Evaluation of Clinical Efficacy of Combined Use of Acupuncture and Medicine in Treating Sleep Disorder in Patients with Anxiety Disorder

[Objectives]To evaluate the clinical efficacy of combined acupuncture and medicine in the treatment of sleep disorders in patients with anxiety disorders.[Methods]A total of 300 anxiety patients with sleep disorders were randomly selected and divided into a research group and a control group,with 150 cases in each group.The control group was administered with western medicine,and the research group was treated with acupuncture and medicine to compare their clinical treatment effects.[Results]The total effective rate of treatment in the research group was significantly higher than that in the control group;after treatment,both the PSQI and SAS scores of the two groups were significantly reduced,and the reduction degree of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).[Conclusions]Combined use of acupuncture and medicine to treat sleep disorders in patients with anxiety disorders has better curative effect and fewer adverse reactions,so it has high clinical application value.

CLINICAL OBSERVATION ON 40 CASES OF ANKYLOSING SPONDYLITIS TREATED WITH ACUPUNCTURE AND CHINESE DRUGS

Objective： To observe the clinical therapeutic effect of acupuncture plus Chinese herbal medicines for ankylceing Methods： A total of 80 cases of AS patients were evenly and randomly divided into treatment group and control group. In treatment group, patients were treated with acupuncture of Jiaji （夹脊 EX-B 2） and oral administration of Yishen Tongdu Won （益肾通督丸,Bolus for Reinforcing the Kidney and Dredging Governor Vessesl） and those of control group treated with oral administration of Sulfasalazin （0.5 g, twice daily）. Before and after treatment, the thoracic-dilaion scale, Schober test, Bath ankylceing spondylitis disease activity index （BASDAI）, Bath ankylosing spondylitis functional index （BASFI）, erythrocyte sedimentation rate （ESR） and C-reaction protein （CRP） were detected separately. Results： After 6 months of treatment, of the both 40cases in treatment and control groups, 27 （67.5%） and 13 （32.5%） were improved remarkably, 11 （27.5%） and 16 （40.0%） effective, and 2 （5.0%） and 11 （27.5%） failed, with the effective rates being 95.0% and 72.5% separately. The therapeutic effect of treatment group was significantly superior to that of control group （P〈 0.05）. After treatment, the thoracicdilaion scale and Schober test values increased significantly （ P〈 0.05）, while BASDAI, BASFI, ESR and CRP lowered considerably （P〈0.01, P〈0.05）. Comparison between two groups indicated that after treatment, the decreased values of BASDAI, BASFI, ESR and CRP of treatment group were significantly lower than those of control group （ P〈 0.01 ）, while those of the thoracio-dilaion scale and Schober test of treatment group were significantly higher than those of control group （ P 〈 0.05, P 〈 0.01 ）. Results displayed that both acupuncture combined with Chinese drugs and Sulfasalazin could lower BASDAI, BASFI, ESR and CRP, raise the thoracic-dilaion scale and Schober test values considerably in AS patients, and the therapeutic effect of combined acupunclure and Chinese drugs was apparently superior to that of Westem medicine. Conclusion： Joint application of acupuncture and Chinese drugs is superior to Western medicine in the therapeutic effect for AS and has fewer side effects.

Effects of acupuncture combined with Kaijingtongmai Decoction on ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in myocardial infarction rats

Objective:To study the effect of combination of acupuncture and medicine on the expression of ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in rats with myocardial infarction,and to study the possible mechanism of combination of acupuncture and medicine on the improvement of myocardial infarction,so as to provide experimental data basis for the development of new treatment methods for myocardial infarction.Methods:65 healthy male SD rats were randomly selected as the control group.The other rats were fed with high-fat food for three weeks.The rats in the control group were injected with normal saline subcutaneously,and the other rats were injected with isoproterenol hydrochloride in the same way.Through ECG comparison,40 successful Mi rats were randomly divided into model group,acupuncture group,western medicine group and acupuncture drug combination group,with 10 rats in each group.After the corresponding treatment,the ECG changes of rats in each group were observed,the pathological changes of rat cardiomyocytes were observed by HE staining,and the expression of ATP sensitive potassium channel(Kir6.1,Kir6.2)protein was detected by Western blot.Results:compared with the control group,40 experimental specimens in the experimental group showed significant changes in cardiomyocyte protein The expression of Kir6.1 and Kir6.2 increased,and the difference was statistically significant.After treatment,compared with the model group,the protein expression of Kir6.1 and Kir6.2 in cardiomyocytes of Western medicine group,acupuncture group and acupuncture drug combination group showed a downward trend,among which the decline degree of acupuncture drug combination group was the most obvious,and the difference was statistically significant.The decline degree of acupuncture group and Western medicine group was not significant,and there was no significant difference Conclusion:acupuncture combined with medicine has a significant effect on improving myocardial infarction in rats,which may be related to the expression of ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in rat cardiomyocytes.

Treatment of Phlegm-and Heat-induced Insomnia by Acupuncture in 120 Cases

Clinical DataThe 120 cases in this series were outpatients suffering from insomnia due to interior-stirring by phlegm-heat, ranging in age from 28 to 67 years. They were randomly divided into a treatment group and a control group.

Effect of acupuncture combined with Chinese medicine on the expression of interstitial cells of Cajal, substance P and nerve nitric oxide synthase in diabetic mice with gastroparesis antrum

Objective To explore the effect of acupuncture combined with Chinese medicine on expression of interstitial cells of Cajal（ICC）, substance P（SP） and nerve nitric oxide synthase（nNOS） in diabetic gastroparesis mice. Methods Eighty Kunming male mice were randomly divided into normal group（group A, 15 mice）, diabetic gastroparesis model mice group（group B, 12 mice）, acupuncture combined with Chinese medicine group（group C, 12 mice）, Chinese medicine group（group D, 13 mice） and western medicine group（group E, 13 mice）. The mice were intraperitoneally injected with steptozotocin and fed with high-fat diet-induced irregular except the normal group mice, that made mouse model of diabetic gastroparesis. And then, the ACM group were treated by acupuncture at the acupoints of Housanli（后三里 ST 36） and Zhōngw n（中脘 CV 12） combined with Chinese medicine, the CM group were only treated by Chinese medicine; the WM group were treated by domperidone and vitamin B 6. Numbers and expression of ICC, SP and n NOS were detected by immunohistochemical methods. Results After treatment, compared with normal group, ICC and SP indexes of model group were significantly reduced. Compared with model group, all indexes in ACM and CM groups were improved significantly（P0.05, P0.01）, but only the positive area and average optical density value in c-Kit and SP in WM group increased obviously（P0.05）. Compared with ACM group, no significant difference in c-Kit and SP of CM group were observed（P0.05）, but expression of nNOS were increased markedly（P0.01）. Besides, c-Kit and SP expressions of WM group were significantly induced was increased remarkably（P0.01）. Conclusion Acupuncture combined with Chinese medicine have much better therapeutic effects for diabetic gastroparesis mice, which may be due to repairing ICC damage, upregulating the expression of SP and lowering the expression of nNOS.

Cerebral mechanism of puncturing at He-Mu point combination for functional dyspepsia: study protocol for a randomized controlled parallel trial

Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging. A total of 105 patients with functional dyspepsia will be allocated into 3 groups： the low-He point group（puncturing at Zusanli（ST36））, Mu point group（puncturing at Zhongwan（CV12））, and He-Mu point combination group（puncturing at ST36 and CV12）. Every participant will receive 20 sessions of manual acupuncture for 4 weeks. The needles will be inserted perpendicularly to a depth of 1 to 2 cun. The angle of rotation and twisting will range from 90 to 180 degrees, while lifting and thrusting will range from 0.3 to 0.5 cm. The various manipulations will be performed 60 to 90 times per minute. The needles will remain in place for 30 minutes, during which manipulation will be applied every 10 minutes. Magnetic resonance imaging will be performed before and after 20 sessions of acupuncture. The primary outcome is symptom improvement according to the Chinese version of the Nepean Dyspepsia Index. Secondary outcomes include the Leeds dyspepsia questionnaire, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Beck Anxiety Inventory, Beck Depression Inventory, and visual analogue scale scores before and after 10 and 20 sessions of acupuncture. Needle sensation and adverse events will be used to assess the therapeutic effects. This study will promote more widespread awareness of the benefits of acupoint combination in the clinical setting and provide a further explanation of the neuromechanism by which acupuncture at the He-Mu point combination for functional dyspepsia. Registration： Chinese Clinical Trial Registry, Chi CTR-IOR-15006402.

Acupuncture, Moxibustion, and Combination Therapies for Insomnia

Insomnia, a common sleep disorder, affects general well-being, hastens the onset of other diseases, and impairs work performance. Hypnotic medications are efficacious in the short term but have obvious side effects. Acupuncture, often used to treat insomnia in traditional Chinese medicine (TCM), is considered to be beneficial in restoring the normal sleep-wake cycle by regulating and restoring the natural flow of qi (energy power). The three main TCM theories for treating insomnia by acupuncture are the tranquilization disturbance, zangfu disturbance (disequilibrium of internal organs), and imbalance of yin and yang theories. Moxibustion, another treatment for insomnia, is usually combined with acupuncture. Acupuncture and moxibustion with tuina (exercise massage), acupuncture with Chinese herbal injection, electroacupuncture, and acupuncture with medication or psychotherapy are other interventions. Some acupuncture-based methods such as needle-rolling acupuncture, auricular acupoint plaster therapy, phlebotomy, and acupoint catgut-embedding therapy are used as well. Although most clinical trials have shown that acupuncture and its combination therapies are significantly effective in insomnia, the beneficial effects may have been overvalued, because of small sample size, nonstrict inclusion and exclusion criteria, flawed methodology, short follow-up, or nonstandardized evaluation. Therefore, clinical studies of high methodological quality are needed to verify the efficacy of acupuncture, moxibustion, and other combination therapies in insomnia.

Treatment of anovulatory infertility with acupuncture and Chinese herbal medicine

Objective To observe the therapeutic effects on anovulatory infertility with acupuncture and Chinese herbal medicine. Methods Fifty patients with anovulatory infertility were divided randomly into 2 groups with 25 in the observation group and 25 in the control group. Both herbal decoctions and acupuncture treatment were applied to the observation group. For Chinese herbal medicine, according to different phases of menstrual cycle, Cu Luanpao Tang （促卵泡汤 follicle promote decoction）, Cu Pailuan Tang （促卵泡汤 ovulation induce decoction） and Cu Huangti Tang （促黄体汤 corpora luteum promote decoction） was given to the patients; and acupoints such as Guanyuan （关元 CV 4）, Zhongji （ 中极 CV 3） and LuSnchao Xue（卵巢穴 Extra point） were selected. The control group was asked to take Clomiphene as well as Chorionic Gonadotropin （HCG） injection. Observation is undertaken continuously for 6 cycles, and statistics of ovulation rate and pregnancy rate were collected. Results There were no statistical significance of difference of ovulation rate between the two groups（P〉0.05） ; the pregnancy rate of the observation group is 44. 0%（11/25）, which is obviously higher than 16.0% （4/25） of the control group （P〈0.05）. Comparison was made on Insler score of the cervical mucus and thickness of the endometrium between the 2 groups, and the result showed that both of the indexes of the observation group were better than those of the control group （P〈0.05, P〈0.01）. Conclusion Both of the methods, namely ovulation induction with acupuncture and herbal decoctions and with Clomiphene and HCG injection, are effective for enhancing the ovulation rate, while the former one is better than the later one in the pregnancy rate.

Clinical Observation on the Combined Use of Acupuncture and Herbal Medicine for Treatment of Chloasma

Objective:To observe the clinical effects of the combined use of acupuncture and herbal medicine for treatment of chloasma.Methods:Totally 60 patients were randomly divided into a treatment group of 30 cases,treated by acupuncture and herbal medicine,and a control group of 30 cases,administered Vitamin C and Vitamin E.The clinical effects were observed.Results:The total effective rate of the treatment group is 93.3%better than that of the control group(76.7%) ,the difference was significant(P<0.01) .Conclusion:Combined use of acupuncture and herbal medicine may yield definite therapeutic effects in treating chloasma patients.

Observation on Treatment of Depression with Acupuncture and Chinese Medicine： A Report of 52 Cases

Objective： To study the effectiveness of combined Acupuncture and Chinese medicine on depression. Methods： Ninety-eight patients were randomly divided into two groups. The treatment group of 52 cases were treated by scalp acupuncture and electroacupuncture, Baihui （GV 20）, Shenting （GV 24）, Taichong （LR 3）, Neiguan （PC 6）, Guanyuan （CV 4）, Zusanli （ST 36）, Sanyinjiao（SP 6）, plus Chinese medicine, modified Xiaoyao Powder （a decoction for soothing liver and relieving depression） and the control group of 46 cases, only with Chinese medicine, modified Xiaoyao Powder. Results： The total effective rate was 94.2% in the treatment group and 78.26% in the control group; with a significantdifference between two groups（P〈0.05） Conclusion： Acupuncture plus Chinese medicine has a marked effect on depression.

Malignant Gastric Cancer Cured by Short-Term Chemotherapy and Long-Term Use of Combined Chinese Medicine:A Case Report

Introduction Gastric cancer is still a major health problem and a leading cause of cancer mortality despite the worldwide decline Jn incidence. Surgery Js the only potentially curative treatment for localized gastric cancer and radical gastrectomy with extended lymphadenectomy is now recognized as a reasonably safe procedure in experienced centers.

Clinical Observations on the Treatment of 90 Chronic Gastritis Patients by Combination of Acupuncture and Herbal Medicine

Objective： To investigate the clinical efficacy of combined acupuncture and herbal medicine based on Prof. QIN Liang-fu＇s experience in treating chronic gastritis. Methods： Ninety chronic gastritis patients were randomly divided into acupuncture, herbal medicine and acupuncture plus herbal medicine groups. The clinical effects were evaluated after 6 months. Results： After 6 months, the clinical effect was better in the acupuncture plus herbal medicine group than in the acupuncture group and in the herbal medicine group（P〈 0.05）. Conclusion： The curative effect on chronic gastritis was better in the acupuncture plus herbal medicine group than in the acupuncture group and in the herbal medicine group.

穴位敏感点揿针配合中药治疗多发性抽动症的疗效观察

目的 观察穴位敏感点揿针配合中药治疗多发性抽动症的临床疗效。方法 将150例多发性抽动症患者随机分为治疗组、对照1组和对照2组,每组50例。治疗组采用穴位敏感点揿针配合中药治疗,对照1组采用揿针配合中药治疗,对照2组采用口服盐酸硫必利片治疗。观察3组治疗前后耶鲁抽动程度综合量表(Yale global tic severity scale, YGTSS)各项评分及各项中医症候积分的变化情况,比较3组临床疗效及不良反应发生率。结果 治疗组总有效率为89.6%,对照1组为80.4%,对照2组为69.6%,治疗组总有效率明显高于对照1组和对照2组(P<0.05),对照1组总有效率明显高于对照2组(P<0.05)。3组治疗后中医证候积分及YGTSS各项评分均较同组治疗前显著下降,差异均具有统计学意义(P<0.05)。治疗组和对照1组治疗后中医证候积分及YGTSS各项评分均明显低于对照2组,差异均具有统计学意义(P<0.05)。治疗组治疗后运动抽动、烦躁易怒、精神倦怠、纳差积分及YGTSS各项评分均明显低于对照1组,差异均具有统计学意义(P<0.05)。治疗组治疗期间不良反应发生率为6.3%,对照1组为8.7%,对照2组为26.1%,治疗组和对照1组不良反应发生率均明显低于对照2组,差异均有统计学意义(P<0.05)。结论 穴位敏感点揿针配合中药治疗脾虚肝旺型多发性抽动症有较好的临床疗效,能够改善多发性抽动症患者的临床症状,安全性较高。

韦企平从肝论治原发性闭角型青光眼经验

原发性闭角型青光眼(PACG)是临床最常见的致盲眼病之一。若眼压控制不佳,常可造成视神经萎缩,导致视力下降、视野缺损,最终失明。西医认为其主要是由于眼前房角部的解剖结构异常或功能障碍,导致房水排出受阻,进而引起眼内压增高。中医学则将本病病因病机归咎于肝火上炎、痰火郁结、肝肾阴虚以及饮邪上犯等因素。这些因素共同作用,引起气血失和、气滞血瘀,从而导致目中玄府闭塞及神水瘀滞,发为PACG。韦企平擅长中西医结合治疗不同发病阶段的PACG,对其病因病机和辨证论治有独到见解,主张本病应从肝论治,在控制眼压的基础上,重视全身辨证论治,采用针药结合治疗PACG导致的视神经萎缩。

温针灸结合理气通腑方治疗脑卒中后气虚秘的疗效观察

目的:观察温针灸结合理气通腑方治疗脑卒中后气虚秘患者的临床疗效。方法:选择64例脑卒中后气虚型便秘的患者,利用SPSS 26.0统计软件产生随机数将其分为对照组和治疗组(每组32例)。两组均接受常规治疗,对照组在此基础上予以常规针刺,治疗组施以温针灸及口服理气通腑方治疗。2周为1个疗程,共治疗2个疗程。采用便秘症状评分、肛门静息压、生活质量量表(PAC-QOL)评分比较两组患者治疗1个疗程及治疗2个疗程后的临床疗效。结果:两组患者治疗1个疗程及治疗结束后便秘症状评分、PAC-QOL评分均较治疗前降低,肛门静息压提高,差异有统计学意义(P<0.01)。治疗组在治疗1个疗程及治疗结束后便秘症状评分、PAC-QOL评分均低于对照组,肛门静息压均高于对照组,差异均有统计学意义(P<0.01)。结论:温针灸结合理气通腑方治疗脑卒中后气虚秘效果更为明显。

针药结合治疗卵巢储备功能减退Meta分析

目的:通过评估针灸结合中药治疗卵巢储备功能减退的疗效,以期获得更有效的治疗方法。方法:检索Cochrane Library、Embase、PubMed、国家生物医疗文献(China Biology Medicine,CBM)、国家知识基础设施数据库(China National Knowledge Infrastructure,CNKI)、维普(China Science and Technology Journal Database),VIP和万方(WanFang Database),检索时间为建库至2023年1月,收集到7个采用针药结合方法改善卵巢储备功能的随机对照试验。经过2位研究人员的评估与审核,采用Review Manager 5.3分析工具,从174篇有效文章中,筛选出23项RCT,将1 635位DOR患者纳入研究。结果:针药结合治疗卵巢储备功能减退有效率远高于单纯西药或单纯中药治疗[RR=1.17,95%CI(1.12~1.23),P<0.01,I^(2)=26%]。针药结合治疗卵巢储备功能减退患者血清FSH水平优于单纯西药或单纯中药治疗[SMD=-0.93,95%CI(-1.04~-0.38),P<0.01]。结论:针药结合治疗卵巢储备功能减退比单独使用西药或单独使用中药具有更好的疗效。但该Meta分析存在纳入的文献质量较低、亚组分析异质性偏大等问题,研究结论有待更大样本量的高质量RCT验证。

帕金森病伴神经精神障碍的发病机制及中医治疗研究进展

帕金森病(PD)是一种高发于中老年人的神经系统退行性疾病,研究发现,PD患者的神经精神障碍可在运动症状出现前数年就已出现。PD伴神经精神障碍包括抑郁、焦虑、轻度认知功能障碍、痴呆和幻觉等,严重影响患者生存质量。大量研究发现,针灸、中药能够通过多种途径改善神经递质水平,改善神经精神障碍对应量表评分,对PD伴神经精神障碍有明显的治疗效果。由于目前尚无应用针刺、中药方剂和针药结合等中医药方法治疗PD伴神经精神障碍进展的研究,因此本文通过对近年来中医药治疗PD伴神经精神障碍的国内外相关文献进行综述,总结当前PD伴神经精神障碍的发病机制及针刺、中药方剂和针药结合等中医药方法治疗PD伴神经精神障碍的研究,为今后治疗PD神经精神障碍提供新的思路。

96例失眠患者的临床特点及中医疗法回顾性分析

目的 探讨失眠患者的临床特点及中医疗法,旨在提高临床医生对失眠的认知和诊治水平。方法 回顾性分析2011年11月至2022年11月我院96例失眠患者的临床病例资料,包括就诊年龄、性别、病程、治疗时间、治疗方法、慢性疾病及诊断类型。采用单因素和多因素Logistic回归分析影响失眠患者治疗效果的因素,并绘制受试者工作特征(ROC)曲线,遴选出能预测影响失眠治疗效果的指标。结果 患者的就诊年龄主要集中在41~70岁,≤30岁及81~90岁的患者较少,不同年龄段的女性患者占比均高于男性。就诊年龄是影响失眠治疗效果的危险因素,而治疗时间和中药联合针灸治疗是影响失眠治疗效果的保护因素(P<0.05)。结论 就诊年龄是影响失眠治疗效果的危险因素,而治疗时间和中药联合针灸疗法是影响失眠治疗效果的保护因素。临床应根据患者的综合特征,科学地将非药物治疗与中医药疗法相结合,从而提高睡眠质量。

中医药治疗斑秃研究进展

斑秃是一种较为常见的非瘢痕性炎症性脱发,禀赋不足气血空虚、饮食不节湿热内蕴、情志失调瘀阻脉络、腠理不固风袭巅顶等皆可导致斑秃的发生,其病性属本虚标实。本病可从肝肾不足、气血亏虚、血虚风燥、血热动风、肝郁血瘀、湿热蕴蒸6个证型辨治。现从辨证论治、专方治疗、中成药治疗、针药并用以及中西医结合治疗角度概括中医药治疗斑秃的研究进展,以期为临床治疗斑秃提供思路。

玉女煎联合针刺治疗气阴亏虚型消渴35例

目的 观察玉女煎加减与针刺联合运用治疗气阴亏虚型消渴的临床疗效。方法 选取35例糖尿病患者为治疗组,采用玉女煎加减配合针刺治疗,并设立对照组35例服用二甲双胍片治疗,治疗组与对照组均治疗12周,观察2组的疗效并进行对比。结果 治疗组总有效率高于对照组(P<0.05);治疗组对于降低空腹血糖、餐后2 h血糖的有效率明显高于对照组(P<0.05)。结论 玉女煎加减联合针刺对治疗气阴亏虚型消渴有良好治疗效果。