Educational data mining based on student cognitive diagnosis analysis can provide an important decision basis for personalized learning tutoring of students,which has attracted extensive attention from scholars at hom...Educational data mining based on student cognitive diagnosis analysis can provide an important decision basis for personalized learning tutoring of students,which has attracted extensive attention from scholars at home and abroad and has made a series of important research progress.To this end,we propose a noise-filtering enhanced deep cognitive diagno-sis method to improve the fitting ability of traditional models and obtain students’skill mastery status by mining the interaction between students and problems nonlinearly through neural networks.First,modeling complex interactions between students and problems with multidimensional features based on cognitive processing theory can enhance the interpretability of the proposed model;second,the neural network is used to predict students’learning performance,diagnose students’skill mastery and provide immediate feedback;finally,by comparing the proposed model with several baseline models,extensive experimental results on real data sets demonstrate that the proposed Finally,by comparing the proposed model with several baseline models,the extensive experimental results on the actual data set demon-strate that the proposed model not only improves the accuracy of predicting students’learning performance but also enhances the interpretability of the neurocognitive diagnostic model.展开更多
Cognitive diagnosis is the judgment of the student’s cognitive ability, is a wide-spread concern in educational science. The cognitive diagnosis model (CDM) is an essential method to realize cognitive diagnosis measu...Cognitive diagnosis is the judgment of the student’s cognitive ability, is a wide-spread concern in educational science. The cognitive diagnosis model (CDM) is an essential method to realize cognitive diagnosis measurement. This paper presents new research on the cognitive diagnosis model and introduces four individual aspects of probability-based CDM and deep learning-based CDM. These four aspects are higher-order latent trait, polytomous responses, polytomous attributes, and multilevel latent traits. The paper also sorts on the contained ideas, model structures and respective characteristics, and provides direction for developing cognitive diagnosis in the future.展开更多
Cognitive diagnosis is an important issue of intelligent education systems,which aims to estimate students'proficiency on specific knowledge concepts.Most existing studies rely on the assumption of static student ...Cognitive diagnosis is an important issue of intelligent education systems,which aims to estimate students'proficiency on specific knowledge concepts.Most existing studies rely on the assumption of static student states and ig-nore the dynamics of proficiency in the learning process,which makes them unsuitable for online learning scenarios.In this paper,we propose a unified temporal item response theory(UTIRT)framework,incorporating temporality and random-ness of proficiency evolving to get both accurate and interpretable diagnosis results.Specifically,we hypothesize that stu-dents'proficiency varies as a Wiener process and describe a probabilistic graphical model in UTIRT to consider temporali-ty and randomness factors.Furthermore,based on the relationship between student states and exercising answers,we hy-pothesize that the answering result at time k contributes most to inferring a student's proficiency at time k,which also re-flects the temporality aspect and enables us to get analytical maximization(M-step)in the expectation maximization(EM)algorithm when estimating model parameters.Our UTIRT is a framework containing unified training and inferenc-ing methods,and is general to cover several typical traditional models such as Item Response Theory(IRT),multidimen-sional IRT(MIRT),and temporal IRT(TIRT).Extensive experimental results on real-world datasets show the effective-ness of UTIRT and prove its superiority in leveraging temporality theoretically and practically over TIRT.展开更多
In the context of personalized learning,the recommendation method aims to provide appropriate exercises for each student.And individualized knowledge status may give more effective recommendation.In this study,a prior...In the context of personalized learning,the recommendation method aims to provide appropriate exercises for each student.And individualized knowledge status may give more effective recommendation.In this study,a priority recommendation method based on cognitive diagnosis model is proposed,and cosine similarity algorithm is applied to improve the accuracy and interpretability of recommendation.Then the performance of the methods was compared under cognitive diagnosis models.The experimental results show that the method proposed achieves more accurate results and better performance.展开更多
Cognitive diagnosis,which aims to diagnose students’knowledge proficiency,is crucial for numerous online education applications,such as personalized exercise recommendation.Existing methods in this area mainly exploi...Cognitive diagnosis,which aims to diagnose students’knowledge proficiency,is crucial for numerous online education applications,such as personalized exercise recommendation.Existing methods in this area mainly exploit students’exercising records,which ignores students’full learning process in online education systems.Besides,the latent relation of exercises with course structure and texts is still underexplored.In this paper,a learning behavior-aware cognitive diagnosis(LCD)framework is proposed for students’cognitive modeling with both learning behavior records and exercising records.The concept of LCD was first introduced to characterize students’knowledge proficiency more completely.Second,a course graph was designed to explore rich information existed in course texts and structures.Third,an interaction function was put forward to explore complex relationships between students,exercises and videos.Extensive experiments on a real-world dataset prove that LCD predicts student performance more effectively,the output of LCD is also interpretable.展开更多
Vascular cognitive impairment(VCI) encompasses the entire range of cognitive deficits associated with cerebrovascular disease(CVD), from mild deficits with little or no functional impairment, such as vascular cogn...Vascular cognitive impairment(VCI) encompasses the entire range of cognitive deficits associated with cerebrovascular disease(CVD), from mild deficits with little or no functional impairment, such as vascular cognitive impairment-no dementia(VCIND), to full-blown vascular dementia(VaD). Accurate diagnosis of vascular cognitive impairment is important but may be difficult. In this review we report advances in VCI in the following areas: etiology, subtypes, neuropsychology, biomarkers, neuroimaging, and diagnostic criteria.展开更多
The development of cognitive competences for police officers and other officers of the uniformed services is crucial The Police Academy in Szczytno (Poland) developed--as part of a research and development project ...The development of cognitive competences for police officers and other officers of the uniformed services is crucial The Police Academy in Szczytno (Poland) developed--as part of a research and development project (2013-2015)---an innovative diagnostic system for training that allows automated assessment of the current fitness level of cognitive functions and their online training. The system consists of three interconnected modules: diagnostic module, training module, and knowledge base. It is a fully functional online platform. Various forms of cognitive training in the form of games have been proposed. The system includes a component in the form of a psychophysiological recorder, which is intended for the training of coping with stress. The innovativeness of this diagnostic training system involves the use of information systems to stimulate the cognitive competence of officers by designing exercises in the form of computer games and to permit to verify their current mental shapes. It is assumed that this solution will develop the personal skills of officers and positively affect their operational readiness. Extending the area of application of this diagnostic training module by other functionalities can contribute to improving the effectiveness and safety of work, especially in occupational groups performing tasks requiring special cognitive and psychomotor predispositions.展开更多
The study evaluated the use of the Mini-Mental State Examination scale (MMSE), Tinettiscale, and Motor Scale for the Elderly (EMTI) toassist in the diagnosis of potential needs observed in elderlies with Mild Cognitiv...The study evaluated the use of the Mini-Mental State Examination scale (MMSE), Tinettiscale, and Motor Scale for the Elderly (EMTI) toassist in the diagnosis of potential needs observed in elderlies with Mild Cognitive Impairment. This was aquasi-experimental research, conducted in a Basic Health Unit in thecityof Rio de Janeiro in 2014. The sample population consisted of 22 elderlies aged 64 to 88 years and 86.36% females. The SAS statistical software (version 9.3.1) and Kruskal-Wallis test were used at a 95% confidence interval and a significance level of 0.05 and demonstrated significant differences in the evaluations performed before and after the intervention. The detected diagnoses were: impaired memory, the risk of falls, and willingness to improved relationships, among others. The evaluations showed MMSE results that were suggestive of cognitive impairment in 22.73% of the elderlies;the Tinetti scale showed a high risk of falls in 31.82% of theelderlies;and EMTI with 88.36 points, which was equivalent to the normal low classification. The intervention took place through ten weekly activity sessions after the initial evaluations. In the second evaluation, the Tinetti showed 59.09% of the elderlies with a moderate risk of falls and the EMTI as the normal average classification with 90.32 points. It was concluded that the scales offered diagnostic possibilities, which allowed for the implementation of necessary interventions according to the detected problems.展开更多
In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as...In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.展开更多
A new fault classification/diagnosis method based on artificial immune system (AIS) algorithms for the structural systems is proposed. In order to improve the accuracy of the proposed method, i.e., higher success rate...A new fault classification/diagnosis method based on artificial immune system (AIS) algorithms for the structural systems is proposed. In order to improve the accuracy of the proposed method, i.e., higher success rate, Gaussian and non-Gaussian noise generating models are applied to simulate environmental noise. The identification of noise model, known as training process, is based on the estimation of the noise model parameters by genetic algorithms (GA) utilizing real experimental features. The proposed fault classification/diagnosis algorithm is applied to the noise contaminated features. Then, the results are compared to that obtained without noise modeling. The performance of the proposed method is examined using three laboratory case studies in two healthy and damaged conditions. Finally three different types of noise models are studied and it is shown experimentally that the proposed algorithm with non-Gaussian noise modeling leads to more accurate clustering of memory cells as the major part of the fault classification procedure.展开更多
This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma (OSCC), the variables related to diagnostic delay ascribable to the ...This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma (OSCC), the variables related to diagnostic delay ascribable to the patient, with particular reference to the cognitive and psychological ones. A total of 156 patients with OSCC (mean age: 62 years, M/F: 2.39 : 1) were recruited at the Universities of Palermo and Naples. Risk factors related to patient delay included: sociodemographic, health-related, cognitive and psychological variables. The analysis was conducted by considering two different delay ranges: dichotomous (≤1 month vs. 〉 1 month) and polytomous (〈1 month, 1-3 months, 〉3 months) delay. Data were investigated by univariate and multivariate analyses and a Pvalue≤0.05 was considered statistically significant. For both delay measurements, the most relevant variables were: 'Personal experience of cancer' (dichotomous delay: P=0.05, odds ratio (0R)=0.33, 95% confidence interval (CI)=0. 11-0.99; polytomous delay: P=0.006, Chi-square= 10.224) and 'Unawareness' (dichotomous delay: P〈0.01, 0R=4.96, 95% CI--2.16-11.37; polytomous delay: P=0.087, Chi-square=4.77). Also 'Denial' (P〈0.01, 0R=6.84, 95% CI=2.31-20.24) and 'Knowledge of cancer' (P=0.079, Chi-square=8.359) were found to be statistically significant both for dichotomous and for polytomous categorization of delay, respectively. The findings of this study indicated that, in the investigated cohorts, the knowledge about cancer issues is strongly linked to the patient delay. Educational interventions on the Mediterranean population are necessary in order to increase the patient awareness and to emphasize his/her key role in early diagnosis of OSCC.展开更多
Mild cognitive impairment(MCI)is a prodrome of Alzheimer’s disease pathology.Cognitive impairment patients often have a delayed diagnosis because there are no early symptoms or conventional diagnostic methods.Exosome...Mild cognitive impairment(MCI)is a prodrome of Alzheimer’s disease pathology.Cognitive impairment patients often have a delayed diagnosis because there are no early symptoms or conventional diagnostic methods.Exosomes play a vital role in cell-to-cell communications and can act as promising biomarkers in diagnosing diseases.This study was designed to identify serum exosomal candidate proteins that may play roles in diagnosing MCI.Mass spectrometry coupled with tandem mass tag approach-based non-targeted proteomics was used to show the differentially expressed proteins in exosomes between MCI patients and healthy controls,and these differential proteins were validated using immunoblot and enzyme-linked immunosorbent assays.Correlation of cognitive performance with the serum exosomal protein level was determined.Nanoparticle tracking analysis suggested that there was a higher serum exosome concentration and smaller exosome diameter in individuals with MCI compared with healthy controls.We identified 69 exosomal proteins that were differentially expressed between MCI patients and healthy controls using mass spectrometry analysis.Thirty-nine exosomal proteins were upregulated in MCI patients compared with those in control patients.Exosomal fibulin-1,with an area under the curve value of 0.81,may be a biomarker for an MCI diagnosis.The exosomal protein signature from MCI patients reflected the cell adhesion molecule category.In particular,higher exosomal fibulin-1 levels correlated with lower cognitive performance.Thus,this study revealed that exosomal fibulin-1 is a promising biomarker for diagnosing MCI.展开更多
Aging is a natural process that leads to debility,disease,and dependency.Alzheimer’s disease(AD)causes degeneration of the brain cells leading to cognitive decline and memory loss,as well as dependence on others to f...Aging is a natural process that leads to debility,disease,and dependency.Alzheimer’s disease(AD)causes degeneration of the brain cells leading to cognitive decline and memory loss,as well as dependence on others to fulfill basic daily needs.AD is the major cause of dementia.Computer-aided diagnosis(CADx)tools aid medical practitioners in accurately identifying diseases such as AD in patients.This study aimed to develop a CADx tool for the early detection of AD using the Intelligent Water Drop(IWD)algorithm and the Random Forest(RF)classifier.The IWD algorithm an efficient feature selection method,was used to identify the most deterministic features of AD in the dataset.RF is an ensemble method that leverages multiple weak learners to classify a patient’s disease as either demented(DN)or cognitively normal(CN).The proposed tool also classifies patients as mild cognitive impairment(MCI)or CN.The dataset on which the performance of the proposed CADx was evaluated was sourced from the Alzheimer’s Disease Neuroimaging Initiative(ADNI).The RF ensemble method achieves 100%accuracy in identifying DN patients from CN patients.The classification accuracy for classifying patients as MCI or CN is 92%.This study emphasizes the significance of pre-processing prior to classification to improve the classification results of the proposed CADx tool.展开更多
文摘Educational data mining based on student cognitive diagnosis analysis can provide an important decision basis for personalized learning tutoring of students,which has attracted extensive attention from scholars at home and abroad and has made a series of important research progress.To this end,we propose a noise-filtering enhanced deep cognitive diagno-sis method to improve the fitting ability of traditional models and obtain students’skill mastery status by mining the interaction between students and problems nonlinearly through neural networks.First,modeling complex interactions between students and problems with multidimensional features based on cognitive processing theory can enhance the interpretability of the proposed model;second,the neural network is used to predict students’learning performance,diagnose students’skill mastery and provide immediate feedback;finally,by comparing the proposed model with several baseline models,extensive experimental results on real data sets demonstrate that the proposed Finally,by comparing the proposed model with several baseline models,the extensive experimental results on the actual data set demon-strate that the proposed model not only improves the accuracy of predicting students’learning performance but also enhances the interpretability of the neurocognitive diagnostic model.
基金supported by the National Natural Science Foundation(Grant Nos.U1811261,62137001,61902055)the Fundamental Research Funds for the Central Universities(N180716010,N2117001).
文摘Cognitive diagnosis is the judgment of the student’s cognitive ability, is a wide-spread concern in educational science. The cognitive diagnosis model (CDM) is an essential method to realize cognitive diagnosis measurement. This paper presents new research on the cognitive diagnosis model and introduces four individual aspects of probability-based CDM and deep learning-based CDM. These four aspects are higher-order latent trait, polytomous responses, polytomous attributes, and multilevel latent traits. The paper also sorts on the contained ideas, model structures and respective characteristics, and provides direction for developing cognitive diagnosis in the future.
基金supported by the National Key Research and Development Program of China under Grant No.2021YFF0901003the National Natural Science Foundation of China under Grant Nos.U20A20229,61922073,and 62106244the Natural Science Foundation of Anhui Province of China under Grant No.2108085QF272.
文摘Cognitive diagnosis is an important issue of intelligent education systems,which aims to estimate students'proficiency on specific knowledge concepts.Most existing studies rely on the assumption of static student states and ig-nore the dynamics of proficiency in the learning process,which makes them unsuitable for online learning scenarios.In this paper,we propose a unified temporal item response theory(UTIRT)framework,incorporating temporality and random-ness of proficiency evolving to get both accurate and interpretable diagnosis results.Specifically,we hypothesize that stu-dents'proficiency varies as a Wiener process and describe a probabilistic graphical model in UTIRT to consider temporali-ty and randomness factors.Furthermore,based on the relationship between student states and exercising answers,we hy-pothesize that the answering result at time k contributes most to inferring a student's proficiency at time k,which also re-flects the temporality aspect and enables us to get analytical maximization(M-step)in the expectation maximization(EM)algorithm when estimating model parameters.Our UTIRT is a framework containing unified training and inferenc-ing methods,and is general to cover several typical traditional models such as Item Response Theory(IRT),multidimen-sional IRT(MIRT),and temporal IRT(TIRT).Extensive experimental results on real-world datasets show the effective-ness of UTIRT and prove its superiority in leveraging temporality theoretically and practically over TIRT.
基金grants from the National Education Scientific Planning Projects(Research on learning paradigms in Adaptive Learning Space)(No.BCA190081).
文摘In the context of personalized learning,the recommendation method aims to provide appropriate exercises for each student.And individualized knowledge status may give more effective recommendation.In this study,a priority recommendation method based on cognitive diagnosis model is proposed,and cosine similarity algorithm is applied to improve the accuracy and interpretability of recommendation.Then the performance of the methods was compared under cognitive diagnosis models.The experimental results show that the method proposed achieves more accurate results and better performance.
基金This work is supported by the National Key Research and Development Program of China(2018YFB1005100)It also got partial support from National Engineering Laboratory for Cyberlearning and Intelligent Technology,and Beijing Key Lab of Networked Multimedia.
文摘Cognitive diagnosis,which aims to diagnose students’knowledge proficiency,is crucial for numerous online education applications,such as personalized exercise recommendation.Existing methods in this area mainly exploit students’exercising records,which ignores students’full learning process in online education systems.Besides,the latent relation of exercises with course structure and texts is still underexplored.In this paper,a learning behavior-aware cognitive diagnosis(LCD)framework is proposed for students’cognitive modeling with both learning behavior records and exercising records.The concept of LCD was first introduced to characterize students’knowledge proficiency more completely.Second,a course graph was designed to explore rich information existed in course texts and structures.Third,an interaction function was put forward to explore complex relationships between students,exercises and videos.Extensive experiments on a real-world dataset prove that LCD predicts student performance more effectively,the output of LCD is also interpretable.
文摘Vascular cognitive impairment(VCI) encompasses the entire range of cognitive deficits associated with cerebrovascular disease(CVD), from mild deficits with little or no functional impairment, such as vascular cognitive impairment-no dementia(VCIND), to full-blown vascular dementia(VaD). Accurate diagnosis of vascular cognitive impairment is important but may be difficult. In this review we report advances in VCI in the following areas: etiology, subtypes, neuropsychology, biomarkers, neuroimaging, and diagnostic criteria.
文摘The development of cognitive competences for police officers and other officers of the uniformed services is crucial The Police Academy in Szczytno (Poland) developed--as part of a research and development project (2013-2015)---an innovative diagnostic system for training that allows automated assessment of the current fitness level of cognitive functions and their online training. The system consists of three interconnected modules: diagnostic module, training module, and knowledge base. It is a fully functional online platform. Various forms of cognitive training in the form of games have been proposed. The system includes a component in the form of a psychophysiological recorder, which is intended for the training of coping with stress. The innovativeness of this diagnostic training system involves the use of information systems to stimulate the cognitive competence of officers by designing exercises in the form of computer games and to permit to verify their current mental shapes. It is assumed that this solution will develop the personal skills of officers and positively affect their operational readiness. Extending the area of application of this diagnostic training module by other functionalities can contribute to improving the effectiveness and safety of work, especially in occupational groups performing tasks requiring special cognitive and psychomotor predispositions.
文摘The study evaluated the use of the Mini-Mental State Examination scale (MMSE), Tinettiscale, and Motor Scale for the Elderly (EMTI) toassist in the diagnosis of potential needs observed in elderlies with Mild Cognitive Impairment. This was aquasi-experimental research, conducted in a Basic Health Unit in thecityof Rio de Janeiro in 2014. The sample population consisted of 22 elderlies aged 64 to 88 years and 86.36% females. The SAS statistical software (version 9.3.1) and Kruskal-Wallis test were used at a 95% confidence interval and a significance level of 0.05 and demonstrated significant differences in the evaluations performed before and after the intervention. The detected diagnoses were: impaired memory, the risk of falls, and willingness to improved relationships, among others. The evaluations showed MMSE results that were suggestive of cognitive impairment in 22.73% of the elderlies;the Tinetti scale showed a high risk of falls in 31.82% of theelderlies;and EMTI with 88.36 points, which was equivalent to the normal low classification. The intervention took place through ten weekly activity sessions after the initial evaluations. In the second evaluation, the Tinetti showed 59.09% of the elderlies with a moderate risk of falls and the EMTI as the normal average classification with 90.32 points. It was concluded that the scales offered diagnostic possibilities, which allowed for the implementation of necessary interventions according to the detected problems.
基金supported by the National Natural Science Foundation of China,No. 30973309
文摘In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.
文摘A new fault classification/diagnosis method based on artificial immune system (AIS) algorithms for the structural systems is proposed. In order to improve the accuracy of the proposed method, i.e., higher success rate, Gaussian and non-Gaussian noise generating models are applied to simulate environmental noise. The identification of noise model, known as training process, is based on the estimation of the noise model parameters by genetic algorithms (GA) utilizing real experimental features. The proposed fault classification/diagnosis algorithm is applied to the noise contaminated features. Then, the results are compared to that obtained without noise modeling. The performance of the proposed method is examined using three laboratory case studies in two healthy and damaged conditions. Finally three different types of noise models are studied and it is shown experimentally that the proposed algorithm with non-Gaussian noise modeling leads to more accurate clustering of memory cells as the major part of the fault classification procedure.
文摘This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma (OSCC), the variables related to diagnostic delay ascribable to the patient, with particular reference to the cognitive and psychological ones. A total of 156 patients with OSCC (mean age: 62 years, M/F: 2.39 : 1) were recruited at the Universities of Palermo and Naples. Risk factors related to patient delay included: sociodemographic, health-related, cognitive and psychological variables. The analysis was conducted by considering two different delay ranges: dichotomous (≤1 month vs. 〉 1 month) and polytomous (〈1 month, 1-3 months, 〉3 months) delay. Data were investigated by univariate and multivariate analyses and a Pvalue≤0.05 was considered statistically significant. For both delay measurements, the most relevant variables were: 'Personal experience of cancer' (dichotomous delay: P=0.05, odds ratio (0R)=0.33, 95% confidence interval (CI)=0. 11-0.99; polytomous delay: P=0.006, Chi-square= 10.224) and 'Unawareness' (dichotomous delay: P〈0.01, 0R=4.96, 95% CI--2.16-11.37; polytomous delay: P=0.087, Chi-square=4.77). Also 'Denial' (P〈0.01, 0R=6.84, 95% CI=2.31-20.24) and 'Knowledge of cancer' (P=0.079, Chi-square=8.359) were found to be statistically significant both for dichotomous and for polytomous categorization of delay, respectively. The findings of this study indicated that, in the investigated cohorts, the knowledge about cancer issues is strongly linked to the patient delay. Educational interventions on the Mediterranean population are necessary in order to increase the patient awareness and to emphasize his/her key role in early diagnosis of OSCC.
基金supported by the National Natural Science Foundation of China,No.81801071(to YJL)Top-notch Postgraduate Talent Cultivation Program of Chongqing Medical University,No.BJRC202106(to BC).
文摘Mild cognitive impairment(MCI)is a prodrome of Alzheimer’s disease pathology.Cognitive impairment patients often have a delayed diagnosis because there are no early symptoms or conventional diagnostic methods.Exosomes play a vital role in cell-to-cell communications and can act as promising biomarkers in diagnosing diseases.This study was designed to identify serum exosomal candidate proteins that may play roles in diagnosing MCI.Mass spectrometry coupled with tandem mass tag approach-based non-targeted proteomics was used to show the differentially expressed proteins in exosomes between MCI patients and healthy controls,and these differential proteins were validated using immunoblot and enzyme-linked immunosorbent assays.Correlation of cognitive performance with the serum exosomal protein level was determined.Nanoparticle tracking analysis suggested that there was a higher serum exosome concentration and smaller exosome diameter in individuals with MCI compared with healthy controls.We identified 69 exosomal proteins that were differentially expressed between MCI patients and healthy controls using mass spectrometry analysis.Thirty-nine exosomal proteins were upregulated in MCI patients compared with those in control patients.Exosomal fibulin-1,with an area under the curve value of 0.81,may be a biomarker for an MCI diagnosis.The exosomal protein signature from MCI patients reflected the cell adhesion molecule category.In particular,higher exosomal fibulin-1 levels correlated with lower cognitive performance.Thus,this study revealed that exosomal fibulin-1 is a promising biomarker for diagnosing MCI.
基金The authors extend their appreciation to the Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia for funding this research work through the project number(IF-PSAU-2021/01/18596).
文摘Aging is a natural process that leads to debility,disease,and dependency.Alzheimer’s disease(AD)causes degeneration of the brain cells leading to cognitive decline and memory loss,as well as dependence on others to fulfill basic daily needs.AD is the major cause of dementia.Computer-aided diagnosis(CADx)tools aid medical practitioners in accurately identifying diseases such as AD in patients.This study aimed to develop a CADx tool for the early detection of AD using the Intelligent Water Drop(IWD)algorithm and the Random Forest(RF)classifier.The IWD algorithm an efficient feature selection method,was used to identify the most deterministic features of AD in the dataset.RF is an ensemble method that leverages multiple weak learners to classify a patient’s disease as either demented(DN)or cognitively normal(CN).The proposed tool also classifies patients as mild cognitive impairment(MCI)or CN.The dataset on which the performance of the proposed CADx was evaluated was sourced from the Alzheimer’s Disease Neuroimaging Initiative(ADNI).The RF ensemble method achieves 100%accuracy in identifying DN patients from CN patients.The classification accuracy for classifying patients as MCI or CN is 92%.This study emphasizes the significance of pre-processing prior to classification to improve the classification results of the proposed CADx tool.