Paederia scandens(Lour.)Merr.is a traditional Chinese medicine,which mainly has the functions of analgesia,detoxification,anti-inflammatory and anticonvulsant.Modern studies show that the main chemical constituents of...Paederia scandens(Lour.)Merr.is a traditional Chinese medicine,which mainly has the functions of analgesia,detoxification,anti-inflammatory and anticonvulsant.Modern studies show that the main chemical constituents of this plant are iridoids and volatile oil,which have biological activities such as analgesia,anti-inflammatory,hepatoprotection,renoprotection and antibacterial.This review highlights the chemical constituents and biological activities of P.scandens based on studies published in last decades and provides the references for the further development and utilization of this medicinal plant.展开更多
A new flavanone was isolated from the roots of Desmos cochinchinensis Lour Its chemical structure was elucidated by spectral analysis as 7 hydroxy 5 methoxy 8 formyl 6 methylflavanone, named desmosflavanone Ⅱ
[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball...[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball granuloma and carrageenan were established respectively,and the anti-inflammatory effects of water and ethanol extract from E.cochinchinensis Lour.on acute and chronic inflammation in mice were evaluated.The experimental mice were equally divided into three groups of high,medium and low dose of E.cochinchinensis Lour.(60,40 and 20 g/kg),dexamethasone(0.006 g/kg)group and blank group(distilled water).In the cotton ball granuloma test in mice,the mice were given intragastric administration continuously for 7 d after cotton ball implantation.In the experiment of inflammation induced by carrageenan,the mice in each group were given intragastric administration once a day for 7 d,and the inflammatory model was made after the last administration.[Results]The granuloma inhibition rates of mice in the high,medium and low dose groups of water extract and ethanol extract from E.cochinchinensis Lour were significantly lower than those in the blank group(P<0.05).The degree of paw edema in each dose group of water and ethanol extract from E.cochinchinensis Lour.was significantly lower than that in the blank group(P<0.05).[Conclusions]The water and ethanol extracts from E.cochinchinensis Lour.had significant anti-inflammatory effects.展开更多
Aim To evaluate the anti-inflammatory effects of ethanol fraction prepared from Disporum cantoniense （Lour.） Merr. 70% ethanol extract with a cellular model of LPS-stimulated RAW264.7 cell. Methods RAW264.7 cells we...Aim To evaluate the anti-inflammatory effects of ethanol fraction prepared from Disporum cantoniense （Lour.） Merr. 70% ethanol extract with a cellular model of LPS-stimulated RAW264.7 cell. Methods RAW264.7 cells were treated with different concentrations of ethanol fraction （25,50 and 100 g · L^-1 ） and stimu- the conditioned media was collected and analyzed. The quantity of ni- lated with LPS （10 μg· L^-1） for 24 hours, tric oxide （NO） was assayed by Griess reagent. The production of inflammatory mediators was determined by en- zyme-linked immunosorbent assay （ELISA）, such as prostaglandin E2 （PGE2）, tumor necrosis factor ot （TNF-ot） interleukin- 1 β （IL-1 β） and interleukin 6 （IL-6） in cell supernatant. The concentrations of inflammatory medi- 9 ators were calculated according to the standard curves generated by each of the recombinant cytokines provided with LPS can induce RAW264.7 cells to promote the pro- the ELISA kits. Results Compared with the control group, TNF-α, IL-1β and IL-6. Compared with the duction of inflammatory mediators （P 〈 0.01 ） , including NO, PGE2, model group, ethanol fraction significantly suppressed LPS induced release of inflammatory mediators such as nitric NO, PGE2, TNF-α, IL-1β and IL-6 in a good dose dependent manner （P 〈 0.05, P 〈 0.01 ）. Conclusions Eth- anol fraction could significantly inhibit the production of LPS-induced inflammatory response in RAW264.7 cells, and its anti-inflammatory effect may be related to reduce the production of inflammatory mediators NO, PGE2, TNF-α, IL-1 β and IL-6. These results demonstrate that the ethanol fraction is the bioactive component of Disporum can- toniense （Lour.） Merr. , and the ethanol fraction will be further developed as a herbal remedy for preventive and/ or curative purposes in various inflammatory diseases.展开更多
Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)...Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glucopyranosyl}]-26-O-[b-D-glucopy- ranosyl]-(25S)-5b-furostane-3b,22a,26-triol 1 and 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glu- copyranosyl}]-26-O-[b-D-glucopyranosyl]-22a-methoxy-(25S)-5b-furostane-3b,26-diol 2 on the basis of spectroscopic techniques and chemical methods.展开更多
A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(...A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(22)-en-3b,26-diol-3-O-a-L-rhamnopyranosyl-(14)-b-D- glucopyranoside on the basis of spectroscopic techniques including 1D and 2D NMR experiments.展开更多
基金Health Industry Research Project of Hainan Province (No.21A200095)Youth Cultivation Fund Project of the First Affiliated Hospital of Hainan Medical College (No.HYYFYPY201909)。
文摘Paederia scandens(Lour.)Merr.is a traditional Chinese medicine,which mainly has the functions of analgesia,detoxification,anti-inflammatory and anticonvulsant.Modern studies show that the main chemical constituents of this plant are iridoids and volatile oil,which have biological activities such as analgesia,anti-inflammatory,hepatoprotection,renoprotection and antibacterial.This review highlights the chemical constituents and biological activities of P.scandens based on studies published in last decades and provides the references for the further development and utilization of this medicinal plant.
文摘A new flavanone was isolated from the roots of Desmos cochinchinensis Lour Its chemical structure was elucidated by spectral analysis as 7 hydroxy 5 methoxy 8 formyl 6 methylflavanone, named desmosflavanone Ⅱ
基金Supported by National Natural Science Foundation(81360524)First Scientific Research Project of High-level Talents in the Affiliated Hospital of Youjiang Medical University for Nationalities in 2019(Y20196311)+3 种基金2019 Project of Improving the Basic Scientific Research Ability of Young Teachers in Guangxi Colleges and Universities(2019KY0341)2019 Youth Fund Project of Guangxi University of Chinese Medicine(2019QN036)School-level Scientific Research Project of Youjiang Medical University for Nationalities(YY2018KY018)Laboratory for Chemical and Quality Analysis of Traditional Chinese(Zhuang)Medicine,Third-level Scientific Research Laboratory of the State Administration of Traditional Chinese Medicine(Guo Zhong Yi Yao Fa200921).
文摘[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball granuloma and carrageenan were established respectively,and the anti-inflammatory effects of water and ethanol extract from E.cochinchinensis Lour.on acute and chronic inflammation in mice were evaluated.The experimental mice were equally divided into three groups of high,medium and low dose of E.cochinchinensis Lour.(60,40 and 20 g/kg),dexamethasone(0.006 g/kg)group and blank group(distilled water).In the cotton ball granuloma test in mice,the mice were given intragastric administration continuously for 7 d after cotton ball implantation.In the experiment of inflammation induced by carrageenan,the mice in each group were given intragastric administration once a day for 7 d,and the inflammatory model was made after the last administration.[Results]The granuloma inhibition rates of mice in the high,medium and low dose groups of water extract and ethanol extract from E.cochinchinensis Lour were significantly lower than those in the blank group(P<0.05).The degree of paw edema in each dose group of water and ethanol extract from E.cochinchinensis Lour.was significantly lower than that in the blank group(P<0.05).[Conclusions]The water and ethanol extracts from E.cochinchinensis Lour.had significant anti-inflammatory effects.
文摘Aim To evaluate the anti-inflammatory effects of ethanol fraction prepared from Disporum cantoniense （Lour.） Merr. 70% ethanol extract with a cellular model of LPS-stimulated RAW264.7 cell. Methods RAW264.7 cells were treated with different concentrations of ethanol fraction （25,50 and 100 g · L^-1 ） and stimu- the conditioned media was collected and analyzed. The quantity of ni- lated with LPS （10 μg· L^-1） for 24 hours, tric oxide （NO） was assayed by Griess reagent. The production of inflammatory mediators was determined by en- zyme-linked immunosorbent assay （ELISA）, such as prostaglandin E2 （PGE2）, tumor necrosis factor ot （TNF-ot） interleukin- 1 β （IL-1 β） and interleukin 6 （IL-6） in cell supernatant. The concentrations of inflammatory medi- 9 ators were calculated according to the standard curves generated by each of the recombinant cytokines provided with LPS can induce RAW264.7 cells to promote the pro- the ELISA kits. Results Compared with the control group, TNF-α, IL-1β and IL-6. Compared with the duction of inflammatory mediators （P 〈 0.01 ） , including NO, PGE2, model group, ethanol fraction significantly suppressed LPS induced release of inflammatory mediators such as nitric NO, PGE2, TNF-α, IL-1β and IL-6 in a good dose dependent manner （P 〈 0.05, P 〈 0.01 ）. Conclusions Eth- anol fraction could significantly inhibit the production of LPS-induced inflammatory response in RAW264.7 cells, and its anti-inflammatory effect may be related to reduce the production of inflammatory mediators NO, PGE2, TNF-α, IL-1 β and IL-6. These results demonstrate that the ethanol fraction is the bioactive component of Disporum can- toniense （Lour.） Merr. , and the ethanol fraction will be further developed as a herbal remedy for preventive and/ or curative purposes in various inflammatory diseases.
文摘Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glucopyranosyl}]-26-O-[b-D-glucopy- ranosyl]-(25S)-5b-furostane-3b,22a,26-triol 1 and 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glu- copyranosyl}]-26-O-[b-D-glucopyranosyl]-22a-methoxy-(25S)-5b-furostane-3b,26-diol 2 on the basis of spectroscopic techniques and chemical methods.
文摘A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(22)-en-3b,26-diol-3-O-a-L-rhamnopyranosyl-(14)-b-D- glucopyranoside on the basis of spectroscopic techniques including 1D and 2D NMR experiments.
