Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated wi...Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated with significant adverse effects.In contrast,fumigation as one of the most often used traditional Chinese medicine(TCM)external therapy has shown both efficacy and safety with less side effect.In light of this,we comple-ment western medicine treatment with TCM fumigation therapy to improve patients’clinical efficacy,alleviate symptoms,and improve prognosis.Objective:To investigate the therapeutic effect of TCM fumigation and modern medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.Methods:A single-center,randomized,controlled study was designed.From January 2022 to December 2022,a total of 60 RA patients with cold-dampness Bi syndrome were enrolled in the study.The control group(30 cases)received conventional modern medicine treatment with methotrexate for 4 weeks,while the observation group(30 cases)for 4 weeks received a combination of TCM fumigation treatment and conventional modern medicine.The effects of the two groups were comprehensively compared,including the changes in TCM symptom scores and laboratory indicators,as well as the use of visual analogue scale(VAS)and health status rating scale(HAQ)before and after treatment.Results:The total effective rate of the observation group was 93.3%,which was significantly higher than that of the control group,which is 70%(P<0.05).Before treatment,there were no significant differences in joint functional activity,pain visual analogue scale(VAS),health assessment questionnaire(HAQ-DI)and laboratory indexes between the two groups(P>0.05).After treatment,each group compared to their initial condition,respectively,showed major improvement of joint functional activity and significantly decreased VAS,HAQ-DI,and RA-related biomarkers(P<0.05);inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients(P<0.05),yet the control group receiving only modern medicine showed better results of the VAS and HAQ-DI.Conclusion:The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness Bi syn-drome,and to enhance their life quality,improving the joint function,and reducing inflammation.展开更多
More than 40 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome treated from eliminating pathogen and strengthening vital qi were sorted out,summarized and...More than 40 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome treated from eliminating pathogen and strengthening vital qi were sorted out,summarized and analyzed,and the theory of treating arthralgia syndrome from eliminating pathogenic factors including dampness,heat,cold,phlegm and blood stasis,and strengthening vital qi basically reflected the academic thought of treating Bi syndrome from eliminating pathogen and strengthening vital qi in traditional Chinese medicine books.展开更多
A 19-year-old Japanese woman was referred to us with the complaints of arthralgia and meralgia following human papillomavirus (HPV) vaccination. She received HPV vaccination at the age of 15 years and three years late...A 19-year-old Japanese woman was referred to us with the complaints of arthralgia and meralgia following human papillomavirus (HPV) vaccination. She received HPV vaccination at the age of 15 years and three years later, she developed intermittent arthralgia, meralgia, and numbness in limbs. There were no orthostatic dysregulation symptoms. She had hypertelorism, and brachydactyly in both the hands, and revealed mild cubitus varus deformity with lateral instability. X-ray examination disclosed hypoplasia of the humeral capitellum and trochlea in elbow joints. G-banded chromosomes were shown to be composed of 48, XXXX. She was, therefore, diagnosed with XXXX syndrome, which explained the reason for her limb symptoms. Although some girls with HPV vaccination complain of various symptoms including limb pain and numbness, exact underlying cause of these symptoms needs to be ascertained carefully for reaching a final diagnosis.展开更多
目的系统评价雷火灸治疗腰椎间盘突出症的疗效。方法研究者通过PubMed、Web of Science、Embase、Cochrane Library、中国知网、万方数据、维普数据库,查询关于雷火灸治疗腰椎间盘突出症的RCT,检索时间为自建库到2023年3月27日,严格筛选...目的系统评价雷火灸治疗腰椎间盘突出症的疗效。方法研究者通过PubMed、Web of Science、Embase、Cochrane Library、中国知网、万方数据、维普数据库,查询关于雷火灸治疗腰椎间盘突出症的RCT,检索时间为自建库到2023年3月27日,严格筛选,提取有效数据,运用RevMan 5.4软件进行Meta分析。结果12项文献被纳入此研究,总样本量有1041例,其中试验组521例,对照组520例。Meta分析结果显示,与对照组相比,加用雷火灸的试验组在临床总有效率、VAS评分、JOA腰椎功能、ODI改善方面治疗效果更好,P<0.001。结论雷火灸治疗腰椎间盘突出症患者有一定疗效,可有效缓解患者疼痛、腿麻等不适症状,未来还需大样本、高质量的随机对照试验来增强其循证依据。展开更多
原发性干燥综合征是一种以外分泌腺损伤为特征的慢性炎症性自身免疫性疾病。干燥综合征起病个体差异性较大,临床症状多样,损伤严重程度各不相同。原发性干燥综合征除了导致腺体损伤外,还可能涉及多个器官和系统,其常见的临床表现之一为...原发性干燥综合征是一种以外分泌腺损伤为特征的慢性炎症性自身免疫性疾病。干燥综合征起病个体差异性较大,临床症状多样,损伤严重程度各不相同。原发性干燥综合征除了导致腺体损伤外,还可能涉及多个器官和系统,其常见的临床表现之一为神经系统症状,中枢神经系统、周围神经系统均可累及。其中干燥综合征首发表现为视神经脊髓炎谱系疾病的情况在临床上较少见,在实际的临床诊疗过程中,询问病史、筛查抗核抗体及抗水通道蛋白4(Aquaporin Protein 4,AQP4)抗体发挥重要的作用。文章报道1例以视神经脊髓炎谱系疾病为首发表现的干燥综合征青年女性患者,该患者以下肢麻木疼痛伴瘙痒为首发表现,多次就诊于皮肤科,发病2个月后才出现干燥症状,确诊后予中西医治疗,治疗后好转,随访1年未见复发。文章通过分析此病例的临床表现、化验检查、诊治预后等,以提高对此类疾病的认识,以便对病情进行早期诊断,以免出现误诊或漏诊,并及时进行中西医联合治疗,控制病情,避免出现不可逆转的损害。同时在此过程中还应注意动态随访,减少复发,提高患者的生活质量。展开更多
基金This tudy was supported and funded by Science and Technology Project of Jiangxi Provincial Administration of Traditional Chinese Medicine(2021B117).
文摘Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated with significant adverse effects.In contrast,fumigation as one of the most often used traditional Chinese medicine(TCM)external therapy has shown both efficacy and safety with less side effect.In light of this,we comple-ment western medicine treatment with TCM fumigation therapy to improve patients’clinical efficacy,alleviate symptoms,and improve prognosis.Objective:To investigate the therapeutic effect of TCM fumigation and modern medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.Methods:A single-center,randomized,controlled study was designed.From January 2022 to December 2022,a total of 60 RA patients with cold-dampness Bi syndrome were enrolled in the study.The control group(30 cases)received conventional modern medicine treatment with methotrexate for 4 weeks,while the observation group(30 cases)for 4 weeks received a combination of TCM fumigation treatment and conventional modern medicine.The effects of the two groups were comprehensively compared,including the changes in TCM symptom scores and laboratory indicators,as well as the use of visual analogue scale(VAS)and health status rating scale(HAQ)before and after treatment.Results:The total effective rate of the observation group was 93.3%,which was significantly higher than that of the control group,which is 70%(P<0.05).Before treatment,there were no significant differences in joint functional activity,pain visual analogue scale(VAS),health assessment questionnaire(HAQ-DI)and laboratory indexes between the two groups(P>0.05).After treatment,each group compared to their initial condition,respectively,showed major improvement of joint functional activity and significantly decreased VAS,HAQ-DI,and RA-related biomarkers(P<0.05);inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients(P<0.05),yet the control group receiving only modern medicine showed better results of the VAS and HAQ-DI.Conclusion:The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness Bi syn-drome,and to enhance their life quality,improving the joint function,and reducing inflammation.
基金"Project of Strengthening Health through Science and Education"of Wuxi Health Commission:Study on the Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘More than 40 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome treated from eliminating pathogen and strengthening vital qi were sorted out,summarized and analyzed,and the theory of treating arthralgia syndrome from eliminating pathogenic factors including dampness,heat,cold,phlegm and blood stasis,and strengthening vital qi basically reflected the academic thought of treating Bi syndrome from eliminating pathogen and strengthening vital qi in traditional Chinese medicine books.
文摘A 19-year-old Japanese woman was referred to us with the complaints of arthralgia and meralgia following human papillomavirus (HPV) vaccination. She received HPV vaccination at the age of 15 years and three years later, she developed intermittent arthralgia, meralgia, and numbness in limbs. There were no orthostatic dysregulation symptoms. She had hypertelorism, and brachydactyly in both the hands, and revealed mild cubitus varus deformity with lateral instability. X-ray examination disclosed hypoplasia of the humeral capitellum and trochlea in elbow joints. G-banded chromosomes were shown to be composed of 48, XXXX. She was, therefore, diagnosed with XXXX syndrome, which explained the reason for her limb symptoms. Although some girls with HPV vaccination complain of various symptoms including limb pain and numbness, exact underlying cause of these symptoms needs to be ascertained carefully for reaching a final diagnosis.
文摘目的系统评价雷火灸治疗腰椎间盘突出症的疗效。方法研究者通过PubMed、Web of Science、Embase、Cochrane Library、中国知网、万方数据、维普数据库,查询关于雷火灸治疗腰椎间盘突出症的RCT,检索时间为自建库到2023年3月27日,严格筛选,提取有效数据,运用RevMan 5.4软件进行Meta分析。结果12项文献被纳入此研究,总样本量有1041例,其中试验组521例,对照组520例。Meta分析结果显示,与对照组相比,加用雷火灸的试验组在临床总有效率、VAS评分、JOA腰椎功能、ODI改善方面治疗效果更好,P<0.001。结论雷火灸治疗腰椎间盘突出症患者有一定疗效,可有效缓解患者疼痛、腿麻等不适症状,未来还需大样本、高质量的随机对照试验来增强其循证依据。
文摘原发性干燥综合征是一种以外分泌腺损伤为特征的慢性炎症性自身免疫性疾病。干燥综合征起病个体差异性较大,临床症状多样,损伤严重程度各不相同。原发性干燥综合征除了导致腺体损伤外,还可能涉及多个器官和系统,其常见的临床表现之一为神经系统症状,中枢神经系统、周围神经系统均可累及。其中干燥综合征首发表现为视神经脊髓炎谱系疾病的情况在临床上较少见,在实际的临床诊疗过程中,询问病史、筛查抗核抗体及抗水通道蛋白4(Aquaporin Protein 4,AQP4)抗体发挥重要的作用。文章报道1例以视神经脊髓炎谱系疾病为首发表现的干燥综合征青年女性患者,该患者以下肢麻木疼痛伴瘙痒为首发表现,多次就诊于皮肤科,发病2个月后才出现干燥症状,确诊后予中西医治疗,治疗后好转,随访1年未见复发。文章通过分析此病例的临床表现、化验检查、诊治预后等,以提高对此类疾病的认识,以便对病情进行早期诊断,以免出现误诊或漏诊,并及时进行中西医联合治疗,控制病情,避免出现不可逆转的损害。同时在此过程中还应注意动态随访,减少复发,提高患者的生活质量。
