We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on t...We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on the upgraded SG-II laser facility. Then, based on thepoint-projection hard x-ray radiography technique, time-resolved radiography of the double shell targets, including that of their near-peakcompression, were obtained. The backlighter source was created by the interactions of a high-intensity short pulsed laser with a metalmicrowire target. Images of the target near peak compression were obtained with an Au microwire. In addition, radiation hydrodynamicsimulations were performed, and the target evolution obtained agrees well with the experimental results. Using the radiographic images, arealdensities of the targets were evaluated.展开更多
Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionm...Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and inconsistency.Existing literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of criteria.In this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision examples.To enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference alternatives.Probabilistic linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise comparisons.To address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of decision-makers.Finally,we conduct a case study and comparative analysis.Results reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information.展开更多
Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord...Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.展开更多
In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back proj...In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back projection analysis.Data in two frequency bands(0.5-2 Hz and 1-3 Hz)are used in the imaging processes.The results show that the rupture of the first event extends about 200 km to the northeast and about 150 km to the southwest,lasting~90 s in total.The southwestern rupture is triggered by the northeastern rupture,demonstrating a sequential bidirectional unilateral rupture pattern.The rupture of the second event extends approximately 80 km in both northeast and west directions,lasting~35 s in total and demonstrates a typical bilateral rupture feature.The cascading ruptures on both sides also reflect the occurrence of selective rupture behaviors on bifurcated faults.In addition,we observe super-shear ruptures on certain fault sections with relatively straight fault structures and sparse aftershocks.展开更多
Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role ...Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability.展开更多
This study comprehensively examines the patterns and regional variation of severe rainfall across the African continent, employing a suite of eight extreme precipitation indices. The analysis extends to the assessment...This study comprehensively examines the patterns and regional variation of severe rainfall across the African continent, employing a suite of eight extreme precipitation indices. The analysis extends to the assessment of projected changes in precipitation extremes using five General Circulation Models (GCMs) from Coupled Model Intercomparison Project Phase 6 (CMIP6) under four Shared Socioeconomic Pathways (SSPs) scenarios at the long-term period (2081-2100) of the 21<sup>st</sup> century. Furthermore, the study investigates potential mechanisms influencing precipitation extremes by correlating extreme precipitation indices with oceanic system indices, specifically Ni?o 3.4 for El Ni?o-Southern Oscillation (ENSO) and Dipole Mode Index (DMI) for the Indian Ocean Dipole (IOD). The findings revealed distinct spatial distributions in mean trends of extreme precipitation indices, indicating a tendency toward decreased extreme precipitation in North Africa, Sahel region, Central Africa and the Western part of South Africa. Conversely, West Africa, East Africa and the Eastern part of South Africa exhibit an inclination toward increased extreme precipitation. The changes in precipitation extreme indices indicate a general rise in both the severity and occurrence of extreme precipitation events under all scenarios by the end of the 21<sup>st</sup> century. Notably, our analysis projects a decrease in consecutive wet days (CWD) in the far-future. Additionally, correlation analysis highlights significant correlation between above or below threshold rainfall fluctuation in East Africa and South Africa with oceanic systems, particularly ENSO and the IOD. Central Africa abnormal precipitation variability is also linked to ENSO with a significant negative correlation. These insights contribute valuable information for understanding and projecting the dynamics of precipitation extreme in Africa, providing a foundation for climate adaptation and mitigation efforts in the region.展开更多
Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role...Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role as both a valuable hydro-power resource and an essential ecological passageway.However,the water resources and security exhibit a high degree of vulnerabil-ity to climate change impacts.This research evaluates climate impacts on the hydrology of the Dulong-Irrawaddy River Basin(DIRB)by using a physical-based hydrologic model.We crafted future climate scenarios using the three latest global climate models(GCMs)from Coupled Model Intercomparison Project 6(CMIP6)under two shared socioeconomic pathways(SSP2-4.5 and SSP5-8.5)for the near(2025-2049),mid(2050-2074),and far future(2075-2099).The regional model using MIKE SHE based on historical hydrologic processes was developed to further project future streamflow,demonstrating reliable performance in streamflow simulations with a val-idation Nash-Sutcliffe Efficiency(NSE)of 0.72.Results showed that climate change projections showed increases in the annual precip-itation and potential evapotranspiration(PET),with precipitation increasing by 11.3%and 26.1%,and PET increasing by 3.2%and 4.9%,respectively,by the end of the century under SSP2-4.5 and SSP5-8.5.These changes are projected to result in increased annual streamflow at all stations,notably at the basin’s outlet(Pyay station)compared to the baseline period(with an increase of 16.1%and 37.0%at the end of the 21st century under SSP2-4.5 and SSP5-8.5,respectively).Seasonal analysis for Pyay station forecasts an in-crease in dry-season streamflow by 31.3%-48.9%and 22.5%-76.3%under SSP2-4.5 and SSP5-8.5,respectively,and an increase in wet-season streamflow by 5.8%-12.6%and 2.8%-33.3%,respectively.Moreover,the magnitude and frequency of flood events are pre-dicted to escalate,potentially impacting hydropower production and food security significantly.This research outlines the hydrological response to future climate change during the 21st century and offers a scientific basis for the water resource management strategies by decision-makers.展开更多
This study assesses the projected changes in the climate zoning of Côte d’Ivoire using the hierarchical classification of principal components (HCPC) method applied to the daily precipitation data of an ensemble...This study assesses the projected changes in the climate zoning of Côte d’Ivoire using the hierarchical classification of principal components (HCPC) method applied to the daily precipitation data of an ensemble of 14 CORDEX-AFRICA simulations under RCP4.5 and RCP8.5 scenarios. The results indicate the existence of three climate zones in Côte d’Ivoire (the coastal, the centre and the north) over the historical period (1981-2005). Moreover, CORDEX simulations project an extension of the surface area of drier climatic zones while a reduction of wetter zones, associated with the appearance of an intermediate climate zone with surface area varying from 77,560 km<sup>2</sup> to 134,960 km<sup>2</sup> depending on the period and the scenario. These results highlight the potential impacts of climate change on the delimitation of the climate zones of Côte d’Ivoire under the greenhouse gas emission scenarios. Thus, there is a reduction in the surface areas suitable for the production of cash crops such as cocoa and coffee. This could hinder the country’s economy and development, mainly based on these cash crops.展开更多
Construction project cost control involves many complex contents,forming a large amount of data information.If the processing method is unreasonable,it will likely affect the cost control efficiency.Therefore,in the c...Construction project cost control involves many complex contents,forming a large amount of data information.If the processing method is unreasonable,it will likely affect the cost control efficiency.Therefore,in the current construction project management,the review of project cost budget settlement is the focus to solve the cost management problems of construction projects and promote the development of the construction industry.This article mainly analyzes the influencing factors and current situation of construction project cost budget settlement review,and based on this,it explores the project cost budget settlement review strategy to promote the healthy development of construction project cost work.展开更多
The financial aspects of large-scale engineering construction projects profoundly influence their success.Strengthening cost control and establishing a scientific financial evaluation system can enhance the project’s...The financial aspects of large-scale engineering construction projects profoundly influence their success.Strengthening cost control and establishing a scientific financial evaluation system can enhance the project’s economic benefits,minimize unnecessary costs,and provide decision-makers with a robust financial foundation.Additionally,implementing an effective cash flow control mechanism and conducting a comprehensive assessment of potential project risks can ensure financial stability and mitigate the risk of fund shortages.Developing a practical and feasible fundraising plan,along with stringent fund management practices,can prevent fund wastage and optimize fund utilization efficiency.These measures not only facilitate smooth project progression and improve project management efficiency but also enhance the project’s economic and social outcomes.展开更多
Various industries today rely on the support of electromechanical equipment,expanding its scope of application and leading to an increase in electromechanical installation projects.However,due to the high level of exp...Various industries today rely on the support of electromechanical equipment,expanding its scope of application and leading to an increase in electromechanical installation projects.However,due to the high level of expertise required and the potential risks involved,it is crucial to emphasize safety management during construction.This paper delves into the significance of construction safety management for electromechanical installation projects,identifies common problems encountered during construction,and proposes solutions.This analysis aims to provide relevant personnel with essential guidance and references for managing electromechanical installation projects safely.展开更多
Estuarine projects can change local topography and influence water transport and saltwater intrusion.The Changjiang(Yangtze)River estuary is a multichannel estuary,and four major reclamation projects have been impleme...Estuarine projects can change local topography and influence water transport and saltwater intrusion.The Changjiang(Yangtze)River estuary is a multichannel estuary,and four major reclamation projects have been implemented in the Changjiang River estuary in recent years:the Xincun Shoal reclamation project(RP-XCS),the Qingcao Shoal reclamation project(RP-QCS),the Eastern Hengsha Shoal reclamation project(RP-EHS),and the Nanhui Shoal reclamation project(RP-NHS).The effects of the four reclamation projects and each project on the saltwater intrusion and water resources in the Changjiang River estuary were simulated in a 3D numerical model.Results show that for a multichannel estuary,local reclamation projects change the local topography and water diversion ratio(WDR)between channels and influence water and salt transport and freshwater utilization in the estuary.During spring tide,under the cumulative effect of the four reclamation projects,the salinity decreases by approximately 0.5in the upper reaches of the North Branch and increases by 0.5-1.0 in the middle and lower reaches of the North Branch.In the North Channel,the salinity decreases by approximately 0.5.In the North Passage,the salinity increases by 0.5-1.0.In the South Passage,the salinity increases by approximately 0.5 in the upper reaches and decreases by 0.2-0.5 on the north side of the middle and lower reaches.During neap tide,the cumulative effects of the four reclamation projects and the individual projects are similar to those during spring tide,but there are some differences.The effects of an individual reclamation project on WDR and saltwater intrusion during spring and neap tides are simulated and analyzed in detail.The cumulative effect of the four reclamation projects favors freshwater usage in the Changjiang River estuary.展开更多
The Qiangtang Basin of the Tibetan Plateau,located in the eastern Tethys tectonic domain,is the largest new marine petroliferous region for exploration in China.The scientific drilling project consisting primarily of ...The Qiangtang Basin of the Tibetan Plateau,located in the eastern Tethys tectonic domain,is the largest new marine petroliferous region for exploration in China.The scientific drilling project consisting primarily of well QK-1 and its supporting shallow boreholes for geological surveys(also referred to as the Project)completed in recent years contributes to a series of new discoveries and insights into the oil and gas preservation conditions and source rock evaluation of the Qiangtang Basin.These findings differ from previous views that the Qiangtang Basin has poor oil and gas preservation conditions and lacks high-quality source rocks.As revealed by well QK-1 and its supporting shallow boreholes in the Project,the Qiangtang Basin hosts two sets of high-quality regional seals,namely an anhydrite layer in the Quemo Co Formation and the gypsum-bearing mudstones in the Xiali Formation.Moreover,the Qiangtang Basin has favorable oil and gas preservation conditions,as verified by the comprehensive study of the sealing capacity of seals,basin structure,tectonic uplift,magmatic activity,and groundwater motion.Furthermore,the shallow boreholes have also revealed that the Qiangtang Basin has high-quality hydrocarbon source rocks in the Upper Triassic Bagong Formation,which are thick and widely distributed according to the geological and geophysical data.In addition,the petroleum geological conditions,such as the type,abundance,and thermal evolution of organic matter,indicate that the Qiangtang Basin has great hydrocarbon-generating potential.展开更多
Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate...Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate models to project future changes in precipitation extremes.The present study aims to assess the future changes in precipitation extremes over South Asia from the Coupled Model Intercomparison Project Phase 6(CMIP6)Global Climate Models(GCMs).The results were derived using the modified Mann-Kendall test,Sen's slope estimator,student's t-test,and probability density function approach.Eight extreme precipitation indices were assessed,including wet days(RR1mm),heavy precipitation days(RR10mm),very heavy precipitation days(RR20mm),severe precipitation days(RR50mm),consecutive wet days(CWD),consecutive dry days(CDD),maximum 5-day precipitation amount(RX5day),and simple daily intensity index(SDII).The future changes were estimated in two time periods for the 21^(st) century(i.e.,near future(NF;2021-2060)and far future(FF;2061-2100))under two Shared Socioeconomic Pathway(SSP)scenarios(SSP2-4.5 and SSP5-8.5).The results suggest increases in the frequency and intensity of extreme precipitation indices under the SSP5-8.5 scenario towards the end of the 21^(st) century(2061-2100).Moreover,from the results of multimodel ensemble means(MMEMs),extreme precipitation indices of RR1mm,RR10mm,RR20mm,CWD,and SDII demonstrate remarkable increases in the FF period under the SSP5-8.5 scenario.The spatial distribution of extreme precipitation indices shows intensification over the eastern part of South Asia compared to the western part.The probability density function of extreme precipitation indices suggests a frequent(intense)occurrence of precipitation extremes in the FF period under the SSP5-8.5 scenario,with values up to 35.00 d for RR1mm and 25.00-35.00 d for CWD.The potential impacts of heavy precipitation can pose serious challenges to the study area regarding flooding,soil erosion,water resource management,food security,and agriculture development.展开更多
Offshore engineering construction projects are large and complex,having the characteristics of multiple execution modes andmultiple resource constraints.Their complex internal scheduling processes can be regarded as r...Offshore engineering construction projects are large and complex,having the characteristics of multiple execution modes andmultiple resource constraints.Their complex internal scheduling processes can be regarded as resourceconstrained project scheduling problems(RCPSPs).To solve RCPSP problems in offshore engineering construction more rapidly,a hybrid genetic algorithmwas established.To solve the defects of genetic algorithms,which easily fall into the local optimal solution,a local search operation was added to a genetic algorithm to defend the offspring after crossover/mutation.Then,an elitist strategy and adaptive operators were adopted to protect the generated optimal solutions,reduce the computation time and avoid premature convergence.A calibrated function method was used to cater to the roulette rules,and appropriate rules for encoding,decoding and crossover/mutation were designed.Finally,a simple network was designed and validated using the case study of a real offshore project.The performance of the genetic algorithmand a simulated annealing algorithmwas compared to validate the feasibility and effectiveness of the approach.展开更多
After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal...After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal regeneration is re-growth of injured neurons themselves,but axons hardly regenerate in the adult mammalian CNS(Silver and Miller,2004).On the other hand,axonal sprouting is new growth from intact or spared neurons to the denervated target by forming axon collaterals,compensating for damaged circuits.This process is a more effective way for circuit remodeling,as it does not necessarily require long axonal elongation.展开更多
In Thailand, the alteration of weather patterns has resulted in an increase in instances of irregular rainfall, contributing to the occurrence of droughts. The decline of water levels in dams, due to the combined effe...In Thailand, the alteration of weather patterns has resulted in an increase in instances of irregular rainfall, contributing to the occurrence of droughts. The decline of water levels in dams, due to the combined effects of climate change and prolonged droughts, has had a significant impact on agricultural productivity. Drought has a profound effect on the terrestrial biosphere and the atmospheric water cycle and can also contribute to air pollution. Researchers have found a strong correlation between air pollution and drought severity. In response to this pressing issue, the Excellence Center of Space Technology and Research (ECSTAR) at King Mongkut’s Institute of Technology Ladkrabang has joined forces with TeroSpace company to launch an initiative aimed at promoting sustainable growth in Chiang Rai, a province in Thailand known for its rich biodiversity. ECSTAR and TeroSpace’s partnership on the sustainable growth initiative in Thailand’s Chiang Rai province focuses on expanding their collaboration to include international organizations such as the Centre National d’Etudes Spatiales (CNES), which will provide access to satellite imagery and climate and weather information to improve decision-making in various areas of development. CNES is a French organization in charge of space-related activities in France. The collaboration between France and Thailand for this project, in the context of the France-Thailand Year of Innovation 2023, will be crucial for the successful initiation and execution of this research project. The project aims to explore the relationship between air pollution and climate change through the deployment of air quality monitoring devices in designated locations, connected to a global data-sharing network. The results of this research will be valuable to policymakers as they consider the interplay between air pollution and climate change and make efforts to address these challenges.展开更多
With the rapid development of Open-Source(OS),more and more software projects are maintained and developed in the form of OS.These Open-Source projects depend on and influence each other,gradually forming a huge OS pr...With the rapid development of Open-Source(OS),more and more software projects are maintained and developed in the form of OS.These Open-Source projects depend on and influence each other,gradually forming a huge OS project network,namely an Open-Source Software ECOsystem(OSSECO).Unfortunately,not all OS projects in the open-source ecosystem can be healthy and stable in the long term,and more projects will go from active to inactive and gradually die.In a tightly connected ecosystem,the death of one project can potentially cause the collapse of the entire ecosystem network.How can we effectively prevent such situations from happening?In this paper,we first identify the basic project characteristics that affect the survival of OS projects at both project and ecosystem levels through the proportional hazards model.Then,we utilize graph convolutional networks based on the ecosystem network to extract the ecosystem environment characteristics of OS projects.Finally,we fuse basic project characteristics and environmental project characteristics and construct a Hybrid Structured Prediction Model(HSPM)to predict the OS project survival state.The experimental results show that HSPM significantly improved compared to the traditional prediction model.Our work can substantially assist OS project managers in maintaining their projects’health.It can also provide an essential reference for developers when choosing the right open-source project for their production activities.展开更多
基金supported by the National Key R&D Program of China(Grant Nos.2022YFA1603300 and 2022YFA1603200)the Science Challenge Project(Grant No.TZ2018005)in China+1 种基金the National Natural Science Foundation of China(Grant Nos.11805188 and 12175209)the Laser Fusion Research Center Funds for Young Talents(Grant No.RCFPD6-2022-1).
文摘We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on the upgraded SG-II laser facility. Then, based on thepoint-projection hard x-ray radiography technique, time-resolved radiography of the double shell targets, including that of their near-peakcompression, were obtained. The backlighter source was created by the interactions of a high-intensity short pulsed laser with a metalmicrowire target. Images of the target near peak compression were obtained with an Au microwire. In addition, radiation hydrodynamicsimulations were performed, and the target evolution obtained agrees well with the experimental results. Using the radiographic images, arealdensities of the targets were evaluated.
文摘Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and inconsistency.Existing literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of criteria.In this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision examples.To enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference alternatives.Probabilistic linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise comparisons.To address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of decision-makers.Finally,we conduct a case study and comparative analysis.Results reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information.
基金supported by Guangdong Provincial Basic and Applied Basic Research Fund,No.2021A1515011299(to KT)。
文摘Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.
基金supported by the National Key R&D Program of China(No.2022YFF0800601)National Scientific Foundation of China(Nos.41930103 and 41774047).
文摘In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back projection analysis.Data in two frequency bands(0.5-2 Hz and 1-3 Hz)are used in the imaging processes.The results show that the rupture of the first event extends about 200 km to the northeast and about 150 km to the southwest,lasting~90 s in total.The southwestern rupture is triggered by the northeastern rupture,demonstrating a sequential bidirectional unilateral rupture pattern.The rupture of the second event extends approximately 80 km in both northeast and west directions,lasting~35 s in total and demonstrates a typical bilateral rupture feature.The cascading ruptures on both sides also reflect the occurrence of selective rupture behaviors on bifurcated faults.In addition,we observe super-shear ruptures on certain fault sections with relatively straight fault structures and sparse aftershocks.
基金supported by the National Natural Science Foundation of China,No.82171521(to CL)the Special Funds ofTaishan Scholars Project of Shandong Province,No.tsqn202211368(to CL)+2 种基金the Natural Science Foundation of Shandong Province,Nos.ZR2022YQ65(to CL),ZR2021MH073(to CL),ZR2019PH109(to WW)the Projects of Medical and Health Technology Development Program in Shandong Province,China,Nos.202003090720(to DZ),202003070728(to JL),2019 WS329(to DW)the Scientific Research Foundation of Binzhou Medical University,No.BY2018KJ21(to DW)。
文摘Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability.
文摘This study comprehensively examines the patterns and regional variation of severe rainfall across the African continent, employing a suite of eight extreme precipitation indices. The analysis extends to the assessment of projected changes in precipitation extremes using five General Circulation Models (GCMs) from Coupled Model Intercomparison Project Phase 6 (CMIP6) under four Shared Socioeconomic Pathways (SSPs) scenarios at the long-term period (2081-2100) of the 21<sup>st</sup> century. Furthermore, the study investigates potential mechanisms influencing precipitation extremes by correlating extreme precipitation indices with oceanic system indices, specifically Ni?o 3.4 for El Ni?o-Southern Oscillation (ENSO) and Dipole Mode Index (DMI) for the Indian Ocean Dipole (IOD). The findings revealed distinct spatial distributions in mean trends of extreme precipitation indices, indicating a tendency toward decreased extreme precipitation in North Africa, Sahel region, Central Africa and the Western part of South Africa. Conversely, West Africa, East Africa and the Eastern part of South Africa exhibit an inclination toward increased extreme precipitation. The changes in precipitation extreme indices indicate a general rise in both the severity and occurrence of extreme precipitation events under all scenarios by the end of the 21<sup>st</sup> century. Notably, our analysis projects a decrease in consecutive wet days (CWD) in the far-future. Additionally, correlation analysis highlights significant correlation between above or below threshold rainfall fluctuation in East Africa and South Africa with oceanic systems, particularly ENSO and the IOD. Central Africa abnormal precipitation variability is also linked to ENSO with a significant negative correlation. These insights contribute valuable information for understanding and projecting the dynamics of precipitation extreme in Africa, providing a foundation for climate adaptation and mitigation efforts in the region.
基金Under the auspices of the Yunnan Scientist Workstation on International River Research of Daming He(No.KXJGZS-2019-005)National Natural Science Foundation of China(No.42201040)+1 种基金National Key Research and Development Project of China(No.2016YFA0601601)China Postdoctoral Science Foundation(No.2023M733006)。
文摘Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role as both a valuable hydro-power resource and an essential ecological passageway.However,the water resources and security exhibit a high degree of vulnerabil-ity to climate change impacts.This research evaluates climate impacts on the hydrology of the Dulong-Irrawaddy River Basin(DIRB)by using a physical-based hydrologic model.We crafted future climate scenarios using the three latest global climate models(GCMs)from Coupled Model Intercomparison Project 6(CMIP6)under two shared socioeconomic pathways(SSP2-4.5 and SSP5-8.5)for the near(2025-2049),mid(2050-2074),and far future(2075-2099).The regional model using MIKE SHE based on historical hydrologic processes was developed to further project future streamflow,demonstrating reliable performance in streamflow simulations with a val-idation Nash-Sutcliffe Efficiency(NSE)of 0.72.Results showed that climate change projections showed increases in the annual precip-itation and potential evapotranspiration(PET),with precipitation increasing by 11.3%and 26.1%,and PET increasing by 3.2%and 4.9%,respectively,by the end of the century under SSP2-4.5 and SSP5-8.5.These changes are projected to result in increased annual streamflow at all stations,notably at the basin’s outlet(Pyay station)compared to the baseline period(with an increase of 16.1%and 37.0%at the end of the 21st century under SSP2-4.5 and SSP5-8.5,respectively).Seasonal analysis for Pyay station forecasts an in-crease in dry-season streamflow by 31.3%-48.9%and 22.5%-76.3%under SSP2-4.5 and SSP5-8.5,respectively,and an increase in wet-season streamflow by 5.8%-12.6%and 2.8%-33.3%,respectively.Moreover,the magnitude and frequency of flood events are pre-dicted to escalate,potentially impacting hydropower production and food security significantly.This research outlines the hydrological response to future climate change during the 21st century and offers a scientific basis for the water resource management strategies by decision-makers.
文摘This study assesses the projected changes in the climate zoning of Côte d’Ivoire using the hierarchical classification of principal components (HCPC) method applied to the daily precipitation data of an ensemble of 14 CORDEX-AFRICA simulations under RCP4.5 and RCP8.5 scenarios. The results indicate the existence of three climate zones in Côte d’Ivoire (the coastal, the centre and the north) over the historical period (1981-2005). Moreover, CORDEX simulations project an extension of the surface area of drier climatic zones while a reduction of wetter zones, associated with the appearance of an intermediate climate zone with surface area varying from 77,560 km<sup>2</sup> to 134,960 km<sup>2</sup> depending on the period and the scenario. These results highlight the potential impacts of climate change on the delimitation of the climate zones of Côte d’Ivoire under the greenhouse gas emission scenarios. Thus, there is a reduction in the surface areas suitable for the production of cash crops such as cocoa and coffee. This could hinder the country’s economy and development, mainly based on these cash crops.
文摘Construction project cost control involves many complex contents,forming a large amount of data information.If the processing method is unreasonable,it will likely affect the cost control efficiency.Therefore,in the current construction project management,the review of project cost budget settlement is the focus to solve the cost management problems of construction projects and promote the development of the construction industry.This article mainly analyzes the influencing factors and current situation of construction project cost budget settlement review,and based on this,it explores the project cost budget settlement review strategy to promote the healthy development of construction project cost work.
文摘The financial aspects of large-scale engineering construction projects profoundly influence their success.Strengthening cost control and establishing a scientific financial evaluation system can enhance the project’s economic benefits,minimize unnecessary costs,and provide decision-makers with a robust financial foundation.Additionally,implementing an effective cash flow control mechanism and conducting a comprehensive assessment of potential project risks can ensure financial stability and mitigate the risk of fund shortages.Developing a practical and feasible fundraising plan,along with stringent fund management practices,can prevent fund wastage and optimize fund utilization efficiency.These measures not only facilitate smooth project progression and improve project management efficiency but also enhance the project’s economic and social outcomes.
文摘Various industries today rely on the support of electromechanical equipment,expanding its scope of application and leading to an increase in electromechanical installation projects.However,due to the high level of expertise required and the potential risks involved,it is crucial to emphasize safety management during construction.This paper delves into the significance of construction safety management for electromechanical installation projects,identifies common problems encountered during construction,and proposes solutions.This analysis aims to provide relevant personnel with essential guidance and references for managing electromechanical installation projects safely.
基金Supported by the Science and Technology Commission of Shanghai Municipality(No.21JC1402500)。
文摘Estuarine projects can change local topography and influence water transport and saltwater intrusion.The Changjiang(Yangtze)River estuary is a multichannel estuary,and four major reclamation projects have been implemented in the Changjiang River estuary in recent years:the Xincun Shoal reclamation project(RP-XCS),the Qingcao Shoal reclamation project(RP-QCS),the Eastern Hengsha Shoal reclamation project(RP-EHS),and the Nanhui Shoal reclamation project(RP-NHS).The effects of the four reclamation projects and each project on the saltwater intrusion and water resources in the Changjiang River estuary were simulated in a 3D numerical model.Results show that for a multichannel estuary,local reclamation projects change the local topography and water diversion ratio(WDR)between channels and influence water and salt transport and freshwater utilization in the estuary.During spring tide,under the cumulative effect of the four reclamation projects,the salinity decreases by approximately 0.5in the upper reaches of the North Branch and increases by 0.5-1.0 in the middle and lower reaches of the North Branch.In the North Channel,the salinity decreases by approximately 0.5.In the North Passage,the salinity increases by 0.5-1.0.In the South Passage,the salinity increases by approximately 0.5 in the upper reaches and decreases by 0.2-0.5 on the north side of the middle and lower reaches.During neap tide,the cumulative effects of the four reclamation projects and the individual projects are similar to those during spring tide,but there are some differences.The effects of an individual reclamation project on WDR and saltwater intrusion during spring and neap tides are simulated and analyzed in detail.The cumulative effect of the four reclamation projects favors freshwater usage in the Changjiang River estuary.
基金funded by projects of the National Natural Science Foundation of China(91955204,42241202)the Second Tibetan Plateau Scientific Expedition and Research(2019QZKK080301)a project entitled Tectonics,Sedimentation,Evolution,and Basic Petroleum Geology of the Qiangtang Basin(2021DJ0801)of the Forward-looking Basic Subjects of PetroChina’s 14th Five-Year Plan.
文摘The Qiangtang Basin of the Tibetan Plateau,located in the eastern Tethys tectonic domain,is the largest new marine petroliferous region for exploration in China.The scientific drilling project consisting primarily of well QK-1 and its supporting shallow boreholes for geological surveys(also referred to as the Project)completed in recent years contributes to a series of new discoveries and insights into the oil and gas preservation conditions and source rock evaluation of the Qiangtang Basin.These findings differ from previous views that the Qiangtang Basin has poor oil and gas preservation conditions and lacks high-quality source rocks.As revealed by well QK-1 and its supporting shallow boreholes in the Project,the Qiangtang Basin hosts two sets of high-quality regional seals,namely an anhydrite layer in the Quemo Co Formation and the gypsum-bearing mudstones in the Xiali Formation.Moreover,the Qiangtang Basin has favorable oil and gas preservation conditions,as verified by the comprehensive study of the sealing capacity of seals,basin structure,tectonic uplift,magmatic activity,and groundwater motion.Furthermore,the shallow boreholes have also revealed that the Qiangtang Basin has high-quality hydrocarbon source rocks in the Upper Triassic Bagong Formation,which are thick and widely distributed according to the geological and geophysical data.In addition,the petroleum geological conditions,such as the type,abundance,and thermal evolution of organic matter,indicate that the Qiangtang Basin has great hydrocarbon-generating potential.
基金supported by the National Natural Science Foundation of China(42130405)the Innovative and Entrepreneurial Talent Program of Jiangsu Province(R2020SC04)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA2006030201)the Research Fund for International Young Scientists of the National Natural Science Foundation of China(42150410381).
文摘Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate models to project future changes in precipitation extremes.The present study aims to assess the future changes in precipitation extremes over South Asia from the Coupled Model Intercomparison Project Phase 6(CMIP6)Global Climate Models(GCMs).The results were derived using the modified Mann-Kendall test,Sen's slope estimator,student's t-test,and probability density function approach.Eight extreme precipitation indices were assessed,including wet days(RR1mm),heavy precipitation days(RR10mm),very heavy precipitation days(RR20mm),severe precipitation days(RR50mm),consecutive wet days(CWD),consecutive dry days(CDD),maximum 5-day precipitation amount(RX5day),and simple daily intensity index(SDII).The future changes were estimated in two time periods for the 21^(st) century(i.e.,near future(NF;2021-2060)and far future(FF;2061-2100))under two Shared Socioeconomic Pathway(SSP)scenarios(SSP2-4.5 and SSP5-8.5).The results suggest increases in the frequency and intensity of extreme precipitation indices under the SSP5-8.5 scenario towards the end of the 21^(st) century(2061-2100).Moreover,from the results of multimodel ensemble means(MMEMs),extreme precipitation indices of RR1mm,RR10mm,RR20mm,CWD,and SDII demonstrate remarkable increases in the FF period under the SSP5-8.5 scenario.The spatial distribution of extreme precipitation indices shows intensification over the eastern part of South Asia compared to the western part.The probability density function of extreme precipitation indices suggests a frequent(intense)occurrence of precipitation extremes in the FF period under the SSP5-8.5 scenario,with values up to 35.00 d for RR1mm and 25.00-35.00 d for CWD.The potential impacts of heavy precipitation can pose serious challenges to the study area regarding flooding,soil erosion,water resource management,food security,and agriculture development.
基金funded by the Ministry of Industry and Information Technology of the People’s Republic of China(Nos.[2018]473,[2019]331).
文摘Offshore engineering construction projects are large and complex,having the characteristics of multiple execution modes andmultiple resource constraints.Their complex internal scheduling processes can be regarded as resourceconstrained project scheduling problems(RCPSPs).To solve RCPSP problems in offshore engineering construction more rapidly,a hybrid genetic algorithmwas established.To solve the defects of genetic algorithms,which easily fall into the local optimal solution,a local search operation was added to a genetic algorithm to defend the offspring after crossover/mutation.Then,an elitist strategy and adaptive operators were adopted to protect the generated optimal solutions,reduce the computation time and avoid premature convergence.A calibrated function method was used to cater to the roulette rules,and appropriate rules for encoding,decoding and crossover/mutation were designed.Finally,a simple network was designed and validated using the case study of a real offshore project.The performance of the genetic algorithmand a simulated annealing algorithmwas compared to validate the feasibility and effectiveness of the approach.
基金supported by MEXT KA KENHI on Dynamic Regulation of Brain Function by Scrap&Build System,No.16H06460 (to NY)JSPS KAKENHI Grant Nos.19H03325 (to NY) and 20J13844 (to LC)
文摘After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal regeneration is re-growth of injured neurons themselves,but axons hardly regenerate in the adult mammalian CNS(Silver and Miller,2004).On the other hand,axonal sprouting is new growth from intact or spared neurons to the denervated target by forming axon collaterals,compensating for damaged circuits.This process is a more effective way for circuit remodeling,as it does not necessarily require long axonal elongation.
文摘In Thailand, the alteration of weather patterns has resulted in an increase in instances of irregular rainfall, contributing to the occurrence of droughts. The decline of water levels in dams, due to the combined effects of climate change and prolonged droughts, has had a significant impact on agricultural productivity. Drought has a profound effect on the terrestrial biosphere and the atmospheric water cycle and can also contribute to air pollution. Researchers have found a strong correlation between air pollution and drought severity. In response to this pressing issue, the Excellence Center of Space Technology and Research (ECSTAR) at King Mongkut’s Institute of Technology Ladkrabang has joined forces with TeroSpace company to launch an initiative aimed at promoting sustainable growth in Chiang Rai, a province in Thailand known for its rich biodiversity. ECSTAR and TeroSpace’s partnership on the sustainable growth initiative in Thailand’s Chiang Rai province focuses on expanding their collaboration to include international organizations such as the Centre National d’Etudes Spatiales (CNES), which will provide access to satellite imagery and climate and weather information to improve decision-making in various areas of development. CNES is a French organization in charge of space-related activities in France. The collaboration between France and Thailand for this project, in the context of the France-Thailand Year of Innovation 2023, will be crucial for the successful initiation and execution of this research project. The project aims to explore the relationship between air pollution and climate change through the deployment of air quality monitoring devices in designated locations, connected to a global data-sharing network. The results of this research will be valuable to policymakers as they consider the interplay between air pollution and climate change and make efforts to address these challenges.
基金This work was supported by the National Social Science Foundation(NSSF)Research on intelligent recommendation of multi-modal resources for children’s graded reading in smart library(22BTQ033)the Science and Technology Research and Development Program Project of China railway group limited(Project No.2021-Special-08).
文摘With the rapid development of Open-Source(OS),more and more software projects are maintained and developed in the form of OS.These Open-Source projects depend on and influence each other,gradually forming a huge OS project network,namely an Open-Source Software ECOsystem(OSSECO).Unfortunately,not all OS projects in the open-source ecosystem can be healthy and stable in the long term,and more projects will go from active to inactive and gradually die.In a tightly connected ecosystem,the death of one project can potentially cause the collapse of the entire ecosystem network.How can we effectively prevent such situations from happening?In this paper,we first identify the basic project characteristics that affect the survival of OS projects at both project and ecosystem levels through the proportional hazards model.Then,we utilize graph convolutional networks based on the ecosystem network to extract the ecosystem environment characteristics of OS projects.Finally,we fuse basic project characteristics and environmental project characteristics and construct a Hybrid Structured Prediction Model(HSPM)to predict the OS project survival state.The experimental results show that HSPM significantly improved compared to the traditional prediction model.Our work can substantially assist OS project managers in maintaining their projects’health.It can also provide an essential reference for developers when choosing the right open-source project for their production activities.