Herein we describe a scalable four-step preparation of a-methylene-y-lactone 3 from steroidal sapogenin. This method allowed a facile synthesis of clionamine D, a natural aminosteroid with potent autophagy bioactivity...Herein we describe a scalable four-step preparation of a-methylene-y-lactone 3 from steroidal sapogenin. This method allowed a facile synthesis of clionamine D, a natural aminosteroid with potent autophagy bioactivity and unprecedented chemical structure.展开更多
文摘Herein we describe a scalable four-step preparation of a-methylene-y-lactone 3 from steroidal sapogenin. This method allowed a facile synthesis of clionamine D, a natural aminosteroid with potent autophagy bioactivity and unprecedented chemical structure.
