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Advantages of nanocarriers for basic research in the field of traumatic brain injury 被引量:2
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作者 Xingshuang Song Yizhi Zhang +1 位作者 Ziyan Tang Lina Du 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期237-245,共9页
A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researche... A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researchers have begun to focus on nanocarriers and other brain-targeting drug delivery systems.In this review,we summarize the epidemiology,basic pathophysiology,current clinical treatment,the establishment of models,and the evaluation indicators that are commonly used for traumatic brain injury.We also report the current status of traumatic brain injury when treated with nanocarriers such as liposomes and vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains in the basic research stage and has yet to be fully translated to the clinic. 展开更多
关键词 blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell nanocarrierS nanoparticles neural restoration traumatic brain injury
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Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier
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作者 KARAN WADHWA PAYAL CHAUHAN +7 位作者 SHOBHIT KUMAR RAKESH PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA SHARMA NEHA RAO DEEPAK KAUSHIK 《Oncology Research》 SCIE 2024年第5期877-897,共21页
Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive tumor.The high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells arou... Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive tumor.The high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the tumormass.Objective:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation therapy.Methods:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several others.Conclusion:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management.Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed. 展开更多
关键词 GLIOBLASTOMA Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles nanocarrierS
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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy 被引量:3
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作者 Qingfei Zhang Gaizhen Kuang +3 位作者 Wenzhao Li Jinglin Wang Haozhen Ren Yuanjin Zhao 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第3期299-331,共33页
Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects.Currently,the development of functional vectors with safety and effectiveness is the intense fo... Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects.Currently,the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy.For this purpose,stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection,prolonged blood circulation,specific tumor accumulation,and controlled release profile of nucleic acid drugs.Besides,synergistic therapy could be achieved when combined with other therapeutic regimens.This review summarizes recent advances in various stimuliresponsive nanocarriers for gene delivery.Particularly,the nanocarriers responding to endogenous stimuli including pH,reactive oxygen species,glutathione,and enzyme,etc.,and exogenous stimuli including light,thermo,ultrasound,magnetic field,etc.,are introduced.Finally,the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed.The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable. 展开更多
关键词 STIMULI-RESPONSIVE nanocarrier Gene therapy Gene delivery CANCER
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Colon cancer and their targeting approaches through nanocarriers:A review 被引量:1
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作者 Richa Kumari Nitin Sharma +1 位作者 Ritu Karwasra Kushagra Khanna 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2023年第3期104-111,共8页
Colon cancer is the fifth most common type of cancer in the world.Colon cancer develops when healthy cells in the lining of the colon or rectum alter and grow uncontrollably to form a mass known as a tumor.Despite maj... Colon cancer is the fifth most common type of cancer in the world.Colon cancer develops when healthy cells in the lining of the colon or rectum alter and grow uncontrollably to form a mass known as a tumor.Despite major medical improvements,colon cancer is still one of the leading causes of cancer-related mortality globally.One of the main issues of chemotherapy is toxicity related to conventional medicines.The targeted delivery systems are considered the safest and most effective by increasing the concentration of a therapeutic substance at the tumor site while decreasing it at other organs.Therefore,these delivery systems required lower doses for high therapeutic value with minimum side effects.The current review focuses on targeting therapeutic substances at the desired site using nanocarriers.Additionally,the diagnostic applications of nanocarriers in colorectal cancer are also discussed. 展开更多
关键词 Colon cancer Targeting approaches Chemotherapies nanocarrierS Gold nanoparticles Liposomes
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DRUG AND PLASMID DNA CO-DELIVERY NANOCARRIERS BASED ON ABC-TYPE POLYPEPTIDE HYBRID MIKTOARM STAR COPOLYMERS 被引量:6
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作者 Tao Liu Yan-feng Zhang 刘世勇 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2013年第6期924-937,共14页
We report on the fabrication of self-assembled micelles from ABC-type miktoarm star polypeptide hybrid copolymers consisting of poly(ethylene oxide), poly(L-lysine), and poly(e-caprolactone) arms, PEO(-b-PLL)-... We report on the fabrication of self-assembled micelles from ABC-type miktoarm star polypeptide hybrid copolymers consisting of poly(ethylene oxide), poly(L-lysine), and poly(e-caprolactone) arms, PEO(-b-PLL)-b-PCL, and their functional applications as co-delivery nanocarriers of chemotherapeutic drugs and plasmid DNA. Miktoarm star copolymer precursors, PEO(-b-PZLL)-b-PCL, were synthesized at first via the combination of consecutive "click" reactions and ring-opening polymerizations (ROP), where PZLL is poly(e-benzyloxycarbonyl-L-lysine). Subsequently, the deprotection of PZLL arm afforded amphiphilic miktoarm star copolymers, PEO(-b-PLL)-b-PCL. In aqueous media at pH 7.4, PEO(-b-PLL)-b-PCL self-assembles into micelles consisting of PCL cores and hydrophilic PEO/PLL hybrid coronas. The hydrophobic micellar cores can effectively encapsulate model hydrophobic anticancer drug, paclitaxel; whereas positively charged PLL arms within mixed micellar corona are capable of forming electrostatic polyplexes with negatively charged plasmid DNA (pDNA) at N/P ratios higher than ca. 2. Thus, PEO(-b-PLL)-b-PCL micelles can act as co-delivery nanovehicles for both chemotherapeutic drugs and genes. Furthermore, polyplexes of pDNA with paclitaxel-loaded PEO(-b- PLL)-b-PCL micelles exhibited improved transfection efficiency compared to that of pDNA/blank micelles. We expect that the reported strategy of varying chain topologies for the fabrication of co-delivery polymeric nanocarriers can be further applied to integrate with other advantageous functions such as targeting, imaging, and diagnostics. 展开更多
关键词 Miktoarm star copolymers Gene delivery co-delivery POLYPEPTIDE SELF-ASSEMBLY
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Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances 被引量:9
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作者 Xiaoqian Niu Jiejian Chen Jianqing Gao 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2019年第5期480-496,共17页
Neurodegenerative diseases including Alzheimer’s disease,Parkinson’s disease,Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and society. Related scientific researches make tard... Neurodegenerative diseases including Alzheimer’s disease,Parkinson’s disease,Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and society. Related scientific researches make tardy progress. One reason is that the known pathogeny is just the tip of the iceberg. Another reason is that various physiological barriers,especially blood-brain barrier(BBB),hamper effective therapeutic substances from reaching site of action. Drugs in clinical treatment of neurodegenerative diseases are basically administered orally. And generally speaking,the brain targeting efficiency is pretty low. Nanodelivery technology brings hope for neurodegenerative diseases. The use of nanocarriers encapsulating molecules such as peptides and genomic medicine may enhance drug transport through the BBB in neurodegenerative disease and target relevant regions in the brain for regenerative processes. In this review,we discuss BBB composition and applications of nanocarriers-liposomes,nanoparticles,nanomicelles and new emerging exosomes in neurodegenerative diseases. Furthermore,the disadvantages and the potential neurotoxicity of nanocarriers according pharmacokinetics theory are also discussed. 展开更多
关键词 NEURODEGENERATIVE diseases Blood-brain barrier nanocarrierS NEUROTOXICITY
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Phage display: development of nanocarriers for targeted drug delivery to the brain 被引量:2
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作者 Babak Bakhshinejad Marzieh Karimi Mohammad Khalaj-Kondori 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第6期862-865,共4页
The blood brain barrier represents a formidable obstacle for the transport of most systemati- cally administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strate... The blood brain barrier represents a formidable obstacle for the transport of most systemati- cally administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strategy that can be used for the construction of nanomaterial peptide libraries. These libraries can be screened for finding brain targeting peptide ligands. Surface functionalization of a variety of nanocarriers with these brain homing peptides is a sophisticated way to develop nanobiotechnology-based drug delivery platforms that are able to cross the blood brain barrier. These efficient drug delivery systems raise our hopes for the diagnosis and treatment of various brain disorders in the future. 展开更多
关键词 blood brain barrier phage display peptide library nanocarrier TARGETING
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Flavonoids Loaded in Nanocarriers: An Opportunity to Increase Oral Bioavailability and Bioefficacy 被引量:2
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作者 Anna Rita Bilia Benedetta Isacchi +2 位作者 Chiara Righeschi Clizia Guccione Maria Camilla Bergonzi 《Food and Nutrition Sciences》 2014年第13期1212-1327,共116页
Flavonoids are among the biggest group of polyphenols, widely distributed in plant-based foods. A plethora of evidence supports the health benefits and value of flavonoids can play in the physiological function treatm... Flavonoids are among the biggest group of polyphenols, widely distributed in plant-based foods. A plethora of evidence supports the health benefits and value of flavonoids can play in the physiological function treatment and in the prevention of disease particularly in the prevention of degenerative conditions including cancers, cardiovascular and neurodegenerative diseases. Hence, flavonoids represent the active constituents of many dietary supplements and herbal remedies, as well as there is an increasing interest in this class of polyphenols as functional ingredients of beverages, food grains and dairy products. Conversely, various studies have also shown that flavonoids have some drawbacks after oral administration such as stability, bioavailability and bioefficacy. This article reviews the current status of novel nanodelivery systems including nanospheres, nanocaspsules, micro- and nanoemulsions, micelles, solid lipid nanoparticles and nanostructured lipid capsules, successfully developed for overcoming the delivery challenges of flavonoids. 展开更多
关键词 FLAVONOIDS Nanodelivery Systems Lipid-Based nanocarrierS Polymer-Based nanocarrierS Improved Stability BIOAVAILABILITY and Bioefficacy
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Synergism of essential oils with lipid based nanocarriers: emerging trends in preservation of grains and related food products 被引量:5
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作者 Satyavani Kaliamurthi Gurudeeban Selvaraj +4 位作者 Lifen Hou Zhao Li Yongkai Wei Keren Gu Dongqing Wei 《Grain & Oil Science and Technology》 2019年第1期21-26,共6页
Grains are one of the major food staples in the world.The cereal grains are easily susceptible to damage by moisture content,flour beetles and food pathogens during storage,harvesting and post harvesting.Food preserva... Grains are one of the major food staples in the world.The cereal grains are easily susceptible to damage by moisture content,flour beetles and food pathogens during storage,harvesting and post harvesting.Food preservative techniques namely drying,freezing,and dehydration,acquire little advantages.However,they cause few undesirable alterations in the organoleptic and nutritional properties of the preserved food items.Therefore,there is a continuous search for new preservation techniques in food industries,to satisfy the customer demands on the addition of natural food preservatives,devoid of pathogenic contaminants and without changes in organoleptic properties.Essential oils(EOs)have been predicted as“natural food additives”in the preservative process.The synergistic potential of EOs with various nanocarriers plays an emerging role in the food industry.Therefore,the present review has focused on the lipid based nanocarriers,and the methods used for the functionalization or encapsulation of EOs and applications in the preservation of food items such as cooked rice,rice flour,grains,sliced breads have also been discussed.The present review ascertains the antimicrobial significance of active EOs loaded lipid nanocarriers in the form of nano emulsions,solid lipid nanoparticles and liposomes for preserving grains and flours. 展开更多
关键词 ANTIMICROBIAL Essential oil Food PATHOGENS Grains nanocarrierS
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Gene transfection mediated by polyethyleneiminepolyethylene glycol nanocarrier prevents cisplatininduced spiral ganglion cell damage 被引量:1
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作者 Guan-gui Chen Min Mao +1 位作者 Li-zi Qiu Qi-ming Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第3期425-431,共7页
Polyethyleneimine-polyethylene glycol (PEI-PEG), a novel nanocarrier, has been used for trans- fection and gene therapy in a variety of cells. In our previous study, we successfully carried out PEI-PEG-mediated gene... Polyethyleneimine-polyethylene glycol (PEI-PEG), a novel nanocarrier, has been used for trans- fection and gene therapy in a variety of cells. In our previous study, we successfully carried out PEI-PEG-mediated gene transfer in spiral ganglion cells. It remains unclear whether PEI-PEG could be used for gene therapy with X-linked inhibitor of apoptosis protein (XIAP) in the inner ear. In the present study, we performed PEI-PEG-mediated XIAP gene transfection in the cochlea of Sprague-Dawley rats, via scala tympani fenestration, before daily cisplatin injections. Audito- ry brainstem reflex tests demonstrated the protective effects of XIAP gene therapy on auditory function. Immunohistochemical staining revealed XIAP protein expression in the cytoplasm of cells in the spiral ganglion, the organ of Corti and the stria vascularis. Reverse transcription-PCR detected high levels of XIAP mRNA expression in the cochlea. The present findings suggest that PEI-PEG nanocarrier-mediated XIAP gene transfection results in XIAP expression in the cochlea, prevents damage to cochlear spiral ganglion cells, and protects hearing. 展开更多
关键词 nerve regeneration polyethyleneimine-polyethylene glycol spiral ganglion cells X-linkedinhibitor of apoptosis protein gene therapy nanocarrier cisplatin neural regeneration OTOTOXICITY COCHLEA
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An understanding of mitochondria and its role in targeting nanocarriers for diagnosis and treatment of cancer 被引量:1
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作者 Devendra Choudhary Hanmant Goykar +3 位作者 Tukaram Karanwad Suraj Kannaujia Vedant Gadekar Manju Misra 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2021年第4期397-418,共22页
Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be ut... Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be utilized for the better treatment of disease. Mitochondria, the so-called powerhouse of cell, portrays significant role in the survival and death of cells, and has emerged as potential target for cancer therapy. Direct targeting and nanotechnology based approaches can be tailor-made to target mitochondria and thus improve the survival rate of patients suffering from cancer. With this backdrop, in present review, we have reemphasized the role of mitochondria in cancer progression and inhibition, highlighting the different targets that can be explored for targeting of disease. Moreover, we have also summarized different nanoparticulate systems that have been used for treatment of cancer via mitochondrial targeting. 展开更多
关键词 Mitochondrial targeting CANCER nanocarrierS Photodynamic therapy Photothermal therapy
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Stimuli-responsive nanocarriers for therapeutic applications in cancer
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作者 Xubo Zhao Jie Bai Wenjing Yang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2021年第2期319-335,共17页
Cancer has become a very serious challenge with aging of the human population.Advances in nanotechnology have provided new perspectives in the treatment of cancer.Through the combination of nanotechnology and therapeu... Cancer has become a very serious challenge with aging of the human population.Advances in nanotechnology have provided new perspectives in the treatment of cancer.Through the combination of nanotechnology and therapeutics,nanomedicine has been successfully used to treat cancer in recent years.In terms of nanomedicine,nanocarriers play a key role in delivering therapeutic agents,reducing severe side effects,simplifying the administration scheme,and improving therapeutic efficacies.Modulations of the structure and function of nanocarriers for improved therapeutic efficacy in cancer have attracted increasing attention in recent years.Stimuli-responsive nanocarriers penetrate deeply into tissues and respond to external or internal stimuli by releasing the therapeutic agent for cancer therapy.Notably,stimuli-responsive nanocarriers reduce the severe side effects of therapeutic agents,when compared with systemic chemotherapy,and achieve controlled drug release at tumor sites.Therefore,the development of stimuli-responsive nanocarriers plays a crucial role in drug delivery for cancer therapy.This article focuses on the development of nanomaterials with stimuli-responsive properties for use as nanocarriers,in the last few decades.These nanocarriers are more effective at delivering the therapeutic agent under the control of external or internal stimuli.Furthermore,nanocarriers with theranostic features have been designed and fabricated to confirm their great potential in achieving effective treatment of cancer,which will provide us with better choices for cancer therapy. 展开更多
关键词 nanocarrierS therapeutic agent NANOMEDICINE stimuli-responsiveness cancer therapy
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Microwave technology enabled transdermal nanocarrier and drug delivery
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作者 Tin Wui Wong 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2016年第1期43-44,共2页
Transdermal drug delivery is impeded by the natural barrier of epidermis known as stratum corneum.This limits the route to transport of drugs with a log octanol–water partition coefficient of 1 to 3,molecular weight ... Transdermal drug delivery is impeded by the natural barrier of epidermis known as stratum corneum.This limits the route to transport of drugs with a log octanol–water partition coefficient of 1 to 3,molecular weight of less than 500 Da and melting point of less than 200°C.Nanotechnology has received a widespread investigation as the nanocarriers are able to fluidize the stratum corneum as a function of size,shape,surface charges,and hydrophilicity–hydrophobicity balance,while delivering drugs across the skin barrier. 展开更多
关键词 MICROWAVE TECHNOLOGY TRANSDERMAL nanocarrier DRUG delivery
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Impact of chitosan-based nanocarriers on cytoskeleton dynamics:Current status and challenges
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作者 M.CAROLINA DI SANTO AGUSTINA ALAIMO +1 位作者 ANA PAULA DOMÍNGUEZ RUBIO OSCAR E.PÉREZ 《BIOCELL》 SCIE 2022年第4期885-891,共7页
Chitosan-based nanocarriers(CS-NCs)show a promising role in improving drugs and bioactive compounds delivery for therapy.However,the effects exerted by CS-NCs at the cellular level,including their recognition and upta... Chitosan-based nanocarriers(CS-NCs)show a promising role in improving drugs and bioactive compounds delivery for therapy.However,the effects exerted by CS-NCs at the cellular level,including their recognition and uptake,have not been fully investigated yet.Many factors,including size,shape,concentration,and surface chemistry of CS-NCs,play an important role in determining the types of intracellular signals triggered.The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells.In the present work,we discuss the effects induced by CS-NCs per se on the cytoskeleton,a key component in cell architecture and physiology.The focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell cytoskeleton.The recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and discussed.Understanding mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-added formulations in the biomedical field.Furthermore,this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-tumoral effects. 展开更多
关键词 Cytoskeletal dynamics Cellular uptake ENDOCYTOSIS nanocarrierS CHITOSAN Bioactive compounds
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Delivery of siRNA/miRNA by nanocarriers to treat colon cancer
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作者 Xiao-Dong Wang 《Precision Medicine Research》 2019年第2期52-60,共9页
Despite the current advances in the discovery of the colorectal cancer biomarkers and in the diagnosis and treatment of CRC, the incidence and mortality of colon cancer are still increasing year by year. At present, m... Despite the current advances in the discovery of the colorectal cancer biomarkers and in the diagnosis and treatment of CRC, the incidence and mortality of colon cancer are still increasing year by year. At present, many patients with colon cancer have been diagnosed in an advanced stage, which always accompanied by liver metastasis and distant metastasis. However, current treatments for advanced colon cancer are limited. Therefore, the delivery of siRNA/miRNA to colon cancer lesions may be a new approach to the treatment of colon cancer. This review provides ideas for the molecular treatment of colon cancer by discussing the biological characteristics of colon cancer and the regulation of important miRNA molecules in colon cancer. Moreover, this review describes the development of nanocarriers in recent years and the important role of nanocarrier materials in the targeted delivery of small molecules. On the one hand, nanocarriers can serve as small carriers or siRNA/miRNAs, and on the other hand, can transport small molecules or siRNA/miRNAs into colon cancer cells, thereby regulating key genes expression affecting colon cancer cell proliferation, metastasis, and apoptosis. Delivery of siRNA/miRNA via nanocarriers may be a novel approach to the treatment of colon cancer. 展开更多
关键词 COLORECTAL cancer MIRNA MARKERS nanocarrierS Gene therapy
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Anti-cancer drugs targeting using nanocarrier niosomes-a review
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作者 Sidharth Mehta 《TMR Cancer》 2020年第4期169-174,共6页
In the last few decades numbers of review and research articles have been published on niosomes. This shows the relevant interest of academias & researchers in niosomes because of the advantages sponsored by them ... In the last few decades numbers of review and research articles have been published on niosomes. This shows the relevant interest of academias & researchers in niosomes because of the advantages sponsored by them over other colloidal drug delivery systems. Niosomes formation occurs when non-ionic surfactant vesicles assemble themselves. Various antineoplastic agents are used in chemotherapy, but they have some drawbacks that these agents cause cell death in normal tissues as well. There are two approaches to overcome this limitation. First, to modify the structure of existing drugs, but this will not possible because it changes the properties of drugs. Second, the development of nano-carriers like liposomes, dendrimers, nanoparticles, niosomes et al. Among all, niosomes (non-ionic surfactant vesicles) have more advantages besides all nano-carriers. Drugs either hydrophilic in nature or hydrophobic in nature, both can be incorporated in niosomes. And by embedding specific ligands over vesicular surface enables us to target the drug to specific cancer cells. 展开更多
关键词 nanocarrierS NIOSOMES Anticancer drugs Targeted drug delivery Non-ionic surfactants vesicles Anti neoplastic agents
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Use of Nanocarrier Systems in Cancer Therapy
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作者 Gamze Guney Lutfi Genc Gokhan Dikmen 《材料科学与工程(中英文版)》 2011年第5期577-582,共6页
关键词 磁性纳米粒子 癌症治疗 载体系统 固体脂质纳米粒 药物输送 输送系统 治疗设备 分子成像
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NanoCarrier/CTT达成合作协议
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作者 曹菊 《国外药讯》 2004年第3期29-29,共1页
关键词 nanocarrier公司 CTT公司 药物传输系统 肿瘤靶向肽 抗肿瘤药 制药企业 药品开发
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纳米药物载体用于治疗胞内菌感染的研究进展
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作者 巨晓洁 宋婉璐 +4 位作者 周宸宇 沈秋彤 廖雨田 龚珏颖 褚良银 《化工学报》 EI CSCD 北大核心 2024年第4期1153-1166,共14页
胞内菌能够逃避机体免疫并在宿主细胞内正常生长繁殖,比起胞外细菌更难清除,容易造成较为严重的感染。传统的抗生素治疗,药物无法突破宿主细胞膜的屏障,并且容易引起较强的毒副作用和多药耐药性。优良的纳米载体具有良好的生物相容性且... 胞内菌能够逃避机体免疫并在宿主细胞内正常生长繁殖,比起胞外细菌更难清除,容易造成较为严重的感染。传统的抗生素治疗,药物无法突破宿主细胞膜的屏障,并且容易引起较强的毒副作用和多药耐药性。优良的纳米载体具有良好的生物相容性且易于修饰,有望通过构建纳米药物递送系统增强抗菌药物的细胞膜穿透性和胞内菌靶向性,在治疗胞内菌感染上具有巨大潜力和广阔前景。介绍了目前可用于治疗胞内菌感染的各种纳米颗粒,归纳总结了增强纳米药物递送系统治疗效果的机制和方法,阐述了目前在使用纳米药物递送系统治疗胞内菌感染时仍存在的问题,以期为构建更优良的纳米药物递送系统治疗胞内菌感染提供启发。 展开更多
关键词 纳米载体 胞内菌 细菌靶向 抗菌策略
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纳米材料在癌症氢治疗中的应用现状
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作者 欧阳瑞镯 薛维锨 缪煜清 《集成技术》 2024年第1期82-95,共14页
氢气可以选择性地清除细胞毒性活性氧。在癌细胞内,氢气的存在会影响癌细胞内活性氧的平衡,从而使癌细胞凋亡。此外,与药物相比,氢气对人体清洁无害,对细胞膜的穿透性高,具有先天优势。然而,口服富氢水和注射富氢生理盐水等手段由于氢... 氢气可以选择性地清除细胞毒性活性氧。在癌细胞内,氢气的存在会影响癌细胞内活性氧的平衡,从而使癌细胞凋亡。此外,与药物相比,氢气对人体清洁无害,对细胞膜的穿透性高,具有先天优势。然而,口服富氢水和注射富氢生理盐水等手段由于氢气在体内无目的性地扩散,难以实现良好的疗效。该文简要介绍了氢气治疗的机理,并通过列举目前的一些利用纳米材料进行氢气治疗的方法,介绍了氢治疗中,传递氢气的几种主要纳米系统,并对纳米材料在癌症氢治疗中的未来进行了展望。 展开更多
关键词 纳米材料 氢治疗 活性氧 原位产氢 纳米载体 癌症治疗
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