目的观察温针灸治疗阳气亏虚血瘀型慢性心力衰竭的临床疗效及对患者心功能和生活质量的影响。方法将60例阳气亏虚血瘀型慢性心力衰竭患者用随机数字表法分为对照组(30例)和研究组(30例)。两组均予内科常规基础治疗,对照组另予常规针刺治...目的观察温针灸治疗阳气亏虚血瘀型慢性心力衰竭的临床疗效及对患者心功能和生活质量的影响。方法将60例阳气亏虚血瘀型慢性心力衰竭患者用随机数字表法分为对照组(30例)和研究组(30例)。两组均予内科常规基础治疗,对照组另予常规针刺治疗,研究组另予温针灸治疗。观察两组治疗前后明尼苏达心功能不全生命质量量表(Minnesota living with heart failure questionnaire,MLHFQ)评分、6分钟步行试验(6-minute walk test,6MWT)结果、心功能指标[左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心室收缩末内径(left ventricular end systolic diameter,LVESD)和左室射血分数(left ventricular ejection fraction,LVEF)]以及血清肾素、醛固酮(aldosterone,ALD)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)和血浆N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)水平的变化,比较两组临床疗效。结果两组治疗后LVEDD、LVESD、肾素水平、ALD水平、AngⅡ水平、NT-proBNP水平和MLHFQ评分均较治疗前降低(P<0.05),LVEF和6MWT水平均较治疗前提高(P<0.05)。研究组治疗后LVEDD、LVESD、肾素水平、ALD水平、AngⅡ水平、NT-proBNP水平和MLHFQ评分均低于对照组(P<0.05),LVEF和6MWT水平均高于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。结论在内科常规治疗基础上,温针灸治疗阳气亏虚血瘀型慢性心力衰竭的临床疗效优于常规针刺,可改善心脏功能,提高生活质量。展开更多
目的观察温针灸配合药物治疗过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndromes,CARAS)的临床疗效及其对血清T细胞免疫球蛋白域黏蛋白域蛋白-1(T-cell immunoglobulin and mucin domain 1,Tim-1)和E-选择素(E-sel...目的观察温针灸配合药物治疗过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndromes,CARAS)的临床疗效及其对血清T细胞免疫球蛋白域黏蛋白域蛋白-1(T-cell immunoglobulin and mucin domain 1,Tim-1)和E-选择素(E-selectin)水平的影响。方法将70例CARAS患者随机分为治疗组和对照组,每组35例。对照组采用常规药物治疗,治疗组在对照组基础上采用温针灸治疗。观察两组治疗前后鼻部症状总评分(total nasal symptom score,TNSS)、哮喘控制测试(asthma control test,ACT)评分、鼻腔生理功能指标(鼻腔黏液纤毛传输时间和清除速度)、肺功能指标[1秒用力呼气量(forced expiratory volume in one second,FEV1)和最大呼气量(peak expiratory flow,PEF)]及血清Tim-1和E-selection水平的变化,比较两组临床疗效。结果治疗组总有效率为97.0%,明显高于对照组的75.0%(P<0.05)。两组治疗后TNSS评分及血清Tim-1和E-selection水平均较显著下降,鼻腔黏液纤毛传输时间均显著缩短,ACT评分、鼻腔黏液纤毛清除速度及肺功能指标均显著上升,差异均具有统计学意义(P<0.05)。治疗组治疗后TNSS和ACT评分、鼻腔生理功能的指标、肺功能指标及血清Tim-1和E-selection水平均优于对照组,差异均具有统计学意义(P<0.05)。结论温针灸配合药物治疗CARAS可缓解鼻炎症状,控制哮喘,改善鼻腔生理功能和肺功能,疗效优于单纯药物治疗,这可能与其降低血清Tim-1和E-selection水平有关。展开更多
目的观察针灸联合补肾健脾活血方对骨质疏松症患者骨代谢、骨密度(bone mineral density,BMD)及免疫功能的影响。方法将80例肾虚血瘀型骨质疏松症患者随机分为对照组和研究组,每组40例。对照组采取补肾健脾活血方治疗,研究组在对照组基...目的观察针灸联合补肾健脾活血方对骨质疏松症患者骨代谢、骨密度(bone mineral density,BMD)及免疫功能的影响。方法将80例肾虚血瘀型骨质疏松症患者随机分为对照组和研究组,每组40例。对照组采取补肾健脾活血方治疗,研究组在对照组基础上联合针灸治疗。观察两组治疗前后BMD、骨代谢参数、中医证候积分变化,并比较两组不良反应。结果治疗后,两组BMD均升高(P<0.05),骨碱性磷酸酶(bone alkaline phosphatase,BAP)、骨钙素(osteocalcin,OC)水平升高(P<0.05),Ⅰ型胶原交联氨基端肽(N-telopeptide of typeⅠcollagen,NTXI)水平下降(P<0.05),CD4^(+)T细胞、CD4^(+)/CD8^(+)水平均升高(P<0.05),CD8^(+)T细胞水平降低(P<0.05),中医证候积分均降低(P<0.05);且研究组上述指标均优于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论针灸联合补肾健脾活血方治疗骨质疏松症,可改善患者骨代谢、BMD和中医证候积分,增强免疫功能。展开更多
Objective:To investigate the efficacy and possible mechanism of action of warm needling moxibustion combined with entecavir in the treatment of compensated cirrhosis due to chronic hepatitis B(CHB).Methods:Ninety pati...Objective:To investigate the efficacy and possible mechanism of action of warm needling moxibustion combined with entecavir in the treatment of compensated cirrhosis due to chronic hepatitis B(CHB).Methods:Ninety patients were randomly divided into a control group and an observation group,with 45 patients in each group.The control group was given oral entecavir,and the observation group was given additional warm needling moxibustion.The serum alanine transaminase(ALT),aspartate transaminase(AST),albumin(ALB)levels,portal vein internal diameter,splenic vein internal diameter,spleen thickness,and liver hardness were compared before and after treatment.The serum hyaluronic acid(HA),laminin(LN),procollagen typeⅢ(PCⅢ),typeⅣcollagen(Ⅳ-C),interleukin(IL)-21,and platelet-derived growth factor(PDGF)levels were also measured.Results:After treatment,the serum ALT and AST levels decreased(P<0.05),and the serum ALB levels increased(P<0.05)in both groups.The serum ALT and AST levels were lower in the observation group than in the control group(P<0.05),and the ALB level was higher in the observation group(P<0.05).The portal vein internal diameter,splenic vein internal diameter,spleen thickness,and liver hardness values were reduced in both groups after treatment(P<0.05),and were lower in the observation group than in the control group(P<0.05).The serum HA,LN,PCⅢ,andⅣ-C levels were reduced in both groups(P<0.05),and were lower in the observation group than in the control group(P<0.05).In the control group,the serum IL-21 level decreased(P<0.05),but the serum PDGF level did not change significantly(P>0.05);in the observation group,the serum IL-21 and PDGF levels decreased significantly(P<0.05)and were lower than those in the control group(P<0.05).Conclusion:Warm needling moxibustion combined with entecavir treatment can improve liver function,reduce the inner diameters of the portal vein and splenic vein,spleen thickness,and liver hardness,and improve liver fibrosis indicators in patients with CHB cirrhosis,which may be related to the reduction of serum IL-21 and PDGF levels.展开更多
文摘目的观察温针灸治疗阳气亏虚血瘀型慢性心力衰竭的临床疗效及对患者心功能和生活质量的影响。方法将60例阳气亏虚血瘀型慢性心力衰竭患者用随机数字表法分为对照组(30例)和研究组(30例)。两组均予内科常规基础治疗,对照组另予常规针刺治疗,研究组另予温针灸治疗。观察两组治疗前后明尼苏达心功能不全生命质量量表(Minnesota living with heart failure questionnaire,MLHFQ)评分、6分钟步行试验(6-minute walk test,6MWT)结果、心功能指标[左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心室收缩末内径(left ventricular end systolic diameter,LVESD)和左室射血分数(left ventricular ejection fraction,LVEF)]以及血清肾素、醛固酮(aldosterone,ALD)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)和血浆N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)水平的变化,比较两组临床疗效。结果两组治疗后LVEDD、LVESD、肾素水平、ALD水平、AngⅡ水平、NT-proBNP水平和MLHFQ评分均较治疗前降低(P<0.05),LVEF和6MWT水平均较治疗前提高(P<0.05)。研究组治疗后LVEDD、LVESD、肾素水平、ALD水平、AngⅡ水平、NT-proBNP水平和MLHFQ评分均低于对照组(P<0.05),LVEF和6MWT水平均高于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。结论在内科常规治疗基础上,温针灸治疗阳气亏虚血瘀型慢性心力衰竭的临床疗效优于常规针刺,可改善心脏功能,提高生活质量。
文摘目的观察温针灸配合药物治疗过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndromes,CARAS)的临床疗效及其对血清T细胞免疫球蛋白域黏蛋白域蛋白-1(T-cell immunoglobulin and mucin domain 1,Tim-1)和E-选择素(E-selectin)水平的影响。方法将70例CARAS患者随机分为治疗组和对照组,每组35例。对照组采用常规药物治疗,治疗组在对照组基础上采用温针灸治疗。观察两组治疗前后鼻部症状总评分(total nasal symptom score,TNSS)、哮喘控制测试(asthma control test,ACT)评分、鼻腔生理功能指标(鼻腔黏液纤毛传输时间和清除速度)、肺功能指标[1秒用力呼气量(forced expiratory volume in one second,FEV1)和最大呼气量(peak expiratory flow,PEF)]及血清Tim-1和E-selection水平的变化,比较两组临床疗效。结果治疗组总有效率为97.0%,明显高于对照组的75.0%(P<0.05)。两组治疗后TNSS评分及血清Tim-1和E-selection水平均较显著下降,鼻腔黏液纤毛传输时间均显著缩短,ACT评分、鼻腔黏液纤毛清除速度及肺功能指标均显著上升,差异均具有统计学意义(P<0.05)。治疗组治疗后TNSS和ACT评分、鼻腔生理功能的指标、肺功能指标及血清Tim-1和E-selection水平均优于对照组,差异均具有统计学意义(P<0.05)。结论温针灸配合药物治疗CARAS可缓解鼻炎症状,控制哮喘,改善鼻腔生理功能和肺功能,疗效优于单纯药物治疗,这可能与其降低血清Tim-1和E-selection水平有关。
文摘目的观察针灸联合补肾健脾活血方对骨质疏松症患者骨代谢、骨密度(bone mineral density,BMD)及免疫功能的影响。方法将80例肾虚血瘀型骨质疏松症患者随机分为对照组和研究组,每组40例。对照组采取补肾健脾活血方治疗,研究组在对照组基础上联合针灸治疗。观察两组治疗前后BMD、骨代谢参数、中医证候积分变化,并比较两组不良反应。结果治疗后,两组BMD均升高(P<0.05),骨碱性磷酸酶(bone alkaline phosphatase,BAP)、骨钙素(osteocalcin,OC)水平升高(P<0.05),Ⅰ型胶原交联氨基端肽(N-telopeptide of typeⅠcollagen,NTXI)水平下降(P<0.05),CD4^(+)T细胞、CD4^(+)/CD8^(+)水平均升高(P<0.05),CD8^(+)T细胞水平降低(P<0.05),中医证候积分均降低(P<0.05);且研究组上述指标均优于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论针灸联合补肾健脾活血方治疗骨质疏松症,可改善患者骨代谢、BMD和中医证候积分,增强免疫功能。
文摘Objective:To investigate the efficacy and possible mechanism of action of warm needling moxibustion combined with entecavir in the treatment of compensated cirrhosis due to chronic hepatitis B(CHB).Methods:Ninety patients were randomly divided into a control group and an observation group,with 45 patients in each group.The control group was given oral entecavir,and the observation group was given additional warm needling moxibustion.The serum alanine transaminase(ALT),aspartate transaminase(AST),albumin(ALB)levels,portal vein internal diameter,splenic vein internal diameter,spleen thickness,and liver hardness were compared before and after treatment.The serum hyaluronic acid(HA),laminin(LN),procollagen typeⅢ(PCⅢ),typeⅣcollagen(Ⅳ-C),interleukin(IL)-21,and platelet-derived growth factor(PDGF)levels were also measured.Results:After treatment,the serum ALT and AST levels decreased(P<0.05),and the serum ALB levels increased(P<0.05)in both groups.The serum ALT and AST levels were lower in the observation group than in the control group(P<0.05),and the ALB level was higher in the observation group(P<0.05).The portal vein internal diameter,splenic vein internal diameter,spleen thickness,and liver hardness values were reduced in both groups after treatment(P<0.05),and were lower in the observation group than in the control group(P<0.05).The serum HA,LN,PCⅢ,andⅣ-C levels were reduced in both groups(P<0.05),and were lower in the observation group than in the control group(P<0.05).In the control group,the serum IL-21 level decreased(P<0.05),but the serum PDGF level did not change significantly(P>0.05);in the observation group,the serum IL-21 and PDGF levels decreased significantly(P<0.05)and were lower than those in the control group(P<0.05).Conclusion:Warm needling moxibustion combined with entecavir treatment can improve liver function,reduce the inner diameters of the portal vein and splenic vein,spleen thickness,and liver hardness,and improve liver fibrosis indicators in patients with CHB cirrhosis,which may be related to the reduction of serum IL-21 and PDGF levels.
