Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstru...Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstruct the remaining neural network. In the motor system, such neural network remodeling is observed as a motor map reorganization. Because of its significant correlation with functional recovery, motor map reorganization has been regarded as a key phenomenon for functional recovery after stroke. Although the mechanism underlying motor map reorganization remains unclear, increasing evidence has shown a critical role for axonal remodeling in the corticospinal tract. In this study, we review previous studies investigating axonal remodeling in the corticospinal tract after stroke and discuss which mechanisms may underlie the stimulatory effect of rehabilitative training. Axonal remodeling in the corticospinal tract can be classified into three types based on the location and the original targets of corticospinal neurons, and it seems that all the surviving corticospinal neurons in both ipsilesional and contralesional hemisphere can participate in axonal remodeling and motor map reorganization. Through axonal remodeling, corticospinal neurons alter their output selectivity from a single to multiple areas to compensate for the lost function. The remodeling of the corticospinal axon is influenced by the extent of tissue destruction and promoted by various therapeutic interventions, including rehabilitative training. Although the precise molecular mechanism underlying rehabilitation-promoted axonal remodeling remains elusive, previous data suggest that rehabilitative training promotes axonal remodeling by upregulating growth-promoting and downregulating growth-inhibiting signals.展开更多
Optical transmission technologies have gone through several generations of development.Spectral efficiency has significant ly improved,and industry has begun to search for an answer to a basic question：What are the f...Optical transmission technologies have gone through several generations of development.Spectral efficiency has significant ly improved,and industry has begun to search for an answer to a basic question：What are the fundamental linear and nonlin ear signal channel limitations of the Shannon theory when there is no compensation in an optical fiber transmission system？Next-generation technologies should exceed the 100G transmis sion capability of coherent systems in order to approach the Shannon limit.Spectral efficiency first needs to be improved be fore overall transmission capability can be improved.The means to improve spectral efficiency include more complex modulation formats and channel encoding/decoding algorithms,prefiltering with multisymbol detection,optical OFDM and Ny quist WDM multicarrier technologies,and nonlinearity compen sation.With further optimization,these technologies will most likely be incorporated into beyond-100G optical transport sys tems to meet bandwidth demand.展开更多
We compared efficiencies of different PMD compensation feedback methods against transmission signal bandwidth, including NRZ, RZ, CRZ format under various duty cycles. We found that the critical factor determining the...We compared efficiencies of different PMD compensation feedback methods against transmission signal bandwidth, including NRZ, RZ, CRZ format under various duty cycles. We found that the critical factor determining the efficiency of PMD compensation is not the modulation format, but the spectral bandwidth of the transmission signal.展开更多
基金supported by the JSPSKAKENHI Grant-in-Aid for Scientific Research(B),Grant Numbers24700572 and 30614276
文摘Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstruct the remaining neural network. In the motor system, such neural network remodeling is observed as a motor map reorganization. Because of its significant correlation with functional recovery, motor map reorganization has been regarded as a key phenomenon for functional recovery after stroke. Although the mechanism underlying motor map reorganization remains unclear, increasing evidence has shown a critical role for axonal remodeling in the corticospinal tract. In this study, we review previous studies investigating axonal remodeling in the corticospinal tract after stroke and discuss which mechanisms may underlie the stimulatory effect of rehabilitative training. Axonal remodeling in the corticospinal tract can be classified into three types based on the location and the original targets of corticospinal neurons, and it seems that all the surviving corticospinal neurons in both ipsilesional and contralesional hemisphere can participate in axonal remodeling and motor map reorganization. Through axonal remodeling, corticospinal neurons alter their output selectivity from a single to multiple areas to compensate for the lost function. The remodeling of the corticospinal axon is influenced by the extent of tissue destruction and promoted by various therapeutic interventions, including rehabilitative training. Although the precise molecular mechanism underlying rehabilitation-promoted axonal remodeling remains elusive, previous data suggest that rehabilitative training promotes axonal remodeling by upregulating growth-promoting and downregulating growth-inhibiting signals.
基金supported by National High-Tech Research and Development Program of China under Grant No.2013AA010501
文摘Optical transmission technologies have gone through several generations of development.Spectral efficiency has significant ly improved,and industry has begun to search for an answer to a basic question：What are the fundamental linear and nonlin ear signal channel limitations of the Shannon theory when there is no compensation in an optical fiber transmission system？Next-generation technologies should exceed the 100G transmis sion capability of coherent systems in order to approach the Shannon limit.Spectral efficiency first needs to be improved be fore overall transmission capability can be improved.The means to improve spectral efficiency include more complex modulation formats and channel encoding/decoding algorithms,prefiltering with multisymbol detection,optical OFDM and Ny quist WDM multicarrier technologies,and nonlinearity compen sation.With further optimization,these technologies will most likely be incorporated into beyond-100G optical transport sys tems to meet bandwidth demand.
文摘We compared efficiencies of different PMD compensation feedback methods against transmission signal bandwidth, including NRZ, RZ, CRZ format under various duty cycles. We found that the critical factor determining the efficiency of PMD compensation is not the modulation format, but the spectral bandwidth of the transmission signal.
