Aim: To analyze the inter-fraction, intra-fraction uncertainties and to verify the delivered total dose with planned dose in the combined intracavitary-interstitial brachytherapy of gynaecological cancer patients usin...Aim: To analyze the inter-fraction, intra-fraction uncertainties and to verify the delivered total dose with planned dose in the combined intracavitary-interstitial brachytherapy of gynaecological cancer patients using microMOSFET in-vivo dosimeter. Materials and Methods: Between May 2014 and March 2016, 22 patients who underwent brachytherapy treatments with an applicator combination of CT/MR compatible tandem, ring and Syed-Neblett template-guided rigid needles were included in this study. Specially designed microMOSFET, after calibration, was used to analyze the variations in dosimetry of combined intracavitary-interstitial application. Results: The standard deviation for Inter-fraction variation among 22 combined intracavitary interstitial applications ranged between 0.86% and 10.92%. When compared with the first fraction dose, the minimum and maximum dose variations were −9.5% and 26.36%, respectively. However, the mean doses varied between −5.95% and 14.49%. Intra-fraction variation, which is the difference of TPS calculated dose with first fraction microMOSFET-measured dose ranges from −6.77% to 8.68%. The variations in the delivered total mean dose in 66 sessions with planned doses were −3.09% to 10.83%. Conclusions: It is found that there was a gradual increase in microMOSFET measured doses as compared to the first fraction with that of subsequent fractions in 19 out of 22 applications. Tumor deformation and edema may be the influencing factors, but the applicator movements played a major role for the variations. We find that the microMOSFET is an easy and reliable system for independent verification of uncertainties during ICBT-ISBT treatments.展开更多
OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent anti...OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor models.We report the use of anovel polymeric microsphere delivery vehicle to release IL-2.We demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat brain.Thees microspheres are used to deliver IL-2,and biodegradable polymer wafers展开更多
Fei Tong Kou Fu Ye(肺通口服液 Fei Tong Oral Liquid) was used to treat 30 cases of intersitial pneumopathy after radio-and/or chemotherapy.In comparsion with the control group(15 cases)treated with hormones,the therape...Fei Tong Kou Fu Ye(肺通口服液 Fei Tong Oral Liquid) was used to treat 30 cases of intersitial pneumopathy after radio-and/or chemotherapy.In comparsion with the control group(15 cases)treated with hormones,the therapeutic effects in improving dyspnea,congh,respiratory rate,cyanosis,findings in X-films and CT examinatioin,partial pressure of oxygen in artery,FVC and VC were found significantly better(P<0.05).The total effective rate obtained was 83.33%.展开更多
目的:比较腔内联合组织间插植治疗与三管式腔内后装治疗在宫颈癌后装近距离中的剂量学差异。方法:回顾性分析我院2017年2月至2017年12月后装治疗宫颈癌患者40例,FIGO分期为Ⅰb-Ⅳa期。其中20例患者采用核通Fletch三通道施源器进行三管...目的:比较腔内联合组织间插植治疗与三管式腔内后装治疗在宫颈癌后装近距离中的剂量学差异。方法:回顾性分析我院2017年2月至2017年12月后装治疗宫颈癌患者40例,FIGO分期为Ⅰb-Ⅳa期。其中20例患者采用核通Fletch三通道施源器进行三管式后装腔内治疗(ICBT),20例患者采用核通Fletch宫腔管联合4针插植进行治疗(IC/ISBT)。在靶区D 90尽量接近600 cGy条件下,评估单次后装治疗靶区适形指数(COIN)、均匀指数(HI)、膀胱及直肠的剂量学差异。结果:IC/ISBT组患者的高危CTV靶区COIN明显高于ICBT组(P=0.000),而HI指数两组患者并无差异(P=0.917)。IC/ISBT组患者膀胱D 1 cm 3和D 2 cm 3剂量明显低于ICBT组( P =0.015, P =0.023)。IC/ISBT组患者直肠D 1 cm 3 剂量明显低于ICBT组( P =0.040),D 2 cm 3 剂量也较ICBT组低( P =0.070),但差异无统计学意义。两组患者总治疗时间差异无统计学意义( P =0.500)。 结论: 腔内联合4针插植治疗较三管式腔内放疗可以显著提高COIN而不改变靶区高剂量区范围和总治疗时间,并降低危及器官膀胱、直肠的受量。展开更多
目的:探讨针刺单穴及腧穴配伍对糖尿病胃轻瘫(Diabetic gastroparesis,DGP)大鼠胃窦Cajal间质细胞(Interstitial Cells of Cajal,ICC)的影响。方法:选取雄性SD大鼠50只,随机分为正常组、模型组、多潘立酮组、足三里组、中脘+足三里组,每...目的:探讨针刺单穴及腧穴配伍对糖尿病胃轻瘫(Diabetic gastroparesis,DGP)大鼠胃窦Cajal间质细胞(Interstitial Cells of Cajal,ICC)的影响。方法:选取雄性SD大鼠50只,随机分为正常组、模型组、多潘立酮组、足三里组、中脘+足三里组,每组10只。以链脲佐菌素(STZ)腹腔注射诱导DGP大鼠模型。采用免疫组化技术观察各组大鼠ICC含量的改变。结果:与正常组相比,模型组大鼠胃窦组织ICC含量明显减少(P<0.01);与模型组比较,多潘立酮组(P<0.01)、足三里组(P<0.05)、中脘+足三里组(P<0.01)大鼠胃窦ICC含量明显提高,且中脘+足三里组优于足三里组(P<0.05)。结论:针刺促进DGP大鼠胃窦ICC含量恢复,腧穴配伍组优于单穴组。展开更多
文摘Aim: To analyze the inter-fraction, intra-fraction uncertainties and to verify the delivered total dose with planned dose in the combined intracavitary-interstitial brachytherapy of gynaecological cancer patients using microMOSFET in-vivo dosimeter. Materials and Methods: Between May 2014 and March 2016, 22 patients who underwent brachytherapy treatments with an applicator combination of CT/MR compatible tandem, ring and Syed-Neblett template-guided rigid needles were included in this study. Specially designed microMOSFET, after calibration, was used to analyze the variations in dosimetry of combined intracavitary-interstitial application. Results: The standard deviation for Inter-fraction variation among 22 combined intracavitary interstitial applications ranged between 0.86% and 10.92%. When compared with the first fraction dose, the minimum and maximum dose variations were −9.5% and 26.36%, respectively. However, the mean doses varied between −5.95% and 14.49%. Intra-fraction variation, which is the difference of TPS calculated dose with first fraction microMOSFET-measured dose ranges from −6.77% to 8.68%. The variations in the delivered total mean dose in 66 sessions with planned doses were −3.09% to 10.83%. Conclusions: It is found that there was a gradual increase in microMOSFET measured doses as compared to the first fraction with that of subsequent fractions in 19 out of 22 applications. Tumor deformation and edema may be the influencing factors, but the applicator movements played a major role for the variations. We find that the microMOSFET is an easy and reliable system for independent verification of uncertainties during ICBT-ISBT treatments.
文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor models.We report the use of anovel polymeric microsphere delivery vehicle to release IL-2.We demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat brain.Thees microspheres are used to deliver IL-2,and biodegradable polymer wafers
文摘Fei Tong Kou Fu Ye(肺通口服液 Fei Tong Oral Liquid) was used to treat 30 cases of intersitial pneumopathy after radio-and/or chemotherapy.In comparsion with the control group(15 cases)treated with hormones,the therapeutic effects in improving dyspnea,congh,respiratory rate,cyanosis,findings in X-films and CT examinatioin,partial pressure of oxygen in artery,FVC and VC were found significantly better(P<0.05).The total effective rate obtained was 83.33%.
文摘目的:比较腔内联合组织间插植治疗与三管式腔内后装治疗在宫颈癌后装近距离中的剂量学差异。方法:回顾性分析我院2017年2月至2017年12月后装治疗宫颈癌患者40例,FIGO分期为Ⅰb-Ⅳa期。其中20例患者采用核通Fletch三通道施源器进行三管式后装腔内治疗(ICBT),20例患者采用核通Fletch宫腔管联合4针插植进行治疗(IC/ISBT)。在靶区D 90尽量接近600 cGy条件下,评估单次后装治疗靶区适形指数(COIN)、均匀指数(HI)、膀胱及直肠的剂量学差异。结果:IC/ISBT组患者的高危CTV靶区COIN明显高于ICBT组(P=0.000),而HI指数两组患者并无差异(P=0.917)。IC/ISBT组患者膀胱D 1 cm 3和D 2 cm 3剂量明显低于ICBT组( P =0.015, P =0.023)。IC/ISBT组患者直肠D 1 cm 3 剂量明显低于ICBT组( P =0.040),D 2 cm 3 剂量也较ICBT组低( P =0.070),但差异无统计学意义。两组患者总治疗时间差异无统计学意义( P =0.500)。 结论: 腔内联合4针插植治疗较三管式腔内放疗可以显著提高COIN而不改变靶区高剂量区范围和总治疗时间,并降低危及器官膀胱、直肠的受量。
文摘目的:探讨针刺单穴及腧穴配伍对糖尿病胃轻瘫(Diabetic gastroparesis,DGP)大鼠胃窦Cajal间质细胞(Interstitial Cells of Cajal,ICC)的影响。方法:选取雄性SD大鼠50只,随机分为正常组、模型组、多潘立酮组、足三里组、中脘+足三里组,每组10只。以链脲佐菌素(STZ)腹腔注射诱导DGP大鼠模型。采用免疫组化技术观察各组大鼠ICC含量的改变。结果:与正常组相比,模型组大鼠胃窦组织ICC含量明显减少(P<0.01);与模型组比较,多潘立酮组(P<0.01)、足三里组(P<0.05)、中脘+足三里组(P<0.01)大鼠胃窦ICC含量明显提高,且中脘+足三里组优于足三里组(P<0.05)。结论:针刺促进DGP大鼠胃窦ICC含量恢复,腧穴配伍组优于单穴组。
