Gyllenberg and Yan(Discrete Contin Dyn Syst Ser B 11(2):347–352,2009)presented a system in Zeeman’s class 30 of 3-dimensional Lotka-Volterra(3D LV)competitive systems to admit at least two limit cycles,one of which ...Gyllenberg and Yan(Discrete Contin Dyn Syst Ser B 11(2):347–352,2009)presented a system in Zeeman’s class 30 of 3-dimensional Lotka-Volterra(3D LV)competitive systems to admit at least two limit cycles,one of which is generated by the Hopf bifurcation and the other is obtained by the Poincaré-Bendixson theorem.Yu et al.(J Math Anal Appl 436:521–555,2016,Sect.3.4)recalculated the first Liapunov coefficient of Gyllenberg and Yan’s system to be positive,rather than negative as in Gyllenberg and Yan(2009),and pointed out that the Poincaré-Bendixson theorem is not applicable for that system.Jiang et al.(J Differ Equ 284:183–218,2021,p.213)proposed an open question:“whether Zeeman’s class 30 can be rigorously proved to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem?”This paper provides four systems in Zeeman’s class 30 to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem and gives an answer to the above question.展开更多
A delayed n-species nonautonomous Lotka-Volterra type competitive system without dominating instantaneous negative feedback is investigated. By means of a suitable Lyapunov functional, sufficient conditions are derive...A delayed n-species nonautonomous Lotka-Volterra type competitive system without dominating instantaneous negative feedback is investigated. By means of a suitable Lyapunov functional, sufficient conditions are derived for the global asymptotic stability of the positive solutions of the system. As a corollary, it is shown that the global asymptotic stability of the positive solution is maintained provided that the delayed negative feedbacks dominate other interspecific interaction effects with delays and the delays are sufficiently small.展开更多
A strongly coupled elliptic system under the homogeneous Dirichlet boundary condition denoting the steady-state system of the Lotka-Volterra two-species competitive system with cross-diffusion effects is considered. B...A strongly coupled elliptic system under the homogeneous Dirichlet boundary condition denoting the steady-state system of the Lotka-Volterra two-species competitive system with cross-diffusion effects is considered. By using the implicit function theorem and the Lyapunov- Schmidt reduction method, the existence of the positive solutions bifurcating from the trivial solution is obtained. Furthermore, the stability of the bifurcating positive solutions is also investigated by analyzing the associated characteristic equation.展开更多
A class of non-autonomous two species Lotka-Volterra competitive system with pure discrete time delays is discussed. Some sufficient conditions on the boundedness, permanence, periodic solution and global attractivity...A class of non-autonomous two species Lotka-Volterra competitive system with pure discrete time delays is discussed. Some sufficient conditions on the boundedness, permanence, periodic solution and global attractivity of the system are established by means of the comparison method and Liapunov functional.展开更多
In this paper, we consider a stochastic non-autonomous Schoener competitive system. Firstly, we prove the existence of positive periodic solution when the coefficients of Schoener competitive system satisfied certain ...In this paper, we consider a stochastic non-autonomous Schoener competitive system. Firstly, we prove the existence of positive periodic solution when the coefficients of Schoener competitive system satisfied certain conditions. Then the global attractiveness of positive periodic solution is also proved by constructing appropriate Lyapunov function. In addition, we show that the stronger noises will lead to the extinction of competitive systems.展开更多
BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating...BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating H.pylori is crucial for treating and preventing these conditions.While conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression therapies.Potassium competitive acid blocker(P-CAB)triple and dual therapy are new regimens for H.pylori eradication.Initially used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for H.pylori eradication.AIM To assess the efficacy of regimens containing P-CABs in eradicating H.pylori infection.METHODS This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating H.pylori were included.Exclusion criteria included case reports,case series,unpublished trials,or conference abstracts.Data variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and H.pylori eradication method were gathered by two independent reviewers.Meta-analysis was performed in R software,and forest plots were generated.RESULTS A total of 256 references were initially retrieved through the search command.Ultimately,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple therapy.The intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention group and 3578 in the PPI control group across these studies.The analysis revealed a significant difference in H.pylori eradication between VPZ triple therapy and PPI triple therapy in both RCTs and observational studies[risk ratio(RR)=1.17,95%confidence interval(CI):1.11-1.22,P<0.0001]and(RR=1.13,95%CI:1.09-1.17,P<0.0001],respectively.However,no significant difference was found between tegoprazan(TPZ)triple therapy and PPI triple therapy in both RCTs and observational studies(RR=1.04,95%CI:0.93-1.16,P=0.5)and(RR=1.03,95%CI:0.97-1.10,P=0.3),respectively.CONCLUSION VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H.pylori,positioning it as a highly effective first-line regimen.Additionally,TPZ-based triple therapy was non-inferior to classical PPI triple therapy.展开更多
A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isotherm...A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted.展开更多
Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerni...Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic gradient.Methods: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to climate.Likelihood methods and information theory were used to select the best model.Results: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their maximum.Conclusions: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of the target tree to competition. The modelling approach should be useful in future research to expand our knowledge of how competition modulates forest communities across environmental gradients.展开更多
The virtuality and openness of online social platforms make networks a hotbed for the rapid propagation of various rumors.In order to block the outbreak of rumor,one of the most effective containment measures is sprea...The virtuality and openness of online social platforms make networks a hotbed for the rapid propagation of various rumors.In order to block the outbreak of rumor,one of the most effective containment measures is spreading positive information to counterbalance the diffusion of rumor.The spreading mechanism of rumors and effective suppression strategies are significant and challenging research issues.Firstly,in order to simulate the dissemination of multiple types of information,we propose a competitive linear threshold model with state transition(CLTST)to describe the spreading process of rumor and anti-rumor in the same network.Subsequently,we put forward a community-based rumor blocking(CRB)algorithm based on influence maximization theory in social networks.Its crucial step is to identify a set of influential seeds that propagate anti-rumor information to other nodes,which includes community detection,selection of candidate anti-rumor seeds and generation of anti-rumor seed set.Under the CLTST model,the CRB algorithm has been compared with six state-of-the-art algorithms on nine online social networks to verify the performance.Experimental results show that the proposed model can better reflect the process of rumor propagation,and review the propagation mechanism of rumor and anti-rumor in online social networks.Moreover,the proposed CRB algorithm has better performance in weakening the rumor dissemination ability,which can select anti-rumor seeds in networks more accurately and achieve better performance in influence spread,sensitivity analysis,seeds distribution and running time.展开更多
Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and K...Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and Kardar–Parisi–Zhang(KPZ) universality classes, respectively. The linear growth systems include the EW equation and the model of random deposition with surface relaxation(RDSR), the nonlinear growth systems involve the KPZ equation and typical discrete models including ballistic deposition(BD), etching, and restricted solid on solid(RSOS). The scaling exponents are obtained in both the(1 + 1)-and(2 + 1)-dimensional competitive growth with the nonlinear growth probability p and the linear proportion 1-p. Our results show that, when p changes from 0 to 1, there exist non-trivial crossover effects from EW to KPZ universality classes based on different competitive growth rules. Furthermore, the growth rate and the porosity are also estimated within various linear and nonlinear growths of cooperation and competition.展开更多
This study focuses on the scheduling problem of unrelated parallel batch processing machines(BPM)with release times,a scenario derived from the moulding process in a foundry.In this process,a batch is initially formed...This study focuses on the scheduling problem of unrelated parallel batch processing machines(BPM)with release times,a scenario derived from the moulding process in a foundry.In this process,a batch is initially formed,placed in a sandbox,and then the sandbox is positioned on a BPM formoulding.The complexity of the scheduling problem increases due to the consideration of BPM capacity and sandbox volume.To minimize the makespan,a new cooperated imperialist competitive algorithm(CICA)is introduced.In CICA,the number of empires is not a parameter,and four empires aremaintained throughout the search process.Two types of assimilations are achieved:The strongest and weakest empires cooperate in their assimilation,while the remaining two empires,having a close normalization total cost,combine in their assimilation.A new form of imperialist competition is proposed to prevent insufficient competition,and the unique features of the problem are effectively utilized.Computational experiments are conducted across several instances,and a significant amount of experimental results show that the newstrategies of CICAare effective,indicating promising advantages for the considered BPMscheduling problems.展开更多
In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to ob...In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to obtain the existence and uniqueness exhibited by a non-negative solution of above mentioned model.A maximum principle helps to carefully verify the existence of the optimal control policy,and tangent-normal cone techniques help to obtain the optimal condition specific to control issue.展开更多
The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have appli...The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have applied analytical models to explore live-streaming strategies for firms in different scenarios.However,the previous literature mainly considers monopolists,while in the real world,competition is not rare.To fill this gap between the literature and practical observations,this paper applies a game theoretical model to study live-streaming adoption and pricing strategy for firms under competitive environments.The results show that,for competitive firms,the equilibrium strategy depends on the relation between the commission rate and the intensity of the market expansion effect.Additionally,compared to the case in which no firm adopts live-streaming,competitive firms do not always benefit from the adoption of live-streaming selling.The paper also shows that competition plays a negative role in inducing a firm to adopt live-streaming.展开更多
BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepat...BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.展开更多
This paper constructs a multiple collaborative service model of industrial competition intelligence with the main purpose of promoting the development of regional industries. The multiple service subjects include ente...This paper constructs a multiple collaborative service model of industrial competition intelligence with the main purpose of promoting the development of regional industries. The multiple service subjects include enterprises, governments, colleges and universities, scientific research institutes, industry associations and for-profit institutions. This article starts from the overall development of regional industrial economy, weighs the mutual relationship between the elements of the service model, and promotes multiple service subjects such as enterprises, governments, universities, research institutes, industry associations, and profit-making organizations to realize the collaborative service of resource intelligence, demand intelligence and data intelligence provides linkage intelligence service for the development and innovation of regional industries. This service model can improve the efficiency of industrial competitive intelligence services and the overall competitiveness of regional industries.展开更多
Wheat is one of the most important cereals in the world, serving as a staple for millions globally. In the wake of the geopolitical crisis between Russia and Ukraine, it has become incumbent for many countries to inve...Wheat is one of the most important cereals in the world, serving as a staple for millions globally. In the wake of the geopolitical crisis between Russia and Ukraine, it has become incumbent for many countries to invest in wheat production. Improving cropping systems for wheat production is paramount. Intercropping cereals with legumes has tremendous advantages. Therefore, this study was designed to optimize wheat production by intercropping it with soybean at different densities. Between March and August 2023, a randomized complete block design trial was conducted in Bambili, North West of Cameroon with treatments T1 (wheat monocrop at 200,000 plants ha<sup>−</sup><sup>1</sup>), T2 (soybean monocrop at 250,000 plants ha<sup>−</sup><sup>1</sup>), T3 (200,000 wheat and 125,000 soybean ha<sup>−</sup><sup>1</sup>), T4 (100,000 wheat and 250,000 soybean ha<sup>−</sup><sup>1</sup>), T5 (200,000 wheat and 250,000 soybean ha<sup>−</sup><sup>1</sup>) and T6 (100,000 wheat and 125,000 soybean ha<sup>−</sup><sup>1</sup>). Results revealed that growth parameters of wheat were not significantly influenced by monocrop or intercrop. The yield of wheat was significantly higher in the monocrop than the intercrop treatments, with slight variation amongst the intercrop treatments. Soybean yield was higher in the monocrop than in the intercrop, with no variations amongst the intercrop treatments. Only the land equivalence ratio (LER) for T5 was greater than 1.0. The competitive ratio for T5 was 0.54 for wheat and 1.90 for soybean, comparatively lower than the other monocrop treatments. Intercropping wheat and soybean at 200,000:250,000 ratio is recommended.展开更多
Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern Ch...Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern China from 2000 to 2018,this study explores the coupling coordination development of port and city environments and its impact on urban economic competitiveness by constructing the coupling coordination degree model and the panel threshold model.The research results show that:(1)In terms of the coupling coordination development of port and city environments,most coastal ports and their hinterland cities are in a state of moderate or serious disorder.Overall,the degree of coupling coordination of port and city environments needs to be further improved;(2)The coupling coordination degree of port and city environments has a significant impact on urban economic competitiveness,and this effect gradually increases with the development of the ports and the urban economy.Among the variables that impact the urban economic competitiveness,fixed assets investment and foreign trade are significant factors that can enhance urban economic competitiveness.(3)At present,there is a“U-shaped”relationship between the coupling coordination degree of port-city environments and the urban economic competitiveness.This relationship lies on the right side of the inflection point of the“U-shaped”curve.Therefore,following the concept of assigning priority to ecological development,expanding fixed assets investment and actively developing foreign trade can further enhance the urban economic competitiveness.展开更多
This research aimed to analyze the enhancement of competitiveness among fruit and vegetable export entrepreneurs,with the case study of the Su-ngai Kolok checkpoint in Narathiwat Province.This research focused on thre...This research aimed to analyze the enhancement of competitiveness among fruit and vegetable export entrepreneurs,with the case study of the Su-ngai Kolok checkpoint in Narathiwat Province.This research focused on three objectives:(1)examining how competitiveness is enhanced through government support and the development of border trade zones,(2)studying the supply chain dynamics,including strategic factors and opportunities in agricultural product management,and(3)developing a model for border trade to strengthen exporters’capabilities.The research employed qualitative methods,with data collected from 25 informants through interviews and employed descriptive methods.The research results revealed that:(1)government agencies play a crucial role in improving competitiveness by developing border economic zones and trade policies;additionally,(2)the research highlighted the importance of strategic partnerships,network building,and efficient logistics along the value chain;(3)the proposed Border Trade Model includes elements for instance government policy,partnerships,entrepreneurial potential,and transportation channels,aiming to enhance the overall efficiency and effectiveness of vegetable and fruit exporters in the region.展开更多
Turkish-made apparel now costs approximately 40%more than similar products from Bangladesh,a gap that was only 15-20%a few years ago.This is creating opportunities for Bangladeshi exporters to attract consumer's a...Turkish-made apparel now costs approximately 40%more than similar products from Bangladesh,a gap that was only 15-20%a few years ago.This is creating opportunities for Bangladeshi exporters to attract consumer's attention.展开更多
To improve the quality of boxing teaching in competitive sports schools,it is necessary to first analyze the strengths and weaknesses of boxing teaching in competitive sports schools,and then optimize the teaching str...To improve the quality of boxing teaching in competitive sports schools,it is necessary to first analyze the strengths and weaknesses of boxing teaching in competitive sports schools,and then optimize the teaching strategy.The strategies include innovating the boxing curriculum system and content,building learning communities inside and outside the classroom,personalizing the teaching forms and methods,using multimedia to broaden the teaching path,focusing on the integration of boxing teaching leagues,and diversifying the teaching incentives and evaluations.展开更多
基金the National Natural Science Foundation of China(NSFC)under Grant No.12171321.
文摘Gyllenberg and Yan(Discrete Contin Dyn Syst Ser B 11(2):347–352,2009)presented a system in Zeeman’s class 30 of 3-dimensional Lotka-Volterra(3D LV)competitive systems to admit at least two limit cycles,one of which is generated by the Hopf bifurcation and the other is obtained by the Poincaré-Bendixson theorem.Yu et al.(J Math Anal Appl 436:521–555,2016,Sect.3.4)recalculated the first Liapunov coefficient of Gyllenberg and Yan’s system to be positive,rather than negative as in Gyllenberg and Yan(2009),and pointed out that the Poincaré-Bendixson theorem is not applicable for that system.Jiang et al.(J Differ Equ 284:183–218,2021,p.213)proposed an open question:“whether Zeeman’s class 30 can be rigorously proved to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem?”This paper provides four systems in Zeeman’s class 30 to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem and gives an answer to the above question.
文摘A delayed n-species nonautonomous Lotka-Volterra type competitive system without dominating instantaneous negative feedback is investigated. By means of a suitable Lyapunov functional, sufficient conditions are derived for the global asymptotic stability of the positive solutions of the system. As a corollary, it is shown that the global asymptotic stability of the positive solution is maintained provided that the delayed negative feedbacks dominate other interspecific interaction effects with delays and the delays are sufficiently small.
基金Supported by the National Natural Science Foundation of China (10961017)"Qinglan" Talent Programof Lanzhou Jiaotong University (QL-05-20A)
文摘A strongly coupled elliptic system under the homogeneous Dirichlet boundary condition denoting the steady-state system of the Lotka-Volterra two-species competitive system with cross-diffusion effects is considered. By using the implicit function theorem and the Lyapunov- Schmidt reduction method, the existence of the positive solutions bifurcating from the trivial solution is obtained. Furthermore, the stability of the bifurcating positive solutions is also investigated by analyzing the associated characteristic equation.
文摘A class of non-autonomous two species Lotka-Volterra competitive system with pure discrete time delays is discussed. Some sufficient conditions on the boundedness, permanence, periodic solution and global attractivity of the system are established by means of the comparison method and Liapunov functional.
文摘In this paper, we consider a stochastic non-autonomous Schoener competitive system. Firstly, we prove the existence of positive periodic solution when the coefficients of Schoener competitive system satisfied certain conditions. Then the global attractiveness of positive periodic solution is also proved by constructing appropriate Lyapunov function. In addition, we show that the stronger noises will lead to the extinction of competitive systems.
文摘BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating H.pylori is crucial for treating and preventing these conditions.While conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression therapies.Potassium competitive acid blocker(P-CAB)triple and dual therapy are new regimens for H.pylori eradication.Initially used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for H.pylori eradication.AIM To assess the efficacy of regimens containing P-CABs in eradicating H.pylori infection.METHODS This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating H.pylori were included.Exclusion criteria included case reports,case series,unpublished trials,or conference abstracts.Data variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and H.pylori eradication method were gathered by two independent reviewers.Meta-analysis was performed in R software,and forest plots were generated.RESULTS A total of 256 references were initially retrieved through the search command.Ultimately,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple therapy.The intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention group and 3578 in the PPI control group across these studies.The analysis revealed a significant difference in H.pylori eradication between VPZ triple therapy and PPI triple therapy in both RCTs and observational studies[risk ratio(RR)=1.17,95%confidence interval(CI):1.11-1.22,P<0.0001]and(RR=1.13,95%CI:1.09-1.17,P<0.0001],respectively.However,no significant difference was found between tegoprazan(TPZ)triple therapy and PPI triple therapy in both RCTs and observational studies(RR=1.04,95%CI:0.93-1.16,P=0.5)and(RR=1.03,95%CI:0.97-1.10,P=0.3),respectively.CONCLUSION VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H.pylori,positioning it as a highly effective first-line regimen.Additionally,TPZ-based triple therapy was non-inferior to classical PPI triple therapy.
基金financially supported by the National Key R&D Program of China (No.2021YFB3700400)the National Natural Science Foundation of China (Nos.52074030,51904021,and 52174294)。
文摘A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted.
基金This publication is based upon work from COST Action CLIMO(CA15226) supported by COST (European Cooperation in Science and Technology)the UMBRACLIM project (PID2019-111781RB-I00)funded by the Spanish Ministry for Science and Innovation. Teresa Valor was contracted with a grant“Juan de la Cierva-Formaci on”(FJC2018-036673-I). Z.S. received funds from the grant no. APVV-20-0365 and from project TreeAdapt supported by the MPRV SR. Aitor Ameztegui is supported by a Serra-Húnter fellowship by the Generalitat de Catalunya。
文摘Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic gradient.Methods: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to climate.Likelihood methods and information theory were used to select the best model.Results: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their maximum.Conclusions: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of the target tree to competition. The modelling approach should be useful in future research to expand our knowledge of how competition modulates forest communities across environmental gradients.
基金supported by the National Social Science Fund of China (Grant No.23BGL270)。
文摘The virtuality and openness of online social platforms make networks a hotbed for the rapid propagation of various rumors.In order to block the outbreak of rumor,one of the most effective containment measures is spreading positive information to counterbalance the diffusion of rumor.The spreading mechanism of rumors and effective suppression strategies are significant and challenging research issues.Firstly,in order to simulate the dissemination of multiple types of information,we propose a competitive linear threshold model with state transition(CLTST)to describe the spreading process of rumor and anti-rumor in the same network.Subsequently,we put forward a community-based rumor blocking(CRB)algorithm based on influence maximization theory in social networks.Its crucial step is to identify a set of influential seeds that propagate anti-rumor information to other nodes,which includes community detection,selection of candidate anti-rumor seeds and generation of anti-rumor seed set.Under the CLTST model,the CRB algorithm has been compared with six state-of-the-art algorithms on nine online social networks to verify the performance.Experimental results show that the proposed model can better reflect the process of rumor propagation,and review the propagation mechanism of rumor and anti-rumor in online social networks.Moreover,the proposed CRB algorithm has better performance in weakening the rumor dissemination ability,which can select anti-rumor seeds in networks more accurately and achieve better performance in influence spread,sensitivity analysis,seeds distribution and running time.
基金supported by Undergraduate Training Program for Innovation and Entrepreneurship of China University of Mining and Technology (CUMT)(Grant No. 202110290059Z)Fundamental Research Funds for the Central Universities of CUMT (Grant No. 2020ZDPYMS33)。
文摘Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and Kardar–Parisi–Zhang(KPZ) universality classes, respectively. The linear growth systems include the EW equation and the model of random deposition with surface relaxation(RDSR), the nonlinear growth systems involve the KPZ equation and typical discrete models including ballistic deposition(BD), etching, and restricted solid on solid(RSOS). The scaling exponents are obtained in both the(1 + 1)-and(2 + 1)-dimensional competitive growth with the nonlinear growth probability p and the linear proportion 1-p. Our results show that, when p changes from 0 to 1, there exist non-trivial crossover effects from EW to KPZ universality classes based on different competitive growth rules. Furthermore, the growth rate and the porosity are also estimated within various linear and nonlinear growths of cooperation and competition.
基金the National Natural Science Foundation of China(Grant Number 61573264).
文摘This study focuses on the scheduling problem of unrelated parallel batch processing machines(BPM)with release times,a scenario derived from the moulding process in a foundry.In this process,a batch is initially formed,placed in a sandbox,and then the sandbox is positioned on a BPM formoulding.The complexity of the scheduling problem increases due to the consideration of BPM capacity and sandbox volume.To minimize the makespan,a new cooperated imperialist competitive algorithm(CICA)is introduced.In CICA,the number of empires is not a parameter,and four empires aremaintained throughout the search process.Two types of assimilations are achieved:The strongest and weakest empires cooperate in their assimilation,while the remaining two empires,having a close normalization total cost,combine in their assimilation.A new form of imperialist competition is proposed to prevent insufficient competition,and the unique features of the problem are effectively utilized.Computational experiments are conducted across several instances,and a significant amount of experimental results show that the newstrategies of CICAare effective,indicating promising advantages for the considered BPMscheduling problems.
基金Supported by the Natural Science Foundation of Ningxia(2023AAC03114)National Natural Science Foundation of China(72464026).
文摘In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to obtain the existence and uniqueness exhibited by a non-negative solution of above mentioned model.A maximum principle helps to carefully verify the existence of the optimal control policy,and tangent-normal cone techniques help to obtain the optimal condition specific to control issue.
基金supported by the National Natural Science Foundation of China(72171219,72201264,71921001,71801206,71971203)the Fundamental Research Funds for the Central Universities(WK2040000027)+1 种基金the New Liberal Arts Fund of USTC(FSSF-A-230104)the Four Batch Talent Programs of China.
文摘The booming live-streaming commerce has significantly changed the traditional e-commerce model,thus attracting much attention from both industry and academia.In recent years,an increasing number of scholars have applied analytical models to explore live-streaming strategies for firms in different scenarios.However,the previous literature mainly considers monopolists,while in the real world,competition is not rare.To fill this gap between the literature and practical observations,this paper applies a game theoretical model to study live-streaming adoption and pricing strategy for firms under competitive environments.The results show that,for competitive firms,the equilibrium strategy depends on the relation between the commission rate and the intensity of the market expansion effect.Additionally,compared to the case in which no firm adopts live-streaming,competitive firms do not always benefit from the adoption of live-streaming selling.The paper also shows that competition plays a negative role in inducing a firm to adopt live-streaming.
基金Supported by the Zhejiang Province Major Science and Technology Project for Medicine and Health,No.WKJ-ZJ-2329.
文摘BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.
文摘This paper constructs a multiple collaborative service model of industrial competition intelligence with the main purpose of promoting the development of regional industries. The multiple service subjects include enterprises, governments, colleges and universities, scientific research institutes, industry associations and for-profit institutions. This article starts from the overall development of regional industrial economy, weighs the mutual relationship between the elements of the service model, and promotes multiple service subjects such as enterprises, governments, universities, research institutes, industry associations, and profit-making organizations to realize the collaborative service of resource intelligence, demand intelligence and data intelligence provides linkage intelligence service for the development and innovation of regional industries. This service model can improve the efficiency of industrial competitive intelligence services and the overall competitiveness of regional industries.
文摘Wheat is one of the most important cereals in the world, serving as a staple for millions globally. In the wake of the geopolitical crisis between Russia and Ukraine, it has become incumbent for many countries to invest in wheat production. Improving cropping systems for wheat production is paramount. Intercropping cereals with legumes has tremendous advantages. Therefore, this study was designed to optimize wheat production by intercropping it with soybean at different densities. Between March and August 2023, a randomized complete block design trial was conducted in Bambili, North West of Cameroon with treatments T1 (wheat monocrop at 200,000 plants ha<sup>−</sup><sup>1</sup>), T2 (soybean monocrop at 250,000 plants ha<sup>−</sup><sup>1</sup>), T3 (200,000 wheat and 125,000 soybean ha<sup>−</sup><sup>1</sup>), T4 (100,000 wheat and 250,000 soybean ha<sup>−</sup><sup>1</sup>), T5 (200,000 wheat and 250,000 soybean ha<sup>−</sup><sup>1</sup>) and T6 (100,000 wheat and 125,000 soybean ha<sup>−</sup><sup>1</sup>). Results revealed that growth parameters of wheat were not significantly influenced by monocrop or intercrop. The yield of wheat was significantly higher in the monocrop than the intercrop treatments, with slight variation amongst the intercrop treatments. Soybean yield was higher in the monocrop than in the intercrop, with no variations amongst the intercrop treatments. Only the land equivalence ratio (LER) for T5 was greater than 1.0. The competitive ratio for T5 was 0.54 for wheat and 1.90 for soybean, comparatively lower than the other monocrop treatments. Intercropping wheat and soybean at 200,000:250,000 ratio is recommended.
基金This research is supported by Hunan Provincial Natural Science Foundation of China(Grant No.2021JJ30304)the General Topics of Hunan Social Science Achievement Evaluation Committee of China(Grant No.XSP22YBC366)the Key Scientific Research Project of Hunan Provincial Department of Education of China(Grant No.21B0592).
文摘Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern China from 2000 to 2018,this study explores the coupling coordination development of port and city environments and its impact on urban economic competitiveness by constructing the coupling coordination degree model and the panel threshold model.The research results show that:(1)In terms of the coupling coordination development of port and city environments,most coastal ports and their hinterland cities are in a state of moderate or serious disorder.Overall,the degree of coupling coordination of port and city environments needs to be further improved;(2)The coupling coordination degree of port and city environments has a significant impact on urban economic competitiveness,and this effect gradually increases with the development of the ports and the urban economy.Among the variables that impact the urban economic competitiveness,fixed assets investment and foreign trade are significant factors that can enhance urban economic competitiveness.(3)At present,there is a“U-shaped”relationship between the coupling coordination degree of port-city environments and the urban economic competitiveness.This relationship lies on the right side of the inflection point of the“U-shaped”curve.Therefore,following the concept of assigning priority to ecological development,expanding fixed assets investment and actively developing foreign trade can further enhance the urban economic competitiveness.
文摘This research aimed to analyze the enhancement of competitiveness among fruit and vegetable export entrepreneurs,with the case study of the Su-ngai Kolok checkpoint in Narathiwat Province.This research focused on three objectives:(1)examining how competitiveness is enhanced through government support and the development of border trade zones,(2)studying the supply chain dynamics,including strategic factors and opportunities in agricultural product management,and(3)developing a model for border trade to strengthen exporters’capabilities.The research employed qualitative methods,with data collected from 25 informants through interviews and employed descriptive methods.The research results revealed that:(1)government agencies play a crucial role in improving competitiveness by developing border economic zones and trade policies;additionally,(2)the research highlighted the importance of strategic partnerships,network building,and efficient logistics along the value chain;(3)the proposed Border Trade Model includes elements for instance government policy,partnerships,entrepreneurial potential,and transportation channels,aiming to enhance the overall efficiency and effectiveness of vegetable and fruit exporters in the region.
文摘Turkish-made apparel now costs approximately 40%more than similar products from Bangladesh,a gap that was only 15-20%a few years ago.This is creating opportunities for Bangladeshi exporters to attract consumer's attention.
文摘To improve the quality of boxing teaching in competitive sports schools,it is necessary to first analyze the strengths and weaknesses of boxing teaching in competitive sports schools,and then optimize the teaching strategy.The strategies include innovating the boxing curriculum system and content,building learning communities inside and outside the classroom,personalizing the teaching forms and methods,using multimedia to broaden the teaching path,focusing on the integration of boxing teaching leagues,and diversifying the teaching incentives and evaluations.