CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role...CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.展开更多
Purpose:This study explores the underlying research topics regarding CRISPR based on the LDA model and figures out trends in knowledge transfer from science to technology in this area over the latest 10 years.Design/m...Purpose:This study explores the underlying research topics regarding CRISPR based on the LDA model and figures out trends in knowledge transfer from science to technology in this area over the latest 10 years.Design/methodology/approach:We collected publications on CRISPR between 2011 and2020 from the Web of Science,and traced all the patents citing them from lens.org.15,904 articles and 18,985 patents in total are downloaded and analyzed.The LDA model was applied to identify underlying research topics in related research.In addition,some indicators were introduced to measure the knowledge transfer from research topics of scientific publications to IPC-4 classes of patents.Findings:The emerging research topics on CRISPR were identified and their evolution over time displayed.Furthermore,a big picture of knowledge transition from research topics to technological classes of patents was presented.We found that for all topics on CRISPR,the average first transition year,the ratio of articles cited by patents,the NPR transition rate are respectively 1.08,15.57%,and 1.19,extremely shorter and more intensive than those of general fields.Moreover,the transition patterns are different among research topics.Research limitations:Our research is limited to publications retrieved from the Web of Science and their citing patents indexed in lens.org.A limitation inherent with LDA analysis is in the manual interpretation and labeling of"topics".Practical implications:Our study provides good references for policy-makers on allocating scientific resources and regulating financial budgets to face challenges related to the transformative technology of CRISPR.Originality/value:The LDA model here is applied to topic identification in the area of transformative researches for the first time,as exemplified on CRISPR.Additionally,the dataset of all citing patents in this area helps to provide a full picture to detect the knowledge transition between S&T.展开更多
Turkey has given importance to the development of the automobile industry since the Ottoman period.While the Ottomans,who were aware of the development process of the automobile industry in the world,provided transpor...Turkey has given importance to the development of the automobile industry since the Ottoman period.While the Ottomans,who were aware of the development process of the automobile industry in the world,provided transportation by horse-drawn carriage,they thought of importing automobiles for the Sultan and high-level bureaucrats in an effort to switch to automobile transportation.However,after the proclamation of the Republic,automobile production started,just like airplanes.While a factory was established for the production of a domestic aircraft,the first automobile production facility was established in Istanbul in 1929 by the American Ford company.This factory was closed after a short time due to the world economic crisis.After the activities of the Kayseri Aircraft Factory,which lasted until 1948,came to an end,this time,Revolution car prototypes could be manufactured completely domestically in 1961.After the project,which did not go into mass production,the KoçGroup started to produce the domestically-made Anadol car with technology transfer from multiple sources in 1967,but the production of Anadol continued until 1984.In 1971,Renault cars started to be produced under the French Renault license,and TOFAŞcars under the Italian FIAT license.Towards the end of the 1970s,creative imitation applications were made in TOFAŞcars with the bird series.In the 1990s,the production of Japanese Honda and Toyota and South Korean Hyundai cars started.In 2011,the idea of producing a domestic automobile emerged,the Devrim automobile was taken as an example in this project,the first Togg prototype was manufactured with technology transfer from multiple sources in December 2018,and it was announced that mass production would begin in March 2023.The 12-year period from 2011 to 2023 is too long for the creation of a domestic automobile.It has been understood that this long process has been passed in order to regain the pre-1980 level of technological ability.However,the most important thing is the transition from the creative imitation stage to the innovation stage.Our wish is that this process can be shortened with phase skipping approaches.展开更多
The paper presents a new analytical framework to discuss the effect of Chinese foreign investment policy on the international technology transfer absorbed by enterprises of different ownership.The US Trade Representat...The paper presents a new analytical framework to discuss the effect of Chinese foreign investment policy on the international technology transfer absorbed by enterprises of different ownership.The US Trade Representative claims that the Chinese government’s requirements regarding joint ventures pressure US companies to transfer intellectual property to Chinese companies.However,we argue that:(1)Based on analysis of the technical fees of technology import contracts and the number of US patents transferred to enterprises registered in the Chinese mainland,China’s foreign investment policy does not pressure US companies to transfer unremunerated technology to Chinese companies.(2)The invention and utility model patents filed by Chinese joint-venture enterprises or Chinese partner companies do not show an abnormally rapid growth,which means China’s FDI policy does not force US companies to transfer intellectual property in exchange for China’s market.(3)After 2012,the US-China technology transfer absorbed by enterprises of different ownership showed a significantly positive effect in reducing China-US trade surplus.展开更多
The move to embrace sustainable building is an international paradigm with the desire for sustainable development in society. Developing countries, however, are the most susceptible regions to unsustainable developmen...The move to embrace sustainable building is an international paradigm with the desire for sustainable development in society. Developing countries, however, are the most susceptible regions to unsustainable development. This study focused on factors influencing Technology Transfer in Construction Management in Nigeria. Questionnaires were applied to collect primary data. A total of 55 registered architectures, quantity surveyors and engineers were interviewed. The data were analyzed and both descriptive and inferential statistics were applied in the study. The findings show that research on sustainability and involvement of stakeholders influence the success of technology transfer. These findings have managerial implications on technology transfer to attain sustained development in the construction industry for many developing countries.展开更多
Since the Belt and Road Initiative was put forward,the agricultural technology exchanges between China and Vietnam have become more and more frequent.With its unique geographical advantages,economic differences and te...Since the Belt and Road Initiative was put forward,the agricultural technology exchanges between China and Vietnam have become more and more frequent.With its unique geographical advantages,economic differences and technological complementarities,China is steadily advancing its agricultural technology transfer to Vietnam.This paper analyzes that the main driving force of Chinese agricultural technology transfer to Vietnam is the existence of technological potential difference.This paper puts forward corresponding countermeasures and suggestions from three aspects of government,agricultural enterprises and scientific research institutions.展开更多
The Chinese government issued a regulation on promoting the transformation of R&D results recently. The new policies, which were jointly formulated by seven governmental departments, are aimed at further encouragi...The Chinese government issued a regulation on promoting the transformation of R&D results recently. The new policies, which were jointly formulated by seven governmental departments, are aimed at further encouraging China’s scientists to commercialize their R&D results, set up new hi-tech business and speed up the process of China’s hi-tech industrialization.展开更多
Sustainable feeding of the growing population in China without ecological destabilization is a grand challenge. In this populous country where agriculture is dominated by smallholder farming, developing innovative tec...Sustainable feeding of the growing population in China without ecological destabilization is a grand challenge. In this populous country where agriculture is dominated by smallholder farming, developing innovative technology and translating scientific knowledge into action for smallholder farmers is a crucial step in addressing this challenge. Here, we present a novel approach for technology innovation and dissemination to achieve sustainable intensification in the fields of smallholder farmers. The Science and Technology Backyard(STB) is a hub in a rural area that links knowledge with practices to promote technology innovation and exchange. In this study, the framework and functions of STB are introduced, and the key implications for sustainable intensification across millions of smallholder farmers are explicitly stated:(i) develop innovative technology based on stated demands of farmers;(ii) disseminate technology by innovative social service models though combined top-down approaches with bottom-up measures to enable smallholders in rural areas. This paper provides a perspective on transformation of small-scale agriculture toward sustainable intensification in China and useful knowledge applicable to other developing countries.展开更多
Rock bolts are one of the primary support systems utilized in underground excavations within the civil and mining engineering industries. Rock bolts support the weakened rock mass adjacent to the opening of an excavat...Rock bolts are one of the primary support systems utilized in underground excavations within the civil and mining engineering industries. Rock bolts support the weakened rock mass adjacent to the opening of an excavation by fastening to the more stable, undisturbed formations further from the excavation. The overall response of such a support element has been determined under varying loading conditions in the laboratory and in situ experiments in the past four decades; however, due to the limitations with conventional monitoring methods of capturing strain, there still exists a gap in knowledge associated with an understanding of the geomechanical responses of rock bolts at the microscale. In this paper, we try to address this current gap in scientific knowledge by utilizing a newly developed distributed optical strain sensing(DOS) technology that provides an exceptional spatial resolution of 0.65 mm to capture the strain along the rock bolt. This DOS technology utilizes Rayleigh optical frequency domain reflectometry(ROFDR) which provides unprecedented insight into various mechanisms associated with axially loaded rebar specimens of different embedment lengths, grouting materials, borehole annulus conditions, and borehole diameters. The embedment length of the specimens was found to be the factor that significantly affected the loading of the rebar. The critical embedment length for the fully grouted rock bolts(FGRBs) was systematically determined to be430 mm. The results herein highlight the effects of the variation of these individual parameters on the geomechanical responses FGRBs.展开更多
In recent years,with high-speed development of economy and society,and fast propulsion of industrialization and urbanization process in the development zone,average annual land demand in the development zone also quic...In recent years,with high-speed development of economy and society,and fast propulsion of industrialization and urbanization process in the development zone,average annual land demand in the development zone also quickly enlarges,and the contradiction between high-speed growth of economy and shortage of land resources is apparent increasingly. Meanwhile,to guarantee crop safety and stick to 0. 12 billion hm2of farmland red line as a rigid constraint which could not be exceeded,the supply-demand contradiction of industrial land is more and more prominent. With industrial land scale continues to enlarge,land resources become more and more scarce,but there exists the phenomenon of low-efficiency land use and even idle. For land use characteristics of the development zone,taking Hefei City Economic and Technological Development Zone as an example,the countermeasures of perfecting industrial land transfer mechanism in the development zone are proposed.展开更多
Continuous and semi-continuous mining technology has become the main trend of modern surface mines in the world. According to the deposit characteristics of coal basin in China and Chinese situation,this paper discuss...Continuous and semi-continuous mining technology has become the main trend of modern surface mines in the world. According to the deposit characteristics of coal basin in China and Chinese situation,this paper discussed the new semi-continuous technology── shovel - transfer wagon-belt conveyor and its application prospect in large surface coal mines in China.展开更多
Surface roughness considerably influences the stamping and coating performance of the automotive plates;however,the surface roughness of the automotive plates is transferred from the roll during the rolling process.Th...Surface roughness considerably influences the stamping and coating performance of the automotive plates;however,the surface roughness of the automotive plates is transferred from the roll during the rolling process.Therefore,the variation and control technology regarding the roughness of the automotive plates and rolls has drawn increasing attention from researchers in China and around the globe.In this study,the research methods,analytical techniques,prediction models,transfer rules,and control technologies regarding the surface roughness of the automotive plates and rolls were reviewed.Among these,an online measurement system for automotive-plate and roll surface roughness has been applied to the production lines of Germany,China,Belgium,Holland,Austria,and other countries and has achieved remarkable results.Online measurement and timely feedback regarding the automotive-plate and roll surface roughness are needed to ensure favorable conditions for the establishment of automotive-plate roughness-control measurement.展开更多
文摘CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.
基金supported by the National Natural Science Foundation of China,Grant numbers:71974167 and 71573225。
文摘Purpose:This study explores the underlying research topics regarding CRISPR based on the LDA model and figures out trends in knowledge transfer from science to technology in this area over the latest 10 years.Design/methodology/approach:We collected publications on CRISPR between 2011 and2020 from the Web of Science,and traced all the patents citing them from lens.org.15,904 articles and 18,985 patents in total are downloaded and analyzed.The LDA model was applied to identify underlying research topics in related research.In addition,some indicators were introduced to measure the knowledge transfer from research topics of scientific publications to IPC-4 classes of patents.Findings:The emerging research topics on CRISPR were identified and their evolution over time displayed.Furthermore,a big picture of knowledge transition from research topics to technological classes of patents was presented.We found that for all topics on CRISPR,the average first transition year,the ratio of articles cited by patents,the NPR transition rate are respectively 1.08,15.57%,and 1.19,extremely shorter and more intensive than those of general fields.Moreover,the transition patterns are different among research topics.Research limitations:Our research is limited to publications retrieved from the Web of Science and their citing patents indexed in lens.org.A limitation inherent with LDA analysis is in the manual interpretation and labeling of"topics".Practical implications:Our study provides good references for policy-makers on allocating scientific resources and regulating financial budgets to face challenges related to the transformative technology of CRISPR.Originality/value:The LDA model here is applied to topic identification in the area of transformative researches for the first time,as exemplified on CRISPR.Additionally,the dataset of all citing patents in this area helps to provide a full picture to detect the knowledge transition between S&T.
文摘Turkey has given importance to the development of the automobile industry since the Ottoman period.While the Ottomans,who were aware of the development process of the automobile industry in the world,provided transportation by horse-drawn carriage,they thought of importing automobiles for the Sultan and high-level bureaucrats in an effort to switch to automobile transportation.However,after the proclamation of the Republic,automobile production started,just like airplanes.While a factory was established for the production of a domestic aircraft,the first automobile production facility was established in Istanbul in 1929 by the American Ford company.This factory was closed after a short time due to the world economic crisis.After the activities of the Kayseri Aircraft Factory,which lasted until 1948,came to an end,this time,Revolution car prototypes could be manufactured completely domestically in 1961.After the project,which did not go into mass production,the KoçGroup started to produce the domestically-made Anadol car with technology transfer from multiple sources in 1967,but the production of Anadol continued until 1984.In 1971,Renault cars started to be produced under the French Renault license,and TOFAŞcars under the Italian FIAT license.Towards the end of the 1970s,creative imitation applications were made in TOFAŞcars with the bird series.In the 1990s,the production of Japanese Honda and Toyota and South Korean Hyundai cars started.In 2011,the idea of producing a domestic automobile emerged,the Devrim automobile was taken as an example in this project,the first Togg prototype was manufactured with technology transfer from multiple sources in December 2018,and it was announced that mass production would begin in March 2023.The 12-year period from 2011 to 2023 is too long for the creation of a domestic automobile.It has been understood that this long process has been passed in order to regain the pre-1980 level of technological ability.However,the most important thing is the transition from the creative imitation stage to the innovation stage.Our wish is that this process can be shortened with phase skipping approaches.
文摘The paper presents a new analytical framework to discuss the effect of Chinese foreign investment policy on the international technology transfer absorbed by enterprises of different ownership.The US Trade Representative claims that the Chinese government’s requirements regarding joint ventures pressure US companies to transfer intellectual property to Chinese companies.However,we argue that:(1)Based on analysis of the technical fees of technology import contracts and the number of US patents transferred to enterprises registered in the Chinese mainland,China’s foreign investment policy does not pressure US companies to transfer unremunerated technology to Chinese companies.(2)The invention and utility model patents filed by Chinese joint-venture enterprises or Chinese partner companies do not show an abnormally rapid growth,which means China’s FDI policy does not force US companies to transfer intellectual property in exchange for China’s market.(3)After 2012,the US-China technology transfer absorbed by enterprises of different ownership showed a significantly positive effect in reducing China-US trade surplus.
文摘The move to embrace sustainable building is an international paradigm with the desire for sustainable development in society. Developing countries, however, are the most susceptible regions to unsustainable development. This study focused on factors influencing Technology Transfer in Construction Management in Nigeria. Questionnaires were applied to collect primary data. A total of 55 registered architectures, quantity surveyors and engineers were interviewed. The data were analyzed and both descriptive and inferential statistics were applied in the study. The findings show that research on sustainability and involvement of stakeholders influence the success of technology transfer. These findings have managerial implications on technology transfer to attain sustained development in the construction industry for many developing countries.
文摘Since the Belt and Road Initiative was put forward,the agricultural technology exchanges between China and Vietnam have become more and more frequent.With its unique geographical advantages,economic differences and technological complementarities,China is steadily advancing its agricultural technology transfer to Vietnam.This paper analyzes that the main driving force of Chinese agricultural technology transfer to Vietnam is the existence of technological potential difference.This paper puts forward corresponding countermeasures and suggestions from three aspects of government,agricultural enterprises and scientific research institutions.
文摘The Chinese government issued a regulation on promoting the transformation of R&D results recently. The new policies, which were jointly formulated by seven governmental departments, are aimed at further encouraging China’s scientists to commercialize their R&D results, set up new hi-tech business and speed up the process of China’s hi-tech industrialization.
基金supported by the National Basic Research Program of China (2015CB150405)
文摘Sustainable feeding of the growing population in China without ecological destabilization is a grand challenge. In this populous country where agriculture is dominated by smallholder farming, developing innovative technology and translating scientific knowledge into action for smallholder farmers is a crucial step in addressing this challenge. Here, we present a novel approach for technology innovation and dissemination to achieve sustainable intensification in the fields of smallholder farmers. The Science and Technology Backyard(STB) is a hub in a rural area that links knowledge with practices to promote technology innovation and exchange. In this study, the framework and functions of STB are introduced, and the key implications for sustainable intensification across millions of smallholder farmers are explicitly stated:(i) develop innovative technology based on stated demands of farmers;(ii) disseminate technology by innovative social service models though combined top-down approaches with bottom-up measures to enable smallholders in rural areas. This paper provides a perspective on transformation of small-scale agriculture toward sustainable intensification in China and useful knowledge applicable to other developing countries.
基金Natural Sciences and Engineering Council of Canada(NSERC)the Canadian Department of National Defense+2 种基金MITACSYield Point Inc.the Royal Military College(RMC) Green Team
文摘Rock bolts are one of the primary support systems utilized in underground excavations within the civil and mining engineering industries. Rock bolts support the weakened rock mass adjacent to the opening of an excavation by fastening to the more stable, undisturbed formations further from the excavation. The overall response of such a support element has been determined under varying loading conditions in the laboratory and in situ experiments in the past four decades; however, due to the limitations with conventional monitoring methods of capturing strain, there still exists a gap in knowledge associated with an understanding of the geomechanical responses of rock bolts at the microscale. In this paper, we try to address this current gap in scientific knowledge by utilizing a newly developed distributed optical strain sensing(DOS) technology that provides an exceptional spatial resolution of 0.65 mm to capture the strain along the rock bolt. This DOS technology utilizes Rayleigh optical frequency domain reflectometry(ROFDR) which provides unprecedented insight into various mechanisms associated with axially loaded rebar specimens of different embedment lengths, grouting materials, borehole annulus conditions, and borehole diameters. The embedment length of the specimens was found to be the factor that significantly affected the loading of the rebar. The critical embedment length for the fully grouted rock bolts(FGRBs) was systematically determined to be430 mm. The results herein highlight the effects of the variation of these individual parameters on the geomechanical responses FGRBs.
文摘In recent years,with high-speed development of economy and society,and fast propulsion of industrialization and urbanization process in the development zone,average annual land demand in the development zone also quickly enlarges,and the contradiction between high-speed growth of economy and shortage of land resources is apparent increasingly. Meanwhile,to guarantee crop safety and stick to 0. 12 billion hm2of farmland red line as a rigid constraint which could not be exceeded,the supply-demand contradiction of industrial land is more and more prominent. With industrial land scale continues to enlarge,land resources become more and more scarce,but there exists the phenomenon of low-efficiency land use and even idle. For land use characteristics of the development zone,taking Hefei City Economic and Technological Development Zone as an example,the countermeasures of perfecting industrial land transfer mechanism in the development zone are proposed.
文摘Continuous and semi-continuous mining technology has become the main trend of modern surface mines in the world. According to the deposit characteristics of coal basin in China and Chinese situation,this paper discussed the new semi-continuous technology── shovel - transfer wagon-belt conveyor and its application prospect in large surface coal mines in China.
文摘Surface roughness considerably influences the stamping and coating performance of the automotive plates;however,the surface roughness of the automotive plates is transferred from the roll during the rolling process.Therefore,the variation and control technology regarding the roughness of the automotive plates and rolls has drawn increasing attention from researchers in China and around the globe.In this study,the research methods,analytical techniques,prediction models,transfer rules,and control technologies regarding the surface roughness of the automotive plates and rolls were reviewed.Among these,an online measurement system for automotive-plate and roll surface roughness has been applied to the production lines of Germany,China,Belgium,Holland,Austria,and other countries and has achieved remarkable results.Online measurement and timely feedback regarding the automotive-plate and roll surface roughness are needed to ensure favorable conditions for the establishment of automotive-plate roughness-control measurement.