Rationale for Treatment of Common Cold and Flu with Multi-Ingredient Combination Products for Multi-Symptom Relief in Adults

This up-to-date overview will look at the rationale for the recommendation of combination products for multi-symptom relief of common cold and flu. Common cold and flu are defined by their multi-symptom nature with data showing a variety of symptoms reported simultaneously each day over the first six days of illness. Multi-ingredient combination products for multi-symptom relief are formulated to safely, simply, and simultaneously treat multiple symptoms when used as directed. The rationale for the formulation combination products for common cold and flu is therefore practical, logical and reasonable. No evidence has been found that multi-symptom relief medicines are inherently less safe than single-active ingredient medicines. Multi-symptom relief combination products containing several active ingredients provide a safe, effective, cost-effective, and convenient way of treating the multiple symptoms of common cold and flu, when used as directed. This therapy requires some special information for the patient to be provided by the physician and the pharmacist.

Regulatory perspectives of combination products

Combination products with a wide range of clinical applications represent a unique class of medical products that are composed of more than a singular medical device or drug/biological product.The product research and development,clinical translation as well as regulatory evaluation of combination products are complex and challenging.This review firstly introduced the origin,definition and designation of combination products.Key areas of systematic regulatory review on the safety and efficacy of device-led/supervised combination products were then presented.Preclinical and clinical evaluation of combination products was discussed.Lastly,the research prospect of regulatory science for combination products was described.New tools of computational modeling and simulation,novel technologies such as artificial intelligence,needs of developing new standards,evidence-based research methods,new approaches including the designation of innovative or breakthrough medical products have been developed and could be used to assess the safety,efficacy,quality and performance of combination products.Taken together,the fast development of combination products with great potentials in healthcare provides new opportunities for the advancement of regulatory review as well as regulatory science.

Numerical Investigation of Combined Production of Natural Gas Hydrate and Conventional Gas

Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.

RESEARCH ON COMBINATION AND PLANNING OF PROCESSING UNITS UNDER CIMS CONDITION

A method of the rational combinging and planning of the given processing machines into units under the condition of computer integrated manufacturing systems is presented. Here the modelling method is a kind of queuing network model with the change of productivity, which has been checked in the reality and effectivencss by a manufacturing case in China

Requirements for Evaluation on Drug-medical Device

The administration of combination products in U.S.Food and Drug Administration(FDA)are analyzed and summarized in this paper.Furthermore,the technical evaluation on drug-medical device in the State Food and Drug Administration of China(SFDA)is also illustrated.Meanwhile,this paper discusses how to promote the development of drug-medical device in the administration and technical evaluation.

Perforation optimization of layer-penetration fracturing for commingling gas production in coal measure strata

Optimization of fracturing perforation is of great importance to the commingling gas production in coal measure strata.In this paper,a 3 D lattice algorithm hydraulic fracturing simulator was employed to study the effects of perforation position and length on hydraulic fracture propagation in coal measures of the Lin-Xing block,China.Based on field data,three lithologic combinations are simulated:1)a thick section of coal seam sandwiched by sandstones;2)a thin coal seam layer overlay by gas-bearing tight sandstone;3)two coal seams separated by a thin layer of sandstone.Our simulation shows that perforation position and length in multi-layer reservoirs play a major role in hydraulic fracture propagation.Achieving maximum stimulated volume requires consideration of lithologic sequence,coal seam thickness,stress states,and rock properties.To improve the combined gas production in coal measure strata,it is possible to simultaneously stimulate multiple coal seams or adjacent gas-bearing sandstones.In these cases,perforation location and length also significantly impact fracture propagation,and therefore should be carefully designed.Our simulation results using 3 D lattice algorithm are qualitatively consistent with laboratory physical simulation.3 D lattice models can be used to effectively simulate the fracture propagation through layers in coal measure strata.The numerical results provide guidance for perforation optimization in the hydraulic fracturing of coal measure strata.

Standards for Tunnel and Road LED Lighting Application Technologies

The paper summarizes the research on the development of standards for tunnels and roads LED lighiing application in Shanghai. analyzes the existing problems on LED road lamps and lighting design, introduces the experiments and testing results, and summarizes current problems of LED street lighting, proposing that LED lighting energy conservation should he ＂systematic energy saving＂ throughout the full life cycle based on the integration of products and applications.

Research on Recreational Intention and Experience in Tourism-Take Nantou Ancient City as an Example

In recent years,under the guidance of the national“all-for-one tourism”and“integration of culture and tourism”development policies,humanistic leisure tourism has become the current hot spot in the development of Chinese tourism industry.In 2013,China promulgated the National Tourism and Leisure Outline(2013-2020),which boosted the development of tourism and leisure consumption of urban and rural residents.In 2016,the State Council issued the“Several Opinions on Further Promoting the Construction of New Urbanization”,which clearly stated that it is necessary to“accelerate the cultivation of characteristic small towns”.The construction of small towns(blocks)led by the integration of culture and tourism has gradually become a new driving force for local economic development.In 2020,the global outbreak of the COVID-19 and normalized prevention and control measures have made the choice of tourism and leisure destinations more localized and short-distance.Characteristic leisure blocks and small towns have increasingly become important destinations for people to travel and leisure activities.Therefore,this article takes Shenzhen Nantou Ancient City as the research area,and uses literature review,questionnaire survey,and statistical survey methods(SPSS.25 and PLS.3.0)to obtain relevant literature and data and describe them.Statistical analysis and confirmatory factor analysis are designed to examine the relationship between the cultural authenticity of leisure blocks,product combination,accessibility,the sense of place identification,recreational intentions,and experience quality,diagnose and discover tourism from them,discover the problems existing on the supply side of tourism object,and provide guidance and suggestions for the construction and development of cultural tourism and leisure characteristic blocks.Finally,this paper tests 10 hypotheses and draws research conclusions:(1)Cultural authenticity has positive impact on recreational intention,place identification,and experience quality in humanistic leisure tourism.(2)Tourism product combination has positive impact on recreational intention and experience quality.(3)Accessibility can affect recreational intention and experience quality in a positive way.(4)Place identification can affect recreational intention in a positive way.(5)Experience quality has positive impact on recreational intention and place identification.

Expediting the transition from replacement medicine to tissue engineering

In this article,an expansive interpretation of“Tissue Engineering”is proposed which is in congruence with classical and recent published definitions.I further simplify the definition of tissue engineering as:“Exerting systematic control of the body’s cells,matrices and fluids.”As a consequence,many medical therapies not commonly considered tissue engineering are placed in this category because of their effect on the body’s responses.While the progress of tissue engineering strategies is inexorable and generally positive,it has been subject to setbacks as have many important medical therapies.Medical practice is currently undergoing a transition on several fronts(academics,start-up companies,going concerns)from the era of“replacement medicine”where body parts and functions are replaced by mechanical,electrical or chemical therapies to the era of tissue engineering where health is restored by regeneration generation or limitation of the body’s tissues and functions by exploiting our expanding knowledge of the body’s biological processes to produce natural,healthy outcomes.

Key issues in development of offshore natural gas hydrate

As a new clean energy resource in the 21st century,natural gas hydrate is considered as one of the most promising strategic resources in the future.This paper,based on the research progress in exploitation of natural gas hydrate(NGH)in China and the world,systematically reviewed and discussed the key issues in development of natural gas hydrate.From an exploitation point of view,it is recommended that the concepts of diagenetic hydrate and non-diagenetic hydrate be introduced.The main factors to be considered are whether diagenesis,stability of rock skeleton structure,particle size and cementation mode,thus NGHs are divided into 6 levels and used unused exploitation methods according to different types.The study of the description and quantitative characterization of abundance in hydrate enrichment zone,and looking for gas hydrate dessert areas with commercial exploitation value should be enhanced.The concept of dynamic permeability and characterization of the permeability of NGH by time-varying equations should be established.The‘Three-gas co-production’(natural gas hydrate,shallow gas,and conventional gas)may be an effective way to achieve early commercial exploitation.Although great progress has been made in the exploitation of natural gas hydrate,there still exist enormous challenges in basic theory research,production methods,and equipment and operation modes.Only through hard and persistent exploration and innovation can natural gas hydrate be truly commercially developed on a large scale and contribute to sustainable energy supply.

Refreshing China’s Labor Education in the New Era: Policy Review on Education Through Physical Labor

Purpose:This study reviews China’s labor education theories and policies to reveal the main objectives,contents,and methods of the new era,as well as analyzes future development in labor education.Design/Approach/Methods:In addition to reviewing the relevant labor education theories,this study examines China’s labor education policies using historical documents and current policy texts.Marxist and traditional approaches to labor education,as well as the historical development of education in China,provide the macroscopic backdrop of this study’s analysis of the persistence and innovativeness of China’s labor education policies.Findings:China’s labor education policy has placed labor education on the same level as that in morality,intellect,sports,and aesthetics,thereby endowing labor education with new meaning.Labor education seeks to cultivate workers with all-round physical and mental development.Becoming more varied over time,labor education now involves the cultivation of skills,technological capacities,creative thinking,labor habits,and emotional development.Approaches and methods include formal programs and teaching,education in daily life at home and school,as well as practical activities outside of school.Originality/Value:This study identifies the meaning of labor education in different eras and analyzes the objectives,contents,and methods of China’s current policies on labor education,as well as its future developmental trends.In doing so,this study provides a useful reference for the implementation of labor education in elementary and middle schools.

Energy dependence of resonance production in relativistic heavy ion collisions

The production of the hadronic resonances K^＊0（892）,φ（1020）,∑^＊（1385）,and Ξ^＊（1530） in central AA collisions at √SNN=17.3,200,and 2760 GeV is systematically studied.The direct production of these resonances at system hadronization is described by the quark combination model and the effects of hadron multiple-scattering stage are dealt with by a ultra-relativistic quantum molecular dynamics model（UrQMD）.We study the contribution of these two production sources to final observation and compare the final spectra with the available experimental data.The pT spectra of K^＊0（892） calculated directly by quark combination model are explicitly higher than the data at low pT≤1.5 GeV,and taking into account the modification of rescattering effects,the resulting final spectra well agree with the data at all three collision energies.The rescattering effect on φ（1020） production is weak and including it can slightly improve our description at low p_T on the basis of overall agreement with the data.We also predict the pT spectra of ∑^＊（1385） and Ξ^＊（1530）,to be tested by the future experimental data.

Some Inequalities for L_p-Dual Mixed Quermassintegrals

Wang and Zhang defined a type of Lp-dual mixed quermassintegrals based on the Lp-radial combinations and dual quermassintegrals of star bodies. In the article, the product inequalities for this Lp-dual mixed quermassintegrals are established. As the applications, we obtain the lower bounds of dual quermassintegrals product. Further, the Brunn-Minkowski type inequality and the cycle inequality for the Lp-dual mixed quermassintegrals are given.