OBJECTIVE To investigate the role of chronochemotherapy in the treatment of nasopharyngeal carcinoma （NPC）. METHODS Sixty NPC patients were randomly designated for induction chrono-chemotherapy plus radiotherapy （C...OBJECTIVE To investigate the role of chronochemotherapy in the treatment of nasopharyngeal carcinoma （NPC）. METHODS Sixty NPC patients were randomly designated for induction chrono-chemotherapy plus radiotherapy （CC, 30 patients） or for induction routine-chemotherapy plus radiotherapy （RC, 30 patients）. The differences in immediate response, side effects and changes in immunologic parameters between these two groups were analyzed. The chemotherapy regimen of the CC group consisted of cisplatin （DDP） 80 mg/m^2 d1 at 10：00-22：00 h, 5-flurouracil （5-FU） 750 mg/m^2/d1-3 at 22：00-10：00 on the next day and 5-CHO-FH4 （CF） 200 mg/m^2/d1-3 starting at 10：00 h, and repeated every 14 days. The regimen of the RC group was the same as the CC group, with the delivery of cisplatin at a conventional rate and the CF via a continuous 24 h venous injection. The radiotherapy regimen was same in the two groups. RESULTS The complete response rates for the CC and RC groups were 36.7% and 20.0%, respectively（P〈0.05）and the response rates （complete response＋partial response ） were 96.7% and 73.3% respectively. The grade I and II myelosuppression was more serious in the RC group, with rates of 43.3% and 70% in the CC and RC groups （P〈0.05） respectively. The differences in CD3, CD4, CD3/CD8, T＋B＋NK and CD8 cell levels between before and after treatment of the CC group were significant （P〈 0.05）, but differences in the RC group were not significant. CONCLUSION The immediate therapeutic response is better with concurrent chronochemotherapy plus radiotherapy and there are fewer side effect compared to concurrent routine-chemotherapy plus radiotherapy.展开更多
文摘OBJECTIVE To investigate the role of chronochemotherapy in the treatment of nasopharyngeal carcinoma （NPC）. METHODS Sixty NPC patients were randomly designated for induction chrono-chemotherapy plus radiotherapy （CC, 30 patients） or for induction routine-chemotherapy plus radiotherapy （RC, 30 patients）. The differences in immediate response, side effects and changes in immunologic parameters between these two groups were analyzed. The chemotherapy regimen of the CC group consisted of cisplatin （DDP） 80 mg/m^2 d1 at 10：00-22：00 h, 5-flurouracil （5-FU） 750 mg/m^2/d1-3 at 22：00-10：00 on the next day and 5-CHO-FH4 （CF） 200 mg/m^2/d1-3 starting at 10：00 h, and repeated every 14 days. The regimen of the RC group was the same as the CC group, with the delivery of cisplatin at a conventional rate and the CF via a continuous 24 h venous injection. The radiotherapy regimen was same in the two groups. RESULTS The complete response rates for the CC and RC groups were 36.7% and 20.0%, respectively（P〈0.05）and the response rates （complete response＋partial response ） were 96.7% and 73.3% respectively. The grade I and II myelosuppression was more serious in the RC group, with rates of 43.3% and 70% in the CC and RC groups （P〈0.05） respectively. The differences in CD3, CD4, CD3/CD8, T＋B＋NK and CD8 cell levels between before and after treatment of the CC group were significant （P〈 0.05）, but differences in the RC group were not significant. CONCLUSION The immediate therapeutic response is better with concurrent chronochemotherapy plus radiotherapy and there are fewer side effect compared to concurrent routine-chemotherapy plus radiotherapy.
