Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five b...Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hostsIll. In China, brucellosis is a national notifiable communicable disease both in animals and in human. In 2009, 35 816 brucellosis cases were reported. The annual incidence was 2.7 per 100 000 population.展开更多
In the history of theQing Dynasty(1644-1911),two DalaiLamas and onePanchen Erdeni went toBeijing for an audiencewith the emperor.Theywere the 5th Dalai Lama,who went in 1652,he
Zhamgyia Hutog-to was the onlyState Tutor whoreceived thehonor from the Gingemperors.As one of thefour major Living Buddhasystems of the Yellow Sect,he was he most influentialLiving Buddha in the Mon-golian area.Of th...Zhamgyia Hutog-to was the onlyState Tutor whoreceived thehonor from the Gingemperors.As one of thefour major Living Buddhasystems of the Yellow Sect,he was he most influentialLiving Buddha in the Mon-golian area.Of the six gen-erations,3rd Zhamgyia(1717-1786)was the mostfamous.展开更多
A player displays his sartorial splendor while inspecting his hand, during one of the many regular Sunday morning card games that characterize the city's public parks.
Since the Yuan Dynasty, Tibet has been formally part of the territory of China. By keeping abreast with developments in the hinterland, Tibet has maintained close relations with other provinces in China and kept up to...Since the Yuan Dynasty, Tibet has been formally part of the territory of China. By keeping abreast with developments in the hinterland, Tibet has maintained close relations with other provinces in China and kept up to date. Mutual interactions were frequent i.e. Tibetans presented tributes to the central government and vice versa, the central governments bestowed largess on Tibetans. The largess included Buddhist statues, porcelains, silks, satins, and fabulous jade ornaments. In book entitled "Memoir of...展开更多
2024年1月4日,在Web of Science网站以“cotton”或“Gossypium”为“Title”(文题)检索词查询“Web of Science Core Collection”和“Chinese Science Citation DatabaseSM”数据库中2023年发表文章,选择被引次数5及其以上文章68篇。
Background: Four factors determine the quality of an implantology kit: 1) Heat generated by the drills;2) Morphology of the osteotomy according to the diameter of the implant;3) Efficiency of collecting autologous bon...Background: Four factors determine the quality of an implantology kit: 1) Heat generated by the drills;2) Morphology of the osteotomy according to the diameter of the implant;3) Efficiency of collecting autologous bone;and 4) Osteotomy execution time. Materials and Methods: This article examines the heat produced by drills during osteotomy, focusing on the effect of the following factors: drilling technique;volume of autologous bone harvested;drilling time;implant primary stability;and the percentage of osseointegrated implants after primary healing. Discussion: The four factors mentioned above are analyzed based on the data obtained for sequential, biological, and One Drill milling techniques. Conclusions: 1) One Drill is the fastest technique for performing the osteotomy;2) All techniques stay within the biological temperature range of living bone, with the lowest increase in temperature achieved using One Drill with irrigation;3) The bone harvested showed no statistically significant differences between biological milling and the One Drill technique, both far superior to the sequential technique;and 4) There is no statistically significant difference in the number of osseointegrated implants among the three techniques analyzed.展开更多
Percutaneous or endoscopic drainage is the initial choice for the treatment of peripancreatic fluid collection in symptomatic patients.Endoscopic transgastric fenestration(ETGF)was first reported for the management of...Percutaneous or endoscopic drainage is the initial choice for the treatment of peripancreatic fluid collection in symptomatic patients.Endoscopic transgastric fenestration(ETGF)was first reported for the management of pancreatic pseu-docysts of 20 patients in 2008.From a surgeon’s viewpoint,ETGF is a similar procedure to cystogastrostomy in that they both produce a wide outlet orifice for the drainage of fluid and necrotic debris.ETGF can be performed at least 4 wk after the initial onset of acute pancreatitis and it has a high priority over the surgical approach.However,the surgical approach usually has a better success rate because surgical cystogastrostomy has a wider outlet(>6 cm vs 2 cm)than ETGF.However,percutaneous or endoscopic drainage,ETGF,and surgical approach offer various treatment options for peripancreatic fluid collection patients based on their conditions.展开更多
Contrast-enhanced endoscopic ultrasound(CH-EUS)can overcome the limi-tations of endoscopic ultrasound-guided acquisition by identifying microvessels inside inhomogeneous tumours and improving the characterization of t...Contrast-enhanced endoscopic ultrasound(CH-EUS)can overcome the limi-tations of endoscopic ultrasound-guided acquisition by identifying microvessels inside inhomogeneous tumours and improving the characterization of these tumours.Despite the initial enthusiasm that oriented needle sampling under CH-EUS guidance could provide better diagnostic yield in pancreatic solid lesions,further studies did not confirm the supplementary values in cases of tissue acquisition guided by CH-EUS.This review details the knowledge based on the available data on contrast-guided procedures.The indications for CH-EUS tissue acquisition include isoechoic EUS lesions with poor visible delineation where CH-EUS can differentiate the lesion vascularisation from the surrounding parenchyma and also the mural nodules within biliopancreatic cystic lesions,which occur in select cases.Additionally,the roles of CH-EUS-guided therapy in patients whose pancreatic fluid collections or bile ducts that have an echogenic content have indications for drainage,and patients who have nonvisualized vessels that need to be highlighted via Doppler EUS are presented.Another indication is represented if there is a need for an immediate assessment of the post-radiofrequency ablation of pancreatic neuroendocrine tumours,in which case CH-EUS can be used to reveal the incomplete tumour destruction.展开更多
This study systematically introduces the development of the world’s first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite(SSPS).First,the OMEGA 2.0 inn...This study systematically introduces the development of the world’s first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite(SSPS).First,the OMEGA 2.0 innovation design was proposed.Second,field-coupling theoretical models of sunlight concentration,photoelectric conversion,and transmitting antennas were established,and a systematic optimization design method was proposed.Third,a beam waveform optimization methodology considering both a high beam collection efficiency and a circular stepped beam shape was proposed.Fourth,a control strategy was developed to control the condenser pointing toward the sun while maintaining the transmitting antenna toward the rectenna.Fifth,a high-efficiency heat radiator design method based on bionics and topology optimization was proposed.Sixth,a method for improving the rectenna array’s reception,rectification,and direct current(DC)power synthesis efficiencies is presented.Seventh,high-precision measurement technology for high-accuracy beam-pointing control was developed.Eighth,a smart mechanical structure was designed and developed.Finally,the developed SSPS ground demonstration and verification system has the capacity for sun tracking,a high concentration ratio,photoelectric conversion,microwave conversion and emission,microwave reception,and rectification,and thus satisfactory results were obtained.展开更多
The motivation for this study is that the quality of deep fakes is constantly improving,which leads to the need to develop new methods for their detection.The proposed Customized Convolutional Neural Network method in...The motivation for this study is that the quality of deep fakes is constantly improving,which leads to the need to develop new methods for their detection.The proposed Customized Convolutional Neural Network method involves extracting structured data from video frames using facial landmark detection,which is then used as input to the CNN.The customized Convolutional Neural Network method is the date augmented-based CNN model to generate‘fake data’or‘fake images’.This study was carried out using Python and its libraries.We used 242 films from the dataset gathered by the Deep Fake Detection Challenge,of which 199 were made up and the remaining 53 were real.Ten seconds were allotted for each video.There were 318 videos used in all,199 of which were fake and 119 of which were real.Our proposedmethod achieved a testing accuracy of 91.47%,loss of 0.342,and AUC score of 0.92,outperforming two alternative approaches,CNN and MLP-CNN.Furthermore,our method succeeded in greater accuracy than contemporary models such as XceptionNet,Meso-4,EfficientNet-BO,MesoInception-4,VGG-16,and DST-Net.The novelty of this investigation is the development of a new Convolutional Neural Network(CNN)learning model that can accurately detect deep fake face photos.展开更多
Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generat...Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense research.Effective progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and informatics.However,individual molecular machines are only capable of producing nanometer work and generally have only a single functionality.In order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new paradigm.In this review,we comprehensively discuss recent developments in the collective behaviors of molecular machines.In particular,collective behavior is divided into two paradigms.One is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional materials.The other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale operations.We discuss design strategies for both modes and focus on the modulation of features and properties.Subsequently,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.展开更多
1.Introduction With the implementation of modern production strategies,such as“Industry 4.0”and“Made in China 2025,”the development of high-end mechanical equipment is gradually reaching a high degree of parameter...1.Introduction With the implementation of modern production strategies,such as“Industry 4.0”and“Made in China 2025,”the development of high-end mechanical equipment is gradually reaching a high degree of parameterization,digitalization,networking,and intelligence[1].High-end mechanical equipment no longer consists of traditional single devices,but is closely linked to the overall production process;that is,a variety of devices interact with each other and collectively form a complex system.However,faults can lead to production delays throughout the system and even seriously threaten the safety of workers[2].In addition,equipment operating in unmanned air or space vehicles(including space robots)cannot be repaired by humans if they break down[3].Until recently,the typical method of addressing machine faults was primarily the“fault cure”method,which involves manually shutting down,inspecting,and repairing the equipment to restore normal operation.Accordingly,the maintenance cycle of the traditional“fault cure”method is time-consuming,and the quality of the maintenance depends on the skills of the technician[4].展开更多
Controlling the size and distribution of potential barriers within a medium of interacting particles can unveil unique collective behaviors and innovative functionalities.We introduce a unique superconducting hybrid d...Controlling the size and distribution of potential barriers within a medium of interacting particles can unveil unique collective behaviors and innovative functionalities.We introduce a unique superconducting hybrid device using a novel artificial spin ice structure composed of asymmetric nanomagnets.This structure forms a distinctive superconducting pinning potential that steers unconventional motion of superconducting vortices,thereby inducing a magnetic nonreciprocal effect,in contrast to the electric nonreciprocal effect commonly observed in superconducting diodes.Furthermore,the polarity of the magnetic nonreciprocity is in situ reversible through the tunable magnetic patterns of artificial spin ice.Our findings demonstrate that artificial spin ice not only precisely modulates superconducting characteristics but also opens the door to novel functionalities,offering a groundbreaking paradigm for superconducting electronics.展开更多
Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical cord.MSCs have gained significa...Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical cord.MSCs have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue repair.MSCs enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC secretome.An increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.展开更多
Quasi-coherent micro-instabilities is one of the key topics of magnetic confinement fusion. This work focuses on the quasi-coherent spectra of ion temperature gradient(ITG) and trapped-electron-mode instabilities usin...Quasi-coherent micro-instabilities is one of the key topics of magnetic confinement fusion. This work focuses on the quasi-coherent spectra of ion temperature gradient(ITG) and trapped-electron-mode instabilities using newly developed far-forward collective scattering measurements within ohmic plasmas in the J-TEXT tokamak.The ITG mode is characterized by frequencies ranging from 30 to 100 k Hz and wavenumbers(k_(θρs)) less than 0.3. Beyond a critical plasma density threshold, the ITG mode undergoes a bifurcation, which is marked by a reduction in frequency and an enhancement in amplitude. Concurrently, enhancements in ion energy loss and degradation in confinement are observed. This ground-breaking discovery represents the first instance of direct experimental evidence that establishes a clear link between ITG instability and ion thermal transport.展开更多
Meroplankton play a crucial role in both benthic and pelagic ecosystems.Existing quantitative research on estimating the quantities of meroplankton groups is both underrepresented and inaccurate.To investigate and eva...Meroplankton play a crucial role in both benthic and pelagic ecosystems.Existing quantitative research on estimating the quantities of meroplankton groups is both underrepresented and inaccurate.To investigate and evaluate the influence of varying mesh sizes(505 and 160μm)on the sampling efficiency of meroplankton,we conducted an examination using two commonly used plankton nets during the spring season in the Southern Yellow Sea(SYS).Our study revealed a total of 12 meroplankton groups,with 9 groups identified in the 505-μm mesh nets and 11 groups in the 160-μm mesh nets.The results demonstrated the superior collection efficiency of the 160-μm net compared to the 505-μm net across the majority of meroplankton groups.Furthermore,we focused on exploring the abundance,distribution patterns,and realized niches of meroplankton collected by the two mesh size nets,and observed that the distribution of meroplankton closely resembled the distribution of possible benthic adults in the SYS.Correlation analysis of the six dominant groups collected in the 160-μm mesh nets revealed that seawater temperature and salinity emerged as the key environmental factors driving variations in meroplankton abundance within the SYS.This study also found that a smaller mesh size net does not necessarily capture meroplankton more comprehensively.A comprehensive understanding of the ecological characteristics of meroplankton requires the combination of two types of nets for research.Our research significantly advances our understanding of the quantification,abundance,and distribution of meroplankton,serving as a valuable contribution to the broader landscape of detailed quantitative meroplankton studies.展开更多
Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in 2021.The pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μm...Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in 2021.The pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μm.The array is divided into 16 subarrays,with pixels of 400 rows×32 columns per subarray.Each pixel incorporates two charge sensors:a diode sensor and a Topmetal sensor.The in-pixel circuit primarily consists of a charge-sensitive amplifier for energy measurements,a discriminator with a peak-holding circuit,and a time-to-amplitude converter for time-of-arrival measurements.The pixel of Topmetal-M2 has a charge input range of~0-3 k e-,a voltage output range of~0-180 mV,and a charge-voltage conversion gain of~59.56μV∕e-.The average equivalent noise charge of Topmetal-M2,which includes the readout electronic system noise,is~43.45 e-.In the scanning mode,the time resolution of Topmetal-M2 is 1 LSB=1.25μs,and the precision is^()7.41μs.At an operating voltage of 1.5 V,Topmetal-M2 has a power consumption of~49 mW∕cm~2.In this article,we provide a comprehensive overview of the chip architecture,pixel working principles,and functional behavior of Topmetal-M2.Furthermore,we present the results of preliminary tests conducted on Topmetal-M2,namely,alpha-particle and soft X-ray tests.展开更多
The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(LQMD.RMF). Using the LQMD.RMF, the properties of collective flow and pion production were investigated sys...The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(LQMD.RMF). Using the LQMD.RMF, the properties of collective flow and pion production were investigated systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the LQMD.RMF are able to describe the experimental data of STAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For various collision energies, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ratio of the pion transverse momentum spectra also increased with decreasing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich systems.However, it is difficult to constrain the stiffness of the symmetry energy with the double ratio because of the lack of threshold energy correction on the pion production.展开更多
文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hostsIll. In China, brucellosis is a national notifiable communicable disease both in animals and in human. In 2009, 35 816 brucellosis cases were reported. The annual incidence was 2.7 per 100 000 population.
文摘In the history of theQing Dynasty(1644-1911),two DalaiLamas and onePanchen Erdeni went toBeijing for an audiencewith the emperor.Theywere the 5th Dalai Lama,who went in 1652,he
文摘Zhamgyia Hutog-to was the onlyState Tutor whoreceived thehonor from the Gingemperors.As one of thefour major Living Buddhasystems of the Yellow Sect,he was he most influentialLiving Buddha in the Mon-golian area.Of the six gen-erations,3rd Zhamgyia(1717-1786)was the mostfamous.
文摘A player displays his sartorial splendor while inspecting his hand, during one of the many regular Sunday morning card games that characterize the city's public parks.
文摘Since the Yuan Dynasty, Tibet has been formally part of the territory of China. By keeping abreast with developments in the hinterland, Tibet has maintained close relations with other provinces in China and kept up to date. Mutual interactions were frequent i.e. Tibetans presented tributes to the central government and vice versa, the central governments bestowed largess on Tibetans. The largess included Buddhist statues, porcelains, silks, satins, and fabulous jade ornaments. In book entitled "Memoir of...
文摘2024年1月4日,在Web of Science网站以“cotton”或“Gossypium”为“Title”(文题)检索词查询“Web of Science Core Collection”和“Chinese Science Citation DatabaseSM”数据库中2023年发表文章,选择被引次数5及其以上文章68篇。
文摘Background: Four factors determine the quality of an implantology kit: 1) Heat generated by the drills;2) Morphology of the osteotomy according to the diameter of the implant;3) Efficiency of collecting autologous bone;and 4) Osteotomy execution time. Materials and Methods: This article examines the heat produced by drills during osteotomy, focusing on the effect of the following factors: drilling technique;volume of autologous bone harvested;drilling time;implant primary stability;and the percentage of osseointegrated implants after primary healing. Discussion: The four factors mentioned above are analyzed based on the data obtained for sequential, biological, and One Drill milling techniques. Conclusions: 1) One Drill is the fastest technique for performing the osteotomy;2) All techniques stay within the biological temperature range of living bone, with the lowest increase in temperature achieved using One Drill with irrigation;3) The bone harvested showed no statistically significant differences between biological milling and the One Drill technique, both far superior to the sequential technique;and 4) There is no statistically significant difference in the number of osseointegrated implants among the three techniques analyzed.
文摘Percutaneous or endoscopic drainage is the initial choice for the treatment of peripancreatic fluid collection in symptomatic patients.Endoscopic transgastric fenestration(ETGF)was first reported for the management of pancreatic pseu-docysts of 20 patients in 2008.From a surgeon’s viewpoint,ETGF is a similar procedure to cystogastrostomy in that they both produce a wide outlet orifice for the drainage of fluid and necrotic debris.ETGF can be performed at least 4 wk after the initial onset of acute pancreatitis and it has a high priority over the surgical approach.However,the surgical approach usually has a better success rate because surgical cystogastrostomy has a wider outlet(>6 cm vs 2 cm)than ETGF.However,percutaneous or endoscopic drainage,ETGF,and surgical approach offer various treatment options for peripancreatic fluid collection patients based on their conditions.
文摘Contrast-enhanced endoscopic ultrasound(CH-EUS)can overcome the limi-tations of endoscopic ultrasound-guided acquisition by identifying microvessels inside inhomogeneous tumours and improving the characterization of these tumours.Despite the initial enthusiasm that oriented needle sampling under CH-EUS guidance could provide better diagnostic yield in pancreatic solid lesions,further studies did not confirm the supplementary values in cases of tissue acquisition guided by CH-EUS.This review details the knowledge based on the available data on contrast-guided procedures.The indications for CH-EUS tissue acquisition include isoechoic EUS lesions with poor visible delineation where CH-EUS can differentiate the lesion vascularisation from the surrounding parenchyma and also the mural nodules within biliopancreatic cystic lesions,which occur in select cases.Additionally,the roles of CH-EUS-guided therapy in patients whose pancreatic fluid collections or bile ducts that have an echogenic content have indications for drainage,and patients who have nonvisualized vessels that need to be highlighted via Doppler EUS are presented.Another indication is represented if there is a need for an immediate assessment of the post-radiofrequency ablation of pancreatic neuroendocrine tumours,in which case CH-EUS can be used to reveal the incomplete tumour destruction.
文摘This study systematically introduces the development of the world’s first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite(SSPS).First,the OMEGA 2.0 innovation design was proposed.Second,field-coupling theoretical models of sunlight concentration,photoelectric conversion,and transmitting antennas were established,and a systematic optimization design method was proposed.Third,a beam waveform optimization methodology considering both a high beam collection efficiency and a circular stepped beam shape was proposed.Fourth,a control strategy was developed to control the condenser pointing toward the sun while maintaining the transmitting antenna toward the rectenna.Fifth,a high-efficiency heat radiator design method based on bionics and topology optimization was proposed.Sixth,a method for improving the rectenna array’s reception,rectification,and direct current(DC)power synthesis efficiencies is presented.Seventh,high-precision measurement technology for high-accuracy beam-pointing control was developed.Eighth,a smart mechanical structure was designed and developed.Finally,the developed SSPS ground demonstration and verification system has the capacity for sun tracking,a high concentration ratio,photoelectric conversion,microwave conversion and emission,microwave reception,and rectification,and thus satisfactory results were obtained.
基金Science and Technology Funds from the Liaoning Education Department(Serial Number:LJKZ0104).
文摘The motivation for this study is that the quality of deep fakes is constantly improving,which leads to the need to develop new methods for their detection.The proposed Customized Convolutional Neural Network method involves extracting structured data from video frames using facial landmark detection,which is then used as input to the CNN.The customized Convolutional Neural Network method is the date augmented-based CNN model to generate‘fake data’or‘fake images’.This study was carried out using Python and its libraries.We used 242 films from the dataset gathered by the Deep Fake Detection Challenge,of which 199 were made up and the remaining 53 were real.Ten seconds were allotted for each video.There were 318 videos used in all,199 of which were fake and 119 of which were real.Our proposedmethod achieved a testing accuracy of 91.47%,loss of 0.342,and AUC score of 0.92,outperforming two alternative approaches,CNN and MLP-CNN.Furthermore,our method succeeded in greater accuracy than contemporary models such as XceptionNet,Meso-4,EfficientNet-BO,MesoInception-4,VGG-16,and DST-Net.The novelty of this investigation is the development of a new Convolutional Neural Network(CNN)learning model that can accurately detect deep fake face photos.
基金supported by National Key R&D Program of China(2018YFA0901700)National Natural Science Foundation of China(22278241)+1 种基金a grant from the Institute Guo Qiang,Tsinghua University(2021GQG1016)Department of Chemical Engineering-iBHE Joint Cooperation Fund.
文摘Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense research.Effective progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and informatics.However,individual molecular machines are only capable of producing nanometer work and generally have only a single functionality.In order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new paradigm.In this review,we comprehensively discuss recent developments in the collective behaviors of molecular machines.In particular,collective behavior is divided into two paradigms.One is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional materials.The other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale operations.We discuss design strategies for both modes and focus on the modulation of features and properties.Subsequently,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.
基金supported by Natural Science Foundation of Beijing(3212010)National Natural Science Foundation of China(51875031 and 52242507).
文摘1.Introduction With the implementation of modern production strategies,such as“Industry 4.0”and“Made in China 2025,”the development of high-end mechanical equipment is gradually reaching a high degree of parameterization,digitalization,networking,and intelligence[1].High-end mechanical equipment no longer consists of traditional single devices,but is closely linked to the overall production process;that is,a variety of devices interact with each other and collectively form a complex system.However,faults can lead to production delays throughout the system and even seriously threaten the safety of workers[2].In addition,equipment operating in unmanned air or space vehicles(including space robots)cannot be repaired by humans if they break down[3].Until recently,the typical method of addressing machine faults was primarily the“fault cure”method,which involves manually shutting down,inspecting,and repairing the equipment to restore normal operation.Accordingly,the maintenance cycle of the traditional“fault cure”method is time-consuming,and the quality of the maintenance depends on the skills of the technician[4].
基金supported by the National Natural Science Foundation of China(Grant Nos.62288101 and 62274086)the National Key R&D Program of China(Grant No.2021YFA0718802)the Jiangsu Outstanding Postdoctoral Program。
文摘Controlling the size and distribution of potential barriers within a medium of interacting particles can unveil unique collective behaviors and innovative functionalities.We introduce a unique superconducting hybrid device using a novel artificial spin ice structure composed of asymmetric nanomagnets.This structure forms a distinctive superconducting pinning potential that steers unconventional motion of superconducting vortices,thereby inducing a magnetic nonreciprocal effect,in contrast to the electric nonreciprocal effect commonly observed in superconducting diodes.Furthermore,the polarity of the magnetic nonreciprocity is in situ reversible through the tunable magnetic patterns of artificial spin ice.Our findings demonstrate that artificial spin ice not only precisely modulates superconducting characteristics but also opens the door to novel functionalities,offering a groundbreaking paradigm for superconducting electronics.
基金supported by the National Centre for the Replacement Refinement & Reduction of Animals in Research Crack It solution “Neuroinflammation and nociception in a dish”(https://nc3rs.org.uk/crackit/news/new-solutionneuroinflammation-and-nociception-dish) fund(to AM)。
文摘Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical cord.MSCs have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue repair.MSCs enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC secretome.An increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.
基金partially supported by the National Natural Science Foundation of China (Grant Nos. 0204131240 and 11575067)the Shenzhen Municipal Collaborative Innovation Technology ProgramInternational Science and Technology (S&T) Cooperation Project (Grant No. GJHZ20220913142609017)the “Fourteenth Five-Year Plan” Basic Technological Research Project (Grant No. JSZL2022XXXX001)。
文摘Quasi-coherent micro-instabilities is one of the key topics of magnetic confinement fusion. This work focuses on the quasi-coherent spectra of ion temperature gradient(ITG) and trapped-electron-mode instabilities using newly developed far-forward collective scattering measurements within ohmic plasmas in the J-TEXT tokamak.The ITG mode is characterized by frequencies ranging from 30 to 100 k Hz and wavenumbers(k_(θρs)) less than 0.3. Beyond a critical plasma density threshold, the ITG mode undergoes a bifurcation, which is marked by a reduction in frequency and an enhancement in amplitude. Concurrently, enhancements in ion energy loss and degradation in confinement are observed. This ground-breaking discovery represents the first instance of direct experimental evidence that establishes a clear link between ITG instability and ion thermal transport.
基金Supported by the Laoshan Laboratory(Nos.LSKJ 202203700,LSKJ 202203704,LSKJ 202204005)the National Natural Science Foundation of China(NSFC)(Nos.42076166,42130411)the NSFC Ship Time Sharing Project(No.42149901)。
文摘Meroplankton play a crucial role in both benthic and pelagic ecosystems.Existing quantitative research on estimating the quantities of meroplankton groups is both underrepresented and inaccurate.To investigate and evaluate the influence of varying mesh sizes(505 and 160μm)on the sampling efficiency of meroplankton,we conducted an examination using two commonly used plankton nets during the spring season in the Southern Yellow Sea(SYS).Our study revealed a total of 12 meroplankton groups,with 9 groups identified in the 505-μm mesh nets and 11 groups in the 160-μm mesh nets.The results demonstrated the superior collection efficiency of the 160-μm net compared to the 505-μm net across the majority of meroplankton groups.Furthermore,we focused on exploring the abundance,distribution patterns,and realized niches of meroplankton collected by the two mesh size nets,and observed that the distribution of meroplankton closely resembled the distribution of possible benthic adults in the SYS.Correlation analysis of the six dominant groups collected in the 160-μm mesh nets revealed that seawater temperature and salinity emerged as the key environmental factors driving variations in meroplankton abundance within the SYS.This study also found that a smaller mesh size net does not necessarily capture meroplankton more comprehensively.A comprehensive understanding of the ecological characteristics of meroplankton requires the combination of two types of nets for research.Our research significantly advances our understanding of the quantification,abundance,and distribution of meroplankton,serving as a valuable contribution to the broader landscape of detailed quantitative meroplankton studies.
基金supported by the National Key Research and Development Program of China(No.2020YFE0202002)the National Natural Science Foundation of China(Nos.11875146 and U1932143)。
文摘Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in 2021.The pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μm.The array is divided into 16 subarrays,with pixels of 400 rows×32 columns per subarray.Each pixel incorporates two charge sensors:a diode sensor and a Topmetal sensor.The in-pixel circuit primarily consists of a charge-sensitive amplifier for energy measurements,a discriminator with a peak-holding circuit,and a time-to-amplitude converter for time-of-arrival measurements.The pixel of Topmetal-M2 has a charge input range of~0-3 k e-,a voltage output range of~0-180 mV,and a charge-voltage conversion gain of~59.56μV∕e-.The average equivalent noise charge of Topmetal-M2,which includes the readout electronic system noise,is~43.45 e-.In the scanning mode,the time resolution of Topmetal-M2 is 1 LSB=1.25μs,and the precision is^()7.41μs.At an operating voltage of 1.5 V,Topmetal-M2 has a power consumption of~49 mW∕cm~2.In this article,we provide a comprehensive overview of the chip architecture,pixel working principles,and functional behavior of Topmetal-M2.Furthermore,we present the results of preliminary tests conducted on Topmetal-M2,namely,alpha-particle and soft X-ray tests.
基金This study was supported by the National Natural Science Foundation ofChina(Nos.12147106,12175072,and 11722546)the Talent Programof South China University of Technology(No.20210115).
文摘The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(LQMD.RMF). Using the LQMD.RMF, the properties of collective flow and pion production were investigated systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the LQMD.RMF are able to describe the experimental data of STAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For various collision energies, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ratio of the pion transverse momentum spectra also increased with decreasing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich systems.However, it is difficult to constrain the stiffness of the symmetry energy with the double ratio because of the lack of threshold energy correction on the pion production.