For a linear dynamical system,we address the problem of devising a bounded feedback control,which brings the system to the origin in finite time.The construction is based on the notion of a common Lyapunov function.It...For a linear dynamical system,we address the problem of devising a bounded feedback control,which brings the system to the origin in finite time.The construction is based on the notion of a common Lyapunov function.It is shown that the constructed control remains effective in the presence of small perturbations.展开更多
A frequency compensation control method for the opposed-piston two-stroke folded-cranktrain( OPFC) diesel engine's common rail system is presented as a result of the study of the loop-shaping theory. A common rail ...A frequency compensation control method for the opposed-piston two-stroke folded-cranktrain( OPFC) diesel engine's common rail system is presented as a result of the study of the loop-shaping theory. A common rail working process and the classical frequency control theory are combined to construct a frequency restriction of common rail pressure. A frequency compensator is utilized to improve the robustness of multiplicative perturbations and disturbance. The loop-shaping method has been applied to design the common rail pressure controller of the OPFC diesel engine. Simulation and bench test results show that in the condition of perturbation that comes from the effect of injection,multi-injection,fuel pumping of a pre-cylinder,and instantaneous pressure fluctuation,the controller indicates high precision. Compared with the original controller,this method improves the control precision by 67. 3%.展开更多
This paper is concerned with controller synthesis for linear switched systems with actuator saturation. Based on common Lyapunov function technique and multiple-Lyapunov function technique, two methods for designing s...This paper is concerned with controller synthesis for linear switched systems with actuator saturation. Based on common Lyapunov function technique and multiple-Lyapunov function technique, two methods for designing state feedback controller are proposed respectively in terms of linear matrix inequalities for the switched systems with saturation. An approach on enlarging the attractive domain is then investigated, The application of the presented approach is illustrated finally by a numerical example.展开更多
Objective:To observe the effect of common salt(NaCl) on immature stages of laboratory reared Aedes aegypti(L).Methods:A laboratory colony of Aedes aegypti mosquitoes of Rajahmundry strain was established in the labora...Objective:To observe the effect of common salt(NaCl) on immature stages of laboratory reared Aedes aegypti(L).Methods:A laboratory colony of Aedes aegypti mosquitoes of Rajahmundry strain was established in the laboratory of National Institute for Communicable Disease(NICD), Rajahmundry unit at(26±2)℃with relative humidity of(70±10)%.1.00%,1.25%and 1.50% solutions of common salt(NaCl) were selected to observe the susceptibility status of immature stages of Aedes aegypti in laboratory.Results:Fifty percent larvae of Aedes aegypti died within 19,31 and 48 hours when exposed to 1.50%,1.25%and 1.00%common salt solution, respectively.Ninety percent of the larvae died within 29,57 and 108 hours when exposed to the same salt solutions,respectively.Very high pupal mortality was observed varying from 81.8% to 40.0%.Formation of pupae was found inversely proportional in the presence of concentration of common salt in breeding water.Conclusions:With easy availability,less toxicity and long lasting nature,common salt may be applied in unused containers,especially in junkyards where surveillance mechanism is poor along with other conventional vector control methods in order to control breeding of Aedes aegypti,the vector of dengue/ dengue hemorrhagic fever and chikungunya.展开更多
A direct injection low compression ratios diesel rotary engine is designed and studied to find the appropriate application of the electronic controlled high pressure common rail injection system. Current development f...A direct injection low compression ratios diesel rotary engine is designed and studied to find the appropriate application of the electronic controlled high pressure common rail injection system. Current development focuses on the applied fuel injection and ignition strategies, especially concerning the combustion configurations of injectors, ignition source, and combustion chamber. The prototype engine, equipped with Bosch common rail system and high performance electronic control unit (ECU), is designed correspondingly. Studies show that the integration of a common rail injection system and the main and pilot duel injectors configurations, assisted with glow plug ignition device and flexible ECU, represents a promising approach to improve the potential of the low compression ratios diesel rotary engine. Currently the engine can run at 6 kr · min^-1 steadily and the power is about 68 kW/(4 kr ·min^- 1).展开更多
This paper presents the design of a controller for the measurement and reduction of conducted Electro Magnetic Interference (EMI) caused in the power electronic circuits. The conducted EMI is also separating the Commo...This paper presents the design of a controller for the measurement and reduction of conducted Electro Magnetic Interference (EMI) caused in the power electronic circuits. The conducted EMI is also separating the Common Mode (CM) and Differential Mode (DM) simultaneously using Line Impedance Stabilization Network (LISN). EMI is mitigated by the fuzzy controller. By comparing common mode voltage with the standard reference value, the generated error can be minimized by using fuzzy controller. Fuzzy controller is varying the PWM signal of the power electronic switching devices for reducing the electromagnetic interference. In this paper, comparison of PI and fuzzy controller of the open loop and closed loop models are implemented using MATLAB<sup>®</sup></sup> SIMULINK for measurement and reduction of the EMI level;and also simulation results of the PI controller and fuzzy controller analysis are presented in this paper. The fuzzy controller is provided to achieve the EMI level of the inverter within the standard limit.展开更多
An adaptive fuzzy tracking control scheme is presented for a class of switched multi-input-multi-output (MIMO) nonlinear systems with disturbances under arbitrary switching. Adaptive fuzzy systems are employed to appr...An adaptive fuzzy tracking control scheme is presented for a class of switched multi-input-multi-output (MIMO) nonlinear systems with disturbances under arbitrary switching. Adaptive fuzzy systems are employed to approximate the unknown functions on line,and a systematic framework for adaptive fuzzy tracking controller design is given,where the dynamic surface control (DSC) approach is used to solve the problem of "explosion of complexity"in the backstepping design procedure. According to the common Lyapunov function theory,it is proved that the proposed controller can guarantee the boundedness of all signals in the closed loop system. Finally,the simulation results demonstrate the validity of the control approach.展开更多
This paper explores the model reference adaptive control problem for a class of switched linear systems under arbitrary switching with no need for the measurability of the system state.Based on the state of reference ...This paper explores the model reference adaptive control problem for a class of switched linear systems under arbitrary switching with no need for the measurability of the system state.Based on the state of reference model and the measurable output error, adaptive laws and controllers are designed for switched systems.Each subsystem may have its individual reference model and controller, which increases the design flexibility.The introduction of the closed-loop reference model is to get a better transient performance of the whole switched systems.A numerical example is provided to verify the effectiveness of the main results.展开更多
Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compare...Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compared to placebo. Methods: 100 healthy participants with recurring infections were randomly assigned to receive either placebo or yeast beta-glucan (Yestimun?;n = 50 each group) over a period of 26 weeks. The subjects had to document each common cold episode in a diary, and rate 6 predefined infections symptoms on a 3-point rating scale during an infection period, resulting in an infection score. The common cold episodes were confirmed by the investigators. Results: A total of 171 common cold episodes were documented. Of these, 76 were experienced by 38 subjects in the beta-glucan group and 96 were experienced by 48 subjects in the placebo group (p = 0.406). The beta-glucan group had significantly more subjects without incidences of common cold than the placebo group (15.6% vs 2.0%;p = 0.019). During the most intense infection season (first 13 weeks of the study), the beta-glucan group had significantly less infections compared to placebo (p = 0.02). Beta-glucan significantly reduced the typical cold symptoms (“sore throat and/or difficulty swallowing”, “hoarseness and/or cough” and “runny nose”) as opposed to placebo. Conclusion: The present study demonstrates a prophylactic effect of yeast beta-glucan on the occurrence of common colds as opposed to placebo. In addition, when these episodes occurred, they were from the beginning less pronounced and subsided faster.展开更多
This paper is concerned with the H-infinity control problem for a class of cascade switched nonlinear systems. Each switched system in this class is composed of a zero-mput asymptotically stable nonlinear part, which ...This paper is concerned with the H-infinity control problem for a class of cascade switched nonlinear systems. Each switched system in this class is composed of a zero-mput asymptotically stable nonlinear part, which is also a switched system, and a linearizable part which is controllable. Conditions under which the H-infinity control problem is solvable under arbitrary switching law and under some designed switching law are derived respectively. The nonlinear state feedback and switching law are designed. We exploit the structural characteristics of the switched nonlinear systems to construct common Lyapunov functions for arbitrary switching and to find a single Lyapunov function for designed switching law. The proposed methods do not rely on the solutions of Hamilton-Jacobi inequalities.展开更多
Wind generation is being increasingly connected at distribution level due to increasing load demand. Permanent magnet synchronous generator (PMSG) is connected to?the wind turbine directly. Through the full power cont...Wind generation is being increasingly connected at distribution level due to increasing load demand. Permanent magnet synchronous generator (PMSG) is connected to?the wind turbine directly. Through the full power control of AC-DC-AC converters, the electrical power is then connected to the power grid. The power conversion circuits are made up of generator-side three phase diode rectifiers, boost converter and the grid-side three bridges and four wire inverters. A boost converter is controlled through an intelligence controller to maintained DC power constant despite of Variable output of PMSG, the grid-connected operation is constructed using the hysteresis current control method. The inverter is controlled to perform following function 1) power converter to inject power generated from RES to the grid, and 2) shunt APF to compensate current unbalance, load current harmonics, load reactive power demand and load neutral current. The model is implemented in MATLAB/ Simulink using sim power system.展开更多
Exserohilum turcicum and Puccinia sorghi cause foliar fungal diseases that affect maize crop in Argentina. These diseases, northern leaf blight and common rust respectively, are presented each year with different leve...Exserohilum turcicum and Puccinia sorghi cause foliar fungal diseases that affect maize crop in Argentina. These diseases, northern leaf blight and common rust respectively, are presented each year with different levels of severity affecting significantly the yield in susceptible hybrids. Disease control usually consists in the use of resistant cultivars and chemical control. Biological control as a preventive method is a viable alternative to evaluate. The aims of this study were to evaluate the natural incidence of both foliar diseases in maize after application of two antagonists, to determine the survival of the antagonists in the maize phyllosphere and to evaluate the effect of inoculation on grain yield at harvest. Plants treated with both biological control agents showed significant reductions in the incidence of both foliar diseases. In northern leaf blight the reduction was higher than 50% during 40 days in plants treated with Bacillus spp. Moreover, grain yield was significantly higher as compared to control treatments.展开更多
Due to the increasing share of renewable energy, new requirements are placed on control room software. Such software is often exclusive to the supplier, but other suppliers could offer new and better methods. For secu...Due to the increasing share of renewable energy, new requirements are placed on control room software. Such software is often exclusive to the supplier, but other suppliers could offer new and better methods. For security reasons, external applications often have no direct data access to control room software. Such software can provide information about the power grid via a periodic file transfer in CIM (Common Information Model) format. These files are often very large, containing complete records, delivering information not always relevant to the external applications. Extracting the relevant information required by external applications can be time-consuming, thus presenting a problem for time-critical applications. This paper presents a method allowing different applications to efficiently access the relevant data from the massive data stream contained in the CIM files. This method has been tested with a distribution system operator and clearly increases performance, allowing different applications to access the relevant data.展开更多
In recent years, geological disasters have occurred frequently. This not only has a serious impact on urban construction, but also directly threatens the safety of life and property. In response to this situation, the...In recent years, geological disasters have occurred frequently. This not only has a serious impact on urban construction, but also directly threatens the safety of life and property. In response to this situation, the control of the construction quality of the geological disaster management process must be strengthened to improve the construction quality of the treatment process. This paper mainly introduces the characteristics of geological hazard management engineering, common geological hazards and geological hazard treatment engineering, and expounds the key points and control measures of geological hazard management engineering quality control, so as to improve the construction quality of geological hazard management engineering.展开更多
Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in commun...Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in community-dwelling adults was compared to a combination of standardized amounts of Echinacea (EC) components. Methods: 44 healthy adults, experiencing new onset of cold symptoms were randomly assigned to receive either BDI-630 (900 mg) or EC (500 mg) twice daily for 10 days. The severity of cold symptoms and the quality of life was assessed by self-reporting of subjects using the Wisconsin Upper Respiratory Symptom Survey (WURSS-21? 2004). Results: The intent-to-treat population (ITT) consisted of 44 subjects (n = 22 for BDI-630;n = 22 for EC). The modified ITT (mITT) population consisted of 40 subjects, excluding four subjects with major protocol deviations related to inclusion/exclusion criteria and/or use of prohibited drugs from the efficacy analysis (n = 3 for BDI-630 and n = 1 for EC). Results indicated a sig-nificant difference between the two groups: the superiority of BDI-630 over EC was particularly noticeable between Day 1 and Day 7, as demonstrated by a 14-fold difference of the mean percentage of change of total score from baseline in the mITT population. Adverse events (AEs) following the intake of BDI-630 were mostly limited to mild gastrointestinal intolerance in less than 10% of the subjects. Conclusions: BDI-630 was shown to be more effective than EC in alleviating cold symptoms in the adult population, particularly during the first 7 days of treatment. BDI-630 was very well tolerated by all subjects.展开更多
基金supported by Russian Foundation for Basic Research(Grant No.08-01-00234,08-01-00411,08-08- 00292)
文摘For a linear dynamical system,we address the problem of devising a bounded feedback control,which brings the system to the origin in finite time.The construction is based on the notion of a common Lyapunov function.It is shown that the constructed control remains effective in the presence of small perturbations.
基金Supported by the National Natural Science Foundation of China(51406013)
文摘A frequency compensation control method for the opposed-piston two-stroke folded-cranktrain( OPFC) diesel engine's common rail system is presented as a result of the study of the loop-shaping theory. A common rail working process and the classical frequency control theory are combined to construct a frequency restriction of common rail pressure. A frequency compensator is utilized to improve the robustness of multiplicative perturbations and disturbance. The loop-shaping method has been applied to design the common rail pressure controller of the OPFC diesel engine. Simulation and bench test results show that in the condition of perturbation that comes from the effect of injection,multi-injection,fuel pumping of a pre-cylinder,and instantaneous pressure fluctuation,the controller indicates high precision. Compared with the original controller,this method improves the control precision by 67. 3%.
基金This work was supported by the National Natural Science Foundation of China(No. 60474034).
文摘This paper is concerned with controller synthesis for linear switched systems with actuator saturation. Based on common Lyapunov function technique and multiple-Lyapunov function technique, two methods for designing state feedback controller are proposed respectively in terms of linear matrix inequalities for the switched systems with saturation. An approach on enlarging the attractive domain is then investigated, The application of the presented approach is illustrated finally by a numerical example.
文摘Objective:To observe the effect of common salt(NaCl) on immature stages of laboratory reared Aedes aegypti(L).Methods:A laboratory colony of Aedes aegypti mosquitoes of Rajahmundry strain was established in the laboratory of National Institute for Communicable Disease(NICD), Rajahmundry unit at(26±2)℃with relative humidity of(70±10)%.1.00%,1.25%and 1.50% solutions of common salt(NaCl) were selected to observe the susceptibility status of immature stages of Aedes aegypti in laboratory.Results:Fifty percent larvae of Aedes aegypti died within 19,31 and 48 hours when exposed to 1.50%,1.25%and 1.00%common salt solution, respectively.Ninety percent of the larvae died within 29,57 and 108 hours when exposed to the same salt solutions,respectively.Very high pupal mortality was observed varying from 81.8% to 40.0%.Formation of pupae was found inversely proportional in the presence of concentration of common salt in breeding water.Conclusions:With easy availability,less toxicity and long lasting nature,common salt may be applied in unused containers,especially in junkyards where surveillance mechanism is poor along with other conventional vector control methods in order to control breeding of Aedes aegypti,the vector of dengue/ dengue hemorrhagic fever and chikungunya.
基金This project is supported by the Commission of Science Technology and Industry for National Defense, China(No.MKPT-02-291).
文摘A direct injection low compression ratios diesel rotary engine is designed and studied to find the appropriate application of the electronic controlled high pressure common rail injection system. Current development focuses on the applied fuel injection and ignition strategies, especially concerning the combustion configurations of injectors, ignition source, and combustion chamber. The prototype engine, equipped with Bosch common rail system and high performance electronic control unit (ECU), is designed correspondingly. Studies show that the integration of a common rail injection system and the main and pilot duel injectors configurations, assisted with glow plug ignition device and flexible ECU, represents a promising approach to improve the potential of the low compression ratios diesel rotary engine. Currently the engine can run at 6 kr · min^-1 steadily and the power is about 68 kW/(4 kr ·min^- 1).
文摘This paper presents the design of a controller for the measurement and reduction of conducted Electro Magnetic Interference (EMI) caused in the power electronic circuits. The conducted EMI is also separating the Common Mode (CM) and Differential Mode (DM) simultaneously using Line Impedance Stabilization Network (LISN). EMI is mitigated by the fuzzy controller. By comparing common mode voltage with the standard reference value, the generated error can be minimized by using fuzzy controller. Fuzzy controller is varying the PWM signal of the power electronic switching devices for reducing the electromagnetic interference. In this paper, comparison of PI and fuzzy controller of the open loop and closed loop models are implemented using MATLAB<sup>®</sup></sup> SIMULINK for measurement and reduction of the EMI level;and also simulation results of the PI controller and fuzzy controller analysis are presented in this paper. The fuzzy controller is provided to achieve the EMI level of the inverter within the standard limit.
基金Sponsored by the National Natural Science Foundation of China (Grant No.60974106,91116017 )the Aeronautical Science Fund (Grant No.20095152028)the Funding for Outstanding Doctoral Dissertation in NUAA (Grant No.BCXJ10-04)
文摘An adaptive fuzzy tracking control scheme is presented for a class of switched multi-input-multi-output (MIMO) nonlinear systems with disturbances under arbitrary switching. Adaptive fuzzy systems are employed to approximate the unknown functions on line,and a systematic framework for adaptive fuzzy tracking controller design is given,where the dynamic surface control (DSC) approach is used to solve the problem of "explosion of complexity"in the backstepping design procedure. According to the common Lyapunov function theory,it is proved that the proposed controller can guarantee the boundedness of all signals in the closed loop system. Finally,the simulation results demonstrate the validity of the control approach.
基金Sponsored by the National Natural Science Foundation of China(Grant No.61233002)the 111 Project(Grant No.B16009)the IAPI Fundamental Research Funds(Grant No.2013ZCX03-01)
文摘This paper explores the model reference adaptive control problem for a class of switched linear systems under arbitrary switching with no need for the measurability of the system state.Based on the state of reference model and the measurable output error, adaptive laws and controllers are designed for switched systems.Each subsystem may have its individual reference model and controller, which increases the design flexibility.The introduction of the closed-loop reference model is to get a better transient performance of the whole switched systems.A numerical example is provided to verify the effectiveness of the main results.
文摘Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compared to placebo. Methods: 100 healthy participants with recurring infections were randomly assigned to receive either placebo or yeast beta-glucan (Yestimun?;n = 50 each group) over a period of 26 weeks. The subjects had to document each common cold episode in a diary, and rate 6 predefined infections symptoms on a 3-point rating scale during an infection period, resulting in an infection score. The common cold episodes were confirmed by the investigators. Results: A total of 171 common cold episodes were documented. Of these, 76 were experienced by 38 subjects in the beta-glucan group and 96 were experienced by 48 subjects in the placebo group (p = 0.406). The beta-glucan group had significantly more subjects without incidences of common cold than the placebo group (15.6% vs 2.0%;p = 0.019). During the most intense infection season (first 13 weeks of the study), the beta-glucan group had significantly less infections compared to placebo (p = 0.02). Beta-glucan significantly reduced the typical cold symptoms (“sore throat and/or difficulty swallowing”, “hoarseness and/or cough” and “runny nose”) as opposed to placebo. Conclusion: The present study demonstrates a prophylactic effect of yeast beta-glucan on the occurrence of common colds as opposed to placebo. In addition, when these episodes occurred, they were from the beginning less pronounced and subsided faster.
文摘This paper is concerned with the H-infinity control problem for a class of cascade switched nonlinear systems. Each switched system in this class is composed of a zero-mput asymptotically stable nonlinear part, which is also a switched system, and a linearizable part which is controllable. Conditions under which the H-infinity control problem is solvable under arbitrary switching law and under some designed switching law are derived respectively. The nonlinear state feedback and switching law are designed. We exploit the structural characteristics of the switched nonlinear systems to construct common Lyapunov functions for arbitrary switching and to find a single Lyapunov function for designed switching law. The proposed methods do not rely on the solutions of Hamilton-Jacobi inequalities.
文摘Wind generation is being increasingly connected at distribution level due to increasing load demand. Permanent magnet synchronous generator (PMSG) is connected to?the wind turbine directly. Through the full power control of AC-DC-AC converters, the electrical power is then connected to the power grid. The power conversion circuits are made up of generator-side three phase diode rectifiers, boost converter and the grid-side three bridges and four wire inverters. A boost converter is controlled through an intelligence controller to maintained DC power constant despite of Variable output of PMSG, the grid-connected operation is constructed using the hysteresis current control method. The inverter is controlled to perform following function 1) power converter to inject power generated from RES to the grid, and 2) shunt APF to compensate current unbalance, load current harmonics, load reactive power demand and load neutral current. The model is implemented in MATLAB/ Simulink using sim power system.
文摘Exserohilum turcicum and Puccinia sorghi cause foliar fungal diseases that affect maize crop in Argentina. These diseases, northern leaf blight and common rust respectively, are presented each year with different levels of severity affecting significantly the yield in susceptible hybrids. Disease control usually consists in the use of resistant cultivars and chemical control. Biological control as a preventive method is a viable alternative to evaluate. The aims of this study were to evaluate the natural incidence of both foliar diseases in maize after application of two antagonists, to determine the survival of the antagonists in the maize phyllosphere and to evaluate the effect of inoculation on grain yield at harvest. Plants treated with both biological control agents showed significant reductions in the incidence of both foliar diseases. In northern leaf blight the reduction was higher than 50% during 40 days in plants treated with Bacillus spp. Moreover, grain yield was significantly higher as compared to control treatments.
文摘Due to the increasing share of renewable energy, new requirements are placed on control room software. Such software is often exclusive to the supplier, but other suppliers could offer new and better methods. For security reasons, external applications often have no direct data access to control room software. Such software can provide information about the power grid via a periodic file transfer in CIM (Common Information Model) format. These files are often very large, containing complete records, delivering information not always relevant to the external applications. Extracting the relevant information required by external applications can be time-consuming, thus presenting a problem for time-critical applications. This paper presents a method allowing different applications to efficiently access the relevant data from the massive data stream contained in the CIM files. This method has been tested with a distribution system operator and clearly increases performance, allowing different applications to access the relevant data.
文摘In recent years, geological disasters have occurred frequently. This not only has a serious impact on urban construction, but also directly threatens the safety of life and property. In response to this situation, the control of the construction quality of the geological disaster management process must be strengthened to improve the construction quality of the treatment process. This paper mainly introduces the characteristics of geological hazard management engineering, common geological hazards and geological hazard treatment engineering, and expounds the key points and control measures of geological hazard management engineering quality control, so as to improve the construction quality of geological hazard management engineering.
文摘Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in community-dwelling adults was compared to a combination of standardized amounts of Echinacea (EC) components. Methods: 44 healthy adults, experiencing new onset of cold symptoms were randomly assigned to receive either BDI-630 (900 mg) or EC (500 mg) twice daily for 10 days. The severity of cold symptoms and the quality of life was assessed by self-reporting of subjects using the Wisconsin Upper Respiratory Symptom Survey (WURSS-21? 2004). Results: The intent-to-treat population (ITT) consisted of 44 subjects (n = 22 for BDI-630;n = 22 for EC). The modified ITT (mITT) population consisted of 40 subjects, excluding four subjects with major protocol deviations related to inclusion/exclusion criteria and/or use of prohibited drugs from the efficacy analysis (n = 3 for BDI-630 and n = 1 for EC). Results indicated a sig-nificant difference between the two groups: the superiority of BDI-630 over EC was particularly noticeable between Day 1 and Day 7, as demonstrated by a 14-fold difference of the mean percentage of change of total score from baseline in the mITT population. Adverse events (AEs) following the intake of BDI-630 were mostly limited to mild gastrointestinal intolerance in less than 10% of the subjects. Conclusions: BDI-630 was shown to be more effective than EC in alleviating cold symptoms in the adult population, particularly during the first 7 days of treatment. BDI-630 was very well tolerated by all subjects.