BACKGROUND Colon cancer(CC)is one of the leading causes of cancer-related morbidity and mortality worldwide.Traditional Chinese medicine(TCM)is widely used in the treatment of various chronic diseases.CC easily metast...BACKGROUND Colon cancer(CC)is one of the leading causes of cancer-related morbidity and mortality worldwide.Traditional Chinese medicine(TCM)is widely used in the treatment of various chronic diseases.CC easily metastasizes and results in high morbidity and mortality rates.CASE SUMMARY A 71-year-old man with a 12-year history of old myocardial infarction and a 7-year history of type 2 diabetes mellitus was diagnosed with CC and underwent right hemicolectomy 1 year ago.Tumor biopsy revealed moderately poorly differentiated adenocarcinoma.Subsequently,chemotherapy with oxaliplatin and paclitaxel was administered.Anastomosis recurrence and pelvic metastasis were noted 37 d later.The patient received eight 21-d cycles of adjuvant chemotherapy with oxaliplatin and capecitabine after recurrence.However,the tumor persisted,and chemotherapy-related liver damage developed gradually.Thus,he was advised to take TCM for the recurrence and pelvic metastasis.The patient’s metastatic CC was cured after receiving TCM combined with long-term chemotherapy.CONCLUSION TCM may be an effective adjunct therapy in the treatment of patients with metastatic CC.展开更多
Colorectal cancer is malignancy of the colon or rectum. Adenocarcinoma is the most common colorectal cancer. These malignant cancer cells grow inside the colon and the rectum. Large clusters of these cells form struct...Colorectal cancer is malignancy of the colon or rectum. Adenocarcinoma is the most common colorectal cancer. These malignant cancer cells grow inside the colon and the rectum. Large clusters of these cells form structures known as tumors. Our treated patient is a 48 year old male who has undergone colorectal adenocarcinoma surgery in stage IIIB. During the surgery he was resected part of the colon with a total length of 57 cm. We started the treatment with Chinese herbs immediately after the surgery with no additional chemotherapy and radiotherapy. Herbs used in the treatment are Cordyceps sinensis, Ganoderma broken spores (Reishi) and Yunnan Baiyao. Before the surgery the patient was pale, exhausted, with abdominal pain on the left side under the ribs, Iron (Fe) was very low—7, tumor marker (CEA) was high—39.64 ng/mL, hematochezia was present and with insulin intake of 34 units (the patient is diabetic). Two months after using the herbs daily, the patient blood analysis was improved, Iron (Fe) is elevated, no hematochezia is detected, organs are with normal findings, normal color of the face is restored, post-operative scar healed very well and quickly and insulin intake is reduced from 34 to 6 units. After 6 months of treatment the results are amazing, the patient is in excellent health condition, the treatment is completed and is no longer taking any medications. With the herbal treatment we succeeded to keep the patient in good health, boost the immune system and improve the Qi energy flow.展开更多
Background:Patients with colon cancer who receive chemotherapy usually experience various gastrointestinal adverse reactions,including nausea,vomiting,and diarrhea,which make it challenging for them to adhere to treat...Background:Patients with colon cancer who receive chemotherapy usually experience various gastrointestinal adverse reactions,including nausea,vomiting,and diarrhea,which make it challenging for them to adhere to treatment.As an effective traditional Chinese medicine,the Jianpi Bushen formula has been widely used to alleviate the side effects of chemotherapy.Objective:To evaluate the efficacy and safety of Jianpi Bushen formulae for patients who undergo chemotherapy.This statistical analysis plan(SAP)is intended to enhance the transparency and research quality of our randomized controlled trial.Methods:Our study is a multicenter,double-blind,randomized controlled clinical trial.This trial aimed to compare the completion rate of chemotherapy in colon cancer patients who are using and not using Jianpi Bushen formula.To attenuate possible selection bias in the final report,we declared the overall trial design,outcome measures,subgroup analyses,and safety measures.Also,we described the data management and statistical analysis methods in detail.Conclusion:The SAP provides more detailed information than the trial protocol for data management and statistical analysis methods.Further post-hoc analyses can be performed by referring to the SAP,and possible selection bias can be attenuated.展开更多
基金Supported by The National Natural Science Foundation of China,No.81904049Beijing Natural Science Foundation,No.7202118+1 种基金The National Traditional Chinese Medicine Inheritance Innovation Project,No.ZYYCXTD-C-202006-9The Basic Scientific Research Foundation of Beijing University of Chinese Medicine,No.2021-JYB-XJSJJ-033.
文摘BACKGROUND Colon cancer(CC)is one of the leading causes of cancer-related morbidity and mortality worldwide.Traditional Chinese medicine(TCM)is widely used in the treatment of various chronic diseases.CC easily metastasizes and results in high morbidity and mortality rates.CASE SUMMARY A 71-year-old man with a 12-year history of old myocardial infarction and a 7-year history of type 2 diabetes mellitus was diagnosed with CC and underwent right hemicolectomy 1 year ago.Tumor biopsy revealed moderately poorly differentiated adenocarcinoma.Subsequently,chemotherapy with oxaliplatin and paclitaxel was administered.Anastomosis recurrence and pelvic metastasis were noted 37 d later.The patient received eight 21-d cycles of adjuvant chemotherapy with oxaliplatin and capecitabine after recurrence.However,the tumor persisted,and chemotherapy-related liver damage developed gradually.Thus,he was advised to take TCM for the recurrence and pelvic metastasis.The patient’s metastatic CC was cured after receiving TCM combined with long-term chemotherapy.CONCLUSION TCM may be an effective adjunct therapy in the treatment of patients with metastatic CC.
文摘Colorectal cancer is malignancy of the colon or rectum. Adenocarcinoma is the most common colorectal cancer. These malignant cancer cells grow inside the colon and the rectum. Large clusters of these cells form structures known as tumors. Our treated patient is a 48 year old male who has undergone colorectal adenocarcinoma surgery in stage IIIB. During the surgery he was resected part of the colon with a total length of 57 cm. We started the treatment with Chinese herbs immediately after the surgery with no additional chemotherapy and radiotherapy. Herbs used in the treatment are Cordyceps sinensis, Ganoderma broken spores (Reishi) and Yunnan Baiyao. Before the surgery the patient was pale, exhausted, with abdominal pain on the left side under the ribs, Iron (Fe) was very low—7, tumor marker (CEA) was high—39.64 ng/mL, hematochezia was present and with insulin intake of 34 units (the patient is diabetic). Two months after using the herbs daily, the patient blood analysis was improved, Iron (Fe) is elevated, no hematochezia is detected, organs are with normal findings, normal color of the face is restored, post-operative scar healed very well and quickly and insulin intake is reduced from 34 to 6 units. After 6 months of treatment the results are amazing, the patient is in excellent health condition, the treatment is completed and is no longer taking any medications. With the herbal treatment we succeeded to keep the patient in good health, boost the immune system and improve the Qi energy flow.
基金funded by the Key R&D project of the Ministry of Science and Technology,China(2017YFC1700604).
文摘Background:Patients with colon cancer who receive chemotherapy usually experience various gastrointestinal adverse reactions,including nausea,vomiting,and diarrhea,which make it challenging for them to adhere to treatment.As an effective traditional Chinese medicine,the Jianpi Bushen formula has been widely used to alleviate the side effects of chemotherapy.Objective:To evaluate the efficacy and safety of Jianpi Bushen formulae for patients who undergo chemotherapy.This statistical analysis plan(SAP)is intended to enhance the transparency and research quality of our randomized controlled trial.Methods:Our study is a multicenter,double-blind,randomized controlled clinical trial.This trial aimed to compare the completion rate of chemotherapy in colon cancer patients who are using and not using Jianpi Bushen formula.To attenuate possible selection bias in the final report,we declared the overall trial design,outcome measures,subgroup analyses,and safety measures.Also,we described the data management and statistical analysis methods in detail.Conclusion:The SAP provides more detailed information than the trial protocol for data management and statistical analysis methods.Further post-hoc analyses can be performed by referring to the SAP,and possible selection bias can be attenuated.
