The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter d...The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.展开更多
本文针对青藏高原部分地区土壤有机质和砾石含量较高的特点,在前人工作的基础上,发展了一个新的参数化方案以描述土壤有机质和砾石对土壤导热率、导水率的影响。通过对通用陆面模式CoLM中的土壤水、热参数化方案以及地表蒸发阻抗三方面...本文针对青藏高原部分地区土壤有机质和砾石含量较高的特点,在前人工作的基础上,发展了一个新的参数化方案以描述土壤有机质和砾石对土壤导热率、导水率的影响。通过对通用陆面模式CoLM中的土壤水、热参数化方案以及地表蒸发阻抗三方面的逐步改进,对青藏高原藏东南站和纳木错站两种不同下垫面进行单点数值模拟分析。对比原方案与最终优化方案的模拟结果表明:采用新方案的CoLM模式对藏东南站土壤湿度模拟性能明显提高,平均偏差减小到0.04,而对纳木错站浅层20 cm以上土壤湿度的模拟偏差略微增大。新方案在藏东南站对土壤内部温度的模拟改善较为显著,平均偏差减小了0.2°C;而在纳木错站40 cm以上有所改进。新参数化方案较好地模拟了两个观测站表面能量通量的时间变化,纳木错站7、8月份的潜热通量改进尤为明显,比原方案减少大约20 W m-2,与观测结果较为接近。展开更多
基金supported by the National Natural Science Foundation of China,No.30672696,81072801the Natural Science Foundation of Beijing in China,No.7093129
文摘The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.
文摘本文针对青藏高原部分地区土壤有机质和砾石含量较高的特点,在前人工作的基础上,发展了一个新的参数化方案以描述土壤有机质和砾石对土壤导热率、导水率的影响。通过对通用陆面模式CoLM中的土壤水、热参数化方案以及地表蒸发阻抗三方面的逐步改进,对青藏高原藏东南站和纳木错站两种不同下垫面进行单点数值模拟分析。对比原方案与最终优化方案的模拟结果表明:采用新方案的CoLM模式对藏东南站土壤湿度模拟性能明显提高,平均偏差减小到0.04,而对纳木错站浅层20 cm以上土壤湿度的模拟偏差略微增大。新方案在藏东南站对土壤内部温度的模拟改善较为显著,平均偏差减小了0.2°C;而在纳木错站40 cm以上有所改进。新参数化方案较好地模拟了两个观测站表面能量通量的时间变化,纳木错站7、8月份的潜热通量改进尤为明显,比原方案减少大约20 W m-2,与观测结果较为接近。