Analysis of the Clinical Interventions for Falls in Elderly Patients in the Community From 2002 To 2022:A Bibliometric Analysis

Objective:To analyze and provide a comprehensive overview of the knowledge structure and research hotspots of clinical interventions for falls in elderly patients in the community.Methods:The search for publications related to clinical interventions for falls in elderly patients in the community from 2002 to 2022 was conducted on the Web of Science Core Collection(WoSCC)database.VOSviewers,CiteSpace,and the R package“bibliometrix”were used to conduct this bibliometric analysis.Results:2091 articles from 70 countries,primarily the United States and Australia,were included.The number of publications related to clinical interventions for falls in elderly patients is increasing yearly.The main research institutions in this field were the University of Sydney,Harvard University,and the University of California.BioMed Central(BMC)Geriatrics was the most popular journal in this field and Journals of the American Geriatrics Society was the most co-cited journal.These publications came from 8984 authors among which author Lord SR had published the most papers and author Tinetti Me had the most co-citations.The main keywords in this research field were“balance,”“exercise,”and“risk factor.”Conclusion:This was the first bibliometric study that comprehensively summarized the research hot spots and development of clinical interventions for falls in elderly patients in the community.This paper aims to provide a reference for scholars and researchers in this particular field.

Heterogeneity of the tumor immune microenvironment and clinical interventions

The tumor immune microenvironment(TIME)is broadly composed of various immune cells,and its heterogeneity is characterized by both immune cells and stromal cells.During the course of tumor formation and progression and anti-tumor treatment,the composition of the TIME becomes heterogeneous.Such immunological heterogeneity is not only present between populations but also exists on temporal and spatial scales.Owing to the existence of TIME,clinical outcomes can differ when a similar treatment strategy is provided to patients.Therefore,a comprehensive assessment of TIME heterogeneity is essential for developing precise and effective therapies.Facilitated by advanced technologies,it is possible to understand the complexity and diversity of the TIME and its influence on therapy responses.In this review,we discuss the potential reasons for TIME heterogeneity and the current approaches used to explore it.We also summarize clinical intervention strategies based on associated mechanisms or targets to control immunological heterogeneity.

Transcranial magnetic stimulation research on reading and dyslexia:a new clinical intervention technique for treating dyslexia?

Nowadays,several noninvasive neuroimaging techniques,including transcranial magnetic stimulation(TMS),exist.The working mechanism behind TMS is a rapidly changing magnetic field that generates an electric current via electromagnetic induction.When the coil is placed on the scalp,the magnetic field generates a physiological reaction in the underlying neural tissue.The TMS-induced change in the participant’s behavior is used by researchers to investigate the causal relations between specific brain areas and cognitive functions such as language.A variant of TMS has been developed,which is called rapid-rate TMS(rTMS).In this review,three databases(Medline,Educational Resources Information Center,and Scopus)were searched for rTMS studies on normal reading and dyslexia with a cut-off date of October 31,2014.rTMS was found to be a valuable tool for investigating questions related to reading research,both on the word and the sentence level.Moreover,it can be successfully used in research on dyslexia.Recently,(high-frequency)rTMS has been used as a“clinical”intervention technique for treating dyslexia and for improving reading performance by exciting underactive reading pathways in the brain.Finally,we end the paper with a discussion of future directions in the field of rTMS research and dyslexia,for instance,the promising prospect of combining TMS with simultaneous electroencephalographic imaging.

The clinical use of interventional chemotherapy and intravesical instillation for preventing recurrence of superficial bladder cancer

Objective To study the therapeutic efficacy of combined interventional chemotherapy and intravesical instillation of mitomycin on preventing bladder cancers from recurring after local ablation. Methods 28 patients with superficial bladder cancers were randomized into combined interventional chemotherapy and intravesical instillation of mitomycin or intravesical instillation of mitomycin alone for preventing recurrence after local ablation. The result was assessed by x2 test. Results The patients have been followed up for 12-26 months (mean 21 months). 1 case has had tumor recurrence in the combined modality therapy group and 4 in the intravesical instillation alone group, the tumor recurrence rate being 7% (1/14) and 29% (4/14) respectively (P【0.05). Conclusion Combined use of interventional chemotherapy and intravesical instillation of mitomycin is effective in preventing superficial bladder cancer from recurring after local ablation with fewer adverse effects. The ragimen is not only reliable but