欧洲空间局的ENVISAT ASAR level 2算法是从合成孔径雷达(SAR)单视复图像反演涌浪方向谱的算法。该算法假设双峰海浪谱的SAR图像交叉谱是涌浪的图像交叉谱和风浪的图像交叉谱之和。实际上双峰海浪谱的SAR图像交叉谱中还有一个混合项,正...欧洲空间局的ENVISAT ASAR level 2算法是从合成孔径雷达(SAR)单视复图像反演涌浪方向谱的算法。该算法假设双峰海浪谱的SAR图像交叉谱是涌浪的图像交叉谱和风浪的图像交叉谱之和。实际上双峰海浪谱的SAR图像交叉谱中还有一个混合项,正是该混合项导致ENVI-SAT ASAR level 2算法有固有误差。利用遥感仿真的方法分析了不同海况条件下该算法的这一固有误差,结果表明,只有在有效波高较小、或风浪的成分较少、或双峰海浪的传播方向较靠近SAR距离向、或波长较长时固有误差才较小,ENVISAT ASAR level 2算法对海浪谱的反演才较为适用。展开更多
目的探讨2型糖尿病湿热困脾证合并血脂紊乱患者胰岛功能变化及其影响因素。方法选择2020年1月—2020年12月医院收治的2型糖尿病湿热困脾证患者100例,根据美国ATPIII评估标准将其分为血脂紊乱组62例与血脂正常组38例。比较各组SF-36积分...目的探讨2型糖尿病湿热困脾证合并血脂紊乱患者胰岛功能变化及其影响因素。方法选择2020年1月—2020年12月医院收治的2型糖尿病湿热困脾证患者100例,根据美国ATPIII评估标准将其分为血脂紊乱组62例与血脂正常组38例。比较各组SF-36积分、胰岛素分泌功能(Homeostasis model assessment-β,HOMA-β)、胰岛素抵抗水平(Homeostasis model assessment-IR,HOMA-IR)、胰岛素敏感指数(Insulin sensitivity index,ISI)、空腹C肽和空腹胰岛素。应用单因素和多因素分析法研究血脂异常的相关因素。结果高甘油三酯组与混合型高脂组空腹胰岛素水平显著高于高胆固醇组与血脂正常组,差异有统计学意义(P<0.05)。高甘油三酯组空腹C肽水平显著高于高胆固醇组,差异有统计学意义(P<0.05)。混合型高脂组与高甘油三酯组的ISI水平低于高胆固醇组(P<0.05)。高甘油三酯组HOMA-β水平明显高于高胆固醇组与血脂正常组,差异有统计学意义(P<0.05)。高甘油三酯组及混合型高脂组HOMA-IR水平显著高于高胆固醇组,差异有统计学意义(P<0.05)。两组患者在躯体疼痛、整体健康、活力、社会功能和精神健康维度方面比较,差异有统计学意义(P<0.01)。多因素Logistic分析显示,喜食油腻、吸烟史、腰围和空腹胰岛素是2型糖尿病湿热困脾证患者血脂异常的危险因素,有氧运动是2型糖尿病湿热困脾证患者血脂异常的保护因素(P<0.05)。结论不同血脂紊乱类型对胰岛功能的影响并不相同,应针对相关因素积极预防,降低胰岛分泌负担,促使胰岛功能恢复。展开更多
For dealing with large static error due to poor immunity of the traditional fuzzy control, a novel interval type-2 fuzzy control system is proposed. By extending the typical membership functions to interval type-2 mem...For dealing with large static error due to poor immunity of the traditional fuzzy control, a novel interval type-2 fuzzy control system is proposed. By extending the typical membership functions to interval type-2 membership functions, the proposed control system can efficiently reduce the uncertain disturbance from real environment without increasing the design complexity. The simulation results on the water tank level control system showed that the proposed method succeeded in better static and dynamic control with stronger robust performance than the traditional fuzzy control method.展开更多
The HY-2A satellite is China’s first independent oceanic dynamic environmental satellite,and has been operating continuously for more than six years.The satellite’s radar altimeter,which is one of the main loads on ...The HY-2A satellite is China’s first independent oceanic dynamic environmental satellite,and has been operating continuously for more than six years.The satellite’s radar altimeter,which is one of the main loads on the satellite,has the ability to realize all-weather and all-day observations of global sea-surface heights,as well as significant wave heights and sea-surface wind speeds.These observed data have been widely used in marine disaster prevention and reduction,along with resource development,maritime security and other fields.In order to achieve a comprehensive understanding of the multi-year overall observational performances of the HY-2A satellite’s radar altimeter,all of the observational data of the IGDR product from October 26,2012 to August 27,2017 were selected in this study for a comprehensive evaluation.The height measurement capability of the HY-2A satellite’s radar altimeter was evaluated using self-crossover and Jason-2 crossover methods.The height discrepancies at the self-crossover point of the HY-2A satellite’s ascending and descending orbits were also calculated.It was found that for the HY-2A satellite’s radar altimeter in global waters under the restriction conditions of ascending and descending orbits,the height anomaly differences were within a range of less than 30 cm.The absolute mean error was determined to be 5.81 cm,and the height anomaly standard deviation was 7.76 cm.Under the conditions of the observational areas being limited within a scope of 60°from the Equator,it was determined that the sea-level height anomaly differences were less than 10 cm at the junction of the ascending and descending orbits,the absolute mean error was 3.95 cm.In addition,the sea-level height anomaly standard deviation was observed to be 4.76cm.Using a mutual cross method with the Jason-2 satellite,it was found that under the conditions of the observational area being within the scope of 66°from the equator,the height anomaly differences at the junction were less than 30cm,and the absolute mean error of HY-2A and Jason-2 sea level height anomaly was 5.86 cm,with a standard deviation of 7.52 cm.It was observed that,if within the sea area the sea level height anomaly difference was limited to within 10cm,then the absolute mean error and standard deviation could reach 4.19cm and 4.98cm,respectively.It was confirmed that the HY-2A satellite’s radar altimeter had successfully reached the height measurement level of similar international altimeters.Therefore,it had the ability to meet the needs of marine scientific research and ocean circulation inversions.展开更多
Because of the environmental and socioeconomic impacts of anthropogenic sea level rise （SLR）, it is very important to understand the processes leading to past and present SLRs towards more reliable future SLR projec...Because of the environmental and socioeconomic impacts of anthropogenic sea level rise （SLR）, it is very important to understand the processes leading to past and present SLRs towards more reliable future SLR projections. A regional ocean general circulation model （ROGCM）, with a grid refinement in the Bohai, Yellow, and East China Seas （BYECSs）, was set up to project SLR induced by the ocean dynamic change in the 21st century. The model does not consider the contributions from ice sheets and glacier melting. Data of all forcing terms required in the model came from the simulation of the Community Climate System Model version 3.0 （CCSM3） under the International Panel on Climate Change （IPCC）-A2 scenario. Simulation results show that at the end of the 21st century, the sea level in the BYECSs will rise about 0.12 to 0.20 m. The SLR in the BYECSs during the 21st century is mainly caused by the ocean mass redistribution due to the ocean dynamic change of the Pacific Ocean, which means that water in the Pacific Ocean tends to move to the continental shelves of the BYECSs, although the local steric sea level change is another factor.展开更多
BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2...BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis.展开更多
Somatic embryogenesis （SE） is one of the most important steps during regeneration of cotton, but the molecular mechanism of SE remains unclear. SOMATIC EMBRYOGENSIS RECEPTOR KINASE （SERK） gene is known to function...Somatic embryogenesis （SE） is one of the most important steps during regeneration of cotton, but the molecular mechanism of SE remains unclear. SOMATIC EMBRYOGENSIS RECEPTOR KINASE （SERK） gene is known to function in SE. A homolog GhSERK2 （accession number： JF430801） was cloned from Upland cotton and characterized for its functions in SE. GhSERK2 expressed in different tissues and showed higher expression level in floral organs than vegetative ones with the highest levels in ovule and anther. GhSERK2 expressed during SE with a high level at globular embryos stage. Upon treatment with indole-3-butytic acid （IBA）, the transcription level of GhSERK2 was induced and promoted SE subsequently. A 2-day treatment of 2,4-dichlorophenoxyacetic acid （2,4-D） induced the expression of GhSERK2, but treatments of 2,4-D for longer periods sharply inhibited the GhSERK2 transcription level of embryogenic callus （EC）. The levels of hormones, including 3-indoleacetic acid （IAA）, abscisic acid （ABA）, and brassinosteroid （BR）, were increased in the initial calli induced from the over-expression of GhSERK2 cotton. Our results indicated that GhSERK2 expression was associated with induction of SE and closely related to hormone levels during tissue culture in Upland cotton, and the gene might play an important role in regeneration of cotton.展开更多
Nitrogen reduction reaction(NRR)under ambient conditions is always a long-standing challenge in science,due to the extreme difficulty in breaking the strong N≡N triple bond.The key to resolving this issue undoubtedly...Nitrogen reduction reaction(NRR)under ambient conditions is always a long-standing challenge in science,due to the extreme difficulty in breaking the strong N≡N triple bond.The key to resolving this issue undoubtedly lies in searching superior catalysts to efficiently activate and hydrogenate the stable nitrogen molecules.We herein evaluate the feasibility of WP_(2) for N2 activation and reduction,and first demonstrate WP_(2) with an impressive ammonia yield rate of 7.13 lg h^(-1)cm^(-2),representing a promising W-based catalyst for NRR.DFT analysis further reveals that the NRR catalysis on WP_(2) proceeds in a distal reaction pathway,and the exceptional NRR activity is originated from superior surface electron energy level matching between WP_(2) and NRR potential which facilitates the interfacial proton-coupled electron transfer dynamics.The successfully unraveling the intrinsic catalytic mechanism of WP_(2) for NRR could offer a powerful platform to manipulate the NRR activity by tuning the electron energy levels.展开更多
文摘欧洲空间局的ENVISAT ASAR level 2算法是从合成孔径雷达(SAR)单视复图像反演涌浪方向谱的算法。该算法假设双峰海浪谱的SAR图像交叉谱是涌浪的图像交叉谱和风浪的图像交叉谱之和。实际上双峰海浪谱的SAR图像交叉谱中还有一个混合项,正是该混合项导致ENVI-SAT ASAR level 2算法有固有误差。利用遥感仿真的方法分析了不同海况条件下该算法的这一固有误差,结果表明,只有在有效波高较小、或风浪的成分较少、或双峰海浪的传播方向较靠近SAR距离向、或波长较长时固有误差才较小,ENVISAT ASAR level 2算法对海浪谱的反演才较为适用。
文摘目的探讨2型糖尿病湿热困脾证合并血脂紊乱患者胰岛功能变化及其影响因素。方法选择2020年1月—2020年12月医院收治的2型糖尿病湿热困脾证患者100例,根据美国ATPIII评估标准将其分为血脂紊乱组62例与血脂正常组38例。比较各组SF-36积分、胰岛素分泌功能(Homeostasis model assessment-β,HOMA-β)、胰岛素抵抗水平(Homeostasis model assessment-IR,HOMA-IR)、胰岛素敏感指数(Insulin sensitivity index,ISI)、空腹C肽和空腹胰岛素。应用单因素和多因素分析法研究血脂异常的相关因素。结果高甘油三酯组与混合型高脂组空腹胰岛素水平显著高于高胆固醇组与血脂正常组,差异有统计学意义(P<0.05)。高甘油三酯组空腹C肽水平显著高于高胆固醇组,差异有统计学意义(P<0.05)。混合型高脂组与高甘油三酯组的ISI水平低于高胆固醇组(P<0.05)。高甘油三酯组HOMA-β水平明显高于高胆固醇组与血脂正常组,差异有统计学意义(P<0.05)。高甘油三酯组及混合型高脂组HOMA-IR水平显著高于高胆固醇组,差异有统计学意义(P<0.05)。两组患者在躯体疼痛、整体健康、活力、社会功能和精神健康维度方面比较,差异有统计学意义(P<0.01)。多因素Logistic分析显示,喜食油腻、吸烟史、腰围和空腹胰岛素是2型糖尿病湿热困脾证患者血脂异常的危险因素,有氧运动是2型糖尿病湿热困脾证患者血脂异常的保护因素(P<0.05)。结论不同血脂紊乱类型对胰岛功能的影响并不相同,应针对相关因素积极预防,降低胰岛分泌负担,促使胰岛功能恢复。
基金Supported by Program for Liaoning Excellent Talents in University (LJQ2011032)the National Natural Science Foundation of China (61203021)the National Science and Technology Support Program (2012BAF05B00)
文摘For dealing with large static error due to poor immunity of the traditional fuzzy control, a novel interval type-2 fuzzy control system is proposed. By extending the typical membership functions to interval type-2 membership functions, the proposed control system can efficiently reduce the uncertain disturbance from real environment without increasing the design complexity. The simulation results on the water tank level control system showed that the proposed method succeeded in better static and dynamic control with stronger robust performance than the traditional fuzzy control method.
基金The National Key Research and Development Program of China under contract No.2016YFC1401004the National Natural Science Foundation of China under contract No.41406207
文摘The HY-2A satellite is China’s first independent oceanic dynamic environmental satellite,and has been operating continuously for more than six years.The satellite’s radar altimeter,which is one of the main loads on the satellite,has the ability to realize all-weather and all-day observations of global sea-surface heights,as well as significant wave heights and sea-surface wind speeds.These observed data have been widely used in marine disaster prevention and reduction,along with resource development,maritime security and other fields.In order to achieve a comprehensive understanding of the multi-year overall observational performances of the HY-2A satellite’s radar altimeter,all of the observational data of the IGDR product from October 26,2012 to August 27,2017 were selected in this study for a comprehensive evaluation.The height measurement capability of the HY-2A satellite’s radar altimeter was evaluated using self-crossover and Jason-2 crossover methods.The height discrepancies at the self-crossover point of the HY-2A satellite’s ascending and descending orbits were also calculated.It was found that for the HY-2A satellite’s radar altimeter in global waters under the restriction conditions of ascending and descending orbits,the height anomaly differences were within a range of less than 30 cm.The absolute mean error was determined to be 5.81 cm,and the height anomaly standard deviation was 7.76 cm.Under the conditions of the observational areas being limited within a scope of 60°from the Equator,it was determined that the sea-level height anomaly differences were less than 10 cm at the junction of the ascending and descending orbits,the absolute mean error was 3.95 cm.In addition,the sea-level height anomaly standard deviation was observed to be 4.76cm.Using a mutual cross method with the Jason-2 satellite,it was found that under the conditions of the observational area being within the scope of 66°from the equator,the height anomaly differences at the junction were less than 30cm,and the absolute mean error of HY-2A and Jason-2 sea level height anomaly was 5.86 cm,with a standard deviation of 7.52 cm.It was observed that,if within the sea area the sea level height anomaly difference was limited to within 10cm,then the absolute mean error and standard deviation could reach 4.19cm and 4.98cm,respectively.It was confirmed that the HY-2A satellite’s radar altimeter had successfully reached the height measurement level of similar international altimeters.Therefore,it had the ability to meet the needs of marine scientific research and ocean circulation inversions.
基金supported by the National Natural Science Foundation of China(Grants No.41206021 and 41276018)the National Basic Research Program of China(Grant No.2012CB955601)+2 种基金the Young Scientist Foundation of the State Oceanic Administration,China(Grant No.2012251)the U.S.National Science Foundation Belmont Forum Program(Grant No.ICER-1342644)the GASI-03-01-01-09
文摘Because of the environmental and socioeconomic impacts of anthropogenic sea level rise （SLR）, it is very important to understand the processes leading to past and present SLRs towards more reliable future SLR projections. A regional ocean general circulation model （ROGCM）, with a grid refinement in the Bohai, Yellow, and East China Seas （BYECSs）, was set up to project SLR induced by the ocean dynamic change in the 21st century. The model does not consider the contributions from ice sheets and glacier melting. Data of all forcing terms required in the model came from the simulation of the Community Climate System Model version 3.0 （CCSM3） under the International Panel on Climate Change （IPCC）-A2 scenario. Simulation results show that at the end of the 21st century, the sea level in the BYECSs will rise about 0.12 to 0.20 m. The SLR in the BYECSs during the 21st century is mainly caused by the ocean mass redistribution due to the ocean dynamic change of the Pacific Ocean, which means that water in the Pacific Ocean tends to move to the continental shelves of the BYECSs, although the local steric sea level change is another factor.
文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis.
基金supported in part by the National Natural Science Foundation of China (31371666)a grant from the National Key Specific Program to Hua Jinping (2016ZX08005-003)
文摘Somatic embryogenesis （SE） is one of the most important steps during regeneration of cotton, but the molecular mechanism of SE remains unclear. SOMATIC EMBRYOGENSIS RECEPTOR KINASE （SERK） gene is known to function in SE. A homolog GhSERK2 （accession number： JF430801） was cloned from Upland cotton and characterized for its functions in SE. GhSERK2 expressed in different tissues and showed higher expression level in floral organs than vegetative ones with the highest levels in ovule and anther. GhSERK2 expressed during SE with a high level at globular embryos stage. Upon treatment with indole-3-butytic acid （IBA）, the transcription level of GhSERK2 was induced and promoted SE subsequently. A 2-day treatment of 2,4-dichlorophenoxyacetic acid （2,4-D） induced the expression of GhSERK2, but treatments of 2,4-D for longer periods sharply inhibited the GhSERK2 transcription level of embryogenic callus （EC）. The levels of hormones, including 3-indoleacetic acid （IAA）, abscisic acid （ABA）, and brassinosteroid （BR）, were increased in the initial calli induced from the over-expression of GhSERK2 cotton. Our results indicated that GhSERK2 expression was associated with induction of SE and closely related to hormone levels during tissue culture in Upland cotton, and the gene might play an important role in regeneration of cotton.
基金financial support from the National Natural Science Foundation of China(Nos.21771169,11804325,11722543,11875258,11505187)the National Key Research and Development Program of China(2017YFA0206703)+3 种基金Anhui Provincial Natural Science Foundation(BJ2060190077)USTC start-up fundingRecruitment Program of Global Expertthe Fundamental Research Funds for the Central Universities(WK2060190074,WK2060190081,WK2310000066)。
文摘Nitrogen reduction reaction(NRR)under ambient conditions is always a long-standing challenge in science,due to the extreme difficulty in breaking the strong N≡N triple bond.The key to resolving this issue undoubtedly lies in searching superior catalysts to efficiently activate and hydrogenate the stable nitrogen molecules.We herein evaluate the feasibility of WP_(2) for N2 activation and reduction,and first demonstrate WP_(2) with an impressive ammonia yield rate of 7.13 lg h^(-1)cm^(-2),representing a promising W-based catalyst for NRR.DFT analysis further reveals that the NRR catalysis on WP_(2) proceeds in a distal reaction pathway,and the exceptional NRR activity is originated from superior surface electron energy level matching between WP_(2) and NRR potential which facilitates the interfacial proton-coupled electron transfer dynamics.The successfully unraveling the intrinsic catalytic mechanism of WP_(2) for NRR could offer a powerful platform to manipulate the NRR activity by tuning the electron energy levels.
