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THE DRUG RELEASE FROM A COATED PLANAR MATRIX WITH A SUB-SATURATION LOADING IN THE CORE 被引量:3
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作者 徐铜文 何炳林文 王绍亭 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 1997年第2期67-76,共10页
A model was proposed for the drug release from a coated matrix system.To validate thismodel,5-Fu/EVAL matrices coated with various polymeric materials with different diffusivities wereprepared and characterized.These ... A model was proposed for the drug release from a coated matrix system.To validate thismodel,5-Fu/EVAL matrices coated with various polymeric materials with different diffusivities wereprepared and characterized.These coated systems were experimentally investigated and graphically andquantitatively compared with theoretical values.The results show a good correlation between theoryand experiment. 展开更多
关键词 coated planar matrix controlled release diffusion.
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A Mathematical Model for Diffusion-Controlled Monolithic Matrix Coated with outer Membrane System 被引量:4
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作者 张国亮 石巍 +1 位作者 张凤宝 刘瑛 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2001年第1期22-27,共6页
A release model for diffusion-controlled monolithic matrix coated with outer membrane system is proposed and solved by using the refined double integral method. The calculated results are in satisfactory agreement wit... A release model for diffusion-controlled monolithic matrix coated with outer membrane system is proposed and solved by using the refined double integral method. The calculated results are in satisfactory agreement with the experimental release data. The present model can be well used to describe the release process for all cd/cs values. In addition, the release effects of the monolithic matrix coated with outer membrane system are discussed theoretically. 展开更多
关键词 controlled release diffusion mercaptopurinum monolithic matrix outer membrane
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RELEASE KINETICS OF MONOLITHIC MATRIX COATED WITH OUTER MEMBRANE SYSTEM 被引量:1
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作者 石巍 张国亮 +1 位作者 张凤宝 刘瑛 《Transactions of Tianjin University》 EI CAS 2001年第1期56-60,共5页
The reservoir-monolithic type of the controlled release systems is investigated currently,however,the existing kinetic model could not describe the release process well because the release kinetics is rather complicat... The reservoir-monolithic type of the controlled release systems is investigated currently,however,the existing kinetic model could not describe the release process well because the release kinetics is rather complicated.In this paper,a simplified release kinetic model for diffusion-controlled monolithic matrix coated with outer membrane systems is proposed and verified by the experimental data of mercaptopurinum release experiment.It shows that the model can well describe the release mechanism (the relative error is under 3%) when drug loading (C d) is above its solubility limit (C s).At the same time,the release characteristics of special cases (D mD f and D mD f) are discussed theoretically.When D mD f the release rate becomes constant,namely,zero order release,and the release rate is independent of the drug membrane.This result provides the theoretical basis for the system of zero order release as well as how to control the release rate and the amount of drug release.When D mD f,the release rate is dependent on the drug release coefficient in the monolithic matrix,solubility and drug loading but independent of the process in the outer membrane,and it is similar to monolithic matrix type. 展开更多
关键词 controlled release diffusion mercaptopurinum monolithic matrix outer membrane
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MATHEMATICAL ANALYSIS OF DRUG RELEASE FROM PLANAR MATRIX WHEN DRUG IS LOADED UNDER THE SOLUBILITY 被引量:1
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作者 徐铜文 何炳林 +2 位作者 张凤宝 张国亮 王绍亭 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 1996年第3期86-92,共7页
1 INTRODUCTIONThe release of a drug from a diffusional matrix has been investigated by variousresearchers for different conditions [1-4].The drug loading in the matrix may beabove or below its solubility limit.If it i... 1 INTRODUCTIONThe release of a drug from a diffusional matrix has been investigated by variousresearchers for different conditions [1-4].The drug loading in the matrix may beabove or below its solubility limit.If it is beyond,the release boundary is generated bythe dissolution of drug,and the concentration in the released region may be propor-tional to the distance and kept at saturation in the unreleased region.Otherwise。 展开更多
关键词 planar matrix controlled release diffusion MATHEMATICAL analysis
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MATHEMATICAL ANALYSIS OF DRUG RELEASE FROM A MONOLITHIC MATRIX WITH AN INITIALLY LINEAR CONCENTRATION DISTRIBUTION
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作者 徐铜文 张国亮 +2 位作者 张凤宝 王淑兰 王绍亭 《Transactions of Tianjin University》 EI CAS 1997年第2期82-87,共6页
Based on the principle of chemical engineering in the multisubject field—drug delivery, the release kinetics of the slab monolithic matrix with an initially linear concentration distribution is studied in this paper.... Based on the principle of chemical engineering in the multisubject field—drug delivery, the release kinetics of the slab monolithic matrix with an initially linear concentration distribution is studied in this paper. It can be used to describe the later stage when drug loading is above its solubility limit. A comprehensive model is proposed and the generalized solutions are acquired by Laplace transformation, from which a special case, i.e. a perfect sink has been deduced. According to the derived equations, the concentration profiles in the matrix has been computed and illustrated and the effect of volume of extraction medium on release has been investigated. 展开更多
关键词 monolithic matrix modelling controlled release diffusion linear concentration distribution Laplace transformation
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Percolation phenomena in diffusion-controlled polymer matrix systems
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作者 徐铜文 何炳林 《Science China Chemistry》 SCIE EI CAS 1997年第6期624-633,共10页
The controlled release of two kinds of drugs,5-fluorouracil (5-FU) and hydrocortisonum (Hydro.) loaded in poly(ethylene-vinylalcohol) (EVAL) was dealt with,of which 5-FU/EVAL and Hydro /EVAL matrix systems are compose... The controlled release of two kinds of drugs,5-fluorouracil (5-FU) and hydrocortisonum (Hydro.) loaded in poly(ethylene-vinylalcohol) (EVAL) was dealt with,of which 5-FU/EVAL and Hydro /EVAL matrix systems are composed.The results were analyzed using the pseudo-steady-diffusion models coupled with the fundamental concepts of percolation theory.The percolation thresholds for the two systems were calculated,which could indicate the contributions of pore diffusion and matrix diffusion. 展开更多
关键词 controlled release PERCOLATION THRESHOLD PORE diffusion matrix diffusion poly (ethylem--vinyl-alcohol)
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乙基纤维素在药物制剂中的应用 被引量:24
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作者 姬静 郭圣荣 方晓玲 《中国医药工业杂志》 CAS CSCD 北大核心 2000年第2期89-92,共4页
乙基纤维素(EC)是应用广泛的水不溶性纤维素衍生物。EC作为药物辅料,可用作药物骨架、包衣材料、载体、粘合剂、囊材等。本文就其制备、性质及在药物制剂中的主要应用作一简要概述。
关键词 EC 骨架 包衣材料 乙基纤维素 药物辅料
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聚合物系统中药物的非扩散控制释放 被引量:19
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作者 徐晖 丁平田 郑俊民 《药学学报》 CAS CSCD 北大核心 2000年第9期710-714,共5页
关键词 非Fick扩散 溶胀控释系统 聚合物控释系统 药物
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扩散型膜控制释放技术的进展 被引量:10
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作者 徐铜文 何炳林 《世界科技研究与发展》 CSCD 2000年第1期20-25,共6页
本文主要介绍了扩散型膜控制释放体系的应用及其动力学研究现状 ,预测了膜控制释放技术的发展趋势和研究方向。
关键词 扩散 膜控制释放 药物利用率
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氯化钾缓释片的处方工艺研究 被引量:6
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作者 徐颖娟 王丽彦 +1 位作者 马丹 邓铁红 《沈阳药科大学学报》 CAS CSCD 2002年第6期410-412,共3页
目的尝试用骨架与膜衣相结合的方法对水易溶性药物释放速度的控制 ,调整体外释药行为 ,应用EUDRAGIT系列辅料进行氯化钾控释片的研究。方法用RSPO和NE 30D与KCl压制成水不溶蚀性骨架片 ,再用RL10 0 ,RS10 0包衣制得。结果体外释放度研... 目的尝试用骨架与膜衣相结合的方法对水易溶性药物释放速度的控制 ,调整体外释药行为 ,应用EUDRAGIT系列辅料进行氯化钾控释片的研究。方法用RSPO和NE 30D与KCl压制成水不溶蚀性骨架片 ,再用RL10 0 ,RS10 0包衣制得。结果体外释放度研究表明其释药行为是 :第2 ,4 ,6h的溶出量分别为标示量的 2 0 %~ 4 0 % ,30 %~ 6 0 % ,75 %以上。结论水易溶性药物 ,通过骨架和膜衣双重控制 。 展开更多
关键词 氯化钾 缓释片剂 非溶蚀性骨架 包衣 释放度 工艺
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丙烯酸树脂系列辅料在药物新剂型中的应用 被引量:7
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作者 刘善奎 钟延强 +1 位作者 孙其荣 张卫星 《药学实践杂志》 CAS 2002年第1期12-15,共4页
本文对丙烯酸树脂系列辅料在缓释微丸、缓释骨架片、固体分散体、微球和微囊、口服结肠定位给药系统及透皮给药系统等药物新剂型中的应用进行了综述 ,认为 :随着新型丙烯酸树脂的研究开发 。
关键词 丙烯酸树脂 包衣 骨架材料 制剂工艺
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美斯地浓缓释片的制备及其初步稳定性研究 被引量:2
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作者 罗文 谭群友 +3 位作者 王睿 熊华蓉 赵春景 张景勍 《华西药学杂志》 CAS CSCD 北大核心 2012年第5期536-539,共4页
目的制备美斯地浓缓释片并初步考察其稳定性。方法采用亲水凝胶骨架与薄膜包衣控释技术制备,并以外观性状、释放度和含量为评价指标考察美斯地浓缓释片在高温、光照和高湿条件下及加速试验、室温留样的变化。结果美斯地浓缓释片的体外... 目的制备美斯地浓缓释片并初步考察其稳定性。方法采用亲水凝胶骨架与薄膜包衣控释技术制备,并以外观性状、释放度和含量为评价指标考察美斯地浓缓释片在高温、光照和高湿条件下及加速试验、室温留样的变化。结果美斯地浓缓释片的体外释放可维持24 h;对光、热稳定性较好,高湿条件下稳定性较差,释放加快。结论亲水凝胶骨架与薄膜包衣控释技术能用于美斯地浓缓释片的制备,且具有较好的光、热稳定性。 展开更多
关键词 美斯地浓 缓释片 稳定性 亲水凝胶骨架 薄膜包衣控释技术
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