Protective effect of borneol combined with safflower on neurovascular unit in rats with ischemic stroke

Background:Compatibility is a characteristic of the clinical application of traditional Chinese medicine,often leading to enhanced therapeutic effects.In the treatment of cerebral ischemia,blood-activating and open orifices herbs are frequently used individually;however,their combination is not commonly practiced.This study aims to investigate the impact of combining safflower and borneol as examples of open orifices herbs and blood-activating herbs on the neurovascular unit in rats with ischemic stroke.The objective is to determine whether this combination exhibits superior therapeutic efficacy compared to using borneol or safflower alone while exploring its underlying mechanism.These findings may provide novel insights for clinical treatments.Methods:SD male rats were randomly divided into 6 groups:sham operation group,model group,borneol group(0.1 g/kg),safflower group(5 g/kg),borneol combined with safflower group(0.1 g/kg+5 g/kg)and nimodipine group(0.01 g/kg).The middle cerebral artery cerebral ischemia(MCAO)model were prepared after continuous intragastric administration for 7 days in each group,the neurological function of each group were scored 24h after operation,and water content in brain tissue were measured by weighing method.The activity of superoxide dismutase(SOD)and the contents of nitric oxide(NO)and malondialdehyde(MDA)in brain tissue and serum were determined by spectrophotometry,and the mRNA expressions of matrix metalloproteinase 2(MMP-2),tight junction protein 1(ZO-1),vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)were detected by Real time PCR.Result:Compared with the model group,the group treated with borneol combined with safflower exhibited a significant decrease in the neural function score of MCAO rats(P<0.01).Additionally,it led to a reduction in brain tissue water content(P<0.01),elevated SOD activity,and reduced levels of NO and MDA in both serum and brain tissue(P<0.01 or P<0.05).Moreover,this treatment resulted in a decrease in the mRNA expression of MMP-2 and an increase in ZO-1 in brain tissue,along with an increase in the mRNA expression of VEGF and BDNF(P<0.01).Conclusion:Borneol combined with safflower demonstrates a protective effect on the neurovascular unit in rats with ischemic stroke.This effect is likely associated with increased SOD activity,reduced MDA and NO content in both serum and brain tissue of MCAO rats,and a decrease in MMP-2 mRNA expression in brain tissue,coupled with an increase in ZO-1,VEGF,and BDNF mRNA expression.These effects were superior to those observed with borneol or safflower administered alone.

Short-Term Scheduling of Combined Cycle Units Using Mixed Integer Linear Programming Solution

Combined cycle plants (CCs) are broadly used all over the world. The inclusion of CCs into the optimal resource scheduling causes difficulties because they can be operated in different operating configuration modes based on the number of combustion and steam turbines. In this paper a model CCs based on a mixed integer linear programming approach to be included into an optimal short term resource optimization problem is presented. The proposed method allows modeling of CCs in different modes of operation taking into account the non convex operating costs for the different combined cycle mode of operation.

Dynamics Analysis of Square Unit and its Combined Mechanism with Joint Clearance

The deployable mechanisms consisting of square units are widely applied in aeronautics and astronautics,biomedicine, architecture and other fields, and joint clearance in such a mechanism is unavoidable. This study is carried out to accurately investigate the dynamic property of the mechanism.Firstly,a dynamics model was built by considering the motion characteristics between elements of joint with clearances. Secondly,based on Floures contact force model and LuGre friction force model,the tangential and normal contact force of revolute pair element with clearance were calculated respectively. Finally,square combined mechanisms' dynamic analytical method considering joint clearance was investigated, and constraint renege problem was resolved by adopting Baumgarte stable constraint method in integration process.Analytical result indicates that the impact of joint clearance on dynamic property of square combined mechanism should not be neglected.

Model Selection of Gas Turbine for Large Scale Gas-Fired Combined Cycle Power Plant

This paper briefs the configuration and performance of large size gas turbines and their composed combined cycle power plants designed and produced by four large renown gas turbine manufacturing firms in the world, providing reference for the relevant sectors and enterprises in importing advanced gas turbines and technologies.

Combined exercise improves gastrointestinal motility in psychiatric in patients

AIM To examine the effect of combined exercise on colonic transit time(CTT) in admitted psychiatric patients. METHODS Over a 6-mo period, consecutive in patients with mental illness were recruited from the Somang Hospital Psychiatry Unit. A combined exercise program that included 60 min per day of exercise 3 d per week for 12 wk was performed. Physical fitness and CTT of the patients were measured twice before and twice after the exercise program. CTT was measured using a multiple marker technique with a radio-opaque marker. Changes in the exercising patients' CTT and weight-,cardiovascular-and fitness-related parameters were statistically assessed.RESULTS After the 12-wk combined exercise intervention, decreased intestinal transit time was observed in all CTTs of the exercise group, including the right CTT(exercise: 15.6 ± 15.2 vs 9.2 ± 11.9, control: 13.1 ± 10.4 vs 10.9 ± 18.7), left CTT(exercise: 19.7 ± 23.5 vs 10.4 ± 13.2, control: 19.2 ± 19.0 vs 16.9 ± 19.8), recto-sigmoid CTT(exercise: 14.3 ± 16.7 vs 6.7 ± 7.9, control: 15.0 ± 14.4 vs 19.3 ± 30.3), and total colonic transit time(TCTT)(exercise: 50.2 ± 38.1 vs 27.1 ± 28.0, control: 47.4 ± 34.6 vs 47.3 ± 47.3). After the 12-wk combined exercise period, TCTT was significantly shortened in the exercise group compared with that in the control group. In addition to eating habits, water intake, and fiber intake, the increased physical activity level as a result of the 12-wk combined exercise program reduced the CTT.

Thermal-environment characteristics and comfort of combined radiant-floor (Korean heating system ondol) and convective cooling system

The thermal-environment characteristics of the existing forced-convection cooling system were compared with those of the convective cooling system, which combined the radiant-floor cooling system using floor-heating panel typically applied to apartments in South Korea with the forced-convection cooling system using improved fan coil unit. The subjective warm/cool-feeling responses to the combined radiant-floor and convective cooling system in the questionnaire survey conducted among the test subjects were analyzed to establish the basic data for the combined cooling system. The results show that in the thermal-equilibrium condition, the vertical air temperature difference in the model living room is larger in the forced-convection-cooling condition. Most of the subjects feel a proper warm/cool feeling on their entire body, but they feel colder on the foot and lower body in the combined-cooling condition.

On units combination and commitment optimization for electric power production

Electric power system is one of the most important and complex engineering in modern society, supplying main and general power for social production and social life. Meanwhile, since it is a productive system with both high input and output, it has an obvious economic significance to improve its operating efficiency. For an example, an unit is 10 GW scale, if its standard coal consumption can be decreased with 1 g/kW·h, it can save about 5 000 tons standard coal per year. It will be discussed mainly that how to establish optimization model and its numerical algorithm for operating management of the electric power system. The idea on establishing optimization model is how to dispatch work state of units or power plants, so that total cost of fuel consumption for generation is reduced to the minimum. Here the dispatch is to decide which unit or plant to operate, which unit or plant to stop running, how much power should be generated for those operating units or plants at each given time interval.

Bond population analysis on combination of favorable growth unit of Al(OH)_3 crystals

The quantum chemical calculation on four representative combination modes of the favorable growth unit Al6(OH)18(H2O)6 of Al(OH)3 crystals and the single unit were calculated. On the base of the prior investigation, and from the point of view of bond population and net atomic charge, the relationships between the combination mode of the favorable growth unit and the relative intensity of chemical bond of the systems were discussed. The quantum chemistry calculations were performed at RB3LYP/6-31G and RHF/6-31G levels by ab initio and DFT methods respectively. From the point of view of bond population, it can be preliminarily presumed that the interatomic bond force of the system with side-face-combination-B mode is weaker to a certain extent. From the point of view of the net charge, when the combination mode is obverse-face-combination-D, the interatomic bond force will be enhanced.

Three-Level Optimal Scheduling and Power Allocation Strategy for Power System ContainingWind-Storage Combined Unit

To mitigate the impact of wind power volatility on power system scheduling,this paper adopts the wind-storage combined unit to improve the dispatchability of wind energy.And a three-level optimal scheduling and power allocation strategy is proposed for the system containing the wind-storage combined unit.The strategy takes smoothing power output as themain objectives.The first level is the wind-storage joint scheduling,and the second and third levels carry out the unit combination optimization of thermal power and the power allocation of wind power cluster(WPC),respectively,according to the scheduling power of WPC and ESS obtained from the first level.This can ensure the stability,economy and environmental friendliness of the whole power system.Based on the roles of peak shaving-valley filling and fluctuation smoothing of the energy storage system(ESS),this paper decides the charging and discharging intervals of ESS,so that the energy storage and wind power output can be further coordinated.Considering the prediction error and the output uncertainty of wind power,the planned scheduling output of wind farms(WFs)is first optimized on a long timescale,and then the rolling correction optimization of the scheduling output of WFs is carried out on a short timescale.Finally,the effectiveness of the proposed optimal scheduling and power allocation strategy is verified through case analysis.

气体封隔器密封单元的增强方法与安全分析

气体封隔器胶筒是实现气井分层分段开采的关键部件。常规三胶筒结构在坐封时易发生初始破坏,导致胶筒整体应力水平降低,密封安全性储备不足。为此,提出一种多材料组合式密封单元的增强方法,用于HPHT105-232-V0型含硫化氢高温高压气体封隔器密封单元的设计;基于拉伸试验和Yeoh理论获得橡胶的本构模型参数;在温度204℃、坐封力200 kN和环空压力70 MPa下,分析了胶筒的应力和变形规律;试验测试了增强单元的密封安全性。分析结果表明:HPHT105-232-V0型封隔器密封单元胶筒的最大变形量为94.785 mm,最大接触应力为240 MPa,位于金属护环与套管接触区域。根据API标准,对HPHT105-232-V0型封隔器实物进行测试试验,坐封时胶筒未发生初始破坏,密封单元的整体应力水平提高;稳压过程胶筒压降幅度小于1%;整个试验测试过程中,密封单元无气泡溢出,封隔器卸载后胶筒结构无明显的塑性变形。研究结果表明,采用该增强方法所设计的多材料组合式密封单元具有良好的密封性能,满足极端环境下的密封安全性要求。

风-火-储耦合系统储能容量配置优化对比

为提升风电富集区域风电消纳水平及燃煤机组的灵活性,提出了基于热电共蓄式压缩空气储能的风-火-储耦合系统及系统调度策略,建立了系统的容量配置优化框架,并对7种布局方案进行了多目标优化。优化结果表明:电锅炉将弃风电量转化为热量时,燃煤机组的运行点向电力负荷下限更低的区域移动,风电上网空间增大,燃煤机组出力水平降低;加入热电共蓄式压缩空气储能子系统,使得燃煤机组电功率水平降低;换热器废热的回收进一步降低了燃煤机组产热水平;通过调整燃煤机组热出力,抽汽蓄热子系统能够实现抽汽热的时空平移,促使燃煤机组运行点向电力负荷下限更低的区域移动,可间接促进风电的消纳。综合来看,3种子系统相组合的最佳耦合方案可实现燃煤机组的热电解耦,从而提升了其深度调峰能力,在更大程度消纳风电能力的同时提升了系统的效率和环保性。

考虑核电灵活参与调峰的多源联合运行低碳经济调度

在含高比例核电机组和新能源发电设备的沿海地区电网,系统调峰压力严峻。为了满足系统调峰需求,充分挖掘核电调峰潜力,建立核电灵活出力参与调峰的核-光-储-蓄-火联合运行优化调度模型。首先,针对核电灵活出力的非线性特性,采用0-1变量进行线性化有效约束;然后,充分考虑各电源的运行特性及成本,建立完整的系统运行约束;最后,在传统的以经济调度为优化目标的基础上,引入不同碳交易机制,并兼顾系统新能源消纳水平。算例分析验证了模型的有效性,结果表明,所提优化调度模型充分实现了核电的灵活出力,有效缓解了系统调峰压力,减少常规火电机组的频繁启停,并有效提高了新能源的消纳水平,使系统运行更加经济性和低碳性。

预制UHPC永久模板钢筋混凝土组合梁抗剪性能有限元分析

为了研究预制超高性能混凝土永久模板钢筋混凝土组合梁抗剪性能,选取合适的U型UHPC预制单元本构关系,建立了钢筋混凝土梁的有限元永久模型,并与已有的试验数据进行比较,验证了模型的可靠性,并分析配箍率、剪跨比等参数对超高性能混凝土组合梁抗剪性能的影响。结果显示:超高性能混凝土预制单元可显著提高斜向开裂荷载和极限荷载;预制单元会限制箍筋的作用,所以配箍率对组合梁影响小;剪跨比对组合梁抗剪性能影响大,但是和配箍率一样都会影响其延性。

低负荷下燃气‒蒸汽联合循环机组与煤气发电机组经济效益分析

马钢北区拥有1台燃气‒蒸汽联合循环发电机组和1台全烧煤气锅炉发电机组,用于平衡马钢北区高、焦、转炉煤气。为提高煤气综合利用效率,采集2台机组不同负荷下煤气消耗数据并进行分析,根据分析结果对2台机组的煤气资源进行最优分配,优化生产运行组织方式,最大可能实现有限煤气资源多发电。

咸淡水组合灌溉对土壤盐分和棉花生长的影响

为揭示不同微咸水(农田排水)与淡水在“先咸后淡”的组合灌溉模式下对土壤容重、盐分迁移和棉花生长的影响。以淡水灌溉为对照(CK),设置7种不同微咸水、淡水组合灌溉(微咸水∶淡水=1∶14(T1)、2∶13(T2)、3∶12(T3)、6∶9(T4)、9∶6(T5)、12∶3(T6)),T7处理采用全额微咸水灌溉,于2022年4-9月进行了棉花田间试验。结果表明,采用微咸水灌溉造成土壤表层盐分积累,0~40 cm土层出现积盐现象,棉花生育期结束后,各处理与淡水对照(CK)比较,T1~T6在0~40 cm土层的电导率分别增加1.16%~26.61%,T7处理电导率增加86.40%;与淡水对照相比,组合灌溉后各处理土层0~40 cm土壤容重明显增加,土壤孔隙度降低,以全额微咸水灌溉T7处理最为显著(容重增加10.24%);微咸水组合灌溉有效提高棉花株高、叶面积指数、茎粗。合理利用微咸水组合灌溉能够为棉花生长提供良好的水盐环境,提高棉花产量,能够为极端干旱区合理利用微咸水提供一种新的灌水模式,为灌区发展节水灌溉及农业可持续发展提供理论支撑。

基于CHP机组碳排放分析的综合能源系统低碳调度优化方法

针对现有研究对于热电联产(CHP)机组碳排放计算不符合实际物理特性的问题,提出了基于CHP碳排放分析的综合能源系统(IES)低碳调度优化方法。从CHP机组内部结构入手,分析CHP机组内部各部分之间能量的传递过程,绘制CHP机组功率与碳排流向图,列写各个部分的功率平衡方程,得到CHP机组排放废气的等效热功率;计及碳排放量与废气排放速率的关系,结合废气排放的热力学方程,得到CHP机组废气排放速率与输入气流量及输出功率的关系;提出基于CHP机组碳排放分析的IES低碳调度优化模型,以总运行成本最小为目标,求解IES低碳调度优化结果;通过算例分析不同CHP机组运行方式下的优化调度结果,并与现有方法进行对比,验证了所提模型在降低碳排放方面的有效性。

计及改进阶梯型碳交易和热电联产机组灵活输出的园区综合能源系统低碳调度

为了进一步降低园区综合能源系统(park-level integrated energy system,PIES)碳排放量,优化热电联产(combined heat and power,CHP)机组出力的灵活性,提出一种考虑改进阶梯型碳交易和CHP热电灵活输出的PIES低碳经济调度策略。首先,将遗传算法与模糊控制相结合,设计一种遗传模糊碳交易参数优化器,从而对现有阶梯型碳交易机制进行改进,实现该机制参数的自适应变化;其次,在传统CHP中加入卡琳娜(Kalina)循环与电锅炉(electricboiler,EB),构造CHP热电灵活输出模型,以同时满足电、热负荷的不同需求;然后,提出一种柔性指标——电、热输出占比率,进而计算出电、热输出占比率区间,以衡量CHP运行灵活性;最后,将改进阶梯型碳交易机制和CHP热电灵活输出模型协同优化,以系统运行成本和碳交易成本之和最小为目标,构建PIES低碳经济优化模型。算例分析表明,所提策略可有效降低经济成本和碳排放量,同时还可扩展CHP灵活输出调节范围,能够为PIES低碳经济调度提供参考。

重症监护病房新生儿重症联合免疫缺陷病筛查结果及致病基因突变分析

目的 探讨在新生儿重症监护病房(NICU)新生儿中开展重症联合免疫缺陷病(SCID)筛查的意义,以及新生儿性别、胎龄、出生体重和感染对干血斑T细胞受体切除环(TREC)拷贝数检测结果的影响。方法 选取2017年11月16日至2020年6月9日在解放军总医院第七医疗中心NICU住院的227例新生儿作为研究对象,分别按性别、胎龄、出生体重和感染情况进行分组,采用多重实时荧光定量PCR的方法检测TREC拷贝数。分析性别、胎龄、出生体重、感染与TREC拷贝数的关系,并对SCID筛查阳性的新生儿进行全外显子测序分析以明确诊断。结果 不同性别NICU新生儿TREC拷贝数差异无统计学意义(P>0.05);极早产儿组、晚期早产儿组TREC拷贝数高于超早产儿组,差异有统计学意义(P<0.05);TREC拷贝数随着出生体重的增加而稍有增加,但是各组TREC拷贝数差异无统计学意义(P>0.05);感染组TREC拷贝数显著高于非感染组(P<0.05)。16例新生儿SCID筛查阳性,均在SCID致病基因ADA上均检测出2个突变,可以确认为ADA-SCID患者。结论 对NICU新生儿进行SCID早期筛查并对筛查阳性新生儿进行全外显子测序可以明确SCID诊断,对提高SCID患儿生存率有重要意义。NICU新生儿性别、胎龄和出生体重与TREC拷贝数的关系需在扩大样本量后进一步探讨。感染性疾病可能导致SCID筛查的假阳性,应该引起重视。

泵站单机组优化调度组合改进粒子群算法

开展泵站节能降耗优化模型算法研究、实现泵站经济运行具有重要的现实意义。动态规划法在泵站优化调度模型求解中较为常用,针对动态规划法决策变量离散处理对精度的影响,引入决策变量在可行域内随机生成并不断更新的粒子群算法,并提出“Sobol序列优化初始种群+实时调整惯性权重+正余弦替代学习因子”多策略融合的改进方法,通过4种基准函数性能测试,验证了改进粒子群算法在搜索能力和计算精度上有显著提升。在此基础上,将改进粒子群算法应用于某大型调水泵站以耗电费用最小为目标的单机组变速优化模型求解中,得到不同时段的最优决策方案及相应的目标最优值,并与动态规划法计算结果进行对比,2种方法最优决策过程基本一致,最优目标值精度相当。结果表明:粒子群算法组合改进策略是可行的,计算结果是可靠的,可以作为泵站优化调度模型求解的一种有效方法。

单轴燃气-蒸汽联合循环机组FCB控制策略研究与应用

为强化本地支撑电源建设,提高应对突发因素造成的大面积停电事故,广东电网对联合循环机组孤网运行能力及“黑启动”功能提出了明确要求。依托某燃机电厂二期基建调试项目,开展了两套AE94.3A型燃气-蒸汽联合循环“一拖一”单轴式机组快速甩负荷(fast cut back,简称FCB)试验。试验模拟了电网外送回路故障,机组通过快切线路断路器,最终实现了汽机跳闸,燃机快速切负荷、输出功率降至带厂用电的“孤网运行”目的,试验过程各参数变化平稳,主辅机设备均为安全停运,试验取得了较好的效果。通过对汽机旁路系统、锅炉过热/再热减温水系统、汽包液位系统、凝结水及真空系统、轴封系统等的控制策略进行针对性的优化与完善,使得机组具备了完整可靠的FCB功能,显著增强了电源侧供电可靠性。相关经验可供后续同类机组参考。