse effects and few requirements in additional training,suggest that ITD may be a favorable new device for improving CPR efficiency.Since the literature is short of studies with clinically meaningful outcomes such as neurological outcome and long term survival,further evidence is still needed.
基金The authors are thankful for funding from the National Natural Science Foundation of China （Nos. 51402063, 51432005, 61405040, 61505010, 51502018, 31270022, and 81471784）, the ＂100 Talents Program＂ of the Chinese Academy of Sciences, Beijing City Committee of science and technology （No. Z151100003315010）, Beijing Natural Science Foundation （Nos. 2164077 and 2164076）, the Fundamental Research Funds of Shandong University （No. 2014QY003）, and the Youth Innovation Promotion Association of the Chinese Academy of Sciences （No. 2015023）. The authors also acknowledge the support from the＂thousands talents＂ program for pioneer researchers and his innovation team, and support from the President Funding of the Chinese Academy of Sciences.
文摘Nanomaterials show promising opportunities to address clinical problems （such as insufficient capture of circulating tumor cells; CTCs） via the high surface area-to-volume ratio and high affinity for biological cells. However, how to apply these nanomaterials as a nano-bio interface in a microfluidic device for efficient CTC capture with high specificity remains a challenge. In the present work, we first found that a titanium dioxide （TiO2） nanorod array that can be conveniently prepared on multiple kinds of substrates has high affinity for tumor cells. Then, the TiO2 nanorod array was vertically grown on the surface of a microchannel with hexagonally patterned Si micropillars via a hydrothermal reaction, forming a new kind of a micro-nano 3D hierarchically structured microfluidic device. The vertically grown TiO2 nanorod array was used as a sensitive nano-bio interface of this 3D hierarchically structured microfluidic device, which showed high efficiency of CTC capture （76.7% ± 7.1%） in an artificial whole-blood sample.
基金supported by the National Basic Research Program of China(2015CB932100,2013CB932703)the National Natural Science Foundation of China(11405185)
文摘Circulating tumor cells(CTCs)are cancer cells that have propagated from primary tumor sites,spreading into the bloodstream as the cellular origin of fatal metastasis,and to secondary tumor sites.Capturing and analyzing CTCs is a kind of‘‘liquid biopsy'of the tumor that provides information about cancer changes over time and tailoring treatment[1].CTC enrichment and detection remains technologically challenging due to their extremely low concentra-
