As the risks associated with air turbulence are intensified by climate change and the growth of the aviation industry,it has become imperative to monitor and mitigate these threats to ensure civil aviation safety.The ...As the risks associated with air turbulence are intensified by climate change and the growth of the aviation industry,it has become imperative to monitor and mitigate these threats to ensure civil aviation safety.The eddy dissipation rate(EDR)has been established as the standard metric for quantifying turbulence in civil aviation.This study aims to explore a universally applicable symbolic classification approach based on genetic programming to detect turbulence anomalies using quick access recorder(QAR)data.The detection of atmospheric turbulence is approached as an anomaly detection problem.Comparative evaluations demonstrate that this approach performs on par with direct EDR calculation methods in identifying turbulence events.Moreover,comparisons with alternative machine learning techniques indicate that the proposed technique is the optimal methodology currently available.In summary,the use of symbolic classification via genetic programming enables accurate turbulence detection from QAR data,comparable to that with established EDR approaches and surpassing that achieved with machine learning algorithms.This finding highlights the potential of integrating symbolic classifiers into turbulence monitoring systems to enhance civil aviation safety amidst rising environmental and operational hazards.展开更多
The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless networks.Specifically,IoT systems are vulnerable to cyberattacks due to its opennes The proposed wo...The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless networks.Specifically,IoT systems are vulnerable to cyberattacks due to its opennes The proposed work intends to implement a new security framework for detecting the most specific and harmful intrusions in IoT networks.In this framework,a Covariance Linear Learning Embedding Selection(CL2ES)methodology is used at first to extract the features highly associated with the IoT intrusions.Then,the Kernel Distributed Bayes Classifier(KDBC)is created to forecast attacks based on the probability distribution value precisely.In addition,a unique Mongolian Gazellas Optimization(MGO)algorithm is used to optimize the weight value for the learning of the classifier.The effectiveness of the proposed CL2ES-KDBC framework has been assessed using several IoT cyber-attack datasets,The obtained results are then compared with current classification methods regarding accuracy(97%),precision(96.5%),and other factors.Computational analysis of the CL2ES-KDBC system on IoT intrusion datasets is performed,which provides valuable insight into its performance,efficiency,and suitability for securing IoT networks.展开更多
Malware attacks on Windows machines pose significant cybersecurity threats,necessitating effective detection and prevention mechanisms.Supervised machine learning classifiers have emerged as promising tools for malwar...Malware attacks on Windows machines pose significant cybersecurity threats,necessitating effective detection and prevention mechanisms.Supervised machine learning classifiers have emerged as promising tools for malware detection.However,there remains a need for comprehensive studies that compare the performance of different classifiers specifically for Windows malware detection.Addressing this gap can provide valuable insights for enhancing cybersecurity strategies.While numerous studies have explored malware detection using machine learning techniques,there is a lack of systematic comparison of supervised classifiers for Windows malware detection.Understanding the relative effectiveness of these classifiers can inform the selection of optimal detection methods and improve overall security measures.This study aims to bridge the research gap by conducting a comparative analysis of supervised machine learning classifiers for detecting malware on Windows systems.The objectives include Investigating the performance of various classifiers,such as Gaussian Naïve Bayes,K Nearest Neighbors(KNN),Stochastic Gradient Descent Classifier(SGDC),and Decision Tree,in detecting Windows malware.Evaluating the accuracy,efficiency,and suitability of each classifier for real-world malware detection scenarios.Identifying the strengths and limitations of different classifiers to provide insights for cybersecurity practitioners and researchers.Offering recommendations for selecting the most effective classifier for Windows malware detection based on empirical evidence.The study employs a structured methodology consisting of several phases:exploratory data analysis,data preprocessing,model training,and evaluation.Exploratory data analysis involves understanding the dataset’s characteristics and identifying preprocessing requirements.Data preprocessing includes cleaning,feature encoding,dimensionality reduction,and optimization to prepare the data for training.Model training utilizes various supervised classifiers,and their performance is evaluated using metrics such as accuracy,precision,recall,and F1 score.The study’s outcomes comprise a comparative analysis of supervised machine learning classifiers for Windows malware detection.Results reveal the effectiveness and efficiency of each classifier in detecting different types of malware.Additionally,insights into their strengths and limitations provide practical guidance for enhancing cybersecurity defenses.Overall,this research contributes to advancing malware detection techniques and bolstering the security posture of Windows systems against evolving cyber threats.展开更多
Cross entropy is a measure in machine learning and deep learning that assesses the difference between predicted and actual probability distributions. In this study, we propose cross entropy as a performance evaluation...Cross entropy is a measure in machine learning and deep learning that assesses the difference between predicted and actual probability distributions. In this study, we propose cross entropy as a performance evaluation metric for image classifier models and apply it to the CT image classification of lung cancer. A convolutional neural network is employed as the deep neural network (DNN) image classifier, with the residual network (ResNet) 50 chosen as the DNN archi-tecture. The image data used comprise a lung CT image set. Two classification models are built from datasets with varying amounts of data, and lung cancer is categorized into four classes using 10-fold cross-validation. Furthermore, we employ t-distributed stochastic neighbor embedding to visually explain the data distribution after classification. Experimental results demonstrate that cross en-tropy is a highly useful metric for evaluating the reliability of image classifier models. It is noted that for a more comprehensive evaluation of model perfor-mance, combining with other evaluation metrics is considered essential. .展开更多
Breast cancer is a deadly disease and radiologists recommend mammography to detect it at the early stages. This paper presents two types of HanmanNets using the information set concept for the derivation of deep infor...Breast cancer is a deadly disease and radiologists recommend mammography to detect it at the early stages. This paper presents two types of HanmanNets using the information set concept for the derivation of deep information set features from ResNet by modifying its kernel functions to yield Type-1 HanmanNets and then AlexNet, GoogLeNet and VGG-16 by changing their feature maps to yield Type-2 HanmanNets. The two types of HanmanNets exploit the final feature maps of these architectures in the generation of deep information set features from mammograms for their classification using the Hanman Transform Classifier. In this work, the characteristics of the abnormality present in the mammograms are captured using the above network architectures that help derive the features of HanmanNets based on information set concept and their performance is compared via the classification accuracies. The highest accuracy of 100% is achieved for the multi-class classifications on the mini-MIAS database thus surpassing the results in the literature. Validation of the results is done by the expert radiologists to show their clinical relevance.展开更多
Biometric recognition refers to the identification of individuals through their unique behavioral features(e.g.,fingerprint,face,and iris).We need distinguishing characteristics to identify people,such as fingerprints...Biometric recognition refers to the identification of individuals through their unique behavioral features(e.g.,fingerprint,face,and iris).We need distinguishing characteristics to identify people,such as fingerprints,which are world-renowned as the most reliablemethod to identify people.The recognition of fingerprints has become a standard procedure in forensics,and different techniques are available for this purpose.Most current techniques lack interest in image enhancement and rely on high-dimensional features to generate classification models.Therefore,we proposed an effective fingerprint classification method for classifying the fingerprint image as authentic or altered since criminals and hackers routinely change their fingerprints to generate fake ones.In order to improve fingerprint classification accuracy,our proposed method used the most effective texture features and classifiers.Discriminant Analysis(DCA)and Gaussian Discriminant Analysis(GDA)are employed as classifiers,along with Histogram of Oriented Gradient(HOG)and Segmentation-based Feature Texture Analysis(SFTA)feature vectors as inputs.The performance of the classifiers is determined by assessing a range of feature sets,and the most accurate results are obtained.The proposed method is tested using a Sokoto Coventry Fingerprint Dataset(SOCOFing).The SOCOFing project includes 6,000 fingerprint images collected from 600 African people whose fingerprints were taken ten times.Three distinct degrees of obliteration,central rotation,and z-cut have been performed to obtain synthetically altered replicas of the genuine fingerprints.The proposal achieved massive success with a classification accuracy reaching 99%.The experimental results indicate that the proposed method for fingerprint classification is feasible and effective.The experiments also showed that the proposed SFTA-based GDA method outperformed state-of-art approaches in feature dimension and classification accuracy.展开更多
Multiple classifier system exhibits strong classification capacity compared with single classifiers,but they require significant computational resources.Selective ensemble system aims to attain equivalent or better cl...Multiple classifier system exhibits strong classification capacity compared with single classifiers,but they require significant computational resources.Selective ensemble system aims to attain equivalent or better classification accuracy with fewer classifiers.However,current methods fail to identify precise solutions for constructing an ensemble classifier.In this study,we propose an ensemble classifier design technique based on the perturbation binary salp swarm algorithm(ECDPB).Considering that extreme learning machines(ELMs)have rapid learning rates and good generalization ability,they can serve as the basic classifier for creating multiple candidates while using fewer computational resources.Meanwhile,we introduce a combined diversity measure by taking the complementarity and accuracy of ELMs into account;it is used to identify the ELMs that have good diversity and low error.In addition,we propose an ECDPB with powerful optimizing ability;it is employed to find the optimal subset of ELMs.The selected ELMs can then be used to forman ensemble classifier.Experiments on 10 benchmark datasets have been conducted,and the results demonstrate that the proposed ECDPB delivers superior classification capacity when compared with alternative methods.展开更多
In this paper,an Observation Points Classifier Ensemble(OPCE)algorithm is proposed to deal with High-Dimensional Imbalanced Classification(HDIC)problems based on data processed using the Multi-Dimensional Scaling(MDS)...In this paper,an Observation Points Classifier Ensemble(OPCE)algorithm is proposed to deal with High-Dimensional Imbalanced Classification(HDIC)problems based on data processed using the Multi-Dimensional Scaling(MDS)feature extraction technique.First,dimensionality of the original imbalanced data is reduced using MDS so that distances between any two different samples are preserved as well as possible.Second,a novel OPCE algorithm is applied to classify imbalanced samples by placing optimised observation points in a low-dimensional data space.Third,optimization of the observation point mappings is carried out to obtain a reliable assessment of the unknown samples.Exhaustive experiments have been conducted to evaluate the feasibility,rationality,and effectiveness of the proposed OPCE algorithm using seven benchmark HDIC data sets.Experimental results show that(1)the OPCE algorithm can be trained faster on low-dimensional imbalanced data than on high-dimensional data;(2)the OPCE algorithm can correctly identify samples as the number of optimised observation points is increased;and(3)statistical analysis reveals that OPCE yields better HDIC performances on the selected data sets in comparison with eight other HDIC algorithms.This demonstrates that OPCE is a viable algorithm to deal with HDIC problems.展开更多
The Repository Mahasiswa(RAMA)is a national repository of research reports in the form of final assignments,student projects,theses,dissertations,and research reports of lecturers or researchers that have not yet been...The Repository Mahasiswa(RAMA)is a national repository of research reports in the form of final assignments,student projects,theses,dissertations,and research reports of lecturers or researchers that have not yet been published in journals,conferences,or integrated books from the scientific repository of universities and research institutes in Indonesia.The increasing popularity of the RAMA Repository leads to security issues,including the two most widespread,vulnerable attacks i.e.,Structured Query Language(SQL)injection and cross-site scripting(XSS)attacks.An attacker gaining access to data and performing unauthorized data modifications is extremely dangerous.This paper aims to provide an attack detection system for securing the repository portal from the abovementioned attacks.The proposed system combines a Long Short–Term Memory and Principal Component Analysis(LSTM-PCA)model as a classifier.This model can effectively solve the vanishing gradient problem caused by excessive positive samples.The experiment results show that the proposed system achieves an accuracy of 96.85%using an 80%:20%ratio of training data and testing data.The rationale for this best achievement is that the LSTM’s Forget Gate works very well as the PCA supplies only selected features that are significantly relevant to the attacks’patterns.The Forget Gate in LSTM is responsible for deciding which information should be kept for computing the cell state and which one is not relevant and can be discarded.In addition,the LSTM’s Input Gate assists in finding out crucial information and stores specific relevant data in the memory.展开更多
For a long time,legal entities have developed and used crime prediction methodologies.The techniques are frequently updated based on crime evaluations and responses from scientific communities.There is a need to devel...For a long time,legal entities have developed and used crime prediction methodologies.The techniques are frequently updated based on crime evaluations and responses from scientific communities.There is a need to develop type-based crime prediction methodologies that can be used to address issues at the subgroup level.Child maltreatment is not adequately addressed because children are voiceless.As a result,the possibility of developing a model for predicting child abuse was investigated in this study.Various exploratory analysis methods were used to examine the city of Chicago’s child abuse events.The data set was balanced using the Borderline-SMOTE technique,and then a stacking classifier was employed to ensemble multiple algorithms to predict various types of child abuse.The proposed approach successfully predicted crime types with 93%of accuracy,precision,recall,and F1-Score.The AUC value of the same was 0.989.However,when compared to the Extra Trees model(17.55),which is the second best,the proposed model’s execution time was significantly longer(476.63).We discovered that Machine Learning methods effectively evaluate the demographic and spatial-temporal characteristics of the crimes and predict the occurrences of various subtypes of child abuse.The results indicated that the proposed Borderline-SMOTE enabled Stacking Classifier model(BS-SC Model)would be effective in the real-time child abuse prediction and prevention process.展开更多
Automatic Speech Emotion Recognition(SER)is used to recognize emotion from speech automatically.Speech Emotion recognition is working well in a laboratory environment but real-time emotion recognition has been influen...Automatic Speech Emotion Recognition(SER)is used to recognize emotion from speech automatically.Speech Emotion recognition is working well in a laboratory environment but real-time emotion recognition has been influenced by the variations in gender,age,the cultural and acoustical background of the speaker.The acoustical resemblance between emotional expressions further increases the complexity of recognition.Many recent research works are concentrated to address these effects individually.Instead of addressing every influencing attribute individually,we would like to design a system,which reduces the effect that arises on any factor.We propose a two-level Hierarchical classifier named Interpreter of responses(IR).Thefirst level of IR has been realized using Support Vector Machine(SVM)and Gaussian Mixer Model(GMM)classifiers.In the second level of IR,a discriminative SVM classifier has been trained and tested with meta information offirst-level classifiers along with the input acoustical feature vector which is used in primary classifiers.To train the system with a corpus of versatile nature,an integrated emotion corpus has been composed using emotion samples of 5 speech corpora,namely;EMO-DB,IITKGP-SESC,SAVEE Corpus,Spanish emotion corpus,CMU's Woogle corpus.The hierarchical classifier has been trained and tested using MFCC and Low-Level Descriptors(LLD).The empirical analysis shows that the proposed classifier outperforms the traditional classifiers.The proposed ensemble design is very generic and can be adapted even when the number and nature of features change.Thefirst-level classifiers GMM or SVM may be replaced with any other learning algorithm.展开更多
A single-qubit quantum classifier(SQC)based on a gradient-free optimization(GFO)algorithm,named the GFO-based SQC,is proposed to overcome the effects of barren plateaus caused by quantum devices.Here,a rotation gate R...A single-qubit quantum classifier(SQC)based on a gradient-free optimization(GFO)algorithm,named the GFO-based SQC,is proposed to overcome the effects of barren plateaus caused by quantum devices.Here,a rotation gate R_(X)(φ)is applied on the single-qubit binary quantum classifier,and the training data and parameters are loaded intoφin the form of vector multiplication.The cost function is decreased by finding the value of each parameter that yields the minimum expectation value of measuring the quantum circuit.The algorithm is performed iteratively for all parameters one by one until the cost function satisfies the stop condition.The proposed GFO-based SQC is demonstrated for classification tasks in Iris and MNIST datasets and compared with the Adam-based SQC and the quantum support vector machine(QSVM).Furthermore,the performance of the GFO-based SQC is discussed when the rotation gate in the quantum device is under different types of noise.The simulation results show that the GFO-based SQC can reach a high accuracy in reduced time.Additionally,the proposed GFO algorithm can quickly complete the training process of the SQC.Importantly,the GFO-based SQC has a good performance in noisy environments.展开更多
One of the most common types of threats to the digital world is malicious software.It is of great importance to detect and prevent existing and new malware before it damages information assets.Machine learning approac...One of the most common types of threats to the digital world is malicious software.It is of great importance to detect and prevent existing and new malware before it damages information assets.Machine learning approaches are used effectively for this purpose.In this study,we present a model in which supervised and unsupervised learning algorithms are used together.Clustering is used to enhance the prediction performance of the supervised classifiers.The aim of the proposed model is to make predictions in the shortest possible time with high accuracy and f1 score.In the first stage of the model,the data are clustered with the k-means algorithm.In the second stage,the prediction is made with the combination of the classifier with the best prediction performance for the related cluster.While choosing the best classifiers for the given clusters,triple combinations of ten machine learning algorithms(kernel support vector machine,k-nearest neighbor,naive Bayes,decision tree,random forest,extra gradient boosting,categorical boosting,adaptive boosting,extra trees,and gradient boosting)are used.The selected triple classifier combination is positioned in two stages.The prediction time of the model is improved by positioning the classifier with the slowest prediction time in the second stage.The selected triple classifier combination is positioned in two tiers.The prediction time of the model is improved by positioning the classifier with the highest prediction time in the second tier.It is seen that clustering before classification improves prediction performance,which is presented using Blue Hexagon Open Dataset for Malware Analysis(BODMAS),Elastic Malware Benchmark for Empowering Researchers(EMBER)2018 and Kaggle malware detection datasets.The model has 99.74%accuracy and 99.77%f1 score for the BODMAS dataset,99.04%accuracy and 98.63%f1 score for the Kaggle malware detection dataset,and 96.77%accuracy and 96.77%f1 score for the EMBER 2018 dataset.In addition,the tiered positioning of classifiers shortened the average prediction time by 76.13%for the BODMAS dataset and 95.95%for the EMBER 2018 dataset.The proposed method’s prediction performance is better than the rest of the studies in the literature in which BODMAS and EMBER 2018 datasets are used.展开更多
Design constraints verification is the most computationally expensive task in evolutionary structural optimization due to a large number of structural analyses thatmust be conducted.Building a surrogatemodel to approx...Design constraints verification is the most computationally expensive task in evolutionary structural optimization due to a large number of structural analyses thatmust be conducted.Building a surrogatemodel to approximate the behavior of structures instead of the exact structural analyses is a possible solution to tackle this problem.However,most existing surrogate models have been designed based on regression techniques.This paper proposes a novel method,called CaDE,which adopts a machine learning classification technique for enhancing the performance of the Differential Evolution(DE)optimization.The proposed method is separated into two stages.During the first optimization stage,the original DE is implemented as usual,but all individuals produced in this phase are stored as inputs of the training data.Based on design constraints verification,these individuals are labeled as“safe”or“unsafe”and their labels are saved as outputs of the training data.When collecting enough data,an AdaBoost model is trained to evaluate the safety state of structures.This model is then used in the second stage to preliminarily assess new individuals,and unpromising ones are rejected without checking design constraints.This method reduces unnecessary structural analyses,thereby shortens the optimization process.Five benchmark truss sizing optimization problems are solved using the proposed method to demonstrate its effectiveness.The obtained results show that the CaDE finds good optimal designs with less structural analyses in comparison with the original DE and four other DE variants.The reduction rate of five examples ranges from 18 to over 50%.Moreover,the proposed method is applied to a real-size transmission tower design problem to exhibit its applicability in practice.展开更多
Managing physical objects in the network’s periphery is made possible by the Internet of Things(IoT),revolutionizing human life.Open attacks and unauthorized access are possible with these IoT devices,which exchange ...Managing physical objects in the network’s periphery is made possible by the Internet of Things(IoT),revolutionizing human life.Open attacks and unauthorized access are possible with these IoT devices,which exchange data to enable remote access.These attacks are often detected using intrusion detection methodologies,although these systems’effectiveness and accuracy are subpar.This paper proposes a new voting classifier composed of an ensemble of machine learning models trained and optimized using metaheuristic optimization.The employed metaheuristic optimizer is a new version of the whale optimization algorithm(WOA),which is guided by the dipper throated optimizer(DTO)to improve the exploration process of the traditionalWOA optimizer.The proposed voting classifier categorizes the network intrusions robustly and efficiently.To assess the proposed approach,a dataset created from IoT devices is employed to record the efficiency of the proposed algorithm for binary attack categorization.The dataset records are balanced using the locality-sensitive hashing(LSH)and Synthetic Minority Oversampling Technique(SMOTE).The evaluation of the achieved results is performed in terms of statistical analysis and visual plots to prove the proposed approach’s effectiveness,stability,and significance.The achieved results confirmed the superiority of the proposed algorithm for the task of network intrusion detection.展开更多
As per World Health Organization report which was released in the year of 2019,Diabetes claimed the lives of approximately 1.5 million individuals globally in 2019 and around 450 million people are affected by diabete...As per World Health Organization report which was released in the year of 2019,Diabetes claimed the lives of approximately 1.5 million individuals globally in 2019 and around 450 million people are affected by diabetes all over the world.Hence it is inferred that diabetes is rampant across the world with the majority of the world population being affected by it.Among the diabetics,it can be observed that a large number of people had failed to identify their disease in the initial stage itself and hence the disease level moved from Type-1 to Type-2.To avoid this situation,we propose a new fuzzy logic based neural classifier for early detection of diabetes.A set of new neuro-fuzzy rules is introduced with time constraints that are applied for thefirst level classification.These levels are further refined by using the Fuzzy Cognitive Maps(FCM)with time intervals for making thefinal decision over the classification process.The main objective of this proposed model is to detect the diabetes level based on the time.Also,the set of neuro-fuzzy rules are used for selecting the most contributing values over the decision-making process in diabetes prediction.The proposed model proved its efficiency in performance after experiments conducted not only from the repository but also by using the standard diabetic detection models that are available in the market.展开更多
Coronary artery disease(CAD)is one of themost authentic cardiovascular afflictions because it is an uncommonly overwhelming heart issue.The breakdown of coronary cardiovascular disease is one of the principal sources ...Coronary artery disease(CAD)is one of themost authentic cardiovascular afflictions because it is an uncommonly overwhelming heart issue.The breakdown of coronary cardiovascular disease is one of the principal sources of death all over theworld.Cardiovascular deterioration is a challenge,especially in youthful and rural countries where there is an absence of humantrained professionals.Since heart diseases happen without apparent signs,high-level detection is desirable.This paper proposed a robust and tuned random forest model using the randomized grid search technique to predictCAD.The proposed framework increases the ability of CADpredictions by tracking down risk pointers and learning the confusing joint efforts between them.Nowadays,the healthcare industry has a lot of data but needs to gain more knowledge.Our proposed framework is used for extracting knowledge from data stores and using that knowledge to help doctors accurately and effectively diagnose heart disease(HD).We evaluated the proposed framework over two public databases,Cleveland and Framingham datasets.The datasets were preprocessed by using a cleaning technique,a normalization technique,and an outlier detection technique.Secondly,the principal component analysis(PCA)algorithm was utilized to lessen the feature dimensionality of the two datasets.Finally,we used a hyperparameter tuning technique,randomized grid search,to tune a random forest(RF)machine learning(ML)model.The randomized grid search selected the best parameters and got the ideal CAD analysis.The proposed framework was evaluated and compared with traditional classifiers.Our proposed framework’s accuracy,sensitivity,precision,specificity,and f1-score were 100%.The evaluation of the proposed framework showed that it is an unrivaled perceptive outcome with tuning as opposed to other ongoing existing frameworks.展开更多
Triple-negative breast cancer(TNBC)poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior.Methods:We analyzed clinical information and mRNA exp...Triple-negative breast cancer(TNBC)poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior.Methods:We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA.Utilizing weighted gene coexpression network analysis,we pinpointed 34 TNBC immune genes linked to survival.The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction.We calculated chemotherapy sensitivity scores using the“pRRophetic”package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and Exclusion algorithm.Results:In this study,34 survival-related TNBC immune gene expression profiles were identified.A least absolute shrinkage and selection operator-Cox regression model was used and 15 candidates were prioritized,with a concomitant establishment of a robust risk immune classifier.The high-risk TNBC immune groups showed increased sensitivity to therapeutic agents like RO-3306,Tamoxifen,Sunitinib,JNK Inhibitor VIII,XMD11-85h,BX-912,and Tivozanib.An analysis of the Search Tool for Interaction of Chemicals database revealed the associations between the high-risk group and signaling pathways,such as those involving Rap1,Ras,and PI3K-Akt.The low-risk group showed a higher immunotherapy response rate,as observed through the tumor immune dysfunction and exclusion analysis in the TCGA-TNBC and METABRIC-TNBC cohorts.Conclusion:This study provides insights into the immune complexities of TNBC,paving the way for novel diagnostic approaches and precision treatment methods that exploit its immunological intricacies,thus offering hope for improved management and outcomes of this challenging disease.展开更多
The necessity of on-time cancer detection is extremely high in the recent days as it becomes a threat to human life.The skin cancer is considered as one of the dangerous diseases among other types of cancer since it c...The necessity of on-time cancer detection is extremely high in the recent days as it becomes a threat to human life.The skin cancer is considered as one of the dangerous diseases among other types of cancer since it causes severe health impacts on human beings and hence it is highly mandatory to detect the skin cancer in the early stage for providing adequate treatment.Therefore,an effective image processing approach is employed in this present study for the accurate detection of skin cancer.Initially,the dermoscopy images of skin lesions are retrieved and processed by eliminating the noises with the assistance of Gaborfilter.Then,the pre-processed dermoscopy image is segmented into multiple regions by implementing cascaded Fuzzy C-Means(FCM)algorithm,which involves in improving the reliability of cancer detection.The A Gabor Response Co-occurrence Matrix(GRCM)is used to extract melanoma parameters in an effi-cient manner.A hybrid Particle Swarm Optimization(PSO)-Whale Optimization is then utilized for efficiently optimizing the extracted features.Finally,the fea-tures are significantly classified with the assistance of Probabilistic Neural Net-work(PNN)classifier for classifying the stages of skin lesion in an optimal manner.The whole work is stimulated in MATLAB and the attained outcomes have proved that the introduced approach delivers optimal results with maximal accuracy of 97.83%.展开更多
基金supported by the Meteorological Soft Science Project(Grant No.2023ZZXM29)the Natural Science Fund Project of Tianjin,China(Grant No.21JCYBJC00740)the Key Research and Development-Social Development Program of Jiangsu Province,China(Grant No.BE2021685).
文摘As the risks associated with air turbulence are intensified by climate change and the growth of the aviation industry,it has become imperative to monitor and mitigate these threats to ensure civil aviation safety.The eddy dissipation rate(EDR)has been established as the standard metric for quantifying turbulence in civil aviation.This study aims to explore a universally applicable symbolic classification approach based on genetic programming to detect turbulence anomalies using quick access recorder(QAR)data.The detection of atmospheric turbulence is approached as an anomaly detection problem.Comparative evaluations demonstrate that this approach performs on par with direct EDR calculation methods in identifying turbulence events.Moreover,comparisons with alternative machine learning techniques indicate that the proposed technique is the optimal methodology currently available.In summary,the use of symbolic classification via genetic programming enables accurate turbulence detection from QAR data,comparable to that with established EDR approaches and surpassing that achieved with machine learning algorithms.This finding highlights the potential of integrating symbolic classifiers into turbulence monitoring systems to enhance civil aviation safety amidst rising environmental and operational hazards.
文摘The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless networks.Specifically,IoT systems are vulnerable to cyberattacks due to its opennes The proposed work intends to implement a new security framework for detecting the most specific and harmful intrusions in IoT networks.In this framework,a Covariance Linear Learning Embedding Selection(CL2ES)methodology is used at first to extract the features highly associated with the IoT intrusions.Then,the Kernel Distributed Bayes Classifier(KDBC)is created to forecast attacks based on the probability distribution value precisely.In addition,a unique Mongolian Gazellas Optimization(MGO)algorithm is used to optimize the weight value for the learning of the classifier.The effectiveness of the proposed CL2ES-KDBC framework has been assessed using several IoT cyber-attack datasets,The obtained results are then compared with current classification methods regarding accuracy(97%),precision(96.5%),and other factors.Computational analysis of the CL2ES-KDBC system on IoT intrusion datasets is performed,which provides valuable insight into its performance,efficiency,and suitability for securing IoT networks.
基金This researchwork is supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project Number(PNURSP2024R411),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘Malware attacks on Windows machines pose significant cybersecurity threats,necessitating effective detection and prevention mechanisms.Supervised machine learning classifiers have emerged as promising tools for malware detection.However,there remains a need for comprehensive studies that compare the performance of different classifiers specifically for Windows malware detection.Addressing this gap can provide valuable insights for enhancing cybersecurity strategies.While numerous studies have explored malware detection using machine learning techniques,there is a lack of systematic comparison of supervised classifiers for Windows malware detection.Understanding the relative effectiveness of these classifiers can inform the selection of optimal detection methods and improve overall security measures.This study aims to bridge the research gap by conducting a comparative analysis of supervised machine learning classifiers for detecting malware on Windows systems.The objectives include Investigating the performance of various classifiers,such as Gaussian Naïve Bayes,K Nearest Neighbors(KNN),Stochastic Gradient Descent Classifier(SGDC),and Decision Tree,in detecting Windows malware.Evaluating the accuracy,efficiency,and suitability of each classifier for real-world malware detection scenarios.Identifying the strengths and limitations of different classifiers to provide insights for cybersecurity practitioners and researchers.Offering recommendations for selecting the most effective classifier for Windows malware detection based on empirical evidence.The study employs a structured methodology consisting of several phases:exploratory data analysis,data preprocessing,model training,and evaluation.Exploratory data analysis involves understanding the dataset’s characteristics and identifying preprocessing requirements.Data preprocessing includes cleaning,feature encoding,dimensionality reduction,and optimization to prepare the data for training.Model training utilizes various supervised classifiers,and their performance is evaluated using metrics such as accuracy,precision,recall,and F1 score.The study’s outcomes comprise a comparative analysis of supervised machine learning classifiers for Windows malware detection.Results reveal the effectiveness and efficiency of each classifier in detecting different types of malware.Additionally,insights into their strengths and limitations provide practical guidance for enhancing cybersecurity defenses.Overall,this research contributes to advancing malware detection techniques and bolstering the security posture of Windows systems against evolving cyber threats.
文摘Cross entropy is a measure in machine learning and deep learning that assesses the difference between predicted and actual probability distributions. In this study, we propose cross entropy as a performance evaluation metric for image classifier models and apply it to the CT image classification of lung cancer. A convolutional neural network is employed as the deep neural network (DNN) image classifier, with the residual network (ResNet) 50 chosen as the DNN archi-tecture. The image data used comprise a lung CT image set. Two classification models are built from datasets with varying amounts of data, and lung cancer is categorized into four classes using 10-fold cross-validation. Furthermore, we employ t-distributed stochastic neighbor embedding to visually explain the data distribution after classification. Experimental results demonstrate that cross en-tropy is a highly useful metric for evaluating the reliability of image classifier models. It is noted that for a more comprehensive evaluation of model perfor-mance, combining with other evaluation metrics is considered essential. .
文摘Breast cancer is a deadly disease and radiologists recommend mammography to detect it at the early stages. This paper presents two types of HanmanNets using the information set concept for the derivation of deep information set features from ResNet by modifying its kernel functions to yield Type-1 HanmanNets and then AlexNet, GoogLeNet and VGG-16 by changing their feature maps to yield Type-2 HanmanNets. The two types of HanmanNets exploit the final feature maps of these architectures in the generation of deep information set features from mammograms for their classification using the Hanman Transform Classifier. In this work, the characteristics of the abnormality present in the mammograms are captured using the above network architectures that help derive the features of HanmanNets based on information set concept and their performance is compared via the classification accuracies. The highest accuracy of 100% is achieved for the multi-class classifications on the mini-MIAS database thus surpassing the results in the literature. Validation of the results is done by the expert radiologists to show their clinical relevance.
文摘Biometric recognition refers to the identification of individuals through their unique behavioral features(e.g.,fingerprint,face,and iris).We need distinguishing characteristics to identify people,such as fingerprints,which are world-renowned as the most reliablemethod to identify people.The recognition of fingerprints has become a standard procedure in forensics,and different techniques are available for this purpose.Most current techniques lack interest in image enhancement and rely on high-dimensional features to generate classification models.Therefore,we proposed an effective fingerprint classification method for classifying the fingerprint image as authentic or altered since criminals and hackers routinely change their fingerprints to generate fake ones.In order to improve fingerprint classification accuracy,our proposed method used the most effective texture features and classifiers.Discriminant Analysis(DCA)and Gaussian Discriminant Analysis(GDA)are employed as classifiers,along with Histogram of Oriented Gradient(HOG)and Segmentation-based Feature Texture Analysis(SFTA)feature vectors as inputs.The performance of the classifiers is determined by assessing a range of feature sets,and the most accurate results are obtained.The proposed method is tested using a Sokoto Coventry Fingerprint Dataset(SOCOFing).The SOCOFing project includes 6,000 fingerprint images collected from 600 African people whose fingerprints were taken ten times.Three distinct degrees of obliteration,central rotation,and z-cut have been performed to obtain synthetically altered replicas of the genuine fingerprints.The proposal achieved massive success with a classification accuracy reaching 99%.The experimental results indicate that the proposed method for fingerprint classification is feasible and effective.The experiments also showed that the proposed SFTA-based GDA method outperformed state-of-art approaches in feature dimension and classification accuracy.
基金supported in part by the Anhui Provincial Natural Science Founda-tion[1908085QG298,1908085MG232]the National Nature Science Foundation of China[91546108,61806068]+5 种基金the National Social Science Foundation of China[21BTJ002]the Anhui Provincial Science:and Technology Major Projects Grant[201903a05020020]the Fundamental Research Funds for the Central Universities[Z2019HGTA0053,JZ2019HG BZ0128]the Humanities and Social Science Fund of Ministry of Education of China[20YJA790021]the Major Project of Philosophy and Social Science Planning of Zhejiang Province[22YJRC07ZD]the Open Research Fund Program of Key Laboratory of Process Optimization and Intelligent Decision-Making(Hefei University of Technology),Ministry of Education.
文摘Multiple classifier system exhibits strong classification capacity compared with single classifiers,but they require significant computational resources.Selective ensemble system aims to attain equivalent or better classification accuracy with fewer classifiers.However,current methods fail to identify precise solutions for constructing an ensemble classifier.In this study,we propose an ensemble classifier design technique based on the perturbation binary salp swarm algorithm(ECDPB).Considering that extreme learning machines(ELMs)have rapid learning rates and good generalization ability,they can serve as the basic classifier for creating multiple candidates while using fewer computational resources.Meanwhile,we introduce a combined diversity measure by taking the complementarity and accuracy of ELMs into account;it is used to identify the ELMs that have good diversity and low error.In addition,we propose an ECDPB with powerful optimizing ability;it is employed to find the optimal subset of ELMs.The selected ELMs can then be used to forman ensemble classifier.Experiments on 10 benchmark datasets have been conducted,and the results demonstrate that the proposed ECDPB delivers superior classification capacity when compared with alternative methods.
基金National Natural Science Foundation of China,Grant/Award Number:61972261Basic Research Foundations of Shenzhen,Grant/Award Numbers:JCYJ20210324093609026,JCYJ20200813091134001。
文摘In this paper,an Observation Points Classifier Ensemble(OPCE)algorithm is proposed to deal with High-Dimensional Imbalanced Classification(HDIC)problems based on data processed using the Multi-Dimensional Scaling(MDS)feature extraction technique.First,dimensionality of the original imbalanced data is reduced using MDS so that distances between any two different samples are preserved as well as possible.Second,a novel OPCE algorithm is applied to classify imbalanced samples by placing optimised observation points in a low-dimensional data space.Third,optimization of the observation point mappings is carried out to obtain a reliable assessment of the unknown samples.Exhaustive experiments have been conducted to evaluate the feasibility,rationality,and effectiveness of the proposed OPCE algorithm using seven benchmark HDIC data sets.Experimental results show that(1)the OPCE algorithm can be trained faster on low-dimensional imbalanced data than on high-dimensional data;(2)the OPCE algorithm can correctly identify samples as the number of optimised observation points is increased;and(3)statistical analysis reveals that OPCE yields better HDIC performances on the selected data sets in comparison with eight other HDIC algorithms.This demonstrates that OPCE is a viable algorithm to deal with HDIC problems.
文摘The Repository Mahasiswa(RAMA)is a national repository of research reports in the form of final assignments,student projects,theses,dissertations,and research reports of lecturers or researchers that have not yet been published in journals,conferences,or integrated books from the scientific repository of universities and research institutes in Indonesia.The increasing popularity of the RAMA Repository leads to security issues,including the two most widespread,vulnerable attacks i.e.,Structured Query Language(SQL)injection and cross-site scripting(XSS)attacks.An attacker gaining access to data and performing unauthorized data modifications is extremely dangerous.This paper aims to provide an attack detection system for securing the repository portal from the abovementioned attacks.The proposed system combines a Long Short–Term Memory and Principal Component Analysis(LSTM-PCA)model as a classifier.This model can effectively solve the vanishing gradient problem caused by excessive positive samples.The experiment results show that the proposed system achieves an accuracy of 96.85%using an 80%:20%ratio of training data and testing data.The rationale for this best achievement is that the LSTM’s Forget Gate works very well as the PCA supplies only selected features that are significantly relevant to the attacks’patterns.The Forget Gate in LSTM is responsible for deciding which information should be kept for computing the cell state and which one is not relevant and can be discarded.In addition,the LSTM’s Input Gate assists in finding out crucial information and stores specific relevant data in the memory.
文摘For a long time,legal entities have developed and used crime prediction methodologies.The techniques are frequently updated based on crime evaluations and responses from scientific communities.There is a need to develop type-based crime prediction methodologies that can be used to address issues at the subgroup level.Child maltreatment is not adequately addressed because children are voiceless.As a result,the possibility of developing a model for predicting child abuse was investigated in this study.Various exploratory analysis methods were used to examine the city of Chicago’s child abuse events.The data set was balanced using the Borderline-SMOTE technique,and then a stacking classifier was employed to ensemble multiple algorithms to predict various types of child abuse.The proposed approach successfully predicted crime types with 93%of accuracy,precision,recall,and F1-Score.The AUC value of the same was 0.989.However,when compared to the Extra Trees model(17.55),which is the second best,the proposed model’s execution time was significantly longer(476.63).We discovered that Machine Learning methods effectively evaluate the demographic and spatial-temporal characteristics of the crimes and predict the occurrences of various subtypes of child abuse.The results indicated that the proposed Borderline-SMOTE enabled Stacking Classifier model(BS-SC Model)would be effective in the real-time child abuse prediction and prevention process.
文摘Automatic Speech Emotion Recognition(SER)is used to recognize emotion from speech automatically.Speech Emotion recognition is working well in a laboratory environment but real-time emotion recognition has been influenced by the variations in gender,age,the cultural and acoustical background of the speaker.The acoustical resemblance between emotional expressions further increases the complexity of recognition.Many recent research works are concentrated to address these effects individually.Instead of addressing every influencing attribute individually,we would like to design a system,which reduces the effect that arises on any factor.We propose a two-level Hierarchical classifier named Interpreter of responses(IR).Thefirst level of IR has been realized using Support Vector Machine(SVM)and Gaussian Mixer Model(GMM)classifiers.In the second level of IR,a discriminative SVM classifier has been trained and tested with meta information offirst-level classifiers along with the input acoustical feature vector which is used in primary classifiers.To train the system with a corpus of versatile nature,an integrated emotion corpus has been composed using emotion samples of 5 speech corpora,namely;EMO-DB,IITKGP-SESC,SAVEE Corpus,Spanish emotion corpus,CMU's Woogle corpus.The hierarchical classifier has been trained and tested using MFCC and Low-Level Descriptors(LLD).The empirical analysis shows that the proposed classifier outperforms the traditional classifiers.The proposed ensemble design is very generic and can be adapted even when the number and nature of features change.Thefirst-level classifiers GMM or SVM may be replaced with any other learning algorithm.
基金Project supported by the National Natural Science Foundation of China(Grant No.62375140)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX190900)。
文摘A single-qubit quantum classifier(SQC)based on a gradient-free optimization(GFO)algorithm,named the GFO-based SQC,is proposed to overcome the effects of barren plateaus caused by quantum devices.Here,a rotation gate R_(X)(φ)is applied on the single-qubit binary quantum classifier,and the training data and parameters are loaded intoφin the form of vector multiplication.The cost function is decreased by finding the value of each parameter that yields the minimum expectation value of measuring the quantum circuit.The algorithm is performed iteratively for all parameters one by one until the cost function satisfies the stop condition.The proposed GFO-based SQC is demonstrated for classification tasks in Iris and MNIST datasets and compared with the Adam-based SQC and the quantum support vector machine(QSVM).Furthermore,the performance of the GFO-based SQC is discussed when the rotation gate in the quantum device is under different types of noise.The simulation results show that the GFO-based SQC can reach a high accuracy in reduced time.Additionally,the proposed GFO algorithm can quickly complete the training process of the SQC.Importantly,the GFO-based SQC has a good performance in noisy environments.
文摘One of the most common types of threats to the digital world is malicious software.It is of great importance to detect and prevent existing and new malware before it damages information assets.Machine learning approaches are used effectively for this purpose.In this study,we present a model in which supervised and unsupervised learning algorithms are used together.Clustering is used to enhance the prediction performance of the supervised classifiers.The aim of the proposed model is to make predictions in the shortest possible time with high accuracy and f1 score.In the first stage of the model,the data are clustered with the k-means algorithm.In the second stage,the prediction is made with the combination of the classifier with the best prediction performance for the related cluster.While choosing the best classifiers for the given clusters,triple combinations of ten machine learning algorithms(kernel support vector machine,k-nearest neighbor,naive Bayes,decision tree,random forest,extra gradient boosting,categorical boosting,adaptive boosting,extra trees,and gradient boosting)are used.The selected triple classifier combination is positioned in two stages.The prediction time of the model is improved by positioning the classifier with the slowest prediction time in the second stage.The selected triple classifier combination is positioned in two tiers.The prediction time of the model is improved by positioning the classifier with the highest prediction time in the second tier.It is seen that clustering before classification improves prediction performance,which is presented using Blue Hexagon Open Dataset for Malware Analysis(BODMAS),Elastic Malware Benchmark for Empowering Researchers(EMBER)2018 and Kaggle malware detection datasets.The model has 99.74%accuracy and 99.77%f1 score for the BODMAS dataset,99.04%accuracy and 98.63%f1 score for the Kaggle malware detection dataset,and 96.77%accuracy and 96.77%f1 score for the EMBER 2018 dataset.In addition,the tiered positioning of classifiers shortened the average prediction time by 76.13%for the BODMAS dataset and 95.95%for the EMBER 2018 dataset.The proposed method’s prediction performance is better than the rest of the studies in the literature in which BODMAS and EMBER 2018 datasets are used.
基金funded by Hanoi University of Civil Engineering(HUCE)in Project Code 35-2021/KHXD-TD.
文摘Design constraints verification is the most computationally expensive task in evolutionary structural optimization due to a large number of structural analyses thatmust be conducted.Building a surrogatemodel to approximate the behavior of structures instead of the exact structural analyses is a possible solution to tackle this problem.However,most existing surrogate models have been designed based on regression techniques.This paper proposes a novel method,called CaDE,which adopts a machine learning classification technique for enhancing the performance of the Differential Evolution(DE)optimization.The proposed method is separated into two stages.During the first optimization stage,the original DE is implemented as usual,but all individuals produced in this phase are stored as inputs of the training data.Based on design constraints verification,these individuals are labeled as“safe”or“unsafe”and their labels are saved as outputs of the training data.When collecting enough data,an AdaBoost model is trained to evaluate the safety state of structures.This model is then used in the second stage to preliminarily assess new individuals,and unpromising ones are rejected without checking design constraints.This method reduces unnecessary structural analyses,thereby shortens the optimization process.Five benchmark truss sizing optimization problems are solved using the proposed method to demonstrate its effectiveness.The obtained results show that the CaDE finds good optimal designs with less structural analyses in comparison with the original DE and four other DE variants.The reduction rate of five examples ranges from 18 to over 50%.Moreover,the proposed method is applied to a real-size transmission tower design problem to exhibit its applicability in practice.
文摘Managing physical objects in the network’s periphery is made possible by the Internet of Things(IoT),revolutionizing human life.Open attacks and unauthorized access are possible with these IoT devices,which exchange data to enable remote access.These attacks are often detected using intrusion detection methodologies,although these systems’effectiveness and accuracy are subpar.This paper proposes a new voting classifier composed of an ensemble of machine learning models trained and optimized using metaheuristic optimization.The employed metaheuristic optimizer is a new version of the whale optimization algorithm(WOA),which is guided by the dipper throated optimizer(DTO)to improve the exploration process of the traditionalWOA optimizer.The proposed voting classifier categorizes the network intrusions robustly and efficiently.To assess the proposed approach,a dataset created from IoT devices is employed to record the efficiency of the proposed algorithm for binary attack categorization.The dataset records are balanced using the locality-sensitive hashing(LSH)and Synthetic Minority Oversampling Technique(SMOTE).The evaluation of the achieved results is performed in terms of statistical analysis and visual plots to prove the proposed approach’s effectiveness,stability,and significance.The achieved results confirmed the superiority of the proposed algorithm for the task of network intrusion detection.
文摘As per World Health Organization report which was released in the year of 2019,Diabetes claimed the lives of approximately 1.5 million individuals globally in 2019 and around 450 million people are affected by diabetes all over the world.Hence it is inferred that diabetes is rampant across the world with the majority of the world population being affected by it.Among the diabetics,it can be observed that a large number of people had failed to identify their disease in the initial stage itself and hence the disease level moved from Type-1 to Type-2.To avoid this situation,we propose a new fuzzy logic based neural classifier for early detection of diabetes.A set of new neuro-fuzzy rules is introduced with time constraints that are applied for thefirst level classification.These levels are further refined by using the Fuzzy Cognitive Maps(FCM)with time intervals for making thefinal decision over the classification process.The main objective of this proposed model is to detect the diabetes level based on the time.Also,the set of neuro-fuzzy rules are used for selecting the most contributing values over the decision-making process in diabetes prediction.The proposed model proved its efficiency in performance after experiments conducted not only from the repository but also by using the standard diabetic detection models that are available in the market.
文摘Coronary artery disease(CAD)is one of themost authentic cardiovascular afflictions because it is an uncommonly overwhelming heart issue.The breakdown of coronary cardiovascular disease is one of the principal sources of death all over theworld.Cardiovascular deterioration is a challenge,especially in youthful and rural countries where there is an absence of humantrained professionals.Since heart diseases happen without apparent signs,high-level detection is desirable.This paper proposed a robust and tuned random forest model using the randomized grid search technique to predictCAD.The proposed framework increases the ability of CADpredictions by tracking down risk pointers and learning the confusing joint efforts between them.Nowadays,the healthcare industry has a lot of data but needs to gain more knowledge.Our proposed framework is used for extracting knowledge from data stores and using that knowledge to help doctors accurately and effectively diagnose heart disease(HD).We evaluated the proposed framework over two public databases,Cleveland and Framingham datasets.The datasets were preprocessed by using a cleaning technique,a normalization technique,and an outlier detection technique.Secondly,the principal component analysis(PCA)algorithm was utilized to lessen the feature dimensionality of the two datasets.Finally,we used a hyperparameter tuning technique,randomized grid search,to tune a random forest(RF)machine learning(ML)model.The randomized grid search selected the best parameters and got the ideal CAD analysis.The proposed framework was evaluated and compared with traditional classifiers.Our proposed framework’s accuracy,sensitivity,precision,specificity,and f1-score were 100%.The evaluation of the proposed framework showed that it is an unrivaled perceptive outcome with tuning as opposed to other ongoing existing frameworks.
文摘Triple-negative breast cancer(TNBC)poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior.Methods:We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA.Utilizing weighted gene coexpression network analysis,we pinpointed 34 TNBC immune genes linked to survival.The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction.We calculated chemotherapy sensitivity scores using the“pRRophetic”package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and Exclusion algorithm.Results:In this study,34 survival-related TNBC immune gene expression profiles were identified.A least absolute shrinkage and selection operator-Cox regression model was used and 15 candidates were prioritized,with a concomitant establishment of a robust risk immune classifier.The high-risk TNBC immune groups showed increased sensitivity to therapeutic agents like RO-3306,Tamoxifen,Sunitinib,JNK Inhibitor VIII,XMD11-85h,BX-912,and Tivozanib.An analysis of the Search Tool for Interaction of Chemicals database revealed the associations between the high-risk group and signaling pathways,such as those involving Rap1,Ras,and PI3K-Akt.The low-risk group showed a higher immunotherapy response rate,as observed through the tumor immune dysfunction and exclusion analysis in the TCGA-TNBC and METABRIC-TNBC cohorts.Conclusion:This study provides insights into the immune complexities of TNBC,paving the way for novel diagnostic approaches and precision treatment methods that exploit its immunological intricacies,thus offering hope for improved management and outcomes of this challenging disease.
文摘The necessity of on-time cancer detection is extremely high in the recent days as it becomes a threat to human life.The skin cancer is considered as one of the dangerous diseases among other types of cancer since it causes severe health impacts on human beings and hence it is highly mandatory to detect the skin cancer in the early stage for providing adequate treatment.Therefore,an effective image processing approach is employed in this present study for the accurate detection of skin cancer.Initially,the dermoscopy images of skin lesions are retrieved and processed by eliminating the noises with the assistance of Gaborfilter.Then,the pre-processed dermoscopy image is segmented into multiple regions by implementing cascaded Fuzzy C-Means(FCM)algorithm,which involves in improving the reliability of cancer detection.The A Gabor Response Co-occurrence Matrix(GRCM)is used to extract melanoma parameters in an effi-cient manner.A hybrid Particle Swarm Optimization(PSO)-Whale Optimization is then utilized for efficiently optimizing the extracted features.Finally,the fea-tures are significantly classified with the assistance of Probabilistic Neural Net-work(PNN)classifier for classifying the stages of skin lesion in an optimal manner.The whole work is stimulated in MATLAB and the attained outcomes have proved that the introduced approach delivers optimal results with maximal accuracy of 97.83%.