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Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury 被引量:1
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作者 Mou Gao Qin Dong +4 位作者 Zhijun Yang Dan Zou Yajuan Han Zhanfeng Chen Ruxiang Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期872-880,共9页
Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regen... Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury. 展开更多
关键词 closed head injury Ctbp2 induced neural stem cell lncRNA H19 miR-325-3p NEUROGENESIS
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Factors Associated with Closely Spaced Pregnancies at the Departmental Hospital Centre of Zou-Collines (Benin) in 2022
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作者 Klikpezo Roger Hounkponou Nouéssewa Fanny Maryline +7 位作者 Atade Sèdjro Raoul Agbegbanou Eudoxie Ahouingnan Yeyinou Salifou Badaryatou Dettin Eric Obossou Achilles Imorou Sidi Salifou Kabibou 《Open Journal of Obstetrics and Gynecology》 2024年第1期89-101,共13页
Introduction: Birth spacing to prevent closely-spaced pregnancies, which are a source of maternal and neonatal morbidity and mortality, is not always respected by our women, as recommended by the World Health Organiza... Introduction: Birth spacing to prevent closely-spaced pregnancies, which are a source of maternal and neonatal morbidity and mortality, is not always respected by our women, as recommended by the World Health Organization (WHO). The objective was to study the factors associated with closely-spaced pregnancies among women followed at the Departmental Hospital Center du Zou et du Colline (DHC/Z-C) in 2022. Study Method: This was a descriptive, analytical cross-sectional study with prospective data collection from 20 May to 30 June 2022. Results: At the end of the study, 83 of the 117 women surveyed had close pregnancies, a frequency of 70.94%. They had an average age of 27.0 ± 6.3 years and were of Fon ethnicity and related in 91.57% of cases. The majority were married (96.60%). The factors significantly associated with these closely spaced pregnancies were age between 25 and 30 years, household occupation, age at first birth, age at marriage, women’s perception of contraceptive method (CM), women’s knowledge of the existence of a center providing family planning services and non-use of MC. Conclusion: Close pregnancies are still very common in the commune of Abomey. It is therefore important to increase the use of contraceptive methods in this part of the country. 展开更多
关键词 close Pregnancy Associated Factors DHC/Z-C
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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury
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作者 Mou Gao Qin Dong +3 位作者 Dan Zou Zhijun Yang Lili Guo Ruxiang Xu 《Neural Regeneration Research》 SCIE CAS 2025年第5期1416-1430,共15页
Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells ... Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury. 展开更多
关键词 Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell MICROGLIA NEUROINFLAMMATION
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Formation of a Rapidly Rotating Classical Be-star in a Massive Close Binary System
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作者 Evgeny Staritsin 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第1期44-50,共7页
This paper investigates the spin-up of a mass-accreting star in a close binary system passing through the first stage of mass exchange in the Hertzsprung gap. Inside an accreting star, angular momentum is carried by m... This paper investigates the spin-up of a mass-accreting star in a close binary system passing through the first stage of mass exchange in the Hertzsprung gap. Inside an accreting star, angular momentum is carried by meridional circulation and shear turbulence. The circulation carries part of the angular momentum of the accreted layers to the accretor's surface. The greater the rate of arrival of angular momentum in the accretor is, the greater this part. It is assumed that this part of the angular momentum can be removed by the disk further from the accretor. If the angular momentum in the matter entering the accretor is more than half the Keplerian value, then the angular momentum obtained by the accretor during mass exchange stage does not depend on the rate of arrival of angular momentum. The accretor may have the characteristics of a Be-star immediately after the end of mass exchange. 展开更多
关键词 (stars:)binaries(including multiple):close stars:emission-line BE stars:early-type stars:rotation
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Sensing-Communication-Computing-Control Closed Loop for NOMA-UAV Systems
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作者 Lei Chengleyang Feng Wei +4 位作者 Wang Jue Wang Yanmin Jin Shi Yin Liuguo Ge Ning 《China Communications》 SCIE CSCD 2024年第8期89-103,共15页
In the areas without terrestrial communication infrastructures,unmanned aerial vehicles(UAVs)can be utilized to serve field robots for mission-critical tasks.For this purpose,UAVs can be equipped with sensing,communic... In the areas without terrestrial communication infrastructures,unmanned aerial vehicles(UAVs)can be utilized to serve field robots for mission-critical tasks.For this purpose,UAVs can be equipped with sensing,communication,and computing modules to support various requirements of robots.In the task process,different modules assist the robots to perform tasks in a closed-loop way,which is referred to as a sensing-communication-computing-control(SC3)loop.In this work,we investigate a UAV-aided system containing multiple SC^(3)loops,which leverages non-orthogonal multiple access(NOMA)for efficient resource sharing.We describe and compare three different modelling levels for the SC^(3)loop.Based on the entropy SC^(3)loop model,a sum linear quadratic regulator(LQR)control cost minimization problem is formulated by optimizing the communication power.Further for the assure-to-be-stable case,we show that the original problem can be approximated by a modified user fairness problem,and accordingly gain more insights into the optimal solutions.Simulation results demonstrate the performance gain of using NOMA in such task-oriented systems,as well as the superiority of our proposed closed-loop-oriented design. 展开更多
关键词 closed loop linear quadratic regulator(LQR) non-orthogonal multiple access(NOMA) power allocation unmanned aerial vehicle(UAV)
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Design and Test of Closed Hydraulic Transmission System of 4WD High-clearance Wheeled Sprayer
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作者 Hengfeng CHEN Xiaobo XU 《Plant Diseases and Pests》 2024年第3期14-20,共7页
In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic sys... In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic system that fulfills the requisite specifications should be designed.The AMESim software model is employed to construct a closed hydraulic transmission system,and the simulation analysis is then performed according to the data of hydraulic components.According to analysis results,the prototype can be optimized and upgraded,and a verification test is further carried out.The test results demonstrate that the designed closed hydraulic transmission system meets the actual working requirements of the high-clearance wheeled sprayer and provides a stable experimental platform for intelligent control of agricultural machinery. 展开更多
关键词 closed hydraulic transmission system High-clearance Wheeled sprayer Modeling and simulation Verification test
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Design and analysis of an advanced thermal management system for the solar close observations and proximity experiments spacecraft
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作者 Liu Liu Kangli Bao +4 位作者 Jianchao Feng Xiaofei Zhu Haoyu Wang Xiaofeng Zhang Jun Lin 《Astronomical Techniques and Instruments》 CSCD 2024年第1期52-61,共10页
In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relat... In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs. 展开更多
关键词 Solar close Observations and Proximity Experiments Adaptive thermal control method Thermal field planning method Pumped liquid cooling system Advanced thermal management system
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Study on the Effect of Behavioral Interventions Based on the Theory of“Knowledge,Attitude,Practice”on Tuberculosis Cognitive Level of Close Contacts
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作者 Beiyan Zhang Yifei Hu +2 位作者 Jun Ji Donghui Hao Xuehui Jiao 《Journal of Clinical and Nursing Research》 2024年第2期123-128,共6页
Objective:Based on the theory of“Knowledge,Attitude,Practice,”health education was carried out for close contact with tuberculosis(TB)at a university in Beijing,and its impact on the students’awareness of TB was st... Objective:Based on the theory of“Knowledge,Attitude,Practice,”health education was carried out for close contact with tuberculosis(TB)at a university in Beijing,and its impact on the students’awareness of TB was studied.This study could provide a reference for effective health education interventions among close contacts of TB in undergraduates.Methods:102 undergraduates who had close contact with one confirmed case of pulmonary TB in April 2021 at a university were randomly divided into a control group and an intervention group.The intervention group was given the“Knowledge,Attitude,Practice”health education intervention by professionally trained doctors,and were asked to complete a self-designed TB-related questionnaire before and after the intervention.Both groups performed the Tuberculin Skin Test(TST)and chest X-ray(CR)examination.Results:The rate of the TST test was 18.6%,and CR examination showed 0 cases of pulmonary TB.The survey results showed that the TB awareness rate(96.1%,49/51)in the intervention group was significantly higher than that of the control group(51.0%,26/51),and the differences in awareness rate between the two groups were statistically significant(P<0.05).Regarding the attitude/skills toward TB,the prevalence rate of tuberculosis-related attitude/behavior in the intervention group(94.1%,47/51)was significantly higher than that of the control group(60.8%,31/51),and the differences between the two groups were statistically significant(P<0.05).Conclusion:Both self-controlled and parallel-controlled studies showed that the health education intervention of“Knowledge,Attitude,Practice”improved the awareness of TB among close contacts of TB in undergraduates. 展开更多
关键词 UNDERGRADUATES close contact of tuberculosis Behavioral intervention Health education
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Effect of periodic wide atmospheric pressure change on CO emission in closed goaf
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作者 Zhuangzhuang Shao Bo Tan +6 位作者 Ruili Hu Xiaozhen Song Yan Guo Tianze Li Shuhui Fu Chaohuan Chen Haiyan Wang 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第4期139-150,共12页
Atmospheric pressure fuctuation is one of the most important factors afecting the climate environment and gas emission in the fre area.To obtain the infuence rule of the surface atmospheric pressure change on the gas ... Atmospheric pressure fuctuation is one of the most important factors afecting the climate environment and gas emission in the fre area.To obtain the infuence rule of the surface atmospheric pressure change on the gas sampling and abnormal emission in the mine closed goaf,the No.1 coal mine in Dananhu was taken as the research object.Using Fourier transform and Fisher harmonic analysis and other statistical methods,the infuence of the periodic variation of atmospheric pressure on the gas leakage and outfow in the closed goaf was studied.The results showed that there were three atmospheric pressure periods of 15.2 d,1 d and 182.2 d,and the probability was greater than 95%.The time period with the highest number of atmospheric pressure peaks was 7:00–8:00,which accounted for 20.2%of total occurrence number in a day.And the time periods with the highest number of atmospheric pressure trough were 2:00,15:00 and 16:00,accounting for 27.4%.The peak-to-trough transition time was mainly concentrated around 6 h,and the diurnal variation curve of atmospheric pressure was mainly bimodal.The atmospheric pressure change rate was mostly concentrated in 10–50 Pa/h.It was determined that the distance that the gas sampling pipe was pre-laid into the inner side of the closed wall should be greater than 44.4 m,and the CO concentration and atmospheric pressure in the closed goaf were both periodic and negative with atmospheric pressure.The research results have important guiding signifcance for the monitoring,early warning and environmental protection of the goaf. 展开更多
关键词 Atmospheric pressure Periodic variation closed goaf CO emission Coal mine
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Performance analyses of two-phase closed thermosyphons for road embankments in the high-latitude permafrost regions
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作者 WANG Guan-fu LIN Chuang +3 位作者 ZHU Long FENG De-cheng XIN Yang-yang ZHANG Feng 《Journal of Mountain Science》 SCIE CSCD 2023年第11期3138-3153,共16页
Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extrem... Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extremely cold region of the Da Xing'anling Mountains.In this study,a series of three-dimensional finite element TPCT embankment models were established based on the ZhanglingMohe highway TPCT test section in Da Xing'anling Mountains,and the thermal characteristics and the cooling effect of the TPCTs were analyzed.The results indicated that the TPCTs installed in the northeastern high-latitude regions is effective in cooling and stabilizing the embankment.The working cycle of the TPCTs is nearly 7 months,and the cooling range of the TPCTs can reach 3 m in this region.However,due to the extremely low temperature,the TPCT generates a large radial gradient in the permafrost layer.Meanwhile,by changing the climate conditions,the same type of TPCT embankment located in the Da Xing'anling Mountains,the Xiao Xing'anling Mountains,and the Qinghai-Tibet Plateau permafrost regions were simulated.Based on the comparison of the climate differences between the Qinghai-Tibet Plateau and Northeast China,the differences in the effectiveness of TPCTs were studied.Finally,the limitations of using existing TPCTs in high-latitude permafrost regions of China were discussed and the potential improvements of the TPCT in cold regions were presented. 展开更多
关键词 PERMAFROST Highway embankment Two-phase closed thermosyphon Numerical simulation Climatic condition Cooling performance
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Closed corner divertor with B×▽B away from the divertor:a promising divertor scenario for tokamak power exhaust
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作者 徐国盛 贾国章 +5 位作者 丁根凡 陶余强 孟令义 余林 王亮 刘建斌 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第10期60-67,共8页
A major challenge facing the steady-state operation of tokamak fusion reactors is to develop a viable divertor solution with order-of-magnitude increase in power handling capability as compared with present experience... A major challenge facing the steady-state operation of tokamak fusion reactors is to develop a viable divertor solution with order-of-magnitude increase in power handling capability as compared with present experience.A recently developed divertor concept for this end has been tested recently on EAST tokamak through combining the effects of a closed divertor corner and E×B drifts.The E×B drifts in the divertor move particles towards the outer divertor corner area in the scrape-off layer for B×▽B directed away from the divertor,which can significantly enhance the particle concentration there,facilitating divertor detachment.In recent EAST experiments,the effects have been demonstrated where the lowest electron temperature at the divertor plate is obtained with strike point located close to the corner in the horizontal target and with B×▽B away from the divertor.These experimental results are in reasonable agreement with SOLPS-ITER simulations including drift effects,suggesting that the new divertor concept potentially provides a promising divertor solution for long-pulse operations of future tokamak fusion reactors with much higher power fluxes. 展开更多
关键词 divertor concept closed divertor corner E×B drifts SOLPS-ITER simulation EAST tokamak
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Parameter Design of Current Double Closed Loop for T-Type Three-Level Grid-Connected Inverter
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作者 Tiankui Sun Mingming Shi +3 位作者 Xiaolong Xiao Ping He Yu Ji Zhiyuan Yuan 《Energy Engineering》 EI 2023年第7期1621-1636,共16页
To reduce current harmonics caused by switching frequency,T-type grid-connected inverter topology with LCL filter is adopted.In view of the disadvantages of the slow response speed of the traditional current control a... To reduce current harmonics caused by switching frequency,T-type grid-connected inverter topology with LCL filter is adopted.In view of the disadvantages of the slow response speed of the traditional current control and the failure to eliminate the influence of the LCL filter on the grid-connected current by using current PI control alone,a current double closed loop PI current tracking control is proposed.Through the theoretical analysis of the grid-connected inverter control principle,the grid-connected inverter control model is designed,and the transfer functionmodel of each control link is deduced,and the current loop PI regulator is designed at last.The simulation results show that the control strategy is feasible. 展开更多
关键词 T-type inverter active damping current double closed loop
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Meta-analysis of the efficacy of volar plate internal fixation versus closed reduction and external fixation in the treatment of adult distal radius fractures
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作者 CHEN Jian-ge ZHANG Hai-ning +4 位作者 ZHAO Hong-zhou LIU Ming-jun XING Jia-hui WANG Ping WANG Wei-min 《Journal of Hainan Medical University》 CAS 2023年第19期44-56,共13页
Objective:To compare the efficacy of open reduction and volar locking plate internal fixation with closed reduction and external fixation in the treatment of distal radius fractures by using meta analysis.Methods:The ... Objective:To compare the efficacy of open reduction and volar locking plate internal fixation with closed reduction and external fixation in the treatment of distal radius fractures by using meta analysis.Methods:The databases of CNKI,Wanfang,Weipu,Chinese biomedical literature,Pubmed,Embase,and Cochrane Library were retrieved,and the randomized controlled studies that directly compared the efficacy of plate internal fixation and closed reduction external fixation in the treatment of distal radius fractures published publicly from the establishment of the database to April 2023 were collected.The two researchers independently screened the retrieved literature according to the inclusion and exclusion criteria,extracted data,used Cochrane risk bias assessment tool for quality assessment,and used RevMan 5.4 software for meta analysis.Results:A total of 10 randomized controlled trials were included,all of which were in English.There were 1042 patients in total,and 9 of them were rated as low risk.Meta analysis results showed that one year after the treatment of distal radius fracture with volar locking plate internal fixation,DASH score[MD=-5.64,95%CI(-7.21,-4.06),P<0.00001];One year later,PRWE score[MD=-5.90,95%CI(-8.88,-2.92),P=0.001];Palm flexion[MD=5.92,95%CI(1.29,10.55),P=0.01];Pronation[MD=2.48,95%CI(0.59,4.36),P=0.01];Postrotation[MD=4.73,95%CI(2.15,7.31),P=0.0003];Grip strength[MD=0.61,95%CI(0.12,1.10),P=0.02];palmar tilt angle[MD=9.84,95%CI(5.66,14.02),P<0.00001];Radial inclination[MD=4.33,95%CI(2.97,5.69),P<0.00001]was superior to closed reduction plaster or splint external fixation.One year later,the European Five dimensional Health Scale(EQ-5D-5L)score[MD=0.02,95%CI(-0.01,0.05),P=0.27];Back extension[MD=2.22,95%CI(-4.15,8.59),P=0.49];Ulnar deviation[MD=3.49,95%CI(-0.80,7.78),P=0.11];Radial deviation[MD=2.05,95%CI(-2.39,6.50),P=0.37];Ulnar variance[MD=-1.14,95%CI(-3.16,0.88),P=0.27];There was no significant difference in complications[MD=0.77,95%CI(0.54,1.10),P=0.16](P>0.05).Conclusion:Based on the current clinical data,internal fixation with volar locking plate is more conducive to mid-term DASH score and grip strength recovery than closed reduction plaster or splint external fixation,but there is no significant difference in the quality of life and complications of patients.For adult distal radius fractures,surgical indications should be carefully grasped,and non operative treatment should be given priority. 展开更多
关键词 Volar plate Internal fixation closed reduction External fixation PLASTER SPLINT Distal radius fracture Meta analysis
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Speckle-interferometric Study of Close Visual Binary System HIP 11253(HD 14874)using Gaia(DR2 and EDR3)
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作者 Hussam Aljboor Ali Taani 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2023年第7期221-228,共8页
We present a comprehensive set of physical and geometrical parameters for each of the components of the close visual binary system HIP 11253(HD 14874).We present an analysis for the binary and multiple stellar systems... We present a comprehensive set of physical and geometrical parameters for each of the components of the close visual binary system HIP 11253(HD 14874).We present an analysis for the binary and multiple stellar systems with the aim to obtain a match between the overall observational spectral energy distribution of the system and the spectral synthesis created from model atmospheres using Al-Wardat's method for analyzing binary and multiple stellar systems.The epoch positions are used to determine the orbital parameters and the total mass.The parameters of both components are derived as:T_(eff)^(a)=6025,T_(eff)^(b)=4710,logg_(a)=4.55,logg_(b)=4.60,R_(a)=1.125 R_(⊙),R_(b)=0.88R_(⊙),L_(a)=1.849 L_(⊙),L_(b)=0.342 L_(⊙).Our analysis shows that the spectral types of the components are F9 and K3.By combining the orbital solution with the parallax measurements of Gaia DR2 and EDR3,we estimate the individual masses using the H-R diagram as M_(a)=1.09 M_(⊙)and M_(b)=0.59 M_(⊙)for using Gaia DR2 parallax and M_(a)=1.10 M_(⊙)and M_(b)=0.61 M_(⊙)for using Gaia EDR3 parallax.Finally,the location of both system's components on the stellar evolutionary tracks is presented. 展开更多
关键词 (stars:)binaries:visual stars:kinematics and dynamics (stars:)binaries(including multiple):close techniques:interferometric techniques:spectroscopic
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关闭/废弃矿井抽水蓄能开发利用现状与进展 被引量:2
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作者 文志杰 姜鹏飞 +3 位作者 宋振骐 李利平 蒋宇静 梁桐凯 《煤炭学报》 EI CAS CSCD 北大核心 2024年第3期1358-1374,共17页
探索清洁能源发展的创新途径是实现我国“双碳”目标的重要推动力。为解决大规模可再生能源电力供应不稳定的难题,新型电力系统的提出与加速成长促进了抽水蓄能电站的建设与发展,但生态保护与地形等因素制约了传统抽水蓄能电站发展。关... 探索清洁能源发展的创新途径是实现我国“双碳”目标的重要推动力。为解决大规模可再生能源电力供应不稳定的难题,新型电力系统的提出与加速成长促进了抽水蓄能电站的建设与发展,但生态保护与地形等因素制约了传统抽水蓄能电站发展。关闭/废弃矿井,由于具有丰富的地下空间及水资源,可创新性地开发抽水蓄能并延长矿区的经济寿命,降低对环境与经济的负面影响。为助力建立适合我国国情的废弃矿井抽水蓄能利用模式和管理体系,通过文献分析法综述了国内外废弃矿井抽水蓄能技术研究与应用进展。详细阐述了关闭/废弃矿井抽水蓄能技术原理、分类及其优缺点;总结了关闭/废弃矿井抽水蓄能电站利用模式,并在前人研究基础上对选址要素进行了修订;梳理了关闭/废弃矿井改建抽水蓄能电站的水-气两相流动特性、水泵水轮机工况特性、地下空间围岩稳定性及地下蓄水空间体积测算等的研究现状,明确了水泵-水轮机关键技术、地下空间稳定性控制关键技术等亟待解决的技术难题。此外,对关闭/废弃矿井抽水蓄能相关的生态与环境保护、市场需求与经济效益、政策与法规等研究成果进行了广泛的文献综述。发展关闭/废弃矿井地下空间抽水蓄能技术可为我国井下空间资源利用提供思路,为保障国家能源安全与经济社会高质量发展提供新途径。 展开更多
关键词 关闭/废弃矿井 抽水蓄能 清洁能源 地下空间 矿区治理
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负压封闭引流联合保留臀上动脉浅支的臀大肌肌皮瓣修复骶尾部IV期压疮的临床效果 被引量:1
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作者 夏卫东 屠卓隆 +3 位作者 赵胜 缪爱梅 刘政军 林才 《温州医科大学学报》 CAS 2024年第4期318-322,共5页
目的:探讨负压封闭引流联合保留臀上动脉浅支的臀大肌旋转肌皮瓣修复骶尾部压疮的临床效果。方法:选取2019年6月—2023年10月温州医科大学附属第一医院收治的12例骶尾部压疮患者,其中男7例,女5例,年龄31~86岁。入院后I期予行负压封闭引... 目的:探讨负压封闭引流联合保留臀上动脉浅支的臀大肌旋转肌皮瓣修复骶尾部压疮的临床效果。方法:选取2019年6月—2023年10月温州医科大学附属第一医院收治的12例骶尾部压疮患者,其中男7例,女5例,年龄31~86岁。入院后I期予行负压封闭引流术,4~7 d后行保留臀上动脉浅支的臀大肌肌皮瓣修复创面。观察术后皮瓣成活情况、并发症发生情况,随访观察皮瓣外形、压疮复发情况。结果:本组12例患者,均因长期卧床致骶尾部受压出现IV期压疮,压疮病因:截瘫患者5例,各种原因所致的长期卧床患者7例,其中脑梗死后遗症患者2例,帕金森病患者3例,老年痴呆症患者1例,股骨颈骨折患者1例。病程2周至8年,清创后创面面积为5.0 cm×5.0 cm~10.0 cm×12.0 cm。12例患者术后皮瓣均完全成活,无皮瓣坏死、静脉淤血、创缘开裂等发生。术后随访2~6个月,皮瓣外形较佳、骶尾部软组织饱满、压疮无复发。结论:保留臀上动脉浅支的臀大肌旋转肌皮瓣血运可靠,设计、操作简单,皮瓣可修复面积大,切取不需要离断臀上动脉浅支,供瓣区一般能直接缝合,修复骶尾部压疮效果较佳。 展开更多
关键词 肌皮瓣 IV期压疮 负压封闭引流 创面修复
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不同支撑剂组合方式下页岩导流能力实验评价 被引量:1
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作者 杨春城 王良 +2 位作者 顾明勇 卢澍韬 宋景杨 《中外能源》 CAS 2024年第3期52-56,共5页
为了深入了解多粒径支撑剂组合条件下页岩储层导流能力的大小,依据达西定律,采用API支撑剂实验装置,评价分析不同支撑剂质量比例、粒径、铺砂浓度、类型、流体类型、岩性等对导流能力的影响。实验结果表明:随着闭合压力增加,各种支撑剂... 为了深入了解多粒径支撑剂组合条件下页岩储层导流能力的大小,依据达西定律,采用API支撑剂实验装置,评价分析不同支撑剂质量比例、粒径、铺砂浓度、类型、流体类型、岩性等对导流能力的影响。实验结果表明:随着闭合压力增加,各种支撑剂组合方式下的导流能力都有很大程度下降;相同条件下,铺砂浓度与导流能力呈正相关关系,覆膜砂的导流能力高于石英砂,清水条件下的导流能力高于破胶液,硬度高的页岩储层导流能力高于硬度低的页岩储层;70/140目陶粒+40/70目覆膜砂+30/50目覆膜砂支撑剂组合,在质量比为1∶6∶3时导流能力最优;在高闭合压力下,70/140目陶粒+40/70目覆膜砂+30/50目覆膜砂组合的导流能力,略高于70/140目陶粒+30/50目覆膜砂+20/40目覆膜砂支撑剂组合。可见,对于较软地层采用覆膜砂组合支撑剂,更有利于长期保持较高的导流能力;压裂液选用时更要注重压裂液配方的低伤害性,以提高导流能力。 展开更多
关键词 支撑剂组合 导流能力 页岩储层 闭合压力 铺砂浓度 覆膜砂
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基于SSA−LSTM的风速异常波动检测方法 被引量:1
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作者 邓立军 袁金波 +1 位作者 刘剑 尚文天 《煤炭科学技术》 EI CAS CSCD 北大核心 2024年第3期139-147,共9页
针对传统统计方法对风门开闭导致传感器监测数据异常波动的漏报率和误报率高的问题,通过挖掘风速传感器中时间序列数据中的数据特征,提出了一种基于奇异谱分析法(SSA)与长短期记忆神经网络(LSTM)组合的SSA−LSTM风速异常波动检测方法。... 针对传统统计方法对风门开闭导致传感器监测数据异常波动的漏报率和误报率高的问题,通过挖掘风速传感器中时间序列数据中的数据特征,提出了一种基于奇异谱分析法(SSA)与长短期记忆神经网络(LSTM)组合的SSA−LSTM风速异常波动检测方法。首先利用SSA对风速传感器监测数据进行预处理,将风速数据分解为趋势分量、周期分量和噪声分量,通过重组趋势分量和噪声分量去除因湍流脉动产生的数据噪声;然后对LSTM进行参数优化,利用优化后的LSTM模型对预处理数据进行预测并得到重构风速;最后以对数概率密度函数计算监测风速与重构风速的异常分数,通过计算训练集数据样本的异常分数设定阈值对监测风速进行异常检测。试验结果表明:SSA去除因湍流脉动产生的数据噪声效果较好,在不影响数据波动情况下去除噪声分量,有助于提高风速重构效果和异常检测准确率;LSTM在无异常波动时能正确重构因湍流脉动导致的小幅波且与实际数据拟合效果较好,在有异常波动时根据历史波动趋势对异常波动段进行重构,可有效提高异常检测的准确率。通过对比分析,所提方法比ARIMA、BP、CNN模型的重构效果更好,异常检测准确率为99.2%,F1-Score为0.97,验证了所提方法的可靠性。表明本文所提方法在检测因风门开闭导致的风速异常波动上具有一定的应用价值。 展开更多
关键词 异常波动 风门开闭 异常检测 奇异谱分析 长短期记忆 时间序列
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团队模式下闭环式健康教育在老年高血压患者护理中的应用观察 被引量:1
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作者 张玲 常峪文 热孜亚·夏吾东 《老年医学与保健》 CAS 2024年第1期84-88,94,共6页
目的探究团队模式下闭环式健康教育在老年高血压患者延伸护理中的应用效果,为治疗该病症提供方法。方法选取2020年3月—2023年3月新疆维吾尔自治区人民医院健康管理中心收治的老年高血压患者共计102例,采用随机数表法分为观察组(n=51)... 目的探究团队模式下闭环式健康教育在老年高血压患者延伸护理中的应用效果,为治疗该病症提供方法。方法选取2020年3月—2023年3月新疆维吾尔自治区人民医院健康管理中心收治的老年高血压患者共计102例,采用随机数表法分为观察组(n=51)以及对照组(n=51)。对照组患者接受常规高血压护理,观察组患者在对照组相同处理的基础上接受团队模式下的闭环式健康教育,干预疗程为3个月。记录并比较2组接受干预前后的24 h平均收缩压和舒张压、自我护理能力量表(ESCA)评分以及高血压患者8项Morisky用药依从性量表(MMAS-8)评分、SF-36生活质量调查表(SF-36)评分、接受干预后研究对象在延伸护理、健康教育、操作与演示、疑问的反馈与解答层面对护理服务的满意度。结果接受干预后,2组的24 h平均收缩压和舒张压比干预前均出现降低,且观察组低于对照组(P<0.05);与此同时,2组的ESCA评分以及MMAS-8评分相比干预前均出现提升,且观察组高于对照组(P<0.05);观察组接受干预后的SF-36评分显著高于对照组,差异存在统计学意义(P<0.05);观察组在延伸护理、健康教育、操作与演示、疑问的反馈与解答领域对护理服务的满意度均高于对照组患者(P<0.05)。结论团队模式下闭环式健康教育应用于老年高血压患者延伸护理能够有效提升高血压控制效果以及患者的自我护理意识,提高患者生活质量对护理服务的满意度,具有一定临床应用价值。 展开更多
关键词 老年 高血压 延伸护理 闭环式健康教育 团队模式 并发症
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三河尖关闭煤矿煤层CO_(2)封存潜力研究 被引量:2
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作者 钱静 易高峰 +4 位作者 周琦忠 汤志刚 彭一轩 王阳 陈尚斌 《煤炭科学技术》 EI CAS CSCD 北大核心 2024年第3期258-268,共11页
关闭煤矿煤层CO_(2)地质封存是CO_(2)封存的重要方式之一,也是短期内实现碳减排指标的有效手段之一。以江苏省徐州市三河尖关闭煤矿为例,分析了已采7号煤和9号煤的煤岩煤质特征,统计了剩余煤炭资源储量,运用模糊综合评价法,选取了稳定... 关闭煤矿煤层CO_(2)地质封存是CO_(2)封存的重要方式之一,也是短期内实现碳减排指标的有效手段之一。以江苏省徐州市三河尖关闭煤矿为例,分析了已采7号煤和9号煤的煤岩煤质特征,统计了剩余煤炭资源储量,运用模糊综合评价法,选取了稳定系数、上覆岩层性质、地质构造复杂程度、地下水指标、封存煤层压温比、封存煤层深厚比、封存煤层渗透率、采空塌陷程度和其他因素等9个主要影响因素指标对7号煤和9号煤封存CO_(2)稳定性进行评价,建立关闭煤矿煤层CO_(2)封存评价方法并评估CO_(2)封存潜力。结果表明,三河尖关闭煤矿7号煤和9号煤剩余储量较大,CO_(2)封存稳定性综合评价结果分别为86.209和87.698,评价等级均为较稳定,封存潜力较高。根据建立的关闭煤矿煤层CO_(2)封存评价方法,计算获得三河尖关闭煤矿7号和9号煤层CO_(2)理论封存量分别为207.6 Mt和80.9 Mt,并据此划分封存有利区为有利区、较有利区和不利区3个等级。研究可为关闭煤矿煤层CO_(2)封存研究提供基础依据。 展开更多
关键词 关闭煤矿 煤层CO_(2)封存 稳定性评价 封存潜力 三河尖煤矿 碳封存
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