Discuss ion on the Correlation Between Yang Deficiency&Cold-dampness and Malignant Tumors Based on"Diseases producing the liquid that is clear and chill all result from coldness"

Tumor is defined as a kind of chronic diseases by the World Health Organization.The integrative traditional Chinese and western medicine works well on the treatment of tumors,even in advanced patients or patients with recurring and metastatic tumor.However,the pathogenic mechanism of tumors is still unclear.Therefore,based on the 19 th pathogenesis in Yellow Emperor's Internal Class that"Diseases producing the liquid that is clear and chill all result from coldness",the paper explore s the etiology pathogenesis of malignant tumors,and the correlation between which and tumor recurrence and metastasis,and also discusses the rules for the treatment of tumors at various stages with great method of warming yang for dispelling cold.

Analysis of the Curative Effect of Cold-Dampness Epidemic Prescription(寒湿疫方)on the Main Symptoms of Quarantined People in Community

Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.

Efficacy of TCM Fumigation Using Dampness-and-cold-dispelling Formula Combined with Methotrexate and Leflunomide Treating Rheumatoid Arthritis with Cold-dampness Bi Syndrome

Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated with significant adverse effects.In contrast,fumigation as one of the most often used traditional Chinese medicine(TCM)external therapy has shown both efficacy and safety with less side effect.In light of this,we comple-ment western medicine treatment with TCM fumigation therapy to improve patients’clinical efficacy,alleviate symptoms,and improve prognosis.Objective:To investigate the therapeutic effect of TCM fumigation and modern medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.Methods:A single-center,randomized,controlled study was designed.From January 2022 to December 2022,a total of 60 RA patients with cold-dampness Bi syndrome were enrolled in the study.The control group(30 cases)received conventional modern medicine treatment with methotrexate for 4 weeks,while the observation group(30 cases)for 4 weeks received a combination of TCM fumigation treatment and conventional modern medicine.The effects of the two groups were comprehensively compared,including the changes in TCM symptom scores and laboratory indicators,as well as the use of visual analogue scale(VAS)and health status rating scale(HAQ)before and after treatment.Results:The total effective rate of the observation group was 93.3%,which was significantly higher than that of the control group,which is 70%(P<0.05).Before treatment,there were no significant differences in joint functional activity,pain visual analogue scale(VAS),health assessment questionnaire(HAQ-DI)and laboratory indexes between the two groups(P>0.05).After treatment,each group compared to their initial condition,respectively,showed major improvement of joint functional activity and significantly decreased VAS,HAQ-DI,and RA-related biomarkers(P<0.05);inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients(P<0.05),yet the control group receiving only modern medicine showed better results of the VAS and HAQ-DI.Conclusion:The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness Bi syn-drome,and to enhance their life quality,improving the joint function,and reducing inflammation.

Clinical Efficacy Observation on Dysmenorrhea of Cold-damp Stagnation Type with Graphene Thermotherapy Based on the Idea of TCM "Preventive Treatment of Disease"

[Objectives] To explore the clinical efficacy of graphene waist protector on dysmenorrhea of cold-damp stagnation type.[Methods]150 patients with cold-damp stagnation type were randomly divided into 3 groups: 50 cases in the experimental group( using graphene waist protector),49 cases in the blank group( using the waist protector for removing the heating plate) and 51 cases in the control group( taking the Tongjingbao granules). After intervening for 3 menstrual cycles,visual analogue scale and the COX menstrual symptom scale were used to evaluate the clinical efficacy of graphene waist protector. [Results] The clinical effective rate of dysmenorrhea in experimental group was 64. 00%,while that of control group was 72. 54%. With the effective rate of symptoms,the test group was 56. 00% and the control group was 64. 70%; VAS dysmenorrhea visual score,duration of dysmenorrhea,severity of COX dysmenorrhea and duration of symptoms after intervention were significantly decreased in both experimental group and control group,the differences were statistically significant( P < 0. 05); for the differences of the scores before and after the intervention: the differences of the experimental group and the control group were statistically significant( P < 0. 05) compared with those of the blank group. There was no significant difference between experimental group and control group( P > 0. 05). [Conclusions] Graphene belt of experimental group and Tongjingbao granules of control group both have therapeutic effects on dysmenorrhea of cold-damp stagnation type. Graphene waist protector can relieve the pain and its accompanying symptoms in patients with primary dysmenorrhea of cold-damp stagnation type.

益气活血通脉法治疗冠心病心绞痛(气虚血瘀证)的临床疗效及对RDW影响的临床研究

目的:观察益气活血通脉法治疗冠心病心绞痛(气虚血瘀证)的临床疗效及对RDW的影响,并探讨其作用机理。方法:将74例气虚血瘀证冠心病稳定型心绞痛患者随机分为补心汤组和对照组,各37例。对照组实际观察36例(1例脱落),给予西医常规治疗,补心汤组实际观察35例(2例脱落),在对照组的基础上加用丹台补心汤,均治疗4周,观察治疗前后两组患者的临床症状。评价两组患者治疗前后在中医证候积分、总有效率、硝酸甘油停减率、血脂水平及RDW等方面的疗效。结果:补心汤组患者治疗后证候总积分(5.14±2.56)分,对照组(8.06±3.19)分,差异具有统计学意义(P<0.05);补心汤组中医证候疗效总有效率为94.29%(33/35)明显优于对照组72.22%(26/36);在硝酸甘油停减率、血脂水平、RDW水平亦优于对照组。结论:益气活血通脉法对冠心病心绞痛(气虚血瘀证)确有疗效,能缓解心绞痛发作,降低中医证候积分,降低血脂及RDW水平,从而改善患者生活质量。

Evaluation of the Therapeutic Effect of Contrast-Enhanced Ultrasound on Different Types of Knee Osteoarthritis in the Elderly

Objective: To evaluate the curative effect of the Traditional Chinese Medicine (TCM) external therapy on knee osteoarthritis patients with different TCM constitutions using musculoskeletal ultrasonography and contrast-enhanced ultrasonography, and to explore the application value of contrast-enhanced ultrasonography in knee joint diseases. Methods: A total of 57 patients diagnosed with knee osteoarthritis in Shaanxi University of Traditional Chinese Medicine from December 2019 to May 2021 were collected, and they were divided into qi stagnation and blood stasis type group (23 cases) and cold-dampness obstruction type group (34 cases) according to the traditional Chinese medicine method. All patients were given acupuncture combined with TCM fumigation and washing. All patients underwent musculoskeletal ultrasonography and contrast-enhanced ultrasonography before and after treatment, observed and recorded relevant data, and compared the treatment effects between the two groups. Results: 85.96% (49/57) of knee osteoarthritis (KOA) patients had suprapatellar bursa effusion, 42.1% (24/57) had iliotibial band bursae effusion, some of which had poor sound transmission, and thickened synovium was seen in most effusions, 33.33% (19/57) had osteophyte formation. Compared with before treatment, the depth of suprapatellar sac effusion in the Qi stagnation and blood stasis type group decreased after treatment (P Conclusion: Musculoskeletal contrast-enhanced ultrasonography was used to quantitatively evaluate the efficacy of TCM external therapy on KOA for different TCM constitutions. Dynamic observation of synovial lesions of knee osteoarthritis provides a valuable imaging method for evaluating the efficacy of traditional Chinese medicine.

Efficacy observation on long snake moxibustion for lumbar disc herniation with cold-dampness syndrome

Objective:To observe and compare the clinical efficacy difference among long snake moxibustion,acupuncture and western medication for treating lumbar disc herniation with cold-dampness syndrome,and to provide a preferred treatment for cold-dampness lumbar disc herniation.Methods:A total of 90 patients with cold-dampness lumbar disc herniation were randomized into three groups according to the random number table,including the long snake moxibustion group(31 cases),the acupuncture group(28 cases)and the western medication group(31 cases).Treated with long snake moxibustion,patients in the long snake moxibustion group.The acupuncture group was treated with conventional acupuncture therapy,by adopting acupoints of Shènshū(肾俞 BL23),Dàchángshū(大肠俞BL25),Yāoyángguān(腰阳关GV3),Wěizhōng(委中 BL40)and local Ashi points.Patients in the western medication group were given oral diclofenac sodium.Visual analogous scale(VAS),Oswestry Dysfunction Index(ODI)score,yang deficiency scale score and clinical efficacy were observed before and after treatment.Results:(1)The VAS scores of the patients after treatment in each group decreased compared with those before the treatment.The long snake moxibustion group decreased from 7.22±1.14 to 1.10±0.75(P<0.05);the acupuncture group,from 6.75±1.18 to 1.46±0.88(P<0.05);and the western medication group,from 7.38±1.02 to 1.51 ±0.81(P<0.05).After treatment,the VAS score of the long snake moxibustion group was lower than that of the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(2)ODI scores of all the groups were lower than those before the treatment.The long snake moxibustion group decreased from 33.35±10.85 to 7.84±3.59(P<0.05);the acupuncture group,from 31.65±8.23 to 9.00±6.10(P<0.05);and the western medication group from 27.77±7.30 to 23.87±10.81(P<0.05).The score of ODI in the long snake moxibustion group was lower than those in the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(3)The scores of yang deficiency scale score in each group were lower than those before treatment.The long snake moxibustion group decreased from 61.81±15.49 to 32.26±6.08(P<0.05);the acupuncture group,from 67.64±12.47 to 62.00±17.77(P<0.05);and the western medication group from 64.68 ± 12.73 to 59.77±14.02(P<0.05).The score of yang deficiency scale of the long snake moxibustion group was lower than those of the acupuncture and western medication groups after treatment,the differences were statistically significant(both P<0.05).(4)The effective rates of the long snake moxibustion group,acupuncture group and western medication group were 93.55%,85.71% and74.19% respectively,and the differences among three groups were statistically significant(all P<0.05).Conclusion:The long snake moxibustion therapy has a significant clinical effect for lumbar disc herniation with cold-damp syndrome,which is better than those of acupuncture and western medication groups,the therapy can effectively improve the patients' physical constitution as a preferred solution for cold-damp lumbar disc herniation by acupuncture therapy.

血浆α－颗粒膜蛋白140测定在原发性肾小球疾病血瘀证中的临床意义

本研究测定５３例血瘀证和非血瘀证原发性肾小球疾病（ＰＧＤ）患者血浆α－颗粒膜蛋白１４０（ＧＭＰ－１４０）浓度，并观察ＰＧＤ患者中高血脂、高血压与ＧＭＰ－１４０的关系。结果显示：ＰＧＤ患者血浆ＧＭＰ－１４０浓度明显高于对照组（Ｐ＜０．０１），血小板处于高度活化状态，其中血瘀证组显著高于非血瘀证组（Ｐ＜０．０１），血瘀证患者中气虚组高于非气虚组（Ｐ＜０．０５），说明ＧＭＰ－１４０是反映ＰＧＤ血瘀证的客观指标，气虚能加重血小板活化，加重血瘀倾向，符合中医“气虚血瘀”理论。高血脂、高血压与ＧＭＰ－１４０异常增高密切相关，是造成ＰＧＤ高凝状态、血瘀倾向的重要因素。

原发性闭角型青光眼患者血液流变学和血液中血栓素、前列腺素的改变

目的：探讨原发性闭角型青光眼患者的发病机理。方法：对４４例原发性闭角型青光眼患者和２５例正常人的血液流变学、血液中血栓素和前列腺素等指标进行了检测。结果：原发性闭角型青光眼患者的低切与高切全血比粘度、血浆粘度，血球压积、红细胞电泳、红细胞聚集指数、血栓素Ｂ２、β一血栓球蛋白、ｖＷＦ和Ｔ／Ｋ比值明显升高（Ｐ＜０．０５或Ｐ＜０．０１），６一ｋｅｔｏ一ＰＧＦ１α。明显降低，与正常组相比，均有显著性意义（Ｐ＜０．００１）。结论：原发性闭角型青光眼患者存在血液流变学异常，并有血管内皮细胞受损、血小板聚集性增强和血液呈现高凝状态的血瘀改变。

不稳定心绞痛TIMI危险分层与中医血瘀证相关性研究

目的研究冠心病不稳定心绞痛(unstable angina pectoris,UAP)患者中医血瘀证积分与心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)危险评分的相关性,分析患者血瘀程度与UAP预后的关系。方法收集114例UAP住院患者一般资料、危险因素、中医症状、证候、冠状动脉造影结果、相关理化检查等,并计算患者Gensini积分、TIMI危险评分及血瘀证积分。结果 114例UAP患者的血瘀证积分与Gensini积分呈显著正相关(r=0.78,P<0.01);冠状动脉三支病变患者血瘀证积分明显高于单支及双支病变患者(P<0.05)。TIMI评分高危组血瘀证积分明显高于中危组和低危组(P<0.01);重度血瘀组的TIMI评分明显高于中度及轻度血瘀组(P<0.05,P<0.01)。血瘀证积分与TIMI危险评分呈显著正相关(r=0.23,P<0.05)。结论 UAP患者冠状动脉病变累及血管越多,血瘀程度越严重;UAP患者TIMI危险评分越高,血瘀程度越严重。

腰宁汤联合祖师麻膏药治疗寒湿瘀阻型慢性腰肌劳损的临床评价

目的评价腰宁汤联合祖师麻膏药治疗寒湿瘀阻型慢性腰肌劳损的临床疗效。方法选取从2016年7月-2018年6月医院收治的慢性腰肌劳损患者60例作为研究对象,该60例患者经中医辨证均为寒湿瘀阻型。对照组采用祖师麻膏药进行治疗,观察组在此基础上加服腰宁汤进行治疗。比较两组患者寒湿瘀阻型腰肌劳损的临床治疗效果,观察记录两组治疗前后患者VAS评分、ODI指数、血液流变学指标和炎症指标的变化差异。结果观察组总有效率93.33%(28/30);对照组总有效率73.33%(22/30)。观察组总有效率明显优于对照组,差异有统计学意义(P<0.05),经治疗两组患者ODI评分和VAS评分显著下降;观察组治疗后ODI及VAS评分明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后,观察组全血黏度(高切、低切)、血浆黏度、血小板聚集率均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组IL-6、CRP、TNF-α均显著低于对照组,差异有统计学意义(P<0.05)。结论腰宁汤联合祖师麻膏药治疗寒湿瘀阻型慢性腰肌劳损的临床疗效确切,能明显改善患者腰肌活动功能、疼痛症状、血液流变学及炎症因子指标。

脑心通胶囊治疗胸痹(冠心病心绞痛)气虚血瘀证的临床疗效观察

目的评价脑心通胶囊治疗胸痹(冠心病心绞痛)气虚血瘀证的临床有效性和安全性。方法以通心络胶囊为对照,进行随机、双盲、对照、多中心试验。采用区组随机化将264例病例按实验组与对照组3∶1的原则随机分成两组,试验组198例,对照组66例。试验组给予脑心通胶囊,对照组给予通心络胶囊。连续服用28d。观察比较两组心绞痛疗效、中医证候疗效、硝酸甘油停减率、心电图改善、心绞痛症状积分、中医证候积分变化等。结果心绞痛疗效总有效率在试验组和对照组分别为90.4%和78.8%,两组间比较差异有统计学意义(P<0.05);心电图疗效总有效率在试验组和对照组分别为39.1%和34.9%,硝酸甘油停减率在试验组和对照组分别为88.8%和89.4%,中医证候疗效总有效率在试验组和对照组分别为88.8%和86.4%,两组间比较差异均无统计学意义(P>0.05),且两组均未发现明显的不良反应。结论脑心通胶囊治疗胸痹(冠心病心绞痛)瘀血闭阻证安全有效。

益气活血散治疗颈动脉粥样硬化的临床疗效

目的:观察自拟益气活血散治疗颈动脉粥样硬化的临床疗效。方法:将筛选合格的符合标准的63例研究对象,按纳入标准,以平行、对照原则分为对照组32例和治疗组31例;对照组采用西医常规治疗,治疗组采用中医自拟益气活血散口服治疗。两组疗程为6个月,观察相关指标并进行统计学分析。结果:治疗组在中医症状及体征、hs-CRP、HCY、颈动脉内膜中层厚度方面较治疗前显著改善,差异均有统计学意义(P<0.05)。在治疗后,治疗组在中医症状及体征、hs-CRP、HCY、颈动脉内膜中层厚度方面改善方面优于对照组,差异均有统计学意义(P<0.05)。结论:益气活血散对颈动脉粥样硬化斑块的治疗具有明确疗效,可以改善颈动脉粥样硬化中医症状及体征、hs-CRP、HCY,减轻颈动脉内膜中层厚度。

浅谈中医对多囊卵巢综合征病机与辨治的认识

多囊卵巢综合征是育龄期妇女常见的妇科疾病之一,临床表现出月经稀少、闭经、不孕等一组内分泌失调的妇科病。本文从中医理论的认识,探讨多囊卵巢综合征的发病机理,认为肾虚是导致本病的首要原因;肾虚血瘀、肾虚痰湿是其常见证型;治疗上补肾为大法,配以活血、化瘀、祛痰来调节冲任,使“肾-天癸-冲任-胞宫”之间恢复协调,达到治愈本病的效果。

王春林教授瓜蒌薤白半夏汤治疗冠心病经验

探讨王春林教授从痰、瘀论治冠心病的方法,总结分析王春林教授从痰论治冠心病的经验。从痰论治疗冠心病疗效明显,值得临床推广运用。

辨证施护在腰痛病临床运用中的体会

目的观察腰痛病患者应用辨证施护方法的临床效果。方法抽取60例腰痛病患者,将其分为常规组和干预组,平均每组30例。常规组患者治疗期间进行常规护理;干预组患者治疗期间进行辨证施护。结果干预组患者的腰痛病治疗效果明显优于常规组,存在不良反应的人数明显少于常规组,治疗结束后症状复发率明显低于常规组。结论中医辨证施护可明显提高腰痛患者的临床疗效。

基于关联规则和复杂系统熵聚类的老年性股骨粗隆间骨折用药规律研究

目的:分析老年股骨粗隆间骨折中药内服处方的用药规律。方法:搜集中国知网、重庆维普、万方、中国生物医学文献数据库2011—2016年治疗老年股骨粗隆间骨折的中药处方,采用TCMISS中医传承辅助平台软件提取分析处方中各药物的使用频次、四气五味归经、归类以及药物之间的关联规则等。结果:对232个中药处方进行分析,使用频率较高的中药有当归、红花、川芎、续断、桃仁、骨碎补、赤芍、牛膝、熟地黄、白芍等。药物的四气分布主要为温、平、凉;五味分布主要为苦、辛、甘;归经分布主要为肝、脾、心、肾;药物归类分布主要为伞形科、毛茛科、菊科。当归、红花、川芎、桃仁、熟地黄、白芍等均为临床治疗老年股骨粗隆间骨折最常用的中药。结论:中药治疗老年股骨粗隆间骨折以活血化瘀为主要治法,常用处方为桃红四物汤,关键药物组合是当归与红花,处方用药应以"活血通络不致血亏,养血化瘀不致脉损"为则。

基于治未病思想探讨痰瘀与心脑疾病的防治

从痰瘀角度探讨心脑疾病的防治。痰瘀与心脑疾病的发生发展、复发难愈密切相关,从痰瘀角度探讨心脑病之"治未病",是其较佳切入点和突破点,且有其独特优势和特色,也为心脑病之未病先防、既病防变与病后防复拓宽了思路和方法。

心肌缺血预适应基础与临床研究进展

预先一次或反复短时间缺血可使心肌在其后长时间缺血中得到保护,使心肌细胞死亡延缓,这种现象称为缺血预适应现象。这种缺血预适应现象可以分为"早期保护"和"延迟保护"。除缺血外,化学损伤等也可引起机体普遍适应现象,一些药物也可以引发预适应现象。缺血预适应现象与再灌注后氧自由基生成增多、细胞内钙超载、细胞凋亡等有关。

仙连颗粒治疗特发性血小板减少性紫癜的临床研究

对特发性血小板减少性紫癜(ITP)患者60例予口服仙连颗粒,观测其血小板计数、骨髓巨核细胞及中医不同证型的疗效比较。结果发现,仙连颗粒能够提高血小板数量,改善巨核细胞成熟障碍,对阴虚血热型疗效较好,对血热妄行型疗效较差,对气虚不摄型的作用介于二型之间。