The present study is to characterize the biochemicai remodeling of ventricular collagen matrix and its natural history following myocardial infarction(MI)in rats.Collagen concentration,the total collagen content and ...The present study is to characterize the biochemicai remodeling of ventricular collagen matrix and its natural history following myocardial infarction(MI)in rats.Collagen concentration,the total collagen content and the ratio of types Ⅰ,Ⅲ collagen (Ⅰ/Ⅲ) were measured at 3,15 and 42 days after MI.The results showed:1)The total collagen content of non-infarcted area (NIA) and right ventricle (RV) foliowing the development of ventricular hypertrophy increased progressively. Although the collagen concentration had no difference in RV, it showed dynamic changes in NIA. Both the collagen concentration and the total collagen content in infarcted area (IA) increased rapidly following reparative fibrosis.2)At the early stage or MI,type Ⅲ collagen in NIA increased significantly;later,type collagen was remarkedly higher in NIA and RV.Ⅰ/Ⅲ of IA showed difrerent patterns than that of NIA.The results suggest:(1) the blochemical remodeling or collagen matrix in NIA, IA and RV occurred following MI and its time courses were different;(2)the mechanism of the biochemlcal remodeling of collagen matrix in ventricles may be different.展开更多
文摘The present study is to characterize the biochemicai remodeling of ventricular collagen matrix and its natural history following myocardial infarction(MI)in rats.Collagen concentration,the total collagen content and the ratio of types Ⅰ,Ⅲ collagen (Ⅰ/Ⅲ) were measured at 3,15 and 42 days after MI.The results showed:1)The total collagen content of non-infarcted area (NIA) and right ventricle (RV) foliowing the development of ventricular hypertrophy increased progressively. Although the collagen concentration had no difference in RV, it showed dynamic changes in NIA. Both the collagen concentration and the total collagen content in infarcted area (IA) increased rapidly following reparative fibrosis.2)At the early stage or MI,type Ⅲ collagen in NIA increased significantly;later,type collagen was remarkedly higher in NIA and RV.Ⅰ/Ⅲ of IA showed difrerent patterns than that of NIA.The results suggest:(1) the blochemical remodeling or collagen matrix in NIA, IA and RV occurred following MI and its time courses were different;(2)the mechanism of the biochemlcal remodeling of collagen matrix in ventricles may be different.
