Study on the Epistemology Development of the Correlation between Human Beings and Nature

This study aimed to alert people that the harmony between human beings and nature has already become an urgent problem. All people are responsible for maintaining the harmony, which is the also the inexorable trend of historical development. Reviewing the evolution history of human kind, the relationship between human beings and nature from harmony to imbalance, from imbalance to a new harmony was analyzed from the macro perspective, and it was pointed out that the present society is in the transitional phase from imbalance to a new harmony and also a phase that people are consciously coordinating their relationship with nature. It was found through the study that a harmonious society relies on the harmony between human beings and nature, and the latter is a necessary condition for a real harmonious society, however, people always forget such a principle. The imbalanced relationship between human beings and nature has seriously influenced many aspects of social harmony, and become instable factors in China and international society, even threatened the development and survival of human beings. Thus, all people should make joint efforts in creating win-win conditions for the development between human beings and nature, and ensuring offspring a healthy and green earth.

The Ecological Landscape with the Integration of Humanistic Culture and Nature Environment —A Case Study of Landscape Transformation in Baoyan Eco-Tourism Garden of Changshu City

Based on the landscape ecology theory,this paper analyzed the ecology concept and the existing misconceptions of landscape design from the perspective of ecology.The misconceptions included the excessive using of ecological concepts,undue emphasis on the natural features of ecology,and endowing landscape with human cultural blindly.Taking Baoyan eco-tourism garden landscape renovation as an example,this study analyzed the superior natural conditions of this garden,the negative status in the current development process which included the conservative development and construction,singleness of entertainment,cultural educational and the other activities,disorder of landscape structure,lack of cultural landscape,weakness of landscape features and the unremarkable competitive advantages.To construct an ecological landscape with integration of humanistic and nature features,this paper proposed "ecological gardens" as the theme,following the design concept which made full integration of creating cultural landscape with the improvement and protection of natural ecological environment.Finally,the author elaborated such kind of ecological landscape from the following 4 aspects,including the integration,protection,restoration,and creation of landscape.

Disitamab vedotin combined with apatinib in gastric cancer: A case report and review of literature

BACKGROUND In patients with human epidermal growth factor receptor 2(HER2)-overex-pressing gastric cancer(GC),the combination of HER2 targeting and a standard first-line chemotherapy regimen has been demonstrated to significantly improve their prognosis.However,in a proportion of patients,cancer progresses within a short period of time,and there is currently no standard treatment after disease progression.CASE SUMMARY This study presents a case of a 51-year-old male with advanced GC who un-derwent radical resection(Billroth type II subtotal gastrectomy and gastrojejun-ostomy)and resection of liver metastases.Immunohistochemical staining revealed a HER2 score of 2+,a dMMR status,and a Ki67 proliferation index of 30%to 40%.The gene test results indicated the presence of ERBB2 amplification and a PD-L1 expression level of less than 5%.Since December 2021,the patient has experienced disease progression during both first-line(two cycles of KN026 combined with KN046)and second-line(five cycles of nivolumab combined with trastuzumab and SOX chemotherapy)treatment regimens.The patient's prognosis following the first and second lines of treatment was unfavorable,with pro-gression occurring in a relatively short time.For third-line therapy,disitamab vedotin(RC48)plus apatinib was used.At the time of this report,the patient had achieved a progression-free survival(PFS)of 25.8 months,which exceeded the median survival time for patients with advanced GC.CONCLUSION Despite the unfavorable prognosis associated with advanced GC,the imple-mentation of personalized treatment approaches may still prove beneficial for select patients.In patients with HER2-positive GC with extensive metastatic involvement,the use of the HER2-targeted combination with apatinib has demonstrated the potential to prolong both PFS and overall survival.

Thymoquinone anticancer activity is enhanced when combined with royal jelly in human breast cancer

BACKGROUND Breast cancer is the most common cause of the majority of cancer-related deaths in women,among which triple-negative breast cancer is the most aggressive type of breast cancer diagnosed with limited treatment options.Thymoquinone(TQ),the main bioactive constituent of Nigella sativa,has been extensively studied as a potent anticancer molecule against various types of cancers.Honeybee products such as the royal jelly(RJ),the nutritive secretion fed to honeybee queens,exhibit a variety of biological activities besides its anticancer effect.However,the anticancer activity of the combination of TQ and RJ against breast cancer is still unknown.AIM To investigate cytotoxicity of RJ in FHs 74 Int cells and the anticancer effects of TQ,RJ,and their combinations in the MDA-MB-231 cell line.METHODS Cells were treated with TQ,RJ,and their combinations for 24 h.Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,we determined the half-maximal inhibitory concentration of TQ.Trypan blue and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were then performed to assess the cell viability in response to different treatment conditions.Cell death and cycle regulation were investigated using propidium iodide deoxyribonucleic acid staining followed by flow cytometry in response to a single dose of TQ,RJ,and their combination.Immunostaining for cleaved caspase 3 and Ki67 expression was used to determine apoptosis induction and changes in cell proliferation.RESULTS TQ alone inhibited cell viability in a dose-dependent manner at concentrations below and above the half-maximal inhibitory concentration.RJ exhibited relatively nontoxic effects against MDA-MB-231 cells and FHs 74 Int small intestinal cells at concentrations below 5μg/mL.High doses of RJ(200μg/mL)had greater toxicity against MDA-MB-231 cells.Interestingly,the inhibition of cell viability was most pronounced in response to 15μmol/L TQ and 5μg/mL RJ.A dose of 15μmol/L TQ caused a significant increase in the PreG1 population,while a more pronounced effect on cell viability inhibition and PreG1 increase was observed in response to TQ and RJ combinations.TQ was the main inducer of caspase 3-dependent apoptosis when applied alone and in combination with RJ.In contrast,no significant regulation of Ki67 expression was observed,indicating that the decrease in cell viability was due to apoptosis induction rather than to inhibition of cell proliferation.CONCLUSION This study is the first to report enhanced anticancer effects of TQ and RJ combination against MDA-MB-231 breast cancer cells,which could confer an advantage for cancer therapy.

ANALYSIS OF HUMAN PLACENTA BY ^(31)P NUCLEAR MAGNETIC RESONANCE AND THIN-LAYER CHROMATOGRAPHY SCANNING COMBINED WITH THE CORRECTIVE METHOD OF ABSORBANCE PROPORTIONAL COEFFICIENT

Five phospholipids in human placenta were determined by phosphorus 31 nuclear magnetic resonance(^(31)P NMR)spectroscopy and thin-layer chromatography(TLC) scanning combined with the corrective method of absorbance proportional coefficient. The NMR spectrometer used this investigation was a Bruker AM-500 spectrometer operating at 202.4 MHz for ^(31)P chemical shifts are relative to 85% phosphoric acid. TIC was carried out by silica gel H plate developed in chloroform-methanol-glacial acetic acid-ethanol-water(25:4:6:2:0.5),with Vaskovsky reagent as colour -developing agent of phospholipids.

The Relationship between Nature and Human Beings in Wide Sargasso Sea

Famous for giving voice to Bertha, the marginalized mad woman in the attic in Jane Eyre, Wide Sargasso Sea is filled with vivid description of nature, which contributes to the successful characterization of main characters and shows the theme of the relationship between nature and human beings. However few attention is paid to that theme. The mythological and archetypal approach is thus adopted to analyze three major characters and fill the gap. Antoinette is viewed as the daughter of nature. Christophine functions as the incarnation of nature. Rochester plays the role of the intruder who does harm to nature. To conclude, Wide Sargasso Sea is not only a criticism of anthropocentrism but also a warning bell to the stereotyped opposition in the western culture. After the successful shaking of the fixed order, Wide Sargasso Sea also drops a hint that there exists the hope to build a new world where human beings and nature, men and women keep a harmonious and balanced relationship.

Comparison and Inspiration of the Theme of Relationship between Human Beings and Nature in the Field of Literature between China and the West

The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and behavior patterns,expressing the relationship between human beings and nature. Through expressions of literature in China and the West,we draw lessons from W estern literary expressions in the developing relationship between man and nature,and get inspiration for the development of Chinese literature.

The Relationship Between Human Being and Nature in The Call of the Wild: A Perspective of Eco-Criticism

The Call of the Wild,one of the most popular novels in the early twentieth-century America,is the first best-selling book of Jack London.As far as this novel is concerned,the main character Buck represents nature.He deals with all kinds of peo⁃ple.The good treat Buck(nature)very well and live harmoniously with him.The evil treat Buck(nature)maliciously,just like fight⁃ing against their enemies.This novel shows the damages people did to nature and the imbalance between human being and nature.The author’s ecological awareness finds its full expression in the novel.The relationship between human and nature in the novel will be analyzed from the perspective of eco-criticism and the ecological theme of the novel will be discussed in a bid to arouse peo⁃ple’s ecological consciousness and environmental protection awareness.

Discussion on Action and Potential of Fenlong Megascience in the Symbiosis between Human and Nature

The fourth new farming model Fenlong is identified as megascience for the first time. Fenlong can be directly applied to farming of farmland, remoulding of mortar black soil and saline alkali land and development of degraded grassland. Deep loosening can create huge soil reservoirs, reduce fertilization, promote indi- rectly the improvement of river water fisheries and water sources and the upgrading of shaping and hydropower industry, thus making a new round of mobilization and pooling of natural resources. As a result, the nature is able to produce good food needed by human, the spatial dimension of the land is increased, the natural pre- cipitation storage is increased, the flood and drought disasters are reduced, the eco-environment is improved, and the economic benefits are increased. Fenlong is not restricted to global application by ecological region and crop variety and is not subject to the time-space constraints for a hundred thousand years. On the basis of utilizing the heaven and earth resources, it brings about a huge effect of mega- science. Compare with traditional farming, the depth under the mode of Fenlong is increased by 2-3 times, the contents of nutrient, water, oxygen and microorganism in the soil are increased by 10%-200%, the content of pale salt is increased by 20%-40%, the temperature is increased by 2-4 ~C, and the photosynthetic efficiency of crops is improved by 10%. Under the cultivation mode of Fenlong, the yield of crop applied with no fertilizers is increased by more than 10%, crop yield is still in- creased by more than 5% when the application amount of chemical fertilizer is re- duced by 10%-20%. Under the farming mode of Fenlong combined with no in- crease in fertilization, the crop yield, crop quality, farming efficiency, natural precipi- tation storage and air humidity are increased by 10%-50%, 5%, 15%, 100% and 5%, respectively, and the emissions of methane and other gases are reduced by more than 5%. Even in mortar black soil, saline alkali land and degraded grassland, the yield is still increased by 15%-50%. These improvement effects can last for many years, helping achieve the real harmonious coexistence between human and nature.

Human Nature: A Reflection of “The Minister’s Black Veil: A Parable”

According to Hawthorne’s "The Minister’s Black Veil: A Parable", we can know that the author thinks human nature is evil. This paper discusses the following questions: what is human nature? Whether human nature exists? And how to realize human nature?

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line chemotherapy.The human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in PDAC.CASE SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 month.She had not developed any grade 2 or above treatment-related adverse events at any point.Percentage of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no radiotherapy.CONCLUSION PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

An Exploration of Human Nature and a Challenge Against Conventional Morality of American South——On the Theme ofThe Adventures of Huckleberry Finn

文章通过对马克.吐温名著《哈克贝利.芬历险记》主题的分析,深刻探讨了马克.吐温对人的本性的探索和对美国南方传统道德的挑战,并进而提出了与现今社会紧密联系的人文关怀问题。

Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer

Objective:To test the anticancer potential activity of the combination of thymoquinone(TQ)and resveratrol(RES) against breast cancer in mice.Methods:The antiproliferative activity of TQ.RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay.The combination index was calculated using isobolographic method.Balb/C mice were inoculated with EMT6/P cells and in vivo antitumor activity was evaluated.Results:The combination therapy caused significant decrease in tumor size with a percentage cure of 60%.The combination therapy induced geographic necrosis,enhanced apoptosis,and decreased VEGF expression.Serum levels of IFN-y were elevated in mice treated with combination therapy with no liver and kidney toxicity.Conclusions:The combination of TQ and RES against breast cancer in mice can work synergistically.The anticancer effect of this combination is mediated by apoptosis induction,angiogenesis inhibition and immune modulation.

Numerical Investigation of Combined Production of Natural Gas Hydrate and Conventional Gas

Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.

From the Subjectivity of Human Rights to the Universality of Human Rights——A Preliminary Interpretation of the Theory on the Subjectivity of Human Rights

Universality is one of the essential characteristics of human rights, but there is a substantive difference between idealism and realism in understanding the concept of universality of human rights. The concepts of radical universality and strong universality based on the concept of natural human rights are too idealistic and thus have a high risk of being alienated into a tool of international re-pression in practice. On the contrary, the theory on the subjectivity of human rights can effectively defuse this risk brought about by radical universality and strong universality. Advocating a transition from the universality of human rights to the subjectivity of human rights not only keeps in line with the actual construction process of international human rights, but can also effectively interpret the practical difficul-ties in the realization process of international human rights. Therefore, it can be used as another alternative theory on human rights beyond the theory of natural human rights.

Twenty-eight Cases of Diabetic Foot Ulcer and Gangrene Treated with the Chinese Herbal Medicine Combined with Injection of Ahylsantinfarctase

Since 1995, the Chinese herbal medicine for supplementing qi and activating blood circulation combined with injection of ahylsantinfarctase into the femoral artery has been used in 28 cases of diabetes complicated with gangrene and ulcer of the foot, with quite good therapeutic effects as reported in the following.……

Process Simulation of a 620 Mw-Natural Gas Combined Cycle Power Plant with Optimum Flue Gas Recirculation

The main objective of this investigation is to obtain an optimum value for the flue gas recirculation ratio in a 620 MW-Natural Gas Combined Cycle (NGCC) power plant with a 100% excess air in order to have a composition of the exhaust gas suitable for an effective absorption by amine solutions. To reach this goal, the recirculated flue gas is added to the secondary air (dilution air) used for cooling the turbine. The originality of this work is that the optimum value of a Flue Gas Recirculation (FGR) ratio of 0.42 is obtained from the change of the slope related to the effects of flue gas recirculation ratio on the molar percentage of oxygen in the exhaust gas. Compared to the NGCC power plant without flue gas recirculation, the molar percentage of carbon dioxide in the flue gas increases from 5% to 9.2% and the molar percentage of oxygen decreases from 10.9% to 3.5%. Since energy efficiency is the key parameter of energy conversion systems, the impact of the flue gas recirculation on the different energy inputs and outputs and the overall efficiency of the power plant are also investigated. It is found the positive effects of the flue gas recirculation on the electricity produced by the steam turbine generator (STG) are more important than its cooling effects on the power output of the combustion turbine generator (CTG). The flue gas recirculation has no effects on the water pump of the steam cycle and the increase of energy consumed by the compressor of flue gas is compensated by the decrease of energy consumed by the compressor of fresh air. Based on the Low heating value (LHV) of the natural gas, the flue gas recirculation increases the overall efficiency of the power plant by 1.1% from 57.5% from to 58.2%.

Thirty Cases of Acute Lumbar Sprain Treated by Acupuncture Combined with Point-Injection at Tianzhu

In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the following.

Systematic and Theoretical Unfolding of Research on Xi Jinping’s Discourses on Respecting and Protecting Human Rights

Xi Jinping’s discourses on respecting and protect-ing human rights stand as a shining example of the sinicization and modernization of Marxist human rights theory,embodying profound theoretical,political,practical,and cultural logic.Existing research has conducted comprehensive and systematic theoretical analysis and academic extractions on the following contents:the core essence in-herent in these important discourses,including the“theory of human rights concepts,”the“theory of human rights paths,”the“theory of human rights practices,”the“theory of human rights protection,”and the“theory of human rights governance,”along with their profound theoretical significance,practical significance,and global signifi-cance.In the future,researchers should emphasize efforts on studying the original texts and understanding the original principles.While focusing on the precision of concepts,the scientific nature of the prop-ositions,the maturity of theoretical systems,and the rigor of internal logic related to Xi Jinping’s discourses on respecting and protecting human rights,researchers should also pay attention to constructing a discourse system on human rights from the dimensions of discourse power,discourse cluster,and discourse field.Researchers should be adept at drawing innovative insights into human rights theory from China’s vibrant human rights practices and the vast masses of people.This approach will facilitate the systematic unfolding,academic trans-formation,and innovative development of Xi Jinping’s discourses on respecting and protecting human rights.

The Evil of Human Nature in Lord of the Flies

William Golding is a very genuinely serious writer because he holds a very strong pessimistic view towards human nature.Lord of the Flies is Golding's first novel.Especially,the novel shows the evil of human nature through little children.In the story,Golding puts those children in an isolated island,which far from the civilization world and without adults'control.The evil nature of human beings explored in the children without the rule of civilization.What's more,Lord of the Flies is a novel which shows the original evil of human's nature.We can learn some evil of human beings from Lord of the Flies as the same as reading Bible.My paper will analyze the evils contained in the novel through three steps.First,analyze main characters and symbol things in the novel.Second,analyze some important things or affaires in the novel.At last,find some more evils of human or society.