Cold Pressor Task中威胁性图片信息相关事件电位研究

目的：本研究选用冷压疼痛诱导范式（Cold Pressor Task,CPT）作为诱发疼痛的手段,探讨疼痛条件下,威胁性信息的ERPs反应。方法：采用组内设计,在CPT中给被试提供威胁型（冻伤和无关威胁）和中性图片。结果：冻伤威胁性信息与无关威胁信息和非威胁信息之间在CPT疼痛的相关事件电位存在显著差异。重复测量方差分析显示刺激类别在150-200 ms区间、200-300 ms区间、300-400ms区间和400-500 ms区间平均波幅的主效应都显著（F值分别为7.80、13.93、6.83、36.21,P〈0.01）,通过两两比较刺激发现,无关威胁图片与中性图片在四个时间区间差异都不显著,P〉0.05,但无关威胁图片和中性图片都与威胁性冻伤图片存在显著差异：150-200ms区间[F1a（1,11）=19.10,P〈0.01;F1b（1,11）=5.78,P〈0.05]。200-300 ms区间中[F2a（1,11）=36.69,P〈0.01;F2b（1,11）=14.56,P〈0.01]。300-400 ms区间[F3a（1,11）=65.28,P〈0.01;F3b（1,11）=35.57,P〈0.01]。400-500ms区间[F4a（1,11）=36.52,P〈0.01;F4b（1,11）=53.51,P〈0.01]。结论：在疼痛情境下,接受与CPT相关的威胁性信息时脑电活动与接受中性信息和无关的威胁信息脑电图活动存在显著不同。相对无关信息刺激,与情境匹配的威胁性信息引起更多的关注和加工。这种不同不仅存在于早期的注意指向阶段,也存在于晚期的随意加工和反应选择阶段。

The Effect of Brief Mindfulness Meditation on Cold-Pressor Induced Pain Responses in Healthy Adults

We hypothesised a 10 minute mindfulness based intervention performed by a novice therapist would have a beneficial effect on pain responses in naive participants. Twenty-four participants were randomly assigned to the control group or mindfulness meditation group. The control group sat quietly for 10 minutes in between two cold pressor tasks. The mindfulness meditation intervention group practiced 10 minutes of mindfulness meditation in between cold-pressor tasks following standardised mindfulness of breathing meditation technique instructions provided by a male investigator. A significant interaction effect was found between anxiety towards pain ratings (pre-intervention vs. post-intervention) and intervention (F = 6.29, p = 0.02). There was a significant decrease (t = 4.07, p = 0.002) in anxiety towards pain ratings in the mindfulness meditation group following intervention. A significant interaction effect was found between pain threshold times (pre-intervention vs. post-intervention) and intervention (F = 18.45, p 0.001) in pain threshold times in the mindfulness meditation group following intervention. A significant interaction effect was found between pain tolerance times (pre-intervention vs. post-intervention) and intervention (F = 18.34, p < 0.001). A significant increase (t = -4.20, p = 0.001) in pain tolerance times in the mindfulness meditation group following intervention was also found. The results suggest a single 10 minute mindfulness meditation intervention administered by a novice therapist can improve pain tolerance, pain threshold and decrease anxiety towards pain in na?ve healthy university aged individuals.