We construct parabolic analogues of(global)eigenvarieties,of patched eigenvarieties and of(local)trianguline varieties,that we call,respectively,Bernstein eigenvarieties,patched Bernstein eigenvarieties,and Bernstein ...We construct parabolic analogues of(global)eigenvarieties,of patched eigenvarieties and of(local)trianguline varieties,that we call,respectively,Bernstein eigenvarieties,patched Bernstein eigenvarieties,and Bernstein paraboline varieties.We study the geometry of these rigid analytic spaces,in particular(generalising results of Breuil-Hellmann-Schraen)we show that their local geometry can be described by certain algebraic schemes related to the generalised Grothendieck-Springer resolution.We deduce several local-global compatibility results,including a classicality result(with no trianguline assumption at p),and new cases towards the locally analytic socle conjecture of Breuil in the non-trianguline case.展开更多
In this paper,we study reduced rings in which every element is a sum of three tripotents that commute,and determine the integral domains over which every n£n matrix is a sum of three tripotents.It is proved that ...In this paper,we study reduced rings in which every element is a sum of three tripotents that commute,and determine the integral domains over which every n£n matrix is a sum of three tripotents.It is proved that for an integral domain R,every matrix in M_(n)(R)is a sum of three tripotents if and only if R■Zp with p=2,3,5 or 7.展开更多
The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant res...The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in cats. The animals were divided into two groups of seven animals each. One group received DNF, and the other consumed commercial extruded dry feed (DCF). The experiment lasted 45 days and we measured daily consumption and collected blood and feces samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than DCF. Cats in the DNF group had a higher volume of feces. DNF cats had lower leukocyte and granulocyte counts and cholesterol levels. Serum enzymatic antioxidant responses and non-enzymatic were higher in DNF cats. Cats in the DNF group showed lower serum acute phase proteins in addition to a tendency toward a higher concentration of transferrin than in the DCF group. Fecal Escherichia coli and total coliform counts of cats fed DNF were higher than DCF. We conclude that the daily consumption of cats is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunological responses.展开更多
Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to...Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients,is becoming more and more important.However,most current US Food and Drug Administration(FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo.Consequently,new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables.They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments.This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx.We believe that this review offers additional details and directions for promoting medical imaging-based CDx development.展开更多
The companion fungus ( Grifola sp.) related to sclerotial formation from hyphae of Grifola umbellata (Pers.) Pilat was isolated from the cavity associated with sclerotia of G. umbellata in natural condition. Experimen...The companion fungus ( Grifola sp.) related to sclerotial formation from hyphae of Grifola umbellata (Pers.) Pilat was isolated from the cavity associated with sclerotia of G. umbellata in natural condition. Experimental results showed that the pure culture of G. umbellata was unable to form sclerotia, whereas sclerotia produced easily in flasks or on trunks when the companion fungus was inoculated together with strain of G. umbellata. The companion fungus is critical for sclerotium formation from hyphae of G. umbellata. Morphological differences were found in cultures of the two fungi. The companion fungus possesses thin-walled narrow hyphae, while G. umbellata is of wider hyphae which are either thick- or thin-walled.展开更多
[Objective]The aim was to solve the weeds existed in seedling period of alfalfa in Chongqing.[Method]The naked oat and common oat were selected.Through the analysis of determiners such as plant number,plant height,yie...[Objective]The aim was to solve the weeds existed in seedling period of alfalfa in Chongqing.[Method]The naked oat and common oat were selected.Through the analysis of determiners such as plant number,plant height,yield and weeds ratio,the oat type and sowing method were screened through all the accompany sowing crops to better control weeds in the seedling period of alfalfa.[Result]Compared with common oat,the tested naked oat as the companion crop of alfalfa seeding can prevent weeds more effectively;the proper companion-seeding disposal of alfalfa sowed in spring in Chongqing area was 15 kg/hm2 of alfalfa and 120 kg/hm2 of naked oat,sowing in strip in 40 cm row spacing;the proper mowing period of oat was during the time from May 11th to May 21st;the proper mowing period of alfalfa was ten days later.[Conclusion]Spring sowing oats with alfalfa can control seedling weeds effectively.展开更多
Spectrin-like protein has been found in a variety of plant cells. In this study, electron microscopic observation of immuno-gold labelled preparations from the leaf petiole of cucumber ( Cucumis sativus L.) shows that...Spectrin-like protein has been found in a variety of plant cells. In this study, electron microscopic observation of immuno-gold labelled preparations from the leaf petiole of cucumber ( Cucumis sativus L.) shows that it also exists in the sieve element-companion cell (SE-CC) complex, being widely distributed in P-protein filaments and sieve element reticulum (SER), in the cytoplasm and mitochondrial membrane of companion cell (CC) and in the branched plasmodesmata between sieve element (SE) and CC as well. The results suggest that this protein could be synthesized in CC and transferred to SE through plasmodesmata. Western blotting showed that spectrin-like protein existed in the protein of phloem exudate of cucumber, and its molecular weight was about 260 kD.展开更多
Healthy relationships are important to functioning in daily life and across the life-span (e.g., Burman and Margolin 1992). Personality factors could predict relationship satisfaction through the influence of indivi...Healthy relationships are important to functioning in daily life and across the life-span (e.g., Burman and Margolin 1992). Personality factors could predict relationship satisfaction through the influence of individuals' relationship schemas (Fiske and Taylor 1991) and perceptions of their partners (Simpson and Rholes 1998). Given the potential importance of attachment styles to relationship mechanisms and the well-established relationship between attachment and interpersonal behavior (Bartholomew and Horowitz 1992; Hazan and Shaver 1987), interpersonal traits may influence relationship satisfaction directly. According to Leary's (1957) interpersonal reflex theory, any interpersonal act elicits responses from the other person that verify, validate, or otherwise reinforce the actor's own self-image and self-presentation, and thus increase the probability that the actor will emit similar interpersonal acts in future interactions. The Impact Message Inventory (IMI) attempts to measure individuals' perceptions of how others impact them by evoking interpersonal acts such as dominance and affiliation. This study examined the influence of perceived partner-evoked behavior and individuals' own interpersonal styles on relationship satisfaction. This study used IMI measures of evoked Dominance and Affiliation as well as revised Liking and Loving measures to predict relationship satisfaction using three different satisfaction outcome measures. The final analyses included 291 participants (134 men and 157 women) who completed a scantron survey. Partner impact, or the interpersonal behaviors, evoked from the individual during interaction, predicted relationship satisfaction well. Evoked affiliation was the most consistently strong predictor of satisfaction across all three outcome measures. Liking (distinct here from affiliation) is a stronger predictor of relationship satisfaction than is loving (distinct here from passion), and it is significant across all three outcome measures. The liking measure appears to reflect a relatively high level of reward in the relationship and intrinsic enjoyment of the partner's company without the comparative cost of loving. Future research should examine interactions between couples, moving beyond intrapsychic self-reports of perceived experiences and feelings, although these are important in their own right.展开更多
Amplification of the human epidermal growth factor receptor 2 (HER2) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. The degree of HER2 ov...Amplification of the human epidermal growth factor receptor 2 (HER2) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. The degree of HER2 overexpression and amplification varies with the location of the carcinoma, with higher expression in the gastroesophageal and proximal parts compared to the distal parts of the stomach. Further, HER2 overexpression and amplification also seems to be related to the Lauren histological classification, with higher levels found in the intestinal phenotype compared to the diffuse and mixed types. The prognostic properties of HER2 overexpression and amplification are still under debate, but a large number of studies seem to indicate that HER2 is a negative prognostic factor. The usefulness of HER2 targeted therapy in gastric cancer was demonstrated in the ToGA trial, where HER2-positive patients with advanced gastric and gastroesophageal junction adenocarcinoma were randomized to receive 5-FU/capecitabine and cisplatin, either alone or in combination with trastuzumab. A statically significant gain in overall survival was seen in patients who received the combined treatment of trastuzumab and chemotherapy. Patients with a strong overexpression of the HER2 protein (IHC3+) specifically benefited from the treatment, with a median overall survival of 17.9 mo. As a consequence of the positive results of the ToGA trial, patients with advanced gastric or gastroesophageal junction adenocarcinoma are now routinely tested for HER2. The ToGA trial must be characterized as a landmark in the treatment of gastric cancer and it has paved the way for a number of new HER2 targeted compounds such as pertuzumab, ado-trastuzumab emtansine, lapatinib, afatinib, and dacomitinib, which are currently undergoing phase II and III clinical testing. Overall, this review will discuss the current status of HER2 in gastric and gastroesophageal junction cancer and the future direction in relation to HER2 target therapy.展开更多
Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric ...Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric cancer, many genetic alterations have been identified as potential targets for its treatment. Multiple novel agents are currently under development as the demand for active agents that improve the survival of gastric cancer patients constantly increases. Based on lessons from previous trials of targeted agents, it is now widely accepted that the establishment of an optimal diagnostic test to select molecularly defined patients is of equal importance to the development of active agents against targetable genetic alterations. Herein, we highlight the current status and future perspectives of companion diagnostics in the treatment of gastric cancer.展开更多
Companion cropping can influence cucumber productivity by altering soil chemical characteristics and microbial communities. However, how these alterations affect the growth of cucumber is still unknown. In this study,...Companion cropping can influence cucumber productivity by altering soil chemical characteristics and microbial communities. However, how these alterations affect the growth of cucumber is still unknown. In this study, seven different plant species were selected as companion plants for testing their effects on cucumber productivity. The effects of different companion plants on changes in soil chemical properties such as electrical conductivity (EC) and contents of essential nutrients as well as the structure and abundance of the soil Pseudomonas community were evaluated. The results showed a higher cucumber yield in the wheat/cucumber companion system than that in the cucumber monocultured and other companion cropping systems. The lowest phosphorus (P) and potassium (K) contents in the soil were found in the cucumber monocultured system, and the highest NO3+-N and NH4*-N contents were observed in the rye/cucumber companion system. PCR-denaturing gradient gel electrophoresis (DGGE) and real-time PCR analysis showed that the trifolium/cucumber companion system increased the diversity of the soil Pseudomonas community, while the chrysanthemum/cucumber companion system increased its abundance. Interestingly, plant-soil feedback trials revealed that inoculating the soil of the wheat/cucumber companion system increased the growth of cucumber seedlings. In conclusion, the effects of different companion plants on cucumber productivity, soil chemical characteristics and the soil Pseudomonas community were different, and wheat was a more suitable companion plant for increasing cucumber productivity. In addition, the altered microbial community caused by companion cropping with wheat contributed to increased cucumber productivity.展开更多
Let R be an associative ring with unity 1. The existence of the Moore-Penrose inverses of block matrices overR is investigated and the sufficient ad necessary conditions for such existence are obtained. Furthermore, ...Let R be an associative ring with unity 1. The existence of the Moore-Penrose inverses of block matrices overR is investigated and the sufficient ad necessary conditions for such existence are obtained. Furthermore, the representation of the Moore-Penrose inverse of M=[0 A C B]is given under the condition of EBF - 0, where E - I - CCT and F - I -AfA. This result generalizes the representation of the Moore-Penrose inverse of the companion matrix M =[0 a In b]due to Pedro Patricio. As for applications, some examples are given to illustrate the obtained results.展开更多
In this paper, solutions to the generalized Sylvester matrix equations AX -XF = BY and MXN -X = TY with A, M ∈ R^n×n, B, T ∈ Rn×r, F, N ∈ R^p×p and the matrices N, F being in companion form, are est...In this paper, solutions to the generalized Sylvester matrix equations AX -XF = BY and MXN -X = TY with A, M ∈ R^n×n, B, T ∈ Rn×r, F, N ∈ R^p×p and the matrices N, F being in companion form, are established by a singular value decomposition of a matrix with dimensions n × (n + pr). The algorithm proposed in this paper for the euqation AX - XF = BY does not require the controllability of matrix pair (A, B) and the restriction that A, F do not have common eigenvalues. Since singular value decomposition is adopted, the algorithm is numerically stable and may provide great convenience to the computation of the solution to these equations, and can perform important functions in many design problems in control systems theory.展开更多
The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and elemen...The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and element free Galerkin method(EFGM), and is a truly meshless method possessing wide prospects in engineering applications. The companion solution and all the other formulas required in the meshless local boundary integral equation for a thin plate were presented, in order to make this method apply to solve the thin plate problem.展开更多
A study was conducted to describe the experiences of primiparous women with the support they received from their birth companions during labour and delivery in Malawi. The study design was descriptive and utilized qua...A study was conducted to describe the experiences of primiparous women with the support they received from their birth companions during labour and delivery in Malawi. The study design was descriptive and utilized qualitative data collection and analysis method on a sample of 20 primiparous women. The women were recruited from the postnatal ward of Bwaila hospital and were interviewed regarding their experiences on the support they received from their birth companions during labour and delivery using an open ended interview guide. Data was manually analyzed using content analysis. Primiparous women described the support they received from their birth companions as useful and beneficial. Birth companions provided advice, physical, emotional and spiritual support to the women during their labour and delivery. In addition, the birth companions were viewed as guardians of the women during labour and delivery. Results however, show that some women were not properly assisted by their companions because both the mothers and companions lacked knowledge on birth companionship. The results further show that birth companions play important roles during the birth and delivery of primiparous women and thereby improving birth outcomes. Therefore, there is a need to train the companions regarding support to a woman during labour and delivery. Primiparous women also need to be trained during antenatal care education so that they properly understand the roles of a birth companion as opposed to those of the midwives.展开更多
We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>...We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>×<i>n</i> Fiedler companion matrix <i>C</i>, sparse companion matrices and triangular Hessenberg matrices are introduced. Then, we identify a special triangular Hessenberg matrix <i>L<sub>r</sub></i>, supposed to provide a good estimation of the roots. By application of Gershgorin’s theorems to this special matrix in case of submultiplicative matrix norms, some estimations of bounds for roots are made. The obtained bounds have been compared to known ones from the literature precisely Cauchy’s bounds, Montel’s bounds and Carmichel-Mason’s bounds. According to the starting formel of <i>L<sub>r</sub></i>, we see that the more we have coefficients closed to zero with a norm less than 1, the more the Sparse method is useful.展开更多
SciM ed Ltd Companion III二通道八深度颈颅多普勒检测仪(前身为EME公司产品)内部结构主要有三大部分组成。电源部分:主机电源部分,采用单相AC 220V输入,提供DC12V和DC5V直流电源输出;二次供电部分,主要为数据采集板提供电源。电脑...SciM ed Ltd Companion III二通道八深度颈颅多普勒检测仪(前身为EME公司产品)内部结构主要有三大部分组成。电源部分:主机电源部分,采用单相AC 220V输入,提供DC12V和DC5V直流电源输出;二次供电部分,主要为数据采集板提供电源。电脑部分:主要采用INTEL公司的迅驰移动式Inter Pen IV CPU,低功耗工业计算机专用主板,展开更多
A closed-form solution to the linear matrix equation AX-EXF = BY with X and Y unknown and matrix F being in a companion form is proposed, and two equivalent forms of this solution are also presented. The results provi...A closed-form solution to the linear matrix equation AX-EXF = BY with X and Y unknown and matrix F being in a companion form is proposed, and two equivalent forms of this solution are also presented. The results provide great convenience to the computation and analysis of the solutions to this class of equations, and can perform important functions in many analysis and design problems in descriptor system theory. The results proposed here are parallel to and more general than our early work about the linear matrix equation AX-XF = BY .展开更多
基金supported by the C.N.R.S and is a member of the A.N.R.project CLap-CLap ANR-18-CE40-0026supported by the NSFC Grant No.8200905010 and No.8200800065.
文摘We construct parabolic analogues of(global)eigenvarieties,of patched eigenvarieties and of(local)trianguline varieties,that we call,respectively,Bernstein eigenvarieties,patched Bernstein eigenvarieties,and Bernstein paraboline varieties.We study the geometry of these rigid analytic spaces,in particular(generalising results of Breuil-Hellmann-Schraen)we show that their local geometry can be described by certain algebraic schemes related to the generalised Grothendieck-Springer resolution.We deduce several local-global compatibility results,including a classicality result(with no trianguline assumption at p),and new cases towards the locally analytic socle conjecture of Breuil in the non-trianguline case.
基金Supported by Key Laboratory of Financial Mathematics of Fujian Province University(Putian University)(JR202203)the NSF of Anhui Province(2008085MA06).
文摘In this paper,we study reduced rings in which every element is a sum of three tripotents that commute,and determine the integral domains over which every n£n matrix is a sum of three tripotents.It is proved that for an integral domain R,every matrix in M_(n)(R)is a sum of three tripotents if and only if R■Zp with p=2,3,5 or 7.
文摘The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in cats. The animals were divided into two groups of seven animals each. One group received DNF, and the other consumed commercial extruded dry feed (DCF). The experiment lasted 45 days and we measured daily consumption and collected blood and feces samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than DCF. Cats in the DNF group had a higher volume of feces. DNF cats had lower leukocyte and granulocyte counts and cholesterol levels. Serum enzymatic antioxidant responses and non-enzymatic were higher in DNF cats. Cats in the DNF group showed lower serum acute phase proteins in addition to a tendency toward a higher concentration of transferrin than in the DCF group. Fecal Escherichia coli and total coliform counts of cats fed DNF were higher than DCF. We conclude that the daily consumption of cats is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunological responses.
基金supported by the National Natural Science Foundation of China[grant number U21A20287]the Shenzhen Science and Technology Program[grant number JCYJ20210324140205013].
文摘Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients,is becoming more and more important.However,most current US Food and Drug Administration(FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo.Consequently,new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables.They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments.This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx.We believe that this review offers additional details and directions for promoting medical imaging-based CDx development.
文摘The companion fungus ( Grifola sp.) related to sclerotial formation from hyphae of Grifola umbellata (Pers.) Pilat was isolated from the cavity associated with sclerotia of G. umbellata in natural condition. Experimental results showed that the pure culture of G. umbellata was unable to form sclerotia, whereas sclerotia produced easily in flasks or on trunks when the companion fungus was inoculated together with strain of G. umbellata. The companion fungus is critical for sclerotium formation from hyphae of G. umbellata. Morphological differences were found in cultures of the two fungi. The companion fungus possesses thin-walled narrow hyphae, while G. umbellata is of wider hyphae which are either thick- or thin-walled.
文摘[Objective]The aim was to solve the weeds existed in seedling period of alfalfa in Chongqing.[Method]The naked oat and common oat were selected.Through the analysis of determiners such as plant number,plant height,yield and weeds ratio,the oat type and sowing method were screened through all the accompany sowing crops to better control weeds in the seedling period of alfalfa.[Result]Compared with common oat,the tested naked oat as the companion crop of alfalfa seeding can prevent weeds more effectively;the proper companion-seeding disposal of alfalfa sowed in spring in Chongqing area was 15 kg/hm2 of alfalfa and 120 kg/hm2 of naked oat,sowing in strip in 40 cm row spacing;the proper mowing period of oat was during the time from May 11th to May 21st;the proper mowing period of alfalfa was ten days later.[Conclusion]Spring sowing oats with alfalfa can control seedling weeds effectively.
文摘Spectrin-like protein has been found in a variety of plant cells. In this study, electron microscopic observation of immuno-gold labelled preparations from the leaf petiole of cucumber ( Cucumis sativus L.) shows that it also exists in the sieve element-companion cell (SE-CC) complex, being widely distributed in P-protein filaments and sieve element reticulum (SER), in the cytoplasm and mitochondrial membrane of companion cell (CC) and in the branched plasmodesmata between sieve element (SE) and CC as well. The results suggest that this protein could be synthesized in CC and transferred to SE through plasmodesmata. Western blotting showed that spectrin-like protein existed in the protein of phloem exudate of cucumber, and its molecular weight was about 260 kD.
文摘Healthy relationships are important to functioning in daily life and across the life-span (e.g., Burman and Margolin 1992). Personality factors could predict relationship satisfaction through the influence of individuals' relationship schemas (Fiske and Taylor 1991) and perceptions of their partners (Simpson and Rholes 1998). Given the potential importance of attachment styles to relationship mechanisms and the well-established relationship between attachment and interpersonal behavior (Bartholomew and Horowitz 1992; Hazan and Shaver 1987), interpersonal traits may influence relationship satisfaction directly. According to Leary's (1957) interpersonal reflex theory, any interpersonal act elicits responses from the other person that verify, validate, or otherwise reinforce the actor's own self-image and self-presentation, and thus increase the probability that the actor will emit similar interpersonal acts in future interactions. The Impact Message Inventory (IMI) attempts to measure individuals' perceptions of how others impact them by evoking interpersonal acts such as dominance and affiliation. This study examined the influence of perceived partner-evoked behavior and individuals' own interpersonal styles on relationship satisfaction. This study used IMI measures of evoked Dominance and Affiliation as well as revised Liking and Loving measures to predict relationship satisfaction using three different satisfaction outcome measures. The final analyses included 291 participants (134 men and 157 women) who completed a scantron survey. Partner impact, or the interpersonal behaviors, evoked from the individual during interaction, predicted relationship satisfaction well. Evoked affiliation was the most consistently strong predictor of satisfaction across all three outcome measures. Liking (distinct here from affiliation) is a stronger predictor of relationship satisfaction than is loving (distinct here from passion), and it is significant across all three outcome measures. The liking measure appears to reflect a relatively high level of reward in the relationship and intrinsic enjoyment of the partner's company without the comparative cost of loving. Future research should examine interactions between couples, moving beyond intrapsychic self-reports of perceived experiences and feelings, although these are important in their own right.
文摘Amplification of the human epidermal growth factor receptor 2 (HER2) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. The degree of HER2 overexpression and amplification varies with the location of the carcinoma, with higher expression in the gastroesophageal and proximal parts compared to the distal parts of the stomach. Further, HER2 overexpression and amplification also seems to be related to the Lauren histological classification, with higher levels found in the intestinal phenotype compared to the diffuse and mixed types. The prognostic properties of HER2 overexpression and amplification are still under debate, but a large number of studies seem to indicate that HER2 is a negative prognostic factor. The usefulness of HER2 targeted therapy in gastric cancer was demonstrated in the ToGA trial, where HER2-positive patients with advanced gastric and gastroesophageal junction adenocarcinoma were randomized to receive 5-FU/capecitabine and cisplatin, either alone or in combination with trastuzumab. A statically significant gain in overall survival was seen in patients who received the combined treatment of trastuzumab and chemotherapy. Patients with a strong overexpression of the HER2 protein (IHC3+) specifically benefited from the treatment, with a median overall survival of 17.9 mo. As a consequence of the positive results of the ToGA trial, patients with advanced gastric or gastroesophageal junction adenocarcinoma are now routinely tested for HER2. The ToGA trial must be characterized as a landmark in the treatment of gastric cancer and it has paved the way for a number of new HER2 targeted compounds such as pertuzumab, ado-trastuzumab emtansine, lapatinib, afatinib, and dacomitinib, which are currently undergoing phase II and III clinical testing. Overall, this review will discuss the current status of HER2 in gastric and gastroesophageal junction cancer and the future direction in relation to HER2 target therapy.
文摘Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric cancer, many genetic alterations have been identified as potential targets for its treatment. Multiple novel agents are currently under development as the demand for active agents that improve the survival of gastric cancer patients constantly increases. Based on lessons from previous trials of targeted agents, it is now widely accepted that the establishment of an optimal diagnostic test to select molecularly defined patients is of equal importance to the development of active agents against targetable genetic alterations. Herein, we highlight the current status and future perspectives of companion diagnostics in the treatment of gastric cancer.
基金supported by the earmarked fund for the China Agriculture Research System (CARS-25)the National Natural Science Foundation of China (31471917)
文摘Companion cropping can influence cucumber productivity by altering soil chemical characteristics and microbial communities. However, how these alterations affect the growth of cucumber is still unknown. In this study, seven different plant species were selected as companion plants for testing their effects on cucumber productivity. The effects of different companion plants on changes in soil chemical properties such as electrical conductivity (EC) and contents of essential nutrients as well as the structure and abundance of the soil Pseudomonas community were evaluated. The results showed a higher cucumber yield in the wheat/cucumber companion system than that in the cucumber monocultured and other companion cropping systems. The lowest phosphorus (P) and potassium (K) contents in the soil were found in the cucumber monocultured system, and the highest NO3+-N and NH4*-N contents were observed in the rye/cucumber companion system. PCR-denaturing gradient gel electrophoresis (DGGE) and real-time PCR analysis showed that the trifolium/cucumber companion system increased the diversity of the soil Pseudomonas community, while the chrysanthemum/cucumber companion system increased its abundance. Interestingly, plant-soil feedback trials revealed that inoculating the soil of the wheat/cucumber companion system increased the growth of cucumber seedlings. In conclusion, the effects of different companion plants on cucumber productivity, soil chemical characteristics and the soil Pseudomonas community were different, and wheat was a more suitable companion plant for increasing cucumber productivity. In addition, the altered microbial community caused by companion cropping with wheat contributed to increased cucumber productivity.
基金The National Natural Science Foundation of China(No.11371089)the Natural Science Foundation of Jiangsu Province(No.BK20141327)+1 种基金Specialized Research Fund for the Doctoral Program of Higher Education(No.20120092110020)the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.15KJB110021)
文摘Let R be an associative ring with unity 1. The existence of the Moore-Penrose inverses of block matrices overR is investigated and the sufficient ad necessary conditions for such existence are obtained. Furthermore, the representation of the Moore-Penrose inverse of M=[0 A C B]is given under the condition of EBF - 0, where E - I - CCT and F - I -AfA. This result generalizes the representation of the Moore-Penrose inverse of the companion matrix M =[0 a In b]due to Pedro Patricio. As for applications, some examples are given to illustrate the obtained results.
基金This work was supported by the Chinese Outstanding Youth Foundation(No.69925308)Program for Changjiang Scholars and Innovative ResearchTeam in University.
文摘In this paper, solutions to the generalized Sylvester matrix equations AX -XF = BY and MXN -X = TY with A, M ∈ R^n×n, B, T ∈ Rn×r, F, N ∈ R^p×p and the matrices N, F being in companion form, are established by a singular value decomposition of a matrix with dimensions n × (n + pr). The algorithm proposed in this paper for the euqation AX - XF = BY does not require the controllability of matrix pair (A, B) and the restriction that A, F do not have common eigenvalues. Since singular value decomposition is adopted, the algorithm is numerically stable and may provide great convenience to the computation of the solution to these equations, and can perform important functions in many design problems in control systems theory.
文摘The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and element free Galerkin method(EFGM), and is a truly meshless method possessing wide prospects in engineering applications. The companion solution and all the other formulas required in the meshless local boundary integral equation for a thin plate were presented, in order to make this method apply to solve the thin plate problem.
文摘A study was conducted to describe the experiences of primiparous women with the support they received from their birth companions during labour and delivery in Malawi. The study design was descriptive and utilized qualitative data collection and analysis method on a sample of 20 primiparous women. The women were recruited from the postnatal ward of Bwaila hospital and were interviewed regarding their experiences on the support they received from their birth companions during labour and delivery using an open ended interview guide. Data was manually analyzed using content analysis. Primiparous women described the support they received from their birth companions as useful and beneficial. Birth companions provided advice, physical, emotional and spiritual support to the women during their labour and delivery. In addition, the birth companions were viewed as guardians of the women during labour and delivery. Results however, show that some women were not properly assisted by their companions because both the mothers and companions lacked knowledge on birth companionship. The results further show that birth companions play important roles during the birth and delivery of primiparous women and thereby improving birth outcomes. Therefore, there is a need to train the companions regarding support to a woman during labour and delivery. Primiparous women also need to be trained during antenatal care education so that they properly understand the roles of a birth companion as opposed to those of the midwives.
文摘We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>×<i>n</i> Fiedler companion matrix <i>C</i>, sparse companion matrices and triangular Hessenberg matrices are introduced. Then, we identify a special triangular Hessenberg matrix <i>L<sub>r</sub></i>, supposed to provide a good estimation of the roots. By application of Gershgorin’s theorems to this special matrix in case of submultiplicative matrix norms, some estimations of bounds for roots are made. The obtained bounds have been compared to known ones from the literature precisely Cauchy’s bounds, Montel’s bounds and Carmichel-Mason’s bounds. According to the starting formel of <i>L<sub>r</sub></i>, we see that the more we have coefficients closed to zero with a norm less than 1, the more the Sparse method is useful.
文摘SciM ed Ltd Companion III二通道八深度颈颅多普勒检测仪(前身为EME公司产品)内部结构主要有三大部分组成。电源部分:主机电源部分,采用单相AC 220V输入,提供DC12V和DC5V直流电源输出;二次供电部分,主要为数据采集板提供电源。电脑部分:主要采用INTEL公司的迅驰移动式Inter Pen IV CPU,低功耗工业计算机专用主板,
基金supported by the Major Program of National Nat-ural Science Foundation of China (No. 60710002) Program for Changjiang Scholars and Innovative Research Team in University
文摘A closed-form solution to the linear matrix equation AX-EXF = BY with X and Y unknown and matrix F being in a companion form is proposed, and two equivalent forms of this solution are also presented. The results provide great convenience to the computation and analysis of the solutions to this class of equations, and can perform important functions in many analysis and design problems in descriptor system theory. The results proposed here are parallel to and more general than our early work about the linear matrix equation AX-XF = BY .