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机场Claws驱鸟器的效能评价 被引量:2
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作者 杨荣 李远征 +2 位作者 吴爱权 朱家蔚 吴孝兵 《安徽师范大学学报(自然科学版)》 CAS 北大核心 2009年第1期60-63,共4页
2007年7-8月,通过调查空军某机场场区内鸟类的种类、数量、飞行频次、飞行方向以及个体行为等参数,对该机场引进的Claws驱鸟器的驱鸟效能进行了定量评价.鸟类调查工作分Claws驱鸟器处理前期、处理期间和处理后期等三个阶段进行.调查结... 2007年7-8月,通过调查空军某机场场区内鸟类的种类、数量、飞行频次、飞行方向以及个体行为等参数,对该机场引进的Claws驱鸟器的驱鸟效能进行了定量评价.鸟类调查工作分Claws驱鸟器处理前期、处理期间和处理后期等三个阶段进行.调查结果表明Claws驱鸟器在控制鸟类的种类和数量上十分有效,但是在处理期间,鸟类飞向跑道的频次比处理前期和处理后期均显著增加,可能危及飞行安全.因此建议在飞行后勤保障过程中,在使用Claws驱鸟器驱鸟的同时,应结合其他驱鸟方法,对鸟类进行综合防治以保证飞行安全. 展开更多
关键词 鸟撞 claws驱鸟器 效能评价
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Claws Out
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作者 JING XIAOLEI 《Beijing Review》 2008年第4期20-21,共2页
In its November 2007 issue,U.S.magazine Science published a photo named"flat cat?"and a column titled"Rare-Tiger Photo Flap Makes Fur Fly in China."The article dealt with the claimed discovery of t... In its November 2007 issue,U.S.magazine Science published a photo named"flat cat?"and a column titled"Rare-Tiger Photo Flap Makes Fur Fly in China."The article dealt with the claimed discovery of the South China tiger,which had been believed extinct in the wild.The photo as well as the article stirred up the already heated controversy in China as to whether the photo was a fake or not. 展开更多
关键词 claws Out SFA
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CLAWS CELEBRE
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作者 TAN YUNFEI 《The World of Chinese》 2019年第4期72-73,共2页
Last July, 100,000 cooked crayfish from Hubei province boarded the Sino-Euro Railway and landed in Russia for the 2018 World Cup--baffling foreign media, but exhilarating Chinese spectators for whom this summer treat ... Last July, 100,000 cooked crayfish from Hubei province boarded the Sino-Euro Railway and landed in Russia for the 2018 World Cup--baffling foreign media, but exhilarating Chinese spectators for whom this summer treat more than made up for the absence of their national team. 展开更多
关键词 claws CELEBRE LAST JULY CRAYFISH
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GET YOUR CLAWS INTO XIAOLONGBAO
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作者 祝伟婧 《The World of Chinese》 2014年第3期80-82,共3页
This crab-based baozi brings you the salty taste of the sea地道江南口味:香滋滋的蟹粉小笼包是怎么炼成的?There is no feeling quite like picking up a fresh dumpling on the verge of bursting out of its semi-transluscent s... This crab-based baozi brings you the salty taste of the sea地道江南口味:香滋滋的蟹粉小笼包是怎么炼成的?There is no feeling quite like picking up a fresh dumpling on the verge of bursting out of its semi-transluscent skin and nibbling a small hole in the skin to suck out the devilishly good filling:orgasmic.And while it’s a big wide world of dumplings 展开更多
关键词 小笼包 GET YOUR claws INTO XIAOLONGBAO 蟹粉
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A Bio-inspired Climbing Robot with Flexible Pads and Claws 被引量:13
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作者 Aihong Ji Zhihui Zhao +3 位作者 Poramate Manoonpong Wei Wang Guangming Chen Zhendong Dai 《Journal of Bionic Engineering》 SCIE EI CSCD 2018年第2期368-378,共11页
Many animals exhibit strong mechanical interlocking in order to achieve efficient climbing against rough surfaces by using their claws in the pads. To maximally use the mechanical interlocking, an innovative robot whi... Many animals exhibit strong mechanical interlocking in order to achieve efficient climbing against rough surfaces by using their claws in the pads. To maximally use the mechanical interlocking, an innovative robot which utilizes flexible pad with claws is designed. The mechanism for attachments of the claws against rough surfaces is further revealed according to the theoretical analysis. Moreover, the effects of the key parameters on the performances of the climbing robots are obtained. It indicates that decreasing the size of the tip of the claws while maintaining its stiffness unchanged can effectively improve the attachment ability. Furthermore, the structure of robot body and two foot trajectories are proposed and the new robot is presented. Using experimental tests, it demonstrates that this robot has high stability and adaptability while climbing on vertical rough surfaces up to a speed of 4.6 cm.s^-1. 展开更多
关键词 bionic climbing robot mechanical interlocking CLAW rough surface
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海洋石油英语文本中介词的翻译研究
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作者 陈柯 刘祎铭 《现代商贸工业》 2023年第5期64-66,共3页
海洋石油英语文本中大量使用由介词和实词组成的句子成分,实词通常能够在汉语中找到含义相对应的字词,但是介词往往难以通过直译表达原句的含义。本文对这一现象作深入研究分析。本文从《中国油气》中选取十篇与海洋石油有关的英文期刊... 海洋石油英语文本中大量使用由介词和实词组成的句子成分,实词通常能够在汉语中找到含义相对应的字词,但是介词往往难以通过直译表达原句的含义。本文对这一现象作深入研究分析。本文从《中国油气》中选取十篇与海洋石油有关的英文期刊作为语料,借助Claws软件词性标注功能和WordSmith软件中Word List词频功能,对海洋石油英语文本中的介词进行分析。希望借此解决海洋石油翻译中的介词翻译难点,从而准确,提高译文质量。 展开更多
关键词 海洋石油英语 介词翻译 claws WORDSMITH
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Design and Performance Analysis of Permanent Magnet Claw Pole Machine with Hybrid Cores 被引量:1
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作者 Chengcheng Liu Zheng Chao +1 位作者 Shaopeng Wang Youhua Wang 《CES Transactions on Electrical Machines and Systems》 CSCD 2023年第3期275-283,共9页
Permanent magnet claw pole machine(PMCPM) is a special kind of transverse flux permanent magnet machine. Compared with other electrical machines, it has the advantages of high torque density and high efficiency for hi... Permanent magnet claw pole machine(PMCPM) is a special kind of transverse flux permanent magnet machine. Compared with other electrical machines, it has the advantages of high torque density and high efficiency for high speed operation. However, because of its complex irregular structure, the manufacturing process using silicon sheets is complicated. Soft magnetic composite material(SMC) is manufactured by powder metallurgy technology, which can produce various shapes of stator core structures, so it is easier to produce various irregular shapes of the stator core. However, the raw SMC material is relatively expensive, and the mechanical strength of SMC is weak. In this paper, a PMCPM with hybrid cores is proposed. With the adoption of hybrid silicon sheet-SMC cores and amorphous alloy-SMC cores, the torque ability of PMCPM can be improved greatly and it can have higher efficiency for more wide operation frequency. Meanwhile, its mechanical strength has been improved and it can be designed for high torque direct drive applications as it is a modular machine. Furthermore, three methods are proposed to reduce the additional eddy current loss which resulted from the employment of hybrid cores in PMCPM. 展开更多
关键词 Permanent magnet claw pole machine(PMCPM) Soft magnetic materials(SMC) Hybrid cores Eddy current loss
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VvAGAMOUS Affect Development of Four Different Grape Species Ovary
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作者 Pengfei Zhang Yuqin Zhang +3 位作者 Qifeng Zhao Tiequan Niu Pengfei Wen Jinjun Liang 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第4期1125-1138,共14页
Grape pistil has an important influence on fruit size and quality.However,there were few studies on grape ovary,and the development process of the ovary is still unclear.Therefore,in this paper,four different grape va... Grape pistil has an important influence on fruit size and quality.However,there were few studies on grape ovary,and the development process of the ovary is still unclear.Therefore,in this paper,four different grape varieties with different lengths of small inflorescences,namely‘Musct Hambourg’grape(Vitis vinifera),‘Concord’grape(Vitis labrusca),‘ShanPuTao’grape(Vitis amurensis)and‘GongNiang2Hao’grape(Vitis amurensis×Vitis vinifera)were used as test materials.Four varieties ovary were significant differences by means of stereomicroscope,paraffin section.The expression of ovary determining gene VvAGAMOUS(VvAG)and its development related genes VvCRABS CLAW(VvCRC)and VvAGAMOUS-LIKE 11(VvAGL11)with similar functions during the development of different grape varieties were preliminarily explored using fluorescence quantitative test.The relationship between VvAG and VvCRC,VvAG and VvAGL11 were analyzed using Y1H assay.Our results showed that there were obvious abdominal sutures on the surface of expect for‘Musct Hambourg’grape,and existing poly carpels.The ovary development of‘ShanPuTao’and‘GongNiang2Hao’grape was completed when the inflorescence length was less than 1 cm,while the‘Concord’and‘Musct Hambourg’grape were fully developed when the length of inflorescence was 3–4 and 4–5 cm,respectively.VvAG and VvCRC began to express in large quantities after the formation of stamen primordia,while VvAGL11 during the forming of ovule primordia.Therefore,VvAG and VvCRC mainly regulated the development of stamens and carpels and also promote the development of ovules,while VvAGL11 major regulated the development of ovules.The promoters of VvCRC and VvAGL11 were bound by VvAG.This study provides an important theoretical basis for further research on the molecular mechanism of grape ovary development. 展开更多
关键词 GRAPE CARPEL OVULE VvAGAMOUS VvCRABS CLAW VvAGAMOUS-LIKE 11 flower development process
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Design Optimization of a Novel Axial-radial Flux Permanent Magnet Claw Pole Machine with SMC Cores and Ferrite Magnets
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作者 Chengcheng Liu Fan Yang +1 位作者 Wenfeng Zhang Youhua Wang 《CES Transactions on Electrical Machines and Systems》 CSCD 2023年第4期358-365,共8页
Soft magnetic composite(SMC)material is an ideal soft magnetic material employed for developing 3D magnetic flux electromagnetic equipment,due to its advantages of 3D magnetic isotropy characteristic,low eddy current ... Soft magnetic composite(SMC)material is an ideal soft magnetic material employed for developing 3D magnetic flux electromagnetic equipment,due to its advantages of 3D magnetic isotropy characteristic,low eddy current loss,and simple manufacturing process.The permanent magnet claw pole machine(PMCPM)with SMC cores is a good case that the SMC to be adopted for developing 3D flux electrical machines.In this paper,a novel axial-radial flux permanent magnet claw pole machine(ARPMCPM)with SMC cores and ferrite magnets is proposed.Compared with the traditional PMCPM,the proposed ARPMCPM is designed with only one spoke PM rotor and its whole structure is quite compact.For the performance prediction,the 3D finite element method(FEM)is used.Meanwhile,for the performance evaluation,a previously developed axial flux claw pole permanent magnet machine(AFCPM)is employed as the benchmark machine and all these machines are optimized by using the combined multilevel robust Taguchi method.It can be seen that the proposed ARPMCPM is with higher torque/weight density and operation efficiency. 展开更多
关键词 Soft magnetic composite(SMC) Permanent magnetic claw pole machine(PMCPM) Axial-radial flux
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网络在线赋码器与英文语料的词性标注
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作者 蔺志渊 《西南科技大学学报(哲学社会科学版)》 2013年第3期55-59,共5页
CLAWS trial service是一款便捷实用、免费提供词性标注的网络在线赋码器。然而当对多个英文文本进行赋码时,操作步骤极其繁琐,且赋码后的文本格式杂乱无章,必将严重影响微型文本库的创建、语篇特征分析等研究。采用添加结构标记、合并... CLAWS trial service是一款便捷实用、免费提供词性标注的网络在线赋码器。然而当对多个英文文本进行赋码时,操作步骤极其繁琐,且赋码后的文本格式杂乱无章,必将严重影响微型文本库的创建、语篇特征分析等研究。采用添加结构标记、合并文本、整理赋码文本格式和拆分文本等方法,可以简化词性赋码程序、优化标注文本格式,以扩大其研究的适用范围。 展开更多
关键词 claws TRIAL SERVICE 词性标注 文本格式 结构标记
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中药猫爪草与cat's claw的不同
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作者 董诚明 张振凌 +1 位作者 王一硕 纪宝玉 《时珍国医国药》 CAS CSCD 北大核心 2005年第5期401-401,共1页
目的:比较中药猫爪草与cat's claw的不同。方法:查阅中外专业期刊及网站有关资料,并进行分析整理。结果:中药猫爪草和cat's claw在来源、形状、制剂、临床应用等方面有不同之处。结论:中药猫爪草和Cat's claw是两种不同的... 目的:比较中药猫爪草与cat's claw的不同。方法:查阅中外专业期刊及网站有关资料,并进行分析整理。结果:中药猫爪草和cat's claw在来源、形状、制剂、临床应用等方面有不同之处。结论:中药猫爪草和Cat's claw是两种不同的植物药。 展开更多
关键词 猫爪草 Cat’s CLAW
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Neighborhood Union of Essential Sets and Hamiltonicity of Claw-Free Graphs
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作者 徐新萍 《Journal of Southeast University(English Edition)》 EI CAS 2002年第2期184-187,共4页
Let G be a graph, an independent set Y in G is called an essential independent set (or essential set for simplicity), if there is {y 1,y 2} Y such that dist (y 1,y 2)=2. In this paper, we wi... Let G be a graph, an independent set Y in G is called an essential independent set (or essential set for simplicity), if there is {y 1,y 2} Y such that dist (y 1,y 2)=2. In this paper, we will use the technique of the vertex insertion on l connected ( l=k or k+1,k≥2 ) claw free graphs to provide a unified proof for G to be hamiltonian or 1 hamiltonian, the sufficient conditions are expressed by the inequality concerning ∑ki=0N(Y i) and n(Y) for each essential set Y={y 0,y 1,...,y k} of G , where Y i={y i,y i-1 ,...,y i-(b-1) }Y for i∈{0,1,...,k} (the subscriptions of y j ’s will be taken modulo k+1 ), b ( 0【b【k+1 ) is an integer, and n(Y)={v∈V(G): dist (v,Y)≤2 }. 展开更多
关键词 HAMILTONICITY claw free graph neighborhood union vertex insertion essential set
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The Influence of Feeding Regimen on the Composition of the Fat Pads in the Bovine Digital Cushion
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作者 Martha Raber Vera Letter +2 位作者 Andre Chassot Hans Geyer Martin R.L.Scheeder 《Agricultural Sciences》 2015年第9期889-899,共11页
The effect of an intensive/extensive feeding regimen on lipid content and fatty acid composition of the bovine digital cushion was investigated in 32 beef cattle of both genders, divided in 2 groups (16 per intensive/... The effect of an intensive/extensive feeding regimen on lipid content and fatty acid composition of the bovine digital cushion was investigated in 32 beef cattle of both genders, divided in 2 groups (16 per intensive/extensive feeding). The beef cattle were calves of different suckler cow husbandries. After the separation from their mothers at the age of 10 months, they were differently fed for 5 months. The animals were slaughtered at the age of 15 months with a mean body weight of 450 kg. The macroscopic claw examination of all beef cattle was made at two defined claws at the beginning of the trial and after slaughter. For applicatory reasons, the fat pads of the claws could only be prepared after slaughter. Samples from fat pads at defined locations of the digital cushion were analysed for lipid content and fatty acid composition determination. Additionally, samples from the digital cushions and few samples of subcutaneous tissue of 9 dairy cows served as comparison. These slaughterhouse cows were mainly fed with hay and grass;further data however were not available. The digital fat pads and the subcutaneous fat of both groups showed obvious differences in the fat content and the fatty acid composition. The fat pads of the intensive fed animals contained fewer lipids and more omega-6-fatty acids. The extensive fed animals had distinctly more omega-3-fatty acids. In the subcutaneous fat of the intensive fed animals, more omega-6-fatty could be found and more omega-3-fatty acids in the extensive fed animals. These results indicate that the feeding can influence the lipid content and the fatty acid composition. The macroscopic hoof horn quality grade of the intensive fed group was better than the extensive fed group. The digital pads of the dairy cows contained more lipids, more monounsaturated fatty acids and less omega-6-fatty acids. 展开更多
关键词 Suckler Cow Husbandry claws NUTRITION Fatty Acids
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“宙斯盾”舰通用对陆攻击作战系统
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作者 赵红艳 《情报指挥控制系统与仿真技术》 2001年第6期4-8,共5页
本文概述了用于支持联合陆上战斗的“宙斯盾”舰上的全综合的通用对陆攻击作战系统。目的是建立一个与制空权或制海权一样的对陆攻击的作战区域。
关键词 对陆攻击 作战系统 "宙斯盾"舰 claws系统 CIC 战术图象
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Multipurpose use of the over-the-scope-clip system(“Bear claw”) in the gastrointestinal tract:Swiss experience in a tertiary center 被引量:17
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作者 Michael Christian Sulz Reto Bertolini +3 位作者 Remus Frei Gian-Marco Semadeni Jan Borovicka Christa Meyenberger 《World Journal of Gastroenterology》 SCIE CAS 2014年第43期16287-16292,共6页
AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted a... AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted at a tertiary care hospital from September 2010 to January 2014.Indications for OTSC application were fistulae,anastomotic leakage,perforation,unroofed submucosal lesion for biopsy,refractory bleeding,and stent fixation in the gastrointestinal(GI)tract.Primary technical success was defined as the adequate deployment of the OTSC on the target lesion.Clinical success was defined as resolution of the problem;for instance,no requirement for surgery or further endoscopic intervention.In cases of recurrence,retreatment of a lesion with a second intervention was possible.Complications were classified into those related to sedation,endoscopy,or deployment of the clip.RESULTS:A total of 28 OTSC system applications werecarried out in 21 patients[median age 64 years(range42-85),33%females].The main indications were fistulae(52%),mostly after percutaneous endoscopic gastrostomy tube removal,and anastomotic leakage after GI surgery(29%).Further indications were unroofed submucosal lesions after biopsy,upper gastrointestinal bleeding,or esophageal stent fixation.The OTSC treatments were applied either in the upper(48%)or lower(52%)GI tract.The mean lesion size was 8 mm(range:2-20 mm).Primary technical success and clinical success rates were 85%and 67%,respectively.In53%of cases,the suction method was used without accessories(e.g.,twin grasper or tissue anchor).No endoscopy-related or OTSC-related complications were observed.CONCLUSION:OTSC is a useful tool for endoscopic closure of various GI lesions,including fistulae and leakages.Future randomized prospective multicenter trials are warranted. 展开更多
关键词 Over-the-scope-clip system OTSC Bear claw Endoscopic closure Gastrointestinal lesion Perforations FISTULAE Leakage
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Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system 被引量:5
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作者 Klaus Mnkemüller Shajan Peter +3 位作者 Basem Alkurdi Jayapal Ramesh Daniel Popa C Mel Wilcox 《World Journal of Gastrointestinal Endoscopy》 CAS 2013年第8期402-406,共5页
Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough ... Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we present a case of successful endoscopic closure of a gastrocolic fistula in a severely malnourished patient with complex post-surgical upper GI anatomy. We strongly believe that this device is a major breakthrough for the management of various types of discontinuity defects or fistulas. In addition, we show the usefulness of placing a direct jejunostomy using the double balloon enteroscopy (DBE) technique during the same procedure. The concept of providing direct jejunal feedings while allowing for upper gas-trointestinal bowel rest to promote the healing of the minimally invasive endoscopic operation is novel. Thus, our case is unique and exemplifies the utility of mini-mally invasive endoscopic endoluminal surgery. 展开更多
关键词 Over-the-scope-clip Bear claw FISTULA ENDOSCOPIC CLOSURE Gastrocolic FISTULA OVER the SCOPE CLIP CLIP
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Non-destructive Measurement of Magnetic Properties of Claw Pole 被引量:2
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作者 Chengliang Hu Xuejiao Bai +2 位作者 Minjun Tang Xiaofeng Tang Zhen Zhao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2019年第5期23-33,共11页
The magnetic properties of the claw pole have a direct effect on the output power of a generator Many methods can be used to measure these magnetic properties,each with its own advantages,but an important shortcoming ... The magnetic properties of the claw pole have a direct effect on the output power of a generator Many methods can be used to measure these magnetic properties,each with its own advantages,but an important shortcoming is that all are destructive.In this study,a new non-destructive method to measure the magnetic properties of claw pole was proposed and a corresponding testing set-up was designed.A finite-element model was constructed to simulate the measurement process.Results proved that the measured magnetization-like curves had good agreement with the trend of the input magnetic curves and the effect of the positioning error in the measuring process could be neglected.To further validate the new method,seven types of claw poles of different materials subjected to different heat-treatment processes were forged and tested by both the new method and the conventional ring-sample method.Compared with the latter,the new method showed better consistency,relatively higher accuracy,and much stronger stability of measurement results;however,its sensitivity needs to be improved.The effects of material compositions and heat-treatment parameters on the magnetic properties of the claw pole were briefly analyzed. 展开更多
关键词 CLAW POLE MAGNETIC property Measurement RING SAMPLE Accuracy Stability
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Neighborhood Conditions for Claw-Free Graphs
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作者 杨治辉 黄昭强 《Journal of Southeast University(English Edition)》 EI CAS 2001年第1期76-78,共3页
Two new sufficient conditions for hamiltonian claw free graphs are given. Some known results become corollaries of the conclusion, the conditions of theorem are the best possible in a sense.
关键词 NEIGHBORHOOD sufficient condition HAMILTONIAN claw free
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Complications and outcomes of descemet stripping automated endothelial keratoplasty with artisan aphakia intraocular lens implantation 被引量:2
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作者 Rong-Mei Peng Yu-Xin Guo +2 位作者 Yuan Qiu Yan-Sheng Hao Jing Hong 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第4期607-611,共5页
AIM: To evaluate the complications and outcomes of descemet stripping automated endothelial keratoplasty(DSAEK) combined with artisan aphakia intraocular lens(IOL) implantation in severely damaged eyes without ca... AIM: To evaluate the complications and outcomes of descemet stripping automated endothelial keratoplasty(DSAEK) combined with artisan aphakia intraocular lens(IOL) implantation in severely damaged eyes without capsular support.METHODS: DSAEK combined with artisan iris claw IOL implantation was performed on 29 eyes. All eyes were of abnormal structure due to complications from prior intraocular surgeries and ocular trauma. Ocular complications observed included graft dislocations, high intraocular pressure(IOP), IOL dislocations, macular edema and hyphema. Best corrected visual acuity(BCVA), IOP and mean central endothelial cell density(ECD) were recorded.RESULTS: Thirteen eyes had a history of ocular trauma, 10 eyes had an anterior chamber IOL, 16 eyes had prior vitrectomy. The iris was abnormal in 22 cases. Graft dislocation occurred in 5(17.2%) of 29 eyes. IOL dislocation occurred in 2 eyes(6.9%). High IOP was found in 9 eyes and was controlled with treatment. The preoperative mean BCVA was 20/286. The 6 mo postoperative mean BCVA was 20/42. The average center ECD was 1965.3 cells/mm^2 at 6 mo, and the rate of the donor cell loss was 34.7%.CONCLUSION: DSAEK combined with artisan aphakia IOL implantation is an alternative option for resolving endothelial and lens disorders in aphakic eyes without capsular support. However, it should be performed cautiously for eyes with severe iris defects. 展开更多
关键词 descemet stripping automated endothelial keratoplasty artisan aphakia iris claw lens iris defect
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Relief of osteoarthritis with a herbal-amino acid supplement: A randomized double-blind placebo controlled trial 被引量:1
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作者 Mark J.S. Miller Ross Butler 《Advances in Bioscience and Biotechnology》 2012年第4期504-510,共7页
A redox active medicinal plant and L-leucine mixture (HLM) was investigated in subjects with established osteoarthritis of the knee in a multi-center, rando- m-ized, placebo-controlled, double-blind clinical trial. A ... A redox active medicinal plant and L-leucine mixture (HLM) was investigated in subjects with established osteoarthritis of the knee in a multi-center, rando- m-ized, placebo-controlled, double-blind clinical trial. A total of 96 subjects with osteoarthritis were enrolled and randomized to either placebo (n = 38) or HLM treatment group (n = 38). The HLM group re- ceived a combination of Uncaria tomentosa (300 mg), Boswellia serrata (200 mg), Lepidium meyenii (1000 mg) and L-Leucine (700 mg) given as 3 capsules once a day. The placebo group received matching capsules with carboxymethylcellulose. The treatment period was 8 weeks, with assessments made at days 7, 14, 28 and 56. The primary outcome was reduction in total WOMAC score. VAS pain, tolerability, investigator assessments, use of rescue medication (acetominophen), and safety assessments of vital signs and laboratory assessments were included. Subject randomization was effective for age, gender and disease severity. In the placebo group 32/38 subjects completed the trial and for HLM 35/38. WOMAC scores (pain, stiffness, physical performance and total) steadily declined over the course of the 8 week study in both groups, but the magnitude was significantly greater for HLM (P < 0.05). Total WOMAC was reduced 46.5% for HLM and 25.4 % for placebo. VAS pain was reduced 21.8% in the placebo group (p < 0.002) but the changes were significantly greater (37.8% p < 0.03) with HLM treatment. Investigator’s global assessment rating of good-excellent was 24/35 (69%) for HLM and 14/32 (44%) for placebo (P = 0.05). Rescue medication consumption and tolerability were comparable for HLM and placebo. No safety issues were evident with either group. As expected a placebo effect was observed, nevertheless HLM was clearly more effective in relieving the symptoms of osteoarthritis. This HLM represents a safe and effective new approach to the management of osteoarthritis symptoms. 展开更多
关键词 OSTEOARTHRITIS Dietary SUPPLEMENT Cat’S Claw L-LEUCINE BOSWELLIA SERRATA Maca Uncaria Tomentosa LEPIDIUM Meyenii Inflammation Cartilage Flexibility Pain Quality of Life Stiffness Arthritis Nutraceutical Natural Product
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