A CLINICOPATHOLOGICAL ANALYSIS OF 22 CASES OF MULTIPLE MALIGNANT TUMORS

To get a better understanding of the location,pathophysiology,etiology and prognosis of multiple malignant tumors (MPMT),we evaluated the medical records of 22 patients with MPMT.Our results suggested that radiotherapy and chemotherapy might play an important role in the pathogenesis of MPMT and follow up is important in detecting a secondary primary malignant tumor (PMT) at an early stage.Surgical removal of tumors is the first choice therapy for MPMT.

乙酰肝素酶在卵巢癌中表达的临床意义

目的探讨卵巢癌组织中乙酰肝素酶(Hpa)表达状况与肿瘤微血管密度(MVD)和卵巢癌临床病理特征的关系。方法应用免疫组化SABC法检测60例卵巢癌组织中Hpa表达及计数MVD。结果Hpa表达和卵巢癌组织浸润深度,分期和淋巴结转移有关,Hpa阳性表达组MVD值(48.8±11.3),显著高于Hpa阴性表达组MVD值(41.5±11.9)(P<0.05)。结论Hpa可促进肿瘤微血管生成加速肿瘤浸润和转移。